Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus. “Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.” https://www.ncbi.nlm.nih.gov/pubmed/27269431
Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.“VRP-N vaccines not only failed to protect from homologous or heterologous challenge, but resulted in enhanced immunopathology with eosinophilic infiltrates within the lungs of SARS-CoV-challenged mice. VRP-N-induced pathology presented at day 4, peaked around day 7, and persisted through day 14, and was likely mediated by cellular immune responses.” https://www.ncbi.nlm.nih.gov/pubmed/17194199
Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets “Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue.”
https://jvi.asm.org/content/78/22/12672.abstract
Animal Models for SARS and MERS coronaviruses. “The concern that is extrapolated from the FIPV vaccine experience to human SARS-CoV vaccines is whether vaccine recipients will develop more severe disease if they are exposed to or infected with SARS-CoV after neutralizing antibody titers decline. The second concern is whether recipients of a SARSCoV vaccine would be at risk of developing pulmonary immunopathology following infection with an unrelated human coronavirus e.g. 229E, OC43, HKU1 or NL63 that usually causes mild, self limited disease. Although findings from preclinical evaluation have revealed these concerns, studies in animal models may not be able to provide data to confirm or allay these concerns.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550498
https://science.sciencemag.org/content/303/5660/944.full
Lab-Made Coronavirus Triggers Debate “…a study on his team’s efforts to engineer a virus with the surface protein of the SHC014 coronavirus, found in horseshoe bats in China, and the backbone of one that causes human-like severe acute respiratory syndrome (SARS) in mice. The hybrid virus could infect human airway cells and caused disease in mice…”
https://www.the-scientist.com/news-opinion/lab-made-coronavirus-triggers-debate-34502
Certainly additional advances have been made in attempts to make Spike-protein related vaccines safer.Feel free to post additional recommended reading.
RECOMMDED RELATED:
CLEAR EVIDENCE it is NOT a Bioweapon. So What’s All This About ACE2 and nCoV-2019 (COVID-2019)?
2019-nCov Vaccine Recommended Readings
Why over the next two weeks the world will learn how bad the 2019 nCoV Coronavirus Pandemic will be
Some viruses are just really difficult to make a vaccine for, HIV, SARS…all very sad that most likely the governments are just fueling false hope, but thank you for telling it “like it is” and to the best of your knowledge.
Ignorance is not “bliss.”
“Some viruses are just really difficult to make a vaccine for”
Actually all viruses are difficult to make a vaccine because they mutate or experience antigen shift/drift. This is why the Flu shot is ineffective and the CDC admitted years ago the virus in the shots mutate. This is why Dr. Stanley Plotkins has said that measles outbreaks are being caused by Genotype B3 and D8 viruses and the Genotype A vaccine has limited ability to neutralize them:
“the circulation of new measles virus genotypes may be important. Genotypes B3 and D8 are now circulating, and these viruses are not as well neutralized by antibodies to the vaccine genotype (ie, genotype A) as by antibodies raised against the new strains”
“Is There a Correlate of Protection for Measles Vaccine”
Stanley Plotkin
Plotkin also admitted in this same paper that:
“the vaccine gives an attenuated infection,”
Maybe I’ve missed this admission in other writings on vaccines but an attenuated infection is an infection which gives creditability to what people have been saying for years: Vaccinated people are contagious.
Plotkin states that these are “new” Genotypes of viruses but Dr. Wakefield states they are mutations of the Genotype A and over vaccination is causing this. If you read the CDC’s own blog on Measles Genotypes you will see that there are 19 Genotypes. I think the only way a virus can be suitable for a vaccine is if the virus does not mutate. People should start looking at vaccines like what has happened with the overuse of antibiotics.
Drug-resistant superbugs are killing thousands of Americans. Here’s what you need to know about them.
The Centers for Disease Control and Prevention found that 2.8 million people are infected and more than 35,000 people die every year from the bugs in the U.S.-
https://www.usatoday.com/story/news/health/2019/11/15/antibiotic-resistant-superbugs-killing-thousands-what-know/4189718002/.
If you want to get an idea of how difficult it is to make a vaccine and all the inherent problems involved you should read:
“Fear Of The Invisible”
Janine Roberts
Of course vaccinated people are often contagious, it is called “viral shedding”. That is why Vaccines for things like Ebola are terrifying to me.
The USA and many other countries are full of Killer Bacteria as well. Borrealia Bergdoferi ( Multiple Strains and the western lot only tests for ONE), and Endemic Typhus which is even worse, and never went away. There were vaccines for Typhus that actually worked for the US army in WWII, the Germans sourced there Vax from Occupied Poland, and got sabotaged. The Lyme vax got pulled off the market not long ago.
In the mean time Multiple Rickettsia type plagues are killing millions in the US of A. So even when we could have protection, diagnosis and/ or proper care, that care is withheld. In fact that care ( for bacteria) should involve YEARS of antibiotic treatment.
Back to 2019 N-Cov, due to the SARS/ MERS backbone of this Virus, it appears that Mutation is not the main issue. If it was Just Mutation, then a vaccine could be made, but it would become less protective over time.
This situation is much worse. Not only is it extremely difficult to make a SARS/ MERS/ 2019 N-Cov Vaccine, but people who recover from this might die in the next outbreak! ( no protection from antibodies)
In any case thank you for the additional Information, I will try and look up what you gave me. As for Dr. Wakefield, it’s very shameful what he has been put through, But I know of worse, much worse.
Some interesting reads on addressing Cytokine Storm.
https://www.prnewswire.com/news-releases/cytosorb-the-wuhan-coronavirus-and-cytokine-storm-300994196.html
https://search.proquest.com/openview/04de2acab5e8c895b069844d98786c3f/1?pq-origsite=gscholar&cbl=39687
Thank you MSWKING
The terminal stage of viral diseases is often the onset of a cyotkine storm, the massive overproduction of cytokines by the body’s immune system. A study published in the journal In Vivo shows Curcumin blocks cytokine release, most importantly the key pro-inflammatory cytokines, interleukin- 1, interleukin-6 and tumor necrosis factor-α, monocyte chemoattractant protein-1 (MCP1) and macrophage inflammatory protein-1α (MIP1α) release from monocytes and macrophages . The suppression of cytokine release by curcumin correlates with clinical improvement in experimental models of disease conditions where a cytokine storm plays a significant role in mortality. The use of curcumin should be investigated in patients with Ebola and cytokine storm. http://iv.iiarjournals.org/content/29/1/1.full
Severe infection by 2019-nCov could result in acute respiratory distress syndrome (ARDS) and sepsis, causing death https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1.full
New research conducted by scientists at The Ohio State University showed that during a severe infection known as sepsis, a deficiency in zinc intake can cause an amplified and potentially deadly immune response. When the body detects an infection, zinc is recruited to help produce immune response proteins, and then it’s used to stop their production.
But zinc deficiency during sepsis appears to cause a catastrophic malfunctioning of the system, resulting in a amplified and prolonged inflammatory response. Zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out-of-control inflammation that can be damaging and even deadly. Zinc-deficient mice developed overwhelming inflammation in response to sepsis and were three times more likely to die than mice on a normal diet https://sha.rest/B1MK2A and https://www.sciencedaily.com/releases/2013/02/130207131344.htm . Ionic Zinc Sulfate. Zinc reduced the incidence of all infections, including respiratory infections https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854541/
Immune responses to infection and vaccination were compromised upon loss of vitamin A, and Retinoic Acid served to activate the T cells driving these responses. Vitamin A insufficiency is associated with increased mortality to common gastrointestinal and lung infections https://sha.rest/guZ1bZ Vitamin A is involved in Zinc metabolism and vice versa. Sars and Wuhan coronavirus uses human ACE2 as its host receptor. This may be of interest “These results suggest that ACE-2 may have additional lower affinity binding site(s) for zinc that interfere with its ability to metabolize its substrates.” https://sha.rest/Os5Cc0 Other important nutrients for immunity are Magnesium, Vitamin D, and Selenium. https://sha.rest/BkFeKw Vitamin C can be used as well in sepsis https://sha.rest/uXcW6l Herbal medicine treating coronavirus from greenmedinfo: https://sha.rest/MaWmHi
Thank you James for your great work . . . and Thanks also MSWKING for bringing up the concept of the cytokine storm. The cytokine storm is likewise the key to ebola’s lethality (here an interview with a virologist and immunologist): https://www.npr.org/sections/goatsandsoda/2014/08/26/342451672/how-ebola-kills-you-its-not-the-virus
Interesting paper from the PRC.
It states that the Virus can incubate for UP TO 24 days. “The median incubation period was 3.0 days (range, 0 to 24.0 days).” I suppose this is the extreme upper limit in over 1,000 patients, that is still very bad news….the 14 day quarantine is simply not sufficient. Add that to the poor test kits that return many false negatives and we have a bad situation.
It claims very low death rate ( 1.36%), but 1029 out of 1099 subjects are still in the hospital, and could still die ( or be dead right now), so that does not appear to be valid. ( see table 3)
https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1.full.pdf
Looking forward to the explanation that a “signature” from a past related virus could rule out that a different part of this current virus has been modified by Humans. @:(~)
Singapore (as of yesterday) had 47 confirmed, with 7 in ICU (critical condition) (15%). If those ICU patients are in a high stage/grade of Cytokine Storm it could be fatal. 9 patients have been cleared and released (17%). Zero dead (0%)
It is a very small sample size, but Singapore has been doing an excellent job reporting the details.
47 confirmed
7 critical = 14.7%
9 recovered = 17%
0 dead = 0%
I suggest visiting the following Singapore website that keeps up-to-date information on the situation.
Singapore statistics – including a case-by-case data
https://www.straitstimes.com/multimedia/graphics/2020/02/spore-virus-cases/index.html?menu
Updated 2/12/20
50 Confirmed
8 critical = 16%
15 recovered = 30%
Dr. Weiler, how do you think people are being tested for this new virus? Are people on cruise ships getting PCR testing? Or has some simple, RELIABLE test already been developed? I am questioning the “tested positive” numbers—having never been tested for a virus in my life. In fact, I saw on the nightly news, one woman posting something from her confinement on a cruise ship, saying that she would never have known she was sick—except that she was told she had tested positive.
Thanks!
Initially samples from lung fluids were tested using genome sequencing.
US CDC has a pcr-based test.
Unlikely that widespread testing will be implement on every case, there are too many too quickly.
Interesting use of NAC here as an anti-viral.