James Lyons-Weiler, PhD – Updated 2/28/2020
Here is a list of a few important things you may not yet know about the novel Coronavirus. There are some technical points up front; details on issues related to government action on quarantine and treatments follow.
I thank Dr. Theron Hutton, MD for leads on treatment.
- The virus is called SARS-COV-2. It is a close relative of SARS. It has a very different Spike protein from SARS, and is a different virus with a distinct disease progression. The disease caused by SARS-CoV-2 is called COVID-19 (IPAK hypothesis of original antigenic sin).
- Because SARS-CoV-2 has a distinct spike protein it is thought to engage a slightly different mechanism for cellular entry (for those up to speed, it binds less strongly to the protein ACE2 on the surface of human cells than SARS). I have found a motif pattern in the Spike protein that might be useful in determining which data from studies from various studies of SARS might be most relevant for SARS-CoV-2.
- Our best available data at this time indicates that this virus was not made in a laboratory. It most likely is an older virus related to SARS and is rare in nature and was transferred to humans either in a laboratory studying the virus or from a spillover event from someone handling an infected animal or its meat. The most likely candidate for the reservoir species is a bat.
- Infected people without symptoms can spread the virus. Infected people without symptoms can spread the virus before they start showing symptoms. The period of asymptomatic transmission is anywhere from one to two weeks – or longer.
- This virus has a basic reproduction number of about 2.6. That means typically people spread the virus to between 2 and 3 people. Superspreaders do exist. However, the lengthy asymptomatic period and multiple modes of transmission means those 2.6 people are easy for the virus to find.
- The virus is thought to spread via body fluids – and, unfortunately aerosolization – and can be found in body fluids and in feces. Masks are best saved for the infected to prevent spread, but knowing who is infected is difficult due to the prolonged asymptomatic prodromal period. It is important to know that greetings in public should no longer involve shaking hands or high-fives, hugging or kissing – even in areas of the world where SARS-CoV-2 has not yet been found. Elbow bumps are ok.
- There is no vaccine for SARS-CoV-2 , and it is extremely unlikely that a vaccine will be will play a role in ending this pandemic. This makes isolation and even mildly effective treatments incredibly important. It is best not to rush to a vaccine with the spiked protein either, because animal studies have shown that animals vaccinated and SARS with a spike protein vaccine have had a high mortality rate. Individuals who have had a past SARS or MERS infection may reasonably be expected to be at increased risk of a serious severe case of COVID-19.
- Treatments under study include nutriceuticals and supplements; Supplements that might have a positive effect, noted by colleague Dr. Theron Hutton, MD, include N- acetyl cystein, selenium, spirulina and high dose glucosamine (See “Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus” and antiviral drugs such as Disulfiram and Chloroquine Phosphate (See: “Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes“. See “Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro“. See “Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia“. Selenium and other micronutrient deficiency is considered to play a role in severity of a coronavirus infection (See: “Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases“). Glycyrrhizin, an active component of liquorice roots, has been found to have few toxic effects and to be clinically effective against SARS-associated coronavirus. (See: See “Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus“)
- The disease from SARS-CoV-2 infection has reasonably high case-fatality rate to take this outbreak seriously. If you contracted coronavirus you currently have about a 2 to 3% chance of dying. However those who die usually have some cardiovascular disease or other problems leading to lung issues. Children seem to not be at as high risk of death from SARS-CoV-2 infection. If everyone with a potential infection shows up at the hospital, it will overwhelm the healthcare system. Better to call ahead to ask if and where you should go. People at risk (with cardiovacular disease, for example) might want to think about purchasing an oxygen generator in case they develop pneumonia (under the advisement of your physician, of course).
- The best way to protect yourself and everyone else to stay away from people. While that is not feasible especially for people in the medical community it is imperative that everyone understand that they can pick up and spread the virus without having any symptoms for a long time. Don’t share food or utensils for cell phones.
- If you have coronavirus in your city or town, you may expect widespread quarantine even for those who do not have symptoms. That means sheltering-in-place in place at home. That means a bit of prepping this and next week.
- Quarantine and even partially effective treatments are really the only tools we have to shut down the spread of this Coronavirus. There are at least two potential treatment that the medical community is aware of that are at least partially effective.
- If you are quarantined you can be expected to be quarantine for 3 to 4 weeks. This means that before the coronavirus is widespread you may want to stock up on non-perishable food items and some extra water. Be sure to buy some energy drinks that can replenish your electrolytes in case you get diarrhea which can be a symptom of coronavirus infection. Food distribution systems will very likely be in place but do not count on that alone.
- While the virus has a 3% case fatality rate most people have a mild illness. However some people with a mild illness can rapidly deteriorate. The best medical support for the coronavirus infection at that time is oxygen support.
- It is possible that this virus can infect domesticated animals and pets. They are for the usual routine quotes affection with your Animal Companions and puss is probably going to be discouraged. For their own protection you may want to designate a room in your house for your pet for animal companion to minimize exposure and to prevent your pet from infecting other family members. When you stock up on food for your household don’t forget to stock up on pet food.
- There is still time to reduce the rate of spread of this virus substantially by adhering to proactive social isolation practices and self-quarantine whenever possible. Employers should encourage employees to work from home if possible.
- If you are caught in a situation where you’re in a hotel or other buildings that is quarantined because someone in the building has come down with a diagnosis of coronavirus do not break the quarantine. Each person quarantined in any building should be isolated – and remain isolated – as much as possible. If feasible, each person in the building should have their own toilet.
- All public spaces should be sanitized by staff members once or twice an hour with lease space disinfectant or with disinfectant that are known to kill coronavirus. The virus likely can last nine days on surfaces without disinfectant. Check the label of your cleaning products label to see if it lists Coronavirus (see #20 for specifical details on disinfectants).
- In end-stage COVID-19, oxygen support is essential. Pairing non-medical sources of oxygen (industrial, e.g, welding) with medical oxygen masks in the homes of those at highest risk of death may help prolong the life of those at risk. Hyperbaric oxygen therapy will certainly aid those with low oxygen levels. Individuals around the world should stop smoking cigarettes and using inhaled products known to cause lung damage such as vaping.
- Some of the best disinfectants are likly Oxivir TB and Lysol Disinfecting, both of which are claimed to kill the virus on a surface after two minutes. See: “Emerging Viral Pathogen Guidance for Antimicrobial Pesticides” See: Read: CORONAVIRUS – WHAT YOU NEED TO KNOW (Arrow Chemical Products). Check the label of the wipes you purchase to be sure its reads “Kills Coronavirus”.
- In-home testing kits are needed.
Additional treatments suggested by readers with example references:
PDE- 5 inhibitor
Where Do We Go From Here?
The governments and people of the world have a stark choice to make – short-term (3-4 week) harsh quarantine and experimental treatments now with antivirals to whatever percentage of the population we can get them to, or prolonged outbreak and cycles of disruption that will last ito an interdeterminantly long future throughout the world.
If it’s not apparent why this is so, watch this video in which I model the outbreak, the effects of what I call Social Isolation, and even moderately effective treatment. Below the video are three files with some information on preparing your home for extended self-quarantine.
this is our program for the next, future life.
thank you and good luck to all !
Important new finding:
Bulk and single-cell transcriptomics identify tobacco-use disparity in lung gene expression of ACE2, the receptor of 2019-nCov
* “We didn’t find significant disparities in ACE2 gene expression between racial groups (Asian vs Caucasian), age groups (>60 vs https://www.nature.com/articles/nature11228
“Our results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis.”
Clinical studies show that vitamin C is very effective in treatment of Covid-19. http://orthomolecular.org/resources/omns/v16n11.shtml
Vitamin C is effective in treatment of Covid-19. orthomolecular.org/resources/omns/v16n11.shtml
how about the pShuttle that was mentioned before as an indicator of a virus being tampered before? Has it been refuted?
“We also show biophysical and structural evidence that the 2019-nCoV (now SARS-Cov-2) S binds [HUMAN] ACE2 with [10 – 20 fold} HIGHER AFFINITY than SARS-CoV S.
Additionally, we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to 2019-nCoV S, suggesting antibody cross-reactivity may be limited between the two RBDs. The structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis.”
1) Why do YOU assert that the binding capacity to ACE-2 is LOWER than SARS-Cov-S?
2) And what about the “unusual …insertion sequences” similiar to gp-120 from HIV (which is NOT a natural virus)
“Pradhan and colleagues described 4 unusual SARS-CoV-2 Spike protein insertion sequences that are discontinuous in the amino acid sequence but are thought to converge at the RBD. Alignments showed that they are not present in any other coronavirus strains but show identity/similarity with sequences in HIV-1 gp120 and Gag, the former of which is also a cellular receptor recognition protein . The authors speculate that these insertions confer additional flexibility to the RBD by forming a hydrophilic loop that mediates virus-host interaction with greater infectivity. they note that their presence is “unlikely to be fortuitous in nature”. …
3) I find the “zoonotic transmission” story not very credible. Why would a virus (adapted to specific bats for centuries) suddenly “jump species”? And how many people come into contact with bats these days? Bats do hybernate (even Chinese ones) in winter, so why would the virus “break out” now? (MERS: Where do bats and camels meet???) The latest nonsense: Beware Turtles!
Besides, we know that hundreds of (ill-guided) scientists have succeeded in “gain-of-function” re-recombination research (increasing viral pathogenicity and/or infectivity)
” WIV-1 COV poised for human emergence” (PNAS Vol 113)
“The research team worked with both full length and chimeric versions of WIV1-CoV. The virus readily and efficiently replicated in cultured human airway tissues..”
These animal viruses are not “poised” at all to “jump” to humans. The bitter truth is that in most cases they are genetically engineered to “augment replication” in human cells. Then this “emerging threat” justifies appeals for more research money to find a costly therapy for the manufactured threat … it is insane and highly immoral …
The mouse-pox disaster is another case for alarm:
At least the involved scientists drew important conclusions (but the madness goes on…):
Ramshaw: “It’s not only public perception but scientific perception as well. Because such a virus would NOT BE RECOVERABLE e once you’ve released it, I wouldn’t personally allow it to be released if I had that kind of authority. When you release a virus into an environment you don’t know what will happen. You don’t know what other animals will be infected. You don’t know whether the genes will be incorporated in other viruses, whether somehow the virus will infect humans. The unknowns are too great to take a chance”.
“… There are many experiments that raise dual-use issues and unless you are—like me now—looking for them, you don’t recognize them. Most people wouldn’t know a dual-use issue if it was in front of them. We know that the myxoma virus only affects rabbits. We know WHY it doesn’t infect HUMANS So we now know HOW TO CONVERT THAT VIRUS into one that DOES INFECT HUIMANS…. Studies like those are being published all the time and probably not even being recognized as a dual-use issue.”
Genes are not “building-blocks” to be cut out, inserted and re-arranged at will .. it is this mechanistic (stupid) view of biology in a profit-driven (insane) economic environment that is the root-problem here…
One more anti-viral not mentioned: MMS (chlorine dioxide) protocol for corona virus is 6 drops MMS activated for 20-30 seconds with 6 drops 5%hcl, add 6 oz. water and drink. Do this every 2 hours for 4-5 times a day. One day should do it, but it can be done a second or third day. I got my info from genesis2church.ch. They also have MMS supplies.
This is basically chemo. Chemo is not indicated for infectious disease. Although the cancer field makes use of it, infectious disease fields have not. AIDS researchers considered it, but abandonded the idea due to high cytotoxicity (toxicity to healthy cells). It is extremely important to understand that pathogenic viruses cause morbidity and mortality via oxidative stress. They provoke a cytokine storm, wherein the patient’s own immune system launches a kamikaze attack without regard for preserving host tissue. This is true in ebola as well as the MERS and SARS viruses. While there is certainly a place for valid anti-virals that directly kill the virus, a large part of therapy for highly pathogenic viruses is supportive care aimed at lowering the inflammation that can cause lethal tissue and organ damage. Powerful antioxidants are in order (NAC, glutathione, CoQ10, PQQ, quercetin, curcumin, C, A, E, selenium to name a few). Adding a cytotoxic molecule such as chlorine dioxide is like pouring gasoline on a fire.
Good list of antioxidants. I would add bromelain (pineapple extract) which works with quercetin. Also, occasional use of herbal supplements like Goldenseal, Olive Leaf, and Oregano Oil (softgels) helps fight infection. Some experts have recommended higher doses of Vitamin D for covid-19, along with the C, A and E.
KAR: Thanks for mentioning bromelain. It’s a proteolytic (‘protein-digesting’) enzyme from the core of pineapples. Another one is papain from papayas. Of course animals, fungi and bacteria make their own proteolytic enzymes as well, and all have anti-inflammatory properties. Significantly, they are ‘fibrinolytic’ (they digest fibrin). Fibrin is a protein contained in scar tissue, mucus, fibrotic tissue, thromboses (blood clots) and even biofilms which microbes use as a shield. NOT medical advice, but clearly anything that is fibrinolytic, such as proteolytic enzymes taken on an empty stomach, has potentially very far-reaching health benefits. There is a ton of scientific research on systemic enzyme therapy, but it may not ever filter down to American clinical practice as it has in countries like Germany and Japan.
Results revealed that the BetaCoV/bat/Yunnan/RaTG13/2013 virus was more similar to the SARS-CoV-2 virus than the coronavirus obtained from the two pangolin samples (SRR10168377 and SRR10168378). We also identified a unique peptide (PRRA) insertion in the human SARS-CoV-2 virus, which may be involved in the proteolytic cleavage of the spike protein by cellular proteases, and thus could impact host range and transmissibility. Interestingly, the coronavirus carried by pangolins did not have the RRAR motif. Therefore, we concluded that the human SARS-CoV-2 virus, which is responsible for the recent outbreak of COVID-19, did not come directly from pangolins. However, due to the limited viral metagenomic data obtained from pangolins, we cannot exclude that other pangolins from China may contain coronaviruses that exhibit greater similarity to the SARS-CoV-2 virus.https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25731 The interaction between the key amino acids of S protein RBD and ACE2 indicated that like previous suggested pangolins and snakes,the turtles (C. picta bellii, C. mydas, and P. sinensis) may act as the potential intermediate hosts transmitting SARS‐CoV‐2 to human, https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25726
Mystery deepens over animal source of coronavirus https://www.nature.com/articles/d41586-020-00548-w
I am lost as to what this doctor is talking about. Could Dr. Weiler shed so light on it:
Eugene Gu, MD
The coronavirus is an enveloped virus—meaning it has an outer membrane made of oil and fat that it steals from our own cells by pinching off a piece of our cell membranes in a process called viral shedding. It allows the virus to evade our immune system but there’s a trade off.
11:48 AM · Mar 2, 2020
Eugene Gu, MD
All enveloped viruses like the coronavirus are extremely susceptible to simple soaps and detergents of any kind. That’s because soap literally explodes the outer membranes of these viruses. Without the envelope, they can’t invade our cells or cause any harm. They just simply die.
Eugene Gu, MD
So while alcohol-based hand sanitizers are effective at killing the coronavirus on our hands, and should be used at every opportunity, nothing can replace the gold standard of washing our hands with good old fashioned soap and water, which also physically removes dirt and debris.
I understand using hand sanitizers, soap & water. That’s just common sense hygiene but what is this envelope virus thing? I’ve never heard of it.
Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future. 500mg of cloroquine per day during 10 days brings a spectacular improvement. jstage.jst.go.jp/article/bst/advpub/0/advpub_2020.01047/_article
in china, We found substantial gender differences in dietary zinc intake and zinc deficiency, with nearly half of the men at risk of zinc deficiency. Males of younger age, with higher education and incomes, and who consumed higher levels of meat, had higher zinc intakes, higher zinc intake densities, and higher rates of meeting the EAR. Among all participants, 31.0% were at risk of zinc deficiency, with dietary zinc intakes of less than the Estimated Average Requirement (EAR) (males 49.2%, females 14.8%, p < 0.050) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986452/
Positive-stranded RNA (+RNA) viruses include many important pathogens. They have evolved a variety of replication strategies, but are unified in the fact that an RNA-dependent RNA polymerase (RdRp) functions as the core enzyme of their RNA-synthesizing machinery. Given their crucial function in the viral replicative cycle, RdRps are key targets for antiviral research. Increased intracellular Zinc concentrations are known to efficiently impair replication of a number of RNA viruses, such as by interfering with correct proteolytic processing of viral polyproteins. Here, we not only show that coronavirus and arterivirus replication can be inhibited by increased Zn2+ levels, but also use both isolated replication complexes and purified recombinant RdRps to demonstrate that this effect may be based on direct inhibition of nidovirus RNA-dependent RNA polymerase (RdRps). Zinc efficiently inhibits the RNA-synthesizing activity of both viruses. More specifically, Zn2+ was found to block the initiation step of EAV RNA synthesis, whereas in the case of the SARS-CoV RdRp elongation was inhibited and template binding reduced. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176
Research conducted by scientists at The Ohio State University showed Zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out-of-control inflammation that can be damaging and even deadly. Zinc-deficient mice developed overwhelming inflammation in response to sepsis and were three times more likely to die than mice on a normal diet https://www.sciencedaily.com/releases/2014/07/140715084928.htm and https://www.sciencedaily.com/releases/2013/02/130207131344.htm
Approximately 87% of adults consumed less vitamin A than the Chinese Estimated Average Requirement (EAR), and only 6% of adults consumed more than Chinese Recommended Nutrient Intake (RNI). Chinese adults derived vitamin A mainly from plant source foods, which is supplied as carotenes (67.4% RE or 56.4% RAE). https://nutritionj.biomedcentral.com/articles/10.1186/s12937-018-0369-3 Converting beta carotene to vitamin A is also extremely variable and estimated that almost half of everyone have variants the BCMO1 gene which cause a 30-70% decrease in the amount of vitamin A that we can convert from beta-carotene. Vitamin A insufficiency is associated with increased mortality to lung infections and immune responses to infection were compromised upon loss of Vitamin A. https://www.medicalnewstoday.com/articles/219513#1 Research shows changes in vitamin A intake have effects on Zinc absorption status, and function while Zinc status influences several aspects of vitamin A metabolism, including its absorption, transport, and utilization including conversion to retinoic acid metabolites.
Stinging Nettle Root may Inhibit coronavirus replication. These data suggested that UDA likely inhibits SARS-CoV infection by targeting early stages of the replication cycle, namely, absorption or penetration. In addition, we demonstrated that UDA neutralizes the virus infectivity, presumably by binding to the SARS-CoV spike (S) glycoprotein https://www.sciencedirect.com/science/article/pii/S0166354211000313?via%3Dihub
Adding onto the previous comment by David about Chloroquine, a treatment drug for malaria this:
“It would be a medical mistake not to give chloroquine against the Chinese virus”, according to Professor Didier Raoult
Professor Didier Raoult in his office in February 2020 – Gérard Julien / AFP
Chinese scientists say in a publication that treatment for malaria can cure coronavirus.
Based on this study, teams from the Mediterranean Infection Institute in Marseille are now planning to use chloroquine to treat the disease.
For its director, Didier Raoult, the reservations expressed by certain colleagues are irrelevant.
A small tablet, known for decades, to treat an as yet unknown epidemic. According to several Chinese scientists, chloroquine, a widely available and inexpensive molecule commonly used to treat malaria, is an effective remedy to cure one of the diseases that cause the most fear today:
In Marseille, the Mediterranean Infection Institute (IHU), a unique reference center in France for the treatment of infectious diseases including Covid-19, has therefore decided to order a stock of chloroquine, with a view to treating ‘possible future Chinese coronavirus patients.
“Coronavirus: Endgame! “Headlines the IHU on its website in an article on the benefits of chloroquine. Professor Didier Raoult, director of the IHU and somewhat annoyed by the reservations, criticisms and other comments raised by this decision, explains to 20 minutes this choice.
Can you explain what chloroquine is?
It is a very old medicine. It is probably the most widely used drug with aspirin in human history. Young people do not know it because they did not know it as an antimalarial. People who lived in Africa like me took chloroquine every day. All the people who went to these hot countries took it during their whole stay, and every day for the two months after their return. There are billions of people who have taken this drug. And it costs nothing: ten cents per tablet. It is a drug that is extremely safe and the cheapest that you can imagine. So this is great news! Everyone who knows about these benefits should take it upon themselves.
Some scientists are less enthusiastic than you about the benefits of chloroquine against the coronavirus, like Professor Astrid Vabret in “Sciences and Future” …
Everyone’s gossip, I don’t care. It does not interest me.
My job has been infectious diseases for forty years. I feel compelled, because I believe that it is now necessary, to communicate what I know, and not opinions, on research in infectious disease. After what you do with it, I’m not a prophet. I do not care. I’m trying to be as clear as possible. When we showed that a drug worked on a hundred people while everyone is having a nervous breakdown, and that there are noodles who say that we are not sure that it works , it does not interest me !
Are you going to use chloroquine at the IHU to treat coronavirus?
Chinese scientists are very serious people. They are not zozos, and they have shown that chloroquine works. It would honestly be a medical mistake not to give chloroquine to the Chinese coronavirus. It does not make sense. Be serious. Tomorrow you start to be short of breath. You have a Chinese coronavirus and you have 40 fever. And people tell you, “You know, I don’t believe in chloroquine against Chinese coronavirus.”
What are you doing ?
At the IHU, we are going to set up a therapeutic protocol. We want to take care of the sick. There are people who come in with a serious illness, and it has been shown that the only treatment for this illness is chloroquine. So, to not give chloroquine, you have to be stuffed! So we are going to warn the minister to tell him that if the people who arrive have a Chinese coronavirus, we will treat them with chloroquine because it is the only treatment that we have been shown to work. That’s all ! It’s not mysterious, it’s medicine, not television gossip!
— Ultraviolet Light Blood Therapy in combination with Ozone Blood Therapy —
This is likely the most effective COVID-19 treatment, as it addresses viruses, including HIV and Ebola.
Cost for the patient is around $300 and takes one hour.
I can tell you personal anecdotes.
See how it took care of my viral pneumonia in 24 hours.
Be sure to read above and below the comment, and follow some of the resource links.
I have a friend who had seen specialists for 7 years to fix a bacterial infection within her hip and leg.
They couldn’t get rid of the infection.
A few weeks prior to her scheduled surgery to amputate a foot, she had one treatment of “Ultraviolet Light Blood Therapy in combination with Ozone Blood Therapy “.
She went in for the scheduled amputation, but before surgery ran tests. They could find no infection. It saved her foot.
This is a great anti-aging protocol.
See Tom Lowe’s YouTube Channel for great information about Ultraviolet Light Blood Therapy, also known as BioPhotonic Therapy or UBI.
Read about it here…
Be sure to click the links provided on the right side of the webpage.
Dr. Robert Rowen has a wealth of first-hand information with his experience in utilizing the treatment of ozone blood therapy. He ‘cured’ Ebola cases. He is easy to search, both YouTube and articles.
See how Dentists and Veterinarians and Medical Doctors use this simple health protocol…
SCROLL to the BOTTOM of the webpage “Dallas For Safer Water .com / News & Activism”
(By the way, a wealth of information about Aluminium is on that webpage.)
— Ultraviolet Light Blood Therapy (UBI or BioPhotonic Therapy) in combination with Ozone Blood Therapy —
I’m really trying to figure out the truth from fiction. In a recent interview you mentioned that reinfection or vaccination for SARS can cause sever responses or high mortality rates. I may be reading this wrong but this published article seems to go against that. Would you please respond https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454321/?fbclid=IwAR0BGZ-zLmUUQI5HLvkr9J2nVpGcuxszJOy6y6kgXyc8Bog2toMW6TjODgs
The conclusions of the study you posted is contradicted by the studies of actual health outcomes. The authors wrote
“One caveat, due to the large nature of our study, was the absence of an Alum control only group and it would be important in the future to investigate the genes regulated by Alum treatment alone.”
These will help clarify.
Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus. “Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.” https://www.ncbi.nlm.nih.gov/pubmed/27269431
Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.“VRP-N vaccines not only failed to protect from homologous or heterologous challenge, but resulted in enhanced immunopathology with eosinophilic infiltrates within the lungs of SARS-CoV-challenged mice. VRP-N-induced pathology presented at day 4, peaked around day 7, and persisted through day 14, and was likely mediated by cellular immune responses.” https://www.ncbi.nlm.nih.gov/pubmed/17194199
Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets “Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue.”
Lab-Made Coronavirus Triggers Debate “…a study on his team’s efforts to engineer a virus with the surface protein of the SHC014 coronavirus, found in horseshoe bats in China, and the backbone of one that causes human-like severe acute respiratory syndrome (SARS) in mice. The hybrid virus could infect human airway cells and caused disease in mice…”
Thank you so much for your response. This is very helpful.
Hello, this article from February seem to state that the virus came from animals to man! But reading more updated articles it seem to state that it after all might have been created in a level 4 lab? Where can I read your absolute latest articles on SARS-CoV-2 origins?! It seems to me that this yet to be 100 % uncovered as of today Mars 15 2020?!
“lab escape” can still mean from animals..
There is no evidence of human modification of the virus.
I see, and is there a way for you to find out if this was Man-made by the Wuhan level 4 lab epicenter or if it 100% is and was a natural virus in an animal!? can the protein spikes help give understanding what the origin of the SARS-coV-2 really is!? Could a wild animal have had this virus or was it infected due to the side effects of a vaccine tested on the animal that first set this off? lot of small questions… hope is ok, thanks 🙂
Hello Dr. Weiler
I run a blog called THE FED UP DEMOCRAT. I met you briefly at the GREAT HARLEM VACCINE DEBATE.
I have a question regarding the validity of the tests being used to identify that an individual actually has the coronavirus.
All of the testing that has been discussed seems to be PCR analysis. As I believe you are aware the inventor of PCR – Dr. Kary Mulis, who won the Nobel Prize for his invention – maintains that PCR can *not* be used to isolate a virus.
Recently Dr. Larry Palevsky posted that a team in Canada has announced they just isolated the COVID-19 virus using isolation. Palevsky said this is – to his knowledge – the first time this virus has been properly isolated.
Can you shed any light on this?
I know you have analyzed a large amount of the science that is available on this issue. You have written about the gene-sequencing and a “spike protein” that the novel coronavirus contains. Was this analysis done from samples that were obtained through traditional isolation, or was it all via PCR techniques. If it was through all PCR, can you explain why those methods of obtaining a virus sample should be considered valid in light of what Dr. Mulis, and many others, often say about PCR’s limitations when purporting to “isolate” a virus?
Thank you for all of your great work!
FED UP DEM
PCR can be used to amplify RNA viruses via a process called reverse transcription. The problem I identified w/the CDC test -and both the CDC and the FDA have been notified – is off-target amplification by 1/4 of their probe sets. Some of their probe set pairs it appears might be amplifying human genes – leading to potential false NEGATIVES as that reaction could consume the resources needed to amplify the viral target sequences.
Viruses are isolated all of the time. Look in to electron microscopic studies of structure of viral proteins. Here’s an example: https://www.ncbi.nlm.nih.gov/pubmed/27807242