After Threatening Forcible Removal of the Public from the Allegheny County Courthouse, a Deaf, Blind, and Dumb Allegheny County Board of Health Votes for a Non-Binding HPV Vaccine Recommendation

After Threatening Forcible Removal of the Public from the Allegheny County Courthouse, a Deaf, Blind, and Dumb Allegheny County Board of Health Votes for a Non-Binding HPV Vaccine Recommendation

TODAY was another kangaroo session in the Allegheny County Board of Health in a meeting in which parents informed the Board of Health on the realities of the risk of widespread HPV vaccination. On … but not on… the agenda today was and “Vaccines”. I had tried to register for public comment on both “Vaccines” and “HPV Vaccine”, but was misinformed by Dr. Karen Hacker’s office that “HPV Vaccine” and “Vaccines” were the same agenda item.

During the public comment period, numerous parents stepped up to the microphone for their three minute opporunity to inform the Allegheny County Board of Health of both the realties of risk associated with HPV vaccination in terms of human morbidity and mortality, such as the death of Chris Tarsell, teens who had been paralyzed and who are now dead.

Many parents correctly schooled the Allegheny County Board of Health that no HPV vaccine safety study used a saline placebo; that the vaccine was rushed to market under FDA’s fast-track mechanism; that the number of HPV-related deaths in the US continues to rise as government pushes the vaccine on more people. There was at least one parent there who was afraid to speak for fear of employment consequences. I provided public comments that informed Allegheny County Board of Health of the sorry state of HPV vaccine safety science (my bullet point comments provided in italics below). The public schooled the Allegheny County Board of Health on the realities that Japan refused to recommend the HPV vaccine for their citizens.

About an hour earlier, I had pulled into a parking lot across the street from the Allegheny County Court House, a box of 20 books under my arm. I spotted the local CBS news station KDKA van and a KDKA car. The occupants of both cars were given copies of “HPV Vaccine On Trial” before I entered the courthouse. I had even sent every member of the Allegheny County Board of Health their own copies of “HPV Vaccine on Trial” with assurance from the USPS that they would arrive by noon – today.

ACHCBOOKS

What transpired in the Courthouse was an outrageous abuse of power. The Allegheny County Board of Health had previously considered mandating the HPV Vaccine for school attendence in Allegheny County – but due to a large showing of parents who were much, much more informed that the medical doctors who had offered public comment, and due to my questioning on whether their pending vote required open public comment period – they had tabled the issue to committee. They even tried to sneak in a vote on a recommendation – without open public comments – and were called out on that, too.

But things were different this time.

Not a single member of the public stood up and spoke in favor of the HPV vaccine.

The Board heard an inaccurate report from Dr. Kristen Mertz, who claimed, among other things, that while moral and philosophical exemptions rates are showing a slight increase in Allegheny County, it is not as bad in Allegheny County as it is in California (there are no moral and philosophical exemptions allowed in California). Mertz reported that HPV vaccine is not required for school attendence, and on HPV vaccine reporting rates by nurses in schools… yes, you read that correctly, the Allegheny County Board of Health has been collecting vaccination statistics on students for a non-mandated vaccine – from school employees (nurses) – using our taxpayer dollars and time to track the uptake of a 100% optional vaccine. Why is anyone tracking that particular medical option? What about rates of autism, ADHD, allergey, rheumatoid arthritis, anxiety, depression, teen suicides, demyelinating disorders, POTS, PANS,, MMF, ASIA and a slew of other conditions that might be caused by aluminum-containing vaccines?

Suddenly, off Agenda, the Board then began discussions about a motion to make a recommendation for HPV vaccination.

The chair, Lee Harrison, handed out a packet and called for a motion

Harrison: “You also have in your packet a resolution on HPV Vaccine, I’m not going to read the entire thing, I’m just going to read the bottom line, which says “Now, therefore be it resolved hereby recommends that any child, in any county, unless otherwise counseled by their physician, receive the HPV vaccine according to the following ACIP recommendation (motioning for a guard to come into the court room)

So when folks are ready, um…

Caroline, did you join in (to the telephone…)

So, Board member Caroline Mitchell has also joined me, thanks for calling in…”

(One Board member speaking, away from the microphone, about having time to read the motion)…

Harrison: “So when folks are ready…”

Harrison: “If I could hear a motion, that would be great…”

(Karen Hacker inaudibly mouthing words to another Board member to the left of Harrison, away from the mic…)

Harrison: “Yeah, right, so we talked about this before, this is not a binding resolution, this is a (waving his hand) recommendation of the board, this is non-binding, this is not a regulation… this is just a resolution from the board… we talked about a recommendation…”

Other board member: (inaudible)

Harrison:“Well, I, I…” (interrupted by The Public)

The Public: “Could you turn your mic up please, I can’t hear you”.

Other board member: “Sorry” (moves microphone into place)

Harrison:The idea is to, is to vote on it as a resolution of the Board of Health.”

Other board member: “Oh, that’s easy.”

Other board member “I’d like to proposal a resolution… to… accept… this (inaudible).”

Harrison: “Second?”

Someone: “Yes, I second.”

The Public: “Point of order question?”

Harrison: “I’m sorry, this is not an interactive session”

Hacker (speaking at the the same time, to The Public: (inaudible)

Harrison (turning to the other board member): “Any… other…”

The Public: “I’m sorry, a point of order question?”

Hacker (motioning to the guard, inaudible)

ABUSEOFPOWER
Allegheny County Board of Health Member Karen Hacker motions to the guard to come into the courtroom at the moment The Public requested information on a point of order on the process.

Harrison: (speaking, inaudible)

The Public: “I have a question on a point of order, please.”

Hacker: “This is not an open session, please sit down (motioning toward the guard) or we will have you removed.”

The Public: “You are pre-judging the question that I have on a point of order”.

Hacker: “This is not a question and answer period.”

The Public: “Is the public not entitled to…”

Hacker: “This is not a question and answer period.”

The Public: “Is the public not entitled to unlim…”

Hacker: “This is not a question and answer period.”

The Public: “Is the public allowed to comment, with unlimited time, on motions put to vote by the Board?”

Hacker: This is not a question and answer period.”

Harrison: “Please sit down…”

Hacker: “Please sit down, or we will have to ask you to leave.”

Harrison: (Addressing the other board member): “Any other comments? Additional
comments before we vote?”

Harrison: Ok…” (Proceeds with the vote) (see video below my comments).

Ignoring all of the information provided by the parents, and provided by a scientist (read below), the motion passed, and the Allegheny County Board of Health refused to hear public comment about a vote on a non-agenda item that had obviously been prepared beforehand, presumable by Dr. Harrison, who provided the rest of the board with “the packet”.

Yes, you have it right. The Allegheny County Board of Health had to threaten The Public with physical removal from the Allegheny Courthouse for its desire to discuss HPV Vaccine benefits and risks before they passed a non-binding resolution that the Allegheny County Board of Health recommends the HPV vaccine.

My arrest would have been binding. Over discussion of a resolutions for a recommendation that is non-binding. Watch for the next chapter in the continuing saga of how The Allegheny County Board of Health is building public trust in the HPV vaccine.

FULL COMMENTS OF DR. JAMES LYONS-WEILER, PHD

  • When the original Gardasil vaccine (Gardisil-4) was being tested, there was no existing HPV vaccine.
  • Therefore, there should have been saline placebo studIES for safety.
  • Instead, the prospective safety trial used Amorphous Aluminum HYDROXYPHOSPHATE SULFATE as a placebo.
  • It has recently come to light that the one true safety study [WHICH ALSO DID NOT HAVE SALINE PLACEBO AND WAS WAS WOEFULLY UNDERPOWERED] INCLUDING THE 11-12 YEAR OLD TARGET AGE GROUP used ½ of the Aluminum-CONTAINING ADJUVANT in the vaccine formulation compared to the product THEN brought to market for teen girls.
  • In the Gardasil-9 trials, the placebo used was Gardasil-4, meaning the current HPV vaccine has MORE THAN 4 times the aluminum-CONTAINING ADJUVANT used in the only PURPORTED CONTROLLED TRIAL FOR THE TARGET 11-12YO AGE GROUP trial, and no HPV vaccine on the market in the US has been tested against a valid placebo.
  • In filings to the FDA (VRBPAC Background Document, Tables 17 and 18), Merck reported studies that found NEGATIVE EFFICACY of HPV vaccination for women over 26 – RELATED TO HPV INFECTION. This means INCREASED risk of CIN 2+ if they had an existing HPV infection.
  • Gardasil-9 targets the 9 most prevalent types of HPV that cause neoplasms in humans.
  • There are >100 other HPVs that the vaccine does not clear; at least 12-18 TYPES ARE CURRENTLY THOUGHT TO BE ONCOGENIC.
  • Many studies, including the CDC’s own data, show increases in non-vaccine targeted types following HPV vaccination.
  • Rarer viruses are rare because they are more virulent (higher morbidity and mortality)
  • This means that rarer, potentially more lethal HPV types can be expected to increase and spread throughout the population, possibility leading to INCREASED rates of HPV-related cancers.
  • Studies that fail to detect type replacement do so as a result of their study design or design of analysis, not because type replacement does not occur.
  • We are experiencing a CRISIS in vaccine safety science in general.
  • We have an epidemic of HPV-vaccine related serious adverse events reporting, so much so that annual HPV vaccine-related serious adverse events outnumber the total number of all serious adverse events reported for all other vaccines combined.
  • Some countries, like Japan, look at the entire picture and have refused to recommend HPV vaccine for their population.
  • Before any vote on any mandate of HPV or any other vaccine, I would like to reserve an unlimited amount of time AS ALLOWED UNDER THE LAW to discuss the actual state of knowledge of the safety and efficacy of this vaccine.
  • MEDICAL DOCTORS TELL THEIR PATIENTS THAT HPV VACCINE PROTECTS THEM FROM HPV INFECTION. THIS IS NOT TRUE. THE US NOW HAS THE HIGHEST RATE OF VENEREAL DISEASE INFECTION AMONG INDUSTRIALIZED COUNTRIES.
  • Allegheny County Board of Health and MEDICAL DOCTORS EVERYWHERE should be telling people that safe sex practices can protect against HPV infection, and they should be pushing Pap smear screening, which is a curative diagnostic.
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A Message to Ethical MDs: The Problem with the 2017-8 Flu Vaccine is the 2016-7 Flu Vaccine

A Message to Ethical MDs: The Problem with the 2017-8 Flu Vaccine is the 2016-7 Flu Vaccine

AMERICANS are highly distracted.  They won’t recall the efficacy of the flu vaccine from year to year.  That’s why Sanjay Gupta can go on the news and remind us that his 30% estimate (likely an overestimate) of how well the flu vaccine works is not like past years, the good old days in which the vaccine was 60-70% effective, and not bat an eye.

But when was the last time the flu vaccine was 60-70% effective?  Eight years ago:

fluAVE

This is the CDC’s data (link).  Clearly, Gupta’s “Years” is, in immunological memory, a singular “Year”. Only once out of the last 14 years was the flu vaccine above 59% – that the value was not 60-70%, it was 60%.

This type of misrepresentation is a consistent penchant within the media and of course from the CDC to exaggerate and highly emphasize only positive views and diminish, dismiss, or ignore any negative views on the safety and efficacy of vaccines.

The reality is the flu vaccination program has an average adjusted efficacy of 40%. In 10/14 years, the efficacy was <50% effective.  That’s deplorable. And the problem is not ‘herd immunity’.  The problem is the vaccine is self-defeating.

The Jury is In: The Flu Vaccine Reduces its Own Efficacy

Too many studies now exist that have independently come to the same conclusion: increases in the uptake of flu vaccine reduces that vaccine’s effectiveness in the following year – and some studies show the negative effects of mass influenza vaccination last two years.

The studies reporting those results are reviewed in my article, “Diseases with Unknown Etiology Trace Back to Mass Vaccination Against Influenza in 1976“, and they are extensive and damning.

That post also includes the results of an analysis that I performed on CDC’s own data, showing that increases in the uptake of flu vaccine in a given year reduces efficacy of the vaccine for the following two years by a factor of -1.167.   Assuming a linear relationship, the model predicts the absurd prediction that at 93% uptake, the flu vaccine will have zero efficacy in the following two years.  That means “negative global efficacy” at or above 94% uptake.

It’s not absurd because the model is wrong; it is absurd because the vaccine reduces net immunity. Enough science exists that shows reduced efficacy due to past uptake (again, all reviewed here). It’s absurd because mass vaccination has unforeseen effects that make it self-defeating.  A better word than absurd would be “disastrous”.  More people would be diagnosed with “flu” that exist in the population at 100% coverage.  What does that tell you?

Well, being the eternal objectivist (not the Ayn Rand type, the other, warmer type), the fact is that extrapolations are not trustworthy.  And that’s true, but not in the universal sense.  If extrapolation could not be made to work, we could not have landed on the moon, on Mars, on Jupiter’s moon Titan, or driven our cars out of our driveways, for that matter.  Sometimes extrapolations do work. The model could also tell be telling us that the extent of immune impairment could be so high that the rate of infections from non-influenza viruses could surpass 100%, meaning many people could have 2, or 3 types of non-influenza respiratory viruses and multiple reasons for diagnosis with “the flu”.

I’m content not to need the extrapolation. The direct evidence that exists that Thimerosal is not safe for the human immune system is overwhelming: it shuts down the protein ERAP1,  We need ERAP1 to shorten proteins bounds for the Class 1 MHC cell surface.   Like pertussis, influenza is also sustained to a degree by silent carriers created by vaccination with non-specific effects.  Certainly live shedding is high among the vaccinated (study cited here).  Why don’t we see CDC informing every doctor to swab for influenza types A and B (including 2009-H1N1), RSV types A and B, parainfluenza types 1–4, metapneumovirus, rhinovirus, coxsackievirus/echovirus, adenovirus types B and E, bocavirus, and coronavirus types NL63, HKU1, 229E, and OC43, all types tested for by the ResPlex II multiplex assay – and each pathogen a type of viral respiratory infection that can mimic the flu?  I don’t have that answer.  But it seems since such a small proportion of cases are H. influenza infection, the default treatment of patients for “flu” without a real diagnosis would be unethical, but that’s precisely what happens.  According to Dr. Hawk, about 2/3 of the cases of “flu” seen are influenza – the rest, he says, would be false positives diagnoses (if made without swabbing).

Patients have a right to know the specific nature of their infections, and survivors in families of those who die from respiratory infections deserve an accurate cause of death. Coroners should certainly be required to provide an accurate cause of death in so-called “flu” mortalities.  Health departments should be required to count only deaths due to confirmed influenza infection as “flu” – otherwise their numbers perpetuate misperception on the risk of influenza infection, and cause fear leading to increased vaccination.  How is this seen as a good thing?  The population deserves good and honest doctors and stewards of public health.

HHS could demand swab results for all suspected cases of “flu deaths” with a press release and enforce them with random audits.  This annual ritual of fear-mongering over “flu-deaths” hides the fact that as long as thimerosal is injected into patients, they are at increased risk of other infections.  And due to heterologous immunity, even without thimerosal, flu vaccines can confuse the immune system and muddle up ineffective immune response by trying to re-purpose B-cells trained on the wrong virus, hobbling the immune system making it unresponsive to similar viruses.  Such as next year’s flu strain.

We do need objectivity to arise immediately throughout the public health system in the US, starting with HHS, then to CDC and to all Health Departments around the country.  Many studies have also found problems with Tamiflu.  But no emergency epidemiological study is addressing the question – why are so many young people dying from “flu”?   Many of the reports I’ve seen include mention that they person had not only been vaccinated, they also had taken Tamiflu. And many had taken Tylenol.   It’s time to ask the tough questions. The science is there on problems with Tylenol for vaccine-induced fever, and it must be taken into consideration.  Fever due to respiratory infections after flu vaccination is still vaccine-induced.

A look at the issues with Tamiflu (see primary scientific literature reviewed here) shows that we cannot ignore the possibility that the human immune system is not infinitely resilient, and that medicine’s approaches to tackling “the flu” is imprecise, not evidence-based, and self-defeating.  I’m not talking about the number of antigens the human body can take; I’m talking about the amount of tweaking it can tolerate, especially given the aluminum-dense childhood vaccination schedule. The allopathic medical community would do very well to heed the studies that show that Vitamin D helps alleviate both vaccine injury and severity of viral infections.  It helps resolve the unfolded protein response without killing the cells. And the science of ER stress (endoplasmic reticulum stress) shows that Thimerosal is, after all, not safe for human use.  Same for aluminum.

Management of Risk vs. Management of Risk Perception

So let’s consider (again) the differences between an organization that has, historically anyway, been provided with our Nation’s trust of the control of risk (reality), and upon failing to do so, works overtime to the control of perception of risk (non-reality).  Public health depends on trust.  The public trust for CDC is not just waning – it’s gone.  They rely on top-down funded advocacy organizations to truss up their tarnished public image – and the individuals invariable end up attacking the character of anyone who dares ask important and relevant questions. Increasing number of academics are calling for an end to CDC policies, such as the blithe use of aluminum, a neurotoxin, in vaccines, and the continued use of Thimerosal in vaccines.

Real Reform is Coming – It’s a Mathematical Certainty

Vaccines injure people every day, and kill people every week.  Each injury and death informs family members, co-workers, and schoolmates.  The flaws in vaccines, combined with misinformation campaigns on safety, fuel the fire and build the vaccine risk aware army.  It’s a peaceful army, filled with individuals who are hurt so badly, they do not want others to suffer the same fate.  They are altruistic.  And under informed, ethical and distributed leadership, they are finding their momentum.

Vaccine safety science reform means removing those in the CDC and HHS that perpetuated the debacle as it grew to proportions that even they could no longer easily deny it.  And that’s fine.  Let them go.  There are many excellent professionals capable of replacing them – people who have not been involved in cooking studies to alter the public’s perception of vaccine risk. People who have withstood unwarranted and unfair criticism by those who live in cowardice of reality.  People who now no longer afraid to publish their views.   An important question is who among my colleagues in Academic Public Health, and which doctors in Pediatric medicine are willing to #bebrave and take on a debacle as huge as a failed national immunization program?  Who will stand up to the AAP and tell them they are wrong?

If you are that type of doctor, it will be easier if you trust those who have worked at this for years. Read Dr. Paul Thomas’ book, The Vaccine Friendly Plan.  After the resignations, have him come and teach the entire CDC and HHS what he knows.  Consider Dr. Alvin Moss’s wisdom – ask him to create a Conflicts of Interest Policy for CDC and HHS, as he has done for the rest of academic medicine. Bring in Dr. Bob Sears from California, who was willing to stare down threats of the loss of his license to practice medicine because he dared to continue to practice medicine in the face of wanton misinformation and pressure from the AAP. Consider Dr. Richard Frye, and Dr. Chris Exley from the UK, who care first and foremost about the truths that impact total health.  Dr. Frye would be great as the new NIH Director, in my opinion. Let these people form a new national public health direction that overrides existing contracts.  There are others.  Like Dr. Judy Mikovits whose character stands much taller than those who tried – and failed – to silence her – on the issue of adventitious agents in viral vaccines (specifically and quite problematic: retroviruses).  Ask Dr. Ted Fogarty about Ethical Vaccinomics, and testing for vaccine injuries. Bring in Dr. John Piesse from Australia and end his persecution there, and put his good will toward safety to work here.  We would be lucky to have him.

Create a Manhattan Project focused on reducing vaccine injuries, not on making currently licensed vaccines safer.  They are old, and stale, and tired, and they, too, need to go.  Bring in exciting new developments in artificial immunization like microneedle patches.  Bring in Dr. Kanduc to screen epitopes that are unsafe.  Drop aluminum, as many have now called for, and bring in calcium carbonate – if needed at all.  Let those pharmaceutical companies who created the disaster make good on their promises to stop making their vaccines.  Then we will see new approaches to artificial immunization that compete on the platform of safety.

Don’t just end COIs at ACIP: End ACIP. Create a Vaccine Safety Commission that enforces Science Integrity. Open up the markets.  Let ideas thrive.  Let consumers choose. Let the FDA do its job.  Let the people’s experiences be heard.  Establish a paradigm in which the end consumer has a say in the quality of the product.  Strip the CDC of the ability to hold patents.  End the CDC Foundation. End the differences between drugs and biologics and require randomized clinical trials – with proper placebos, not aluminum hydroxide – for vaccines.  Repeal the 1986 Act that protects drug companies from liability for faulty vaccines. Perform random spot checks of vaccines in practices for contamination. The total sum of policies in the National Immunization Program, and the burden of morbidity on the population is a serious threat to our National Security.

Let some new faces and voices drive this reform. Bring in Dr. Dan Neides who had to escape the Cleveland Clinic after speaking his conscience.  Let him oversee the transition.  Bring in Dr. Brian Hooker to personally issue the pink slips to those who must now go from the CDC.  Let all of those named here share his or her experience with Congress.  Have Dr. Thompson testify.  We need truth and reconciliation.  And we need it 42 years ago.

There are MDs who sit in the shadows, silent, and afraid of job loss, sanction, ridicule.  Step up.  Let your views be known to the current Administration.  Join Physicians for Informed Consent.  You are not alone.  You can help be part of the solution.  Attend Health Department meetings and speak up for Informed Consent.  Speak up for vaccine exclusions for kids in homes with high lead levels.  Speak up for spacing out vaccines and skipping them.  Speak up for tolerance and understanding of the pain and anguish parents of kids with autism experience when they are told it’s genetic, they know it’s environmental, and they are told they have to vaccinate their other babies.  Speak up against calling CPS for parents who want to take the time they have under the law to consider vaccinations. And, of course, do right by your patients.  Listen to their concerns.  Inform them of both risks and benefits, as required by Federal Regulations.  Let them know they are enrolling themselves or their children (and unborn baby) in post-licensure vaccine safety clinical trials (as required by Federal Regulations). Provide medical and philosophical exemptions for school waivers as required by the laws of your state and the rule of your own conscience.  The AAP does not represent the rights and will of the people of the United States of America.  Our legislation does.

Let’s aim to not make 2020 vaccination look anything like 2019.  We have solutions.  We’re now aiming for Healthy People 2050, and the current vaccines have very little to do with our vision.  By the way, these ideas don’t come (exclusively) from me. They are shared by hundreds of thousands of American citizens, many of whom have been made sick or lost loved ones to vaccines. #werenotgoingaway #releasetheothermemos #hearthiswell #notmine #Vaxxed #cdctruth #saveourbabies #bebrave #ipak #cdcwhistleblower #rfkcommission #educatebeforeyouvaccinate #vaxxed #learntherisk #wedid #cdclied #stopmandatoryvaccination #learntherisk

why-doesnt-the-flu-vaccine-work-all-the-time
http://www.davegranlund.com/cartoons/2014/12/11/flu-shots-less-effective/

 

 

 

Social Contracts, Body Autonomy and the Vaccine Issue

YOUR RIGHT TO SWING YOUR ARMS ENDS WHERE MY NOSE BEGINS.

We are a society at odds with itself. We Americans, conditioned by cold war rhetoric to huddle under the protectorate government in our fear of annihilation, can barely think for ourselves. We are conditioned to respond to threats of each and every type of childhood illness as if it were the next Ebola.  We are strangely at once completely against generalizations about race, creed, religion, and gender, while at the same time not willing to hear the manifold pleas of those fall under the rubric of “antivaxxers”.  We want our guns, yes, but with restrictions to access for those who we personally feel are at highest risk of abusing the right to bear arms, because they might do something.

It wasn’t that long ago that that type of thinking – restricting someone’s liberties, or rights on the pre-supposition that they might do something, was anathema to being American.  Ok, felons might not be the best party to which might warrant unrestricted access to guns.  But restricting the rights of someone who has never hurt another human being simply based on a presupposition of what might happen, well, that was the topic of The Minority Report.

When the majority in this country thinks and speaks of vaccine risk, they mostly repeat, verbatim, the misinformation that CDC and Pharma has worked diligently and tirelessly to embed in their minds. Forget that we are imbued with inalienable rights wherein no one – not even especially the government – has the right to violate the sanctity of our bodies.  We have sovereign rights that literally begin where our skin starts – and anyone – ANYONE who trespasses that inviolable boundaries of our very selves – has not only violated our person.  They have violated the law.

A man cannot rape a woman, it’s her body. No one can tell a woman she can’t have an abortion, it’s her body.  No one can take any part of your body and use it for medical experimentation without your consent. It’s your body.

Patient – Society Contact

If our children have a fever, they are expected to stay home from school, to reduce the chance they might spread a cold virus.  This seems like a good intention, but the school usually cannot enforce this. But there seems to be form of a social contract that some people abide by – they won’t go to work if they believe they have a serious cold, or they may forestall or skip a visit to family or friends for fear of making them ill.  But there is no law that compels them to stay put.  It’s a form of social contract.  And the individuals who abide by that contract sacrifice a little for others.

When it comes to vaccines, the sacrifice being asked of many is not little. In some cases, it’s everything. Their very life, or the life of their child.  Their lifelong health.  Their child’s neurodevelopment. The risk, we are told, is small.  We’ve been told that vaccines are “unavoidably unsafe” by the US Supreme Court.  At the same time, we’re told that “Vaccines are Safe” by the media.

Never before has so obvious a misinformation campaign been delivered so blatantly with complete disregard for reality.

But what if only people with blue eyes suffered the risk of vaccine injury? Or only people with red hair?  Would we still be so blithe as to say “It’s for the greater good?”

Our willingness to impart risk seems to be a function of whether SPECIFIC RISK applies to a given group of identifiable individuals.  Imparting risk on others for our own benefit is anathema to the American ideal of self-sufficiency. It would be nearly universally seen as wrong if only an identifiable minority were asked to suffer all of the vaccine injuries, for the greater good.

A minority of people suffer serious adverse events.  They are not considered identifiable, in part because there has not been sufficient effort on research to find risk factors and markers of susceptibility to vaccine injury.  Instead, we have fallen into a pattern consistent with groupthink, a form of mob rule, fostered by billions spent on advertising campaigns to market vaccines as perfectly safe.  A taboo exists among professionals in the medical community and at Universities who must persist in their careers as if vaccine injury risk is small; as if vaccines do not cause autism.  This taboo is unwise, and unnecessary.  It has stifled research in the area of neurodevelopment for at least fifteen years.  It has thwarted research on ways of revering the brain burden of toxins from industry, agriculture and medicine, for the same period of time.

Medical Community – Public Contract

It is difficult to consider the contract between the medical community and the public in this age, in part because it has substantially changed over the last fifteen years. These changes include how health care is organized and funded, with increasing direct influence over medical options determined by “partners” (insurers) and also, in a less overt manner, by options provided by pharmaceutical companies.  The medical community has changed how professionalism is expressed, with increasing intolerance of an increasingly informed public.  Medical privacy has restricted family members’ input, with an increasing emphasis on medicine as transaction, reduction in time to service (to increase throughput) under watchful influence of administrators.

In their hearts, medical professionals by and large seek the identity of the healer.  The increasing disconnect between the pursued role and identity of the medical professional as healer, and that which can be achieved, can render an identity crisis, and it seems to be a factor in the high rates of practitioner burn-out.

The written portions of the social contract of medical professionals and their employees, associations, and the government define both the specific obligations of these professionals, and the limits of how they can ethically conduct themselves.  Adherence to these codes of conduct are legally enforceable; however, as a profession, there appears to be an additional layer of austerity imbued in staying within the confine the accepted medical practice owing to the ancient trust in the healer, with “caring” being a core principle, combined with compassion, sincere interest in the well-being of others (something like altruism), yielding a professional identity that reflects more than their job or career.  Doctors carry an identifiable position within a community held in high regard; this regard is afforded them as a form a quid pro quo in return for time and expertise focused on others’ well-being.

The unwritten portion of the social contract for the medical professional resides mostly in the expectation of derived benefit from a visit, especially for routine medical care. Both the written and unwritten social contracts have been – and are being – redefined, with corporate influences increasing every year.  Since pharma has acquired increasing undue influence  over regulatory agencies, it is clear that these allowances and restrictions have become increasingly influenced by profit incentive. The types of medicine practiced increasingly reflect a type of conformity that is partially imparted upon the community by agency regulation, such as FDA approval of new drugs, devices and biologics.

For any medical specialty, by some means this convoluted process results in some form of consensus.  While individual practicioners may vary in their adherence to medical norms, the details of the exact process by which new guidelines for accepted practices are adopted in not always, and is sometimes far from, transparent.  Medical authorities often rely on their status as authorities for the determination of proper medical procedures, and I offer that minor differences of opinion aside, the profit motive has one singular and over-arching effect on medicine: homogenization of options, and corporate monopoly.  Institutional inertia is a extraordinarily large in medicine, and thus medicine, for all of the billions pumped into research for innovation, is staunchly conservative.  The emergent consensus cannot be said to be independent of market influences, and the larger the effect of the profit motive, the more the social contract imbuing altruism is violated by the medical establishment.

THE AMERICAN PUBLIC is demanding a re-negotiation of its social contract with the medical community on the issue of vaccines, and the medical community believes their practices and norms will protect them from this sea change.  Even though the law protects vaccine manufacturers and medical doctors from serious adverse events that fall into the run-of-the-mill risk categories,  and in spite of billions spent by Pharma and regulatory agencies to mislead the public, the biological truth is larger than the manufactured non-reality.  Millions of people have been seriously harmed by vaccines, and the law, the governmental agencies, the media and the medical profession have all contributed to a strategy in which vaccine risk denialism feeds more and more people into the vaccine risk awareness army.  What the vaccine risk denialists fail to see that is people don’t choose to become vaccine risk aware; they are conscripted by the very injuries being denied by pundits, by doctors who misinform patients, and by others who have a clear professional obligation to act in the better interest of the public.

BODY AUTONOMY DEFINES THE BOUNDARY

In spite of those with their heads in the sand, that stubborn epithelial layer of body autonomy persists.  We have a right to say “No”.  An infuriated medical community exists that would love to strip of us that right.  Indeed, because long-term vaccine safety science relies on post-market surveillance as a primary source of evidence of the ill effects of vaccines, if you are vaccinated in America, you have been denied your right to informed consent for participation in clinical studies.  Take a moment to consider: did your doctor give you Vaccine Information Sheets from the CDC with each and every vaccine administered to you, or your child?  If the answer is no, you have been denied the informed consent required by law.

We don’t just need reform.  We need revolution.  When they try to mandate adult vaccines, and come for adults with threats of no jab, no pay, or deny your driver’s license, or deny your health coverage (which you have paid for), you will know.

And you will seek change.

But for now, you won’t do anything.  Because it’s not you.

You don’t have a social contract with those people who have specific mutations that confer increased risk of vaccine injury.

Because they are not you.

Yet.

Because they have not yet mandated a vaccine from which you, or your children, or your grandchildren are genetically predisposed to have a serious, life-altering adverse reaction.

Yet.

Since they are planning 290 additional vaccines, I’d say it’s only a matter of time before most Americans are at very high risk of suffering a debilitating illness due to vaccines.

New communications from schools about health education programs in Washington mean intensive indoctrination of your children on vaccines.  New laws in NY allowing minors, motivated by headphones, to make medical decisions, should make all ethical medical professionals cringe.

But, more than cringe, it’s time for them to speak out.  If you’re a medical professional, it’s your time. You are the ones who can make change faster than the public.  We won’t figure out that we control state laws on vaccines, not pharma, until it’s too late.  We won’t figure out that we can pass legislation re-affirming and re-asserting our bodily autonomy and protect ourselves from unwanted medical experimentation, until it’s too late.  We won’t figure out that regulations already exist that Federal level that provide special protections pregnant women, and children from experimentation, until it’s too late.Image result for medical paintings

So, medical doctors, pediatricians, our civilization awaits your answer to your professional calling.  Heal our society.

First, do no further harm.

Second, rise up and overthrow those who have.  That means outlawing kickbacks to practices.  That means not counting the medically exempt as candidates for vaccines.  That means using what we know about family risk autoimmune diseases and vaccines.  That means starting a private practice if need be.  That means refusing to bend to corporate pressures.  That means working to unshackle Congress from the yokes of corporate donations.

Third, demand innovation on new technologies for artificial immunization.  You are the learned intermediaries.  Play your part. Do your job.

Watch VaXxed.  See part of the truth. Read “Causes“.  And above all,  #bebrave.  You’re not alone.  Join Physicians for Informed Consent.

When is “Genetic Autism” Not Genetic?

THE FOCUS ON THE CONTRIBUTION OF GENES to the risk of diagnosis of autism seems warranted, if you look at the press.  Each week, sometimes each day. a new study comes out about a gene that is an important contributor, the stories go, to our understanding of autism.  Here’s one that touts the gene SCN2a as a “Rosetta Stone” for understanding risk of autism.  It’s poorly written because it misrepresents the full knowledge base. The media’s coverage is, to some extent, dependent on their ability to comprehend genetics, and what they are told by investigators.  I get hype for research; it’s a form of marketing that is essential to communicating our the value of our activities to the public.  But the story conveys a sense that autism “is genetic”. It also makes no reference to other studies of a similar gene, SCN1a, related to Dravet’s syndrome and seizures. Here’s one I cite in “Causes”. We’ll come back to that later.

Considering autism genetics can be complex. When there are genes that are found to contribute to the risk of autism, and individual genes are headlines, and yet there are hundreds of genes that contribute, none of which are known to contribute to more than 1-2% of the cases of autism, what is really going on?

Much of the landscape of autism genetics, the roles of environmental factors, and, importantly, the role of the interactions between genes and environment is mapped out in “Causes”.  I reviewed over 2,000 studies on autism to come to grips with a number of important unanswered questions, not the least of which is “which is more important in autism: genes, or environment?” It may appear to be a simple question, for given the dramatic rise in autism diagnosis, we cannot expect that such an increase in less than a generation to be attributed to genetics.  And that view is nearly 100% correct.  But at the risk of incurring the wrath of individuals who may fear that today’s post, and my book, is another attempt to make people think “autism is genetic”, let’s proceed.

pedigree

First, we need to contrast some definitions.  Here is a list of similar terms that, importantly, the autism community must keep clear in their minds if they are to communicate meaningfully, say, with genetics researchers, or even with genetic counselors:

  1. risk vs. liability
  2. genetic risk vs. familial risk
  3. mutation vs. variation
  4. heritability vs. concordance

RISK vs. LIABILITY

To say “autism is genetic” is to make very specific claim about where the risk of autism came from. In the vast majority of people’s minds, it means that the risk of autism in children comes from their parents. And to the extent that our genetic information comes from our parents in the form of our DNA, usually packaged into 23 pairs of chromosomes in our genome, some of the risk of autism is surely “genetic”. However, much of that risk was not present in past generations, because a high proportion of the genetic information that appears to contribute to autism has been found to be in form of de novo mutations.  They are new mutations that occur in the formation of the sperm and the egg, in the parent’s body during cellular division leading to gamete formation (meiosis).

This is where the distinction between risk and liability is important. (First, be clear, we are on journey toward understanding: “Liability” is a not synonymous with “Blame”. We’ll see why later). Truly genetic risk exists because the parents not only shared the genetic variation that contributed risk, but they also shared, to a lesser or greater degree, the risk of autism due to that genetic variation.  The “lesser or greater” degree here is meted by two important factors:

(A) Dominance, and Heterozyosity/Homozygosity. Some truly genetic traits are expressed regardless of whether we have one or two copies of the specific variation leading to the trait; these traits are considered dominant, and the risk of seeing the trait is 100% if one carries the variation from either mother, or father, or both.  Other traits require the specific variant (or similar enough variant) from both parents to be observed in the offspring; these are called recessive traits.

(B) Single vs. Multi-locus Traits. Some traits seem more blended than other.  When multiple genes contribute to these traits, the inheritance of risk still exists, but the resulting pattern of the appearance of traits in offspring may be considerably more variable than for simple genetic traits. These are called ‘multi-locus’ traits because genetic information located at multiple positions on chromosome are observed to contribute to the trait of interest.

I already hinted at the fact that hundreds of genes have been found that “contribute to autism”, and therefore you likely have figured out that much of the behavioral traits seen in autism are not simple traits encoded by individual genes.  In fact, in “Causes”, citing the results of numerous genetic studies, I conclude because any individual genetic variant that is truly genetic (with both variant and risk of trait seen in the parental generation) is so low in frequency in the population, purely “genetic” autism is perhaps never seen in our species. Each variant is so low in the population, usually much less than 1%, that the odds of 2, 3, or 4 of these variants being inherited in any individual in our species is vanishingly small.  So while the beautifully conducted Pinto et al. (2014) study show that the odds of autism increases with the number of these inherited variants, the actual and the expected rates of seeing individuals who inherit 2-3 variations from their parents leading to autism approaches zero.  Although there are a very large number genes that encode proteins involved in synaptic transmission (as this image adapted from Pinto et al. shows:

synapsepinto

And there are myriad other pathways involved in autism, the risk of “genetic” autism due to “multiple hits” is very, very low:

pintomultiplehit

So the risk of purely genetic autism is very low, and yet the two largest genetic studies conducted to date conclude that overall genetic liability of autism is around 50%.  They attribute the remainder of the risk to environmental causes.  So what’s the difference between RISK and LIABILITY?

Risk is an inherent characteristic of an individual; each of us have an individual risk of developing cancer. Liability is the degree to which genetics, or environmental factors, can be said to ‘explain’ the incidence of a trait (usually a disease trait) in a population.  So with hundreds of genes each contributing “to autism” in small percentages, the total population-wide occurrence of increases in traits can be explained, in part, by “genetics”.  I use “genetics” in quotes here because I mean the combined total population risk due to both inherited genetic variations, and de novo mutations.  Up to 20% of autistics show increases in new genetic variations, not found in either of their parents.  And thus while the information is carried in the gametes in the genome sequence, the trait “risk of diagnosis of autism” is not inherited, because it is not shared by the parents.

Many of the other conceptual contrasts can now also be made clear. GENETIC VS. FAMILIAL RISK, for example, is seen as the risk of a trait appearing in offspring due to inherited risk of the disease trait due to genetic information seen in either or both the parents and in the children, whereas FAMILIAL RISK is seen as the overall risk found in children born to the same parents whether the source of that risk is genetic, or due to a common environment. It should be noted that it is possible that some families are at overall higher GENETIC RISK of having de novo mutations (such as mutations in post-replication mismatch repair genes active in meiosis), and therefore the GENETIC RISK of de novo mutations may be shared among siblings.  This characteristic would tend to be shared among siblings both with, and without autism, but may be expected to be higher (more concordant) in twins and in siblings with autism.

The distinction between CONCORDANCE vs. HERITABILITY is an important one to make.  CONCORDANCE is the rate of shared occurrence of traits among siblings in the same family, and is a mix of genetic contributed liability and liability due to shared environment, whereas HERITABILITY is the rate of share occurrence of traits between parents and offspring.  Obviously, since parents of most autistics born since 2005 do not have autism themselves, the pattern of traits across millions of pedigrees indicates that the evidence of autism risk cannot come from HERITABILITY of risk, again, implying a large role for shared environments explaining any studies with high rates of CONCORDANCE of autism or traits associated with autism.

Autism Risk is No More than 50% Genetic, and AT LEAST 50% Environmental

I outline very strongly in “Causes” that genetic studies, as conducted thus far, cannot truly estimate that relative contribution of genes and environmental factors as long as they only study genes.  “Geneticists are doomed to find genes” is the phrase I drop. However, it can be seen in the largest studies, because they have not studied environmental exposures, that if the apparent contribution of genes is estimated at 50%, leaving around 50% liability for environmental factors, but the studies could not estimate the GENETIC X ENVIRONMENT interactions, that the real contribution of environmental factors is likely GREATER than 50%, because if the genetic liability (inherited variants attached to inherited risk) is G, and the environmental liability is E, then

TOTAL LIABILITY = G + E + (G x E)                                                      (1)

Where G X E is the interaction between environmental and genetic factors.

Clearly (G x E) is not zero in autism, given that purely genetic autism is perhaps no more than 1-2% of cases of autism. So if E+(G x E) = >98% of autism, either E is huge, or (G x E) is huge, or both are huge.

But we cannot forget the “genetic” contribution of de novo variations.  Let’s distinguish between inherited risk tied to inherited genetic information (G1) from risk newly derived from new variation (G2):

TOTAL LIABILITY  = G1 + G2 + (G1,G2 x E)                                           (2)

Now we can see that if G2 is being increased, the importance of the apparent “genetic” contribution of de novo variations cannot be known until they are studied in the context of environmental factors.  We should expect that environmental factors, and both G1 and G2 type genetic factors are causal; and none are mere ‘triggers’.

What is Causing Increased Rates of G2 de Novo Variation in Autistics?

So where is the genetic contribution to the “genetic” liability coming from?  This is an important question, because if 20% or more of autistics have increased numbers of de novo copy number variations, effecting apparently hundreds of genes, whatever is causing those increases of copy number variations must be identified.  Some hypotheses are being looked into, from, as I indicated, the DNA repair genes involved in meiosis. Scant evidence exists one way or the other (many readers will appreciate that careful distinction, can I get an “Amen!” for Science?), but it is interesting that there appears to be decreased risk of cancer in autistics.  To me, this implies the loss of individuals with cancer risk from the population of autistics, perhaps in the womb, due to excessive genetic load.  Variations (inherited and de novo) that contribute “to autism” may (I speculate) already pose such difficulties for developing embryos that variation in the critical DNA repair genes may simply be screened out by lethality of genetic (G1 + G2) burden.  It would be interesting to see if siblings of children with autism have a higher overall incidence of cancer risk or increased variations known to contribute to cancer risk because they represent individuals who survived embryonic development with mutations.

Another hypothesis that could explain the increased rates of de novo variations, posed by radiologist Dr. Edward Fogarty, is the increase in the use of pelvic CT scans.  No evidence exists yet (again, a call FOR SCIENCE, not a call for No More Science), but straightforward looks at the rates of pelvic CT and other radiologic exposures in parents with of autistics compared to parents of neurotypicals could be critically important.  Two lines of evidence make this compelling. The first is the association detected between access to health care and rates of autism.  There could be other obvious contributors to the association of access to healthcare and rates of autism, including exposures to neurotoxins in vaccines (mercury, aluminum) and more likely diagnosis.  But neither of those factors can be expected to lead necessarily to increases in de novo variations.  The other line of evidence is the association of the age of parent with autism; older parents are more likely to have had multiple exposures to medical diagnostic radiation.  Dr. Fogarty and I will be looking into these environmental factors in 2017.

The final thought on when “genetic” autism is actually not genetic derives from my knowledge of biological pathways.  In canvassing the 2,000 studies on autism, including hundreds of genetic studies and way fewer environmental studies, it became apparent to me that understanding the role of genetics and environment (and their interaction) requires putting “autism genes” into three categories

(1) Autism Risk Genes – Genes that contribute directly to G1 (inherited trait risk)

(2) Environmental Susceptibility Genes – Genes that contribute to increased susceptibility of neurological disorders due to environmental toxin (developmental and otherwise)

(3) Autism Phenotype Modifier Genes – Genes that contribute to traits often associated with autism in the population, but that also show heritability in the entire population, not just the autistic population (language skills, some social skills, intellectual ability).

I offer examples of each of these three categories in “Causes” as hypotheses. Recognizing these three categories of genes will be essential for a fully understanding not only of autism, but of the many conditions that are thought to be co-morbid with autism, especially seizures, intellectual ability, and propensity for anger. Because many of these traits or tendencies involve pathways that clearly overlap with pathways that influence the core characteristics of language and communication, social abilities, and repetitive motions used to diagnose autism, it is very clear (to me at least) that every child with autism, or on the spectrum, and every child with a familial risk should have their genome sequenced and studied and their particular constellation of variants determined to be inherited (G1) or de novo (G2) studied to see if they are at risk of these other traits, and to see if they are at risk of suffering due to specific environmental exposures.

We have a long way to go before we can tell families which environmental exposures individual families or individual family members should avoid.  See this remarkably clear study by Scott Faber and colleagues at the Children’s Institute in Pittsburgh, PA that shows that the severity of behavioral traits associated with autism increases in autistics with cumulative exposures to environmental toxins:

faber

And some of the suspects they found:

faber2

They did not study vaccines. Autism is, for the most part, environmental. Our species did not evolve in a world with highly irradiated pelvises, and a toxic soup that challenges a growing identifiable minority of individuals who will get sick, or die, or whose normative neurologic development program will be altered.  And as we (all) become increasingly sick, what is the logical outcome of increasing the baseline of toxic exposures by packing the untested CDC schedule with increasing numbers of vaccines?

The logic around vaccine safety science has been replaced by a shell game, mixed with false dichotomies. Remember SCN1a, which I promised we would come back to?  It turns about that because a few studies found that Dravet syndrome patients with encephalopathy were conducted, and they found and reported small numbers of patients w/mutations in SCN1a. Because they existed in these patients, the studies concluded that the encephalopathy could (potentially) be due to the mutations. Prior to these studies, vaccines had been (and still is) attributed as the cause of encephalopathy in these patients.  Do those mutation case series exonerate vaccines?

No.

It requires science to rule out vaccines. Mutations do not exonerate vaccines as a cause of encephalopathy simply because the mutations were found second.  The studies had no control groups (patients with Dravet’s with no history of vaccination), so it is certainly plausible that, as in many complex disorders, the risk is additive, or these mutations (or others) interact with toxins from vaccines in identifiable way.  We need multifactorial thinking in vaccine safety science, not merely “either/or” contrasts.

magic

Due in part to this errant “either/or” thinking about autism risk factors,  we can’t yet specifically predict which families should avoid which toxins.  Therefore, in the meantime, let us all adopt an attitude of tolerance and respect for individuals who wish to reduce their risk by reducing their own, or their child’s exposures to environmental toxins, including the neurotoxins in vaccines.  Let us stand firm on informed consent and require a full accounting of risks (as required by law) in each and every encounter in the clinic on vaccines.  Let us stop the draconian practice of destroying careers of medical professionals and journalists who become aware that with vaccines, we are taking some of the most toxic parts of our environment, and injecting them into babies. Let us use Science to formalize our approaches to using known risk factors of adverse events.  Let us use Science to develop biomarkers for serious adverse events.  Let us stop public shaming, and name-calling, and let’s get down to the business of public health considering all dimensions of risk of illness and disease.   If we are all protected from infectious diseases from vaccines, we owe everything to those who have taken the hit in the form of vaccine injuries. Let us not deny vaccine-injured children and their families justice, and due compensation. They are STILL trying to protect us, every day, by increasing  Vaccine Risk Awareness. Let us stop minimizing the perception of risk, while doing nothing to minimize the actual risk. That is a recipe for disaster. Vaccine court Special Masters, stop obfuscating with broken logic and give awards to kids whose toxin tolerance was pushed over the edge by vaccines (“via”, as you say, encephalopathy):

conditional2

And please stop using non-sequitur molecular excuses like “channelopathy” to hide “autism”. The damage done to sodium channel functioning via mutation, or via environmental exposures, is identical.  It’s called “phenomimicry”.

Journal editors, stop retracting papers because a vocal minority of individuals say they cannot live with those published results.  Journalists, #bebrave and report on the environmental factors, including vaccines. Let us have #the conversation, so we can enact a sea change.  If you all start reporting at once, Pharma will not pull their funding from everyone.  Mass resistance WILL WORK.  Parents, continue to tell your stories, to Polly at #vaxxed and any outlet you can find.

For heaven’s sake, let’s stop using Thimerosal in flu shots for pregnant women (and for everyone, while we’re at it) and stop vaccinating pre-term babies altogether.  This study shows that Thimerosal specifically inhibits a protein called ERAP1, which is responsible for proper shortening of ALL proteins during translational expression.  Who in their right mind would want to alter protein editing processes in anyone, not to mention developing fetuses?  And why in the world is 850 micrograms of aluminum the safe dose limit for a 150 pound adult, and the same dose limit for a 7.5 pound baby?  Why is 5 micrograms the limit of aluminum in biologics other than vaccines, and yet pre-term infants receive 250 micrograms after a few days?  Where is pediatric dosing in vaccines?  Where is the vaccine safety science? More importantly, where is the integrity in vaccine safety science?

If we return to Science, we can make vaccines safer.  Totally safe? Maybe not. Much safer? Certainly. Spacing out vaccines is not a crime. It’s informed caution. We can screen for epitopes that make vaccines unsafe for some because they match human proteins. We can develop and use means of artificial immunization that elicit dendritic cell responses – without aluminum. Vaccine safety science must look at tallied cumulative exposures, not vaccinated vs. vaccinated. Clinicians, petition Medicare to count medical exemptions TOWARD, not AGAINST, the 60% rate you need to enjoy your bonuses.  Were it not for their medical conditions, after all, they would be on schedule! Researchers, stop burying associations and model overfit.  CDC, publish all of the comments on the proposed weakening of the risk of MMR, and uncensor my comment. Oh, and fix your website, it looks like there are zero comments.  Congress, one last time, PLEASE  subpoena William Thompson. We all know what happened. It’s getting embarrassing.  We’re moving on. Either way, you’ll be hearing from us.

All of this can be done. All of it MUST be done.

week

I dedicate this blog article to The World Mercury Project, and I wholeheartedly endorse Mr. Kennedy as Chairperson for the Vaccine Safety Science Commission.  Their logo here is used without permission, and WMP has nothing to do with my blog, or any of its articles.

 

wmp

I am grateful for everyone who has helped me to this point. There are so many.  You know who you are.

smiley

The Slaughtering of our Constitutional Rights

JOHN STUART MILL is sometimes attributed with the quote “Your right to swing your fist ends where my nose begins”.  In reality, the quote seems to have arisen during prohibition protests.

Everyone understands that there are times when individuals must be called upon to secure our liberties and rights as a nation, at the risk of cost to individuals. The military draft, for example, is seen by many as a necessary evil from time to time, but even the de facto suspension of individual liberties during the draft is seen as extraordinary – no draft would be acceptable during a non-emergency period. The draft, for example, would never have been acceptable during Bush’s elective war in Iraq.

Lately there have been moves on the part of governments and other organizations to reduce, limit, or remove individual liberties and rights, and a full accounting of which rights are impinged in the name of saving humanity from infectious diseases seems worth considering.

1st Amendment Right to Free Speech

I was stunned to read a legal “scholars”‘s treatment of the question of whether we should tolerate free and open discussion of questions of vaccine safety. Claiming that discussing vaccine safety was akin to “shouting gunfire in a crowded theater”, the authors of the article in the Jurist concluded that perhaps American citizens’ rights to discuss their knowledge of the risks of vaccination should be rescinded.

Luckily, the issue was aptly taken up by Mary Holland, a legal scholar at New York University, who wisely stated (in brief) that the right to yell “gunfire” becomes a moral imperative when gunfire has, indeed, erupted in a theater.

Rights to Informed Consent

Vaccine defenders trample all over individuals’ rights to informed consent for medical procedures, both inside and outside the doctor’s office. Inside the office, they routinely deny informed consent by minimizing what is known about risks of vaccine injury, both in terms of the diversity of injuries that may occur, and their frequency. Patients who ask too many questions about vaccine injury are seen as problematic, rather than being seen as exercising their right (in all states) to know specific risks.  Information on the known HPV vaccine adverse events provided by your doctor are incomplete, and if you ask for the vaccine insert, you will find that it, too states that it is incomplete in its listing of the known adverse events, and it refers you back to your doctor for a full list!

If patients or parents decide to exercise their legally guaranteed right (in 47/50 states) to refuse vaccination, or to modify the schedule, or to skip or delay any specific vaccination due to their individual concern over risk, they are treated as problematic by healthcare workers, including medical doctors and office staff. The disdain and disregard for the law in such a setting by medical professionals is obvious.

California bill SB277 is a highly contested example of a state overreaching the authority intended by previous cases. It specifically strips Californians of the right to non-medical exemptions, and those who persist in exercising their Federal rights to refuse medical treatment once fully informed of the risks are stripped of their rights to access a public education, a right specifically provided by the California state constitution.

AAP Codifies Patient Harassment and Abrogation of the Hippocratic Oath

Doctors and healthcare workers around the country have been reported to use coercion, shame, and threats to deny patients access to medical care if they are vaccine-risk aware, and choose any of the legally provided options other than the CDC schedule. Last week, the AAP codified this disregard for the law by approving pediatricians’ practice of refusing to provide medical treatment to citizens who exercise their legal rights to non-medical exemptions. Citizens in nearly every states with mandatory vaccination for school attendance have the right to exercise religious, philosophical, moral and personal belief exemptions, whether pediatricians like it or not.

eximmunmap15-tuesday

Sept 2016: Forty-seven states honor individual and parental rights to refuse vaccination – without their doctor’s permission to do so. AAP, CDC, and Pharma want that number to be ZERO.

In some states, the medical community has tried claim that doctors should ascertain for the state whether a person’s request for a religious exemption is genuine. Such laws and practices  are clearly a violation of the freedom of religion, which is a constitutionally protected right provided in the religion clauses of the First Amendment.  A moment’s review of the contents of some vaccines (aborted fetal cells, pig products) will reveal that recipients who are forced to receive those contents into their bodies are also being forced to deny central tenets of their faith.

Across the US, patients are denied informed consent in myriad other ways as well.  The fact that pharmaceutical companies are exempt from liability prevents news stories of companies held accountable for harm – and also prevents motivating companies from making vaccines safer.  Instead, consumers pay a tax on every vaccine to pay damages via the National Vaccine Injury Compensation Program – which sounds good, until one realizes how extremely tortured the logic has been to make vaccine-induced encephalopathy a replacement vaccine injury for autism so the program does not have to pay for vaccine-induced encephalopathy-mediated autism.

Right to Refuse Medical Experimentation

After the Nuremberg trial, it became both common international and national law in the US that no citizen shall be subject to medical experimentation without their express, fully informed consent. The law that protects American citizens’ right fall under the FDA’s domain, which requires that all medical researchers conducting human subjects research acquire specific consent after reviewing the full list of known and potential risks associated with experimental drugs and medical procedures.

Much of what the CDC calls vaccine safety research is conducted using post-market surveillance. US citizens are not informed that their reaction to a given vaccine may be used by the government or government-funded researchers to assess vaccine safety. By definition, then, we are all enrolled in an uncontrolled medical experiment without consent. We are never given the opportunity to refuse to be enrolled in this massive medical experiment. Not that it matters much for the sake of the science; the studies conducted using data from the passive Vaccine Adverse Events Reporting System (VAERS) and the Vaccine Safety Datalink (VSD) are nearly universally retrospective descriptive correlational studies, and thus any suggestion or hint of increased rates of serious adverse events can easily either be cooked away by repeated rounds of data analysis (analysis-to-result), as has been the practice at the CDC for studies on the question of vaccine-induced encephalopathy-mediated autism, or the results can be dismissed as merely ‘correlational’.

When a new vaccine is being added to the CDC pediatric schedule, the prospective studies that are conducted do not test the cumulative effect of the vaccine schedule against unvaccinated individuals, but rather existing schedule vs. modified. Those that do use ‘placebo’ tend to use the adjuvant (additive designed to enrage the immune system) vs the vaccine, and thus the rates of mild, moderate and serious adverse events for vaccines are unknown.

13th and 14th Amendment Rights: The only way so far to identify individuals – and families – who are at risk of vaccine injury is to vaccinate them, and thereby injure them. These subgroups of individuals are potentially identifiable – if only research priorities allowed us to focus on the development of biomarkers to predict who might be at risk of specific harm. In America, minority citizens have, under the 13th and 14th Amendments, the rights to equal protection. The first step to predicting who among us are at special risk is to admit that vaccines cause harm. In denying the link between vaccines and autism, not only are the rights to informed consent denied, and rights to compensation for harm being denied, but the right to protection by the state as a genetic minority are also denied because the science to identify specific biomarkers for specific serious adverse events for specific subgroups cannot be conducted when autism denialists write the rules.

CDC Proposes Their Totalitarian Rule

In a stunning move made under the guise of medical emergencies caused by emerging infectious diseases, CDC has proposed new rules for themselves to be able to apprehend and detain American citizens indefinitely, without access to legal counsel; to disallow citizens’ rights to cease communicating with the CDC (First Amendment; Fifth Amendment); to access (without consent) our electronic communications (Fourth Amendment); to forcibly vaccinate American citizens against their will (Rights to Informed Consent); and to deny them any compensation whatsoever for any harm done to them physically  or to their attempts to enjoy their rights to life, liberty and the pursuit of happiness.  Defenders will say that this is only for instances in which an emergency has been declared, and they list specific diseases for which they imagine they may have to impose totalitarian rule (Ebola, Marburg, and others (see a full accounting by James Grundvig here). They also, of course, give themselves the right to add more diseases, and thus vaccines, to this list. CDC wish to grant itself open-ended police powers in a manner that is not only not consistent with the Constitution: their power grab is not consistent with America.

I am sure that I have not fully counted the number of rights seized by the CDC Totalitarian Rule, but they must be stopped. They should not be granted powers to suspend most of the Constitution.

CDC employees have an odd, paramilitary culture that is not necessary in a free and open society.  Perhaps they are nervous and this bluster is a threat. Perhaps they will apprehend people who write blog articles. Perhaps they will apprehend people who make movies. Perhaps you will be arrested by a Rear Admiral and force-vaccinated against all of these diseases because you told your sister about “The Environmental and Genetic Causes of Autism“.

We must immediately, forcefully and collectively assert and affirm our rights to:

  • Rights to Free Speech
  • Religious Rights
  • Rights to Refuse Medical Treatment
  • Right to Refuse to Participate in Medical Experiments
  • Rights to Equal Protection
  • Life, Liberty and the Pursuit of Happiness.

Summary

The reality is that open-end legislation at Federal, State, and County levels on vaccine mandates are dangerous, because no science is done to tell us about the risks of adding an ever-increasing number of vaccines, and this newly proposed ’emergency’ authority to force vaccination upon American citizens a list of vaccines to which CDC can add at their whim cut deep across the grain of American sensibility and our traditional respect for the rights of individuals.

The attack on Constitutionally guaranteed and protected rights being visited upon the American public is sometimes described using the word “impingement”.  The aggregate effects of these moves is not an impingement – it is a dismantling of our safeguards against a totalitarian state. It’s a wholescale slaughter of the Constitution.

What are your thoughts? What other rights are being threatened by vaccine risk denialists?  Let’s have #thediscussion – while we still can.

References

The Constitution of the United States of America

Holland, MS. 2011. Legally Censoring Speech on Vaccines and Autism: A Response. The Jurist http://www.jurist.org/forum/2015/12/mary-holland-vaccines-autism.php

Vaccine Safety Datalink


About the Author:

Dr. Lyons-Weiler is the CEO of The Institute for Pure and Applied Knowledge, former Senior Research Scientist and Scientific Director of the Bioinformatics Analysis Core at the University of Pittsburgh, and former faculty member in the Department of Pathology and Department of Biomedical Informatics (University of Pittsburgh), and former full faculty member in The University of Pittsburgh Cancer Institute. He is the author of three books (Ebola: An Evolving Story; Cures vs. Profits: Successes in Translational Research and The Environmental and Genetic Causes of Autism). To book Dr. Lyons-Weiler for speaking engagements, email ebolapromo@gmail.com

Visit Dr. Lyons-Weiler’s Facebook author page.

How to Nip HPV Vaccine Mandates in the Bud: Lessons from Pennsylvania

ACBH

MANY OF MY FELLOW sojourners on Facebook have thanked me for fighting back at the – read this slow – proposal to write a proposal for a mandate for HPV vaccination in Allegheny County, PA that the Allegheny County Board of Health (ACBH) was contemplating.  While it’s true I’ve been involved the spotlight really goes to the ladies of the local contingent of the Pennsylvanian Coalition for Informed Consent and the members of the general public who stood up and said #nohpvmandatePA.

I was invited to participate in a meeting w/these truth warriors and defenders of health rights, and I can attest that no board, no committee, no legislative body will ever succeed in mandating HPV in the Pennsylvania as long as they have to deal with this coalition.  They are organized, informed, dedicated, and, most importantly, growing.

My personal experience in this is consistent with my own growing awareness of passive-aggressive, bureaucratic, non-representational means of government that are being experimented with in all levels of regulatory government.  Rather than deal with issues that effect each and every Pennsylvania head-on with legislation that mandates HPV vaccines, the ACBH attempted one of three things (I’m still unsure of which of the three they were contemplating), outside the legislative process:

  • To mandate HPV vaccine in 11- and 12-yr olds prior to entering 7th grade
  • To consider writing a proposal recommending a mandatory HPV vaccination for 11- and 12-yr olds prior to entering 7th grade
  • To gather information on how the public feels about HPV mandates.

A series of public speakers offered their opinion.  NOT A SINGLE MEMBER OF THE LAY PUBLIC STOOD UP FOR MANDATORY VACCINATION.  The only people speaking up for mandatory vaccination were medical doctors.  And Dr. Lee Harrison, chair of the ACBH, who, in comparison to the 3-minutes given each member of the public, had to apologize for how long his presentation was during the Board’s discussion of the issue.

We’ll learn more about Dr. Harrison later, but for now, let me bullet point the issues that the lay public, and the scientist in the room, shared with the Board of Health.

A procedural inquiry was made on the fact that public speakers were only given 3 minutes; it also included an inquiry on whether mandating a vaccine was overreach on the part of the board.  The person providing this procedural inquiry had asked if she could make the inquiry, and then give public comment, and was told yes.  When she began her inquiry, she was interrupted and informed that her procedural inquiry was in fact going to be taken as public comment.  Thus, she forfeited her 3 minutes for her public comment.

The board never answered her questions during the public comment session; however, we learned later (from the Board Member who identified herself as Constitutional Lawyer) that if the ACBH votes on a new policy, that there must be public HEARINGS, at which case any member of the public has as long as they need, and can make presentations, etc…

Other speakers addressed or had previously addressed the following concerns:

  • The Board is an appointed, not an elected body – NO VACCINATION WITHOUT REPRESENTATION;
  • 48 states have NO MANDATE for HPV vaccine;
  • Countries like Japan and Denmark have stopped recommending HPV vaccine altogether due to safety concerns;
  • VAERS data shows large numbers of HPV-vaccine induced injuries;
  • Two statements from medical doctors (read by PCIC members) that such a mandate goes against everything that medicine stands for;
  • No science has shown that HPV vaccine prevents cancer;
  •  A mom (wearing a VAXXED shirt) told the story of her vaccine-injured child, and told the Board about the ongoing Congressional inquiry into Dr. William Thompson, who revealed that the CDC altered the results (by omission) of a study to make the public think that vaccines were safer than they are.

My own points were that I’d already provided the Board with studies that show type replacement occurs, and that a Dr. Miriam Cremer claimed in an editorial at the Pittsburgh Post Gazette that my reports of type replacement (whereby rare, potentially more lethal HPV types replace those targeted by the vaccine) were “absolutely false”.  Evidence of Dr. Cremer’s conflicts of interest as receiving funds directly from Merck over the years were handed to the ACBH.  I told that board that since we last met, another study had come out showing type replacement, and informed them that I had emailed them the study for their review earlier in the morning.

I urged them (again) to not dismiss parents’ reports of HPV and vaccine-related injuries; I asked them if they know how it sounds to a parent to hear that their observations are not proof of cause:

“It sounds like this: If a parent says, look, I saw my child get hit by truck, and you say to them ‘We know you saw the truck hit your child, and you have the license plate, and make and model of the truck, but correlation does not imply causation'” (Thanks Ali! for sharing this analogy).

I reminded them that according to the American Cancer Society, throat cancers have been DECLINING at a rate of 2-3% percent per year due to larger numbers of people quitting smoking.

A doctor absent from the proceeding whose name had been called clearly waited to be the last speaker – another trick to try to carry the issue.  It didn’t work.

During the Board’s discussion, Dr. Lee Harrison, the Chair, gave a presentation on “HPV and HPV Vaccines”.  He took this opportunity to try to (emphasis TRY TO) ‘clarify’ some ‘misconceptions’ about HPV vaccines. After revealing that he has no conflict of interest with “HPV Vaccines” specifically, he did NOT reveal whether he had any COIs with companies that manufacture, distribute, or sell vaccines.

He then leisurely told the Board and the room that yes, 95% of the cases of HPV virus cleared within the first two years.  But, he said, those are not the patients we care about.

Really?  You’re trying to mandate a vaccine to 100% of students, 95% of whom do not need it.  And you don’t care about those 95%.  Or their risks of adverse events.   Got it.  You said, it, Dr. Harrison, YOU DON’T CARE about them.

He admitted type replacement is real. He said that type replacement is not a valid scientific reason not to vaccinate because they can always add more types to future vaccines if it happens.  He ignored, of course the fact that their “information campaign” says that HPV vaccination will protect you from “HPV infection” and “cervical cancer”, causing young people to engage in riskier sex behaviors, leading to type replacement and increased risk of cervical cancer once they are infected with the rarer types.  He showed that vaccination of those already infected is not efficacious, but failed to realize or show that therefore partial immunization NOW will make FUTURE vaccines ineffective once type replacement occurs.  He did NOT report that CDC’s own data shows NO NET CHANGE in overall HPV infection rates after the vaccines came on the market. He tried to say that type replacement did not appear to occur in HPV because the study (uncited, no references, I presume he means Markowitz et al. (2016) did not find significant changes in the increase of many individual HPV types.  How ridiculous that he did NOT report the full results of that study which showed NO NET CHANGE in OVERALL infection.

There are two ways to have NO NET CHANGE  in OVERALL infection rates in the Markowitz et al. study: (1) low power in the individual univariate tests for individual types, and (2) type replacement.  They are not mutually exclusive.  But Dr. Harrison did not report that finding from the CDC, thus misleading the Board and the public on type replacement.  He also did not cite ANY of the studies which I had sent to the ACBH that show type replacement and find that yes, rarer, more lethal types increase in the population as a result of HPV vaccination.

His presentation was completely one-sided; while he reviewed the side effects of HPV vaccine, and stressed how syncope can be serious (“they fall like rocks”) he did not mention that some kids die after HPV due to car accidents caused by syncope.

He reviewed the clinical research on HPV-4 vs. ‘alum’, and tried to explain that the adjuvant placebo comparison was sufficient.  It clearly was not: aluminum is a serious neurotoxin, and the HPV-4 study result he focused on (alum vs. HPV-4) could not possibly represent a safety test of HPV-4 because that result did not include the effects of aluminum.

He then presented results of HPV-9 vs. HPV-4… which are irrelevant because the question at hand is not to mandate that HPV-4 vaccinated people be upgraded to HPV-9, but rather should HPV-vaccine naive people be given HPV-9.  So no science was presented on vaccinated vs. unvaccinated for safety and efficacy.

Their was public outcry for the lack of fairness that the CDC (I mean, Dr. Harrison) got as much time as he wanted, and the public only had 3 minutes, on a topic that COULD HAVE gone to a vote.

Dr. Lee Harrison?

So who is Dr. Lee Harrison?  Dr. Harrison is a member of CDC’s Advisory Committee on Immunization Practices (ACIP).  That’s right.  Our COUNTY board has a member of the CDC’s ACIP driving and pushing for an HPV vaccine mandate.

Dr. Harrison incorrectly claimed and thus misinformed the public that Pharma pays for the cost of findings of harm by the Vaccine Claims/Office of Special Masters  .  Each vaccine has a $0.75 to $1.50 tax levied upon the taxpayers for the $3 billion dollars that have been so far paid out for vaccine injury award by the ‘Vaccine Court’.

Dr. Harrison’s incomplete disclosure of non-HPV vaccine conflicts of interest is a matter of deep concern, and they are being looked into.

After the CDC’s (Dr. Harrison’s) presentation to the Board, a motion was made by a board member to consider a second option for a PR campaign to increase HPV vaccine uptake (the specific wording will be provided here soon).  A board member made the comment that he was very touched by the parents’ stories of vaccine injuries, and that he was amazed that, outside of this room, many parents came to him who were pro-vaccine, but against the mandate. Another board member, Dr. Donald Burke, Dean of the Graduate School of Public Health at the University of Pittsburgh, wondered if the Board could find a way to interface with the concerned public as part of the motion to approve action on a PR campaign.  Dr. Burke’s had to repeat his statement three times for clarification, and I noticed that initially he said “vaccine efficacy and risk” but that changed to “vaccine efficacy and safety“.

The Constitutional Lawyer on the Board inquired of a third option altogether, to hold public hearings to hear the parents out on their concern. That option was not further commented on, as Dr. Harrison pointed to the screen and said (paraphrasing now) that he thought they should focus on the two options on the screen.  He was clearly on  a mission to have one of the two options move forward.

Not that these two ideas were the only floated. Among other comments, the idea came forward that the administrative group that assists the ACBH propose a plan to the Board on how to increase HPV vaccine uptake via an informational program (again, the precise wording here awaits the minutes).

It was clear that the vote for this option was an option to avoid voting on either the other two options.

A board member made another proposal (at the suggestion of a doctor from the audience) that the issuing of a mandate be changed to issuing a recommendation.

At that point, I stood, and offered the following:

“Excuse me board, but you have a procedural inquiry from a lady (turning, motioning to Janet Cook) that was given to you during the public comment session.  She told you it was a procedural inquiry, and you told her it was  public comment.  She forfeited her three minutes of public comment to provide you the procedural inquiry, and I recommend that you see it as such”.

The idea to vote on a recommendation of HPV vaccination did not move further.

The Board did discuss in areas of high HPV vaccine uptake, what seemed to work other than mandate.  The answer was unclear – but we did learn that “high” HPV vaccine uptake was not >60% (females, I presume, males are always lower).

We must be clear on this: the Board did not vote to not mandate  They voted to have their administrative group devise a plan to promote the public’s awareness of the benefits of HPV vaccination – a PR campaign, essentially – which if it comes to a vote can be countered with the fact the Merck does not need help promoting its products.  They already have an ad running under fire for being emotionally manipulative and for making unfounded claims (see the FTC Petition to nail Merck for this infamous ad).

Further discussion of having the administrative group draw up a plan for educating the public included one comment from a board member who stated that plan could also be to mandate.

The Board voted for the plan to have the administrative group propose a plan to the committee, and all but one (the Constitutional Lawyer) voted against.

What’s my take-away?  There are a few:

(A) The ACBH has been coapted by a representative from Pharma – Dr. Lee Harrison – to try to (a) get a mandate through, or (b) use County funds to create and advertise for Pharma products.

(B) By my count, the Board never had the votes for a mandate.

(C) The administrative group’s proposal will be a target of high interest and intense scrutiny.  No County funds should pay for Merck’s advertising campaigns.

(D) We have a lot to do to educate the Board members of what they science REALLY says.  Dr. Lee’s biased and incorrect representation of the science left out key findings from the CDC study that showed no NET CHANGE IN OVERALL INFECTION RATES of HPV infection before and after the product came to market, and he should in my view be reprimanded for cherry-picking not only the studies he brought forward but also in cherry-picking the results to show.  He did not provide references.

(E) This “victory” was a battle victory.  The war is not yet won. Clearly this means that the work of groups like PCIC, those in the VAXXED community, the NVIC, and researchers looking at the totality of the data at IPAK, MUST continue.  The Board COUNTED the emails for, and against, and noted whether the email authors noted their place of residence.  PEOPLE’S VOICES MATTER.  Call, fax, email on your concerns – and find others who will email, too.

(F) In my view, the most effective strategies were massive email campaign to the Board and PEOPLE showing up for the public comment sessions:

#1. Parent’s statements of their child’s vaccine injuries.

#2. Statistics on vaccine injuries.

#3. Moving the discussion toward conflicts of interest.

#4. Statements from doctors on how egregious a mandate for this vaccine would be (see Kristi Weess public comments, below).

#5. The rest of the science (esp. inefficacy due to type replacement and the fact that there is a drug (Ranpirnase) that COMPLETELY clears the virus from infected individuals.  If 95% of people clear it without any treatment, and the rest can be readily treated without surgery, why vaccinate?

Residents of Allegheny County have a lot of people to thank for showing up.  This includes Kristi Wees, Alison Mullins, Alison Fujito, A.R., Janet Cook, Jessica Fitzgerald, Michelle Sprague, and Erin Rogers.  And of course Kelly Sotomayor, who had shared the story of her daughter with A.R. to share w/the Board. There are others whose input has been critical to causes the Board to reconsider mandating this unnecessary vaccine.

Of course I am grateful to the VAXXED team, especially Del Bigtree and Polly Tommey, who interviewed me on this issue during their Pittsburgh stop.  They have a huge ROAD TRIP planned, a BUS TOUR, so watch for that!

Some Public Comments

Here are the  comments by Kristi Wees:

“Hello and thank you to the Board of Health for allowing me to comment today.

My name is Kristi Wees, I am a resident of Allegheny County, and I am here today as an informed citizen and concerned mother. My educational training is in chemistry and I hold a Master’s degree from UCLA and a Bachelor’s degree from Penn State.

Because of our family’s personal experience witnessing our daughter’s health steadily decline after each well baby visit and round of childhood vaccines, we embarked on a journey to find out what was ailing our sweet baby girl. That journey led us to the research that has been conducted by Dr. Derrick Lonsdale, in the specific field of thiamine deficiency.

Derrick Lonsdale M.D., is a Fellow of the American Academy of Pediatrics (FAAP), American College of Nutrition (FACN), the American College for Advancement in Medicine (FACAM). Though he is now retired, Dr. Lonsdale was a practitioner in pediatrics at the Cleveland Clinic for 20 years and was Head of the Section of Biochemical Genetics. Dr. Lonsdale has written over 100 published papers and 3 books.

Dr. Lonsdale has provided me with this letter he wrote for today’s meeting and has given me permission to read it on his behalf.

From Dr. Lonsdale-

“To whom it may concern,

Report by Derrick Lonsdale M.D. FAAP Associate Emeritus, Cleveland clinic Foundation, Cleveland, Ohio.

In 2013 I became aware of five adolescents with Postural Orthostatic Tachycardia Syndrome (POTS) initiated immediately after the Gardasil vaccine, all of whom had been crippled by the disease for several years. All of them were reported to be superior athletes and students before they received the vaccine. Genomic analysis had shown that all five of these adolescents had minor changes in their DNA that put them at serious risk for thiamine deficiency, precipitated by the stress of the vaccine. The frequency of the genetic risk factors is unknown. By themselves they appear to be relatively harmless. POTS following the HPV vaccination has been reported in the European Journal of Neurology (Blitsheyn S. Postural tachycardia syndrome following human papilloma virus vaccination. Eur J Neurol 2014; 21 (1): 135-9).

Conclusion
Gardasil is a yeast based vaccine using a yeast that contains an enzyme that destroys thiamine. Superior individuals have a superior energy requirement that is governed by the presence of thiamine. If they have a genetic risk, the symptoms of POTS are identical to those of early beriberi, the classic vitamin B1 deficiency disease. The stress of the vaccine, imposed on a genetically determined risk for incurring thiamine deficiency, may be crippling “the brightest and the best”. Considering that there are thousands of adolescents in America, Denmark and Japan with post Gardasil POTS, this incidence needs to be compared with the expected incidence of cancer of the cervix in unvaccinated individuals. Research is urgently needed.”

End of Dr. Lonsdale’s comments

Based on my own experience with my daughter, and with the call for more research into these risk factors by Dr. Lonsdale, I strongly oppose any mandates of the HPV vaccine. There is NO testing being done on the recipients of the vaccine before this vaccine is given. There is no way to know by looking at a person, if they are genetically susceptible to vaccine injury. In my opinion, if you know a vaccine may cause harm to some and you mandate that every person get that vaccine, then you are not upholding a fundamental precept of bioethics taught in medical schools nation-wide, and that is to “first do NO harm”.”

“Hello, my name is Amy Rafferty. I want to mention that I have no vested interest in the HPV vaccine as I do not profit from, nor do I work for someone who profits from, the manufacture, distribution or sale of vaccinations.
I am appalled that the Allegheny County Health Department and Health Board would even consider mandating this controversial vaccine. HPV9 is new to the market and has not established a safety record or success rate in the population yet. I have not heard one doctor quote any research study that proves that this vaccine prevents cancer.
HPV is not a communicable disease and, therefore, will not be spread in a school setting.

So, why make this vaccine mandatory for school attendance? There is obviously not a health emergency in the county either, as throat cancer is on the decline because fewer people are smoking now according to the American Cancer Society. Cervical and uterine cancer combined only make up two tenths of one percent of all deaths in Allegheny County and one percent of all cancer deaths in Allegheny County, according to the Pennsylvania Health Department EDDIE database. This is certainly not an emergency.

Let’s see what other state and federal health Departments think of this vaccine. The country of Japan has stopped recommending the HPV vaccine due to numerous deaths and serious adverse reactions. Japan, Spain, France, Denmark and India join a growing list of countries in which criminal lawsuits have been filed against manufacturers of the HPV vaccine claiming fraudulent and misleading safety information.

Right now, there are 48 states that have chosen NOT to include this vaccine in their state’s list of mandated vaccines.

Allegheny County is the ONLY COUNTY in the USA to ever consider mandating the HPV vaccine. That’s a pretty bold attempt and over-reach for an unelected, unaccountable group of officials, wouldn’t you say? Is the county prepared to deal with the large number of preteen deaths and vaccine injuries that have resulted in each of the other states and countries that have mandated this HPV vaccine?

Who is footing the bill for those who cannot afford this vaccine? This vaccine is the most expensive vaccine of all, costing $450-$500 for a complete set. With approximately 25,500 students in 5th and 6th grade in the county, it will cost $12,748,000. Merck will profit greatly from this mandate.

Since vaccination is a medical procedure carrying risk, Parents need to make the decision, with input from their doctor, on whether or not to have their child receive this controversial HPV vaccination.

I’d appreciate it if any doctors or medical personnel speaking today would use research when saying that the HPV vaccine prevents cancer because I have not found any nor have the people on my team.

I would appreciate it if anyone saying there are no serious adverse event or deaths from this vaccine, to look the parents in this room in the eye, whose daughters have been crippled for years since they got this vaccine.

Thank you for your time.”

You can listen to the HPV vaccine mandate public comments here.

NOHPV

Sign the petition to the FTC to nail Merck for false advertising!

 

hpvadboy

Protect Baby’s Brain from Aluminum Neurotoxicity – It’s Not Just the Vaccines

Anyone who reads my writings will know that I tend to not hold back in the “should” department – because ethics and morals in society depends not only in the proper conduct of science, but also in the proper translation into general knowledge and public health policy.  Those with their hands on the reins of public health policy appear to be more interested in defending flawed policies, and those of us who have come to learn of flaws in the science used to bolster those policies are bound by moral contract with a duty to warn our fellow human beings.

Well, at least some of feel that way.

I would be worthy of being labeled hypocritical, therefore, if I did not shout from my blog the news that there are other sources of aluminum that pregnant and nursing moms may well expose their developing babies to – one that is so commonly available, and the dose of aluminum so high that I shudder to think of any pregnant woman or nursing mom (or individual who likes their brain) taking a single dose.

That product is antacids.

In a chapter reviewing aluminum neurotoxicity (yes, Dr. Offit, aluminum is a long-known neurotoxin), Dr. Robert Yokel in 2012 reviewed estimates of the amount of aluminum absorbed from exposure from various sources, and the results certainly do not bode well for vaccines.  Here is a screen shot of the chapter:

Yokel1

And here is a screenshot of his Table 1, with aluminum from vaccines at 0.07ug daily exposure and aluminum from antacids at 80ug per day:

yolkel1

The low amount calculated “per day”from vaccines, however, is misleading: the dose from a vaccine is given in a single day – and the body has to deal with 100% absorption in real time.  So the numbers to compare are 12-300µg/dose in a day to 80µg/day.  Se the “up to 5,000,000 µg” ingested?  The fact that only 80µg are absorbed per day shows you how little aluminum a normal-functioning GI tract actually absorbs. But that’s a lot for a mom to have in her body while she’s pregnant.  So much for the dismissive position that babies get more aluminum from baby formula. Mothers should breastfeed anyway – unbelievable, CDC recently said moms should not breastfeed to give the vaccines a chance to be more effective.

Add to the 80 from antacids and aluminum in the vaccines offered during pregnancy (bad idea in the first place), and add later aluminum to the baby after via vaccines after birth, you can see we may successively and repeatedly dose our youngest with a neurotoxicant. Aluminum (in a wide variety of forms) causes chronic microglial activation, which occurs when certain cells (microglia) in our brains get stuck in the “destroy” mode and take out dendrites trying to make connections and baby nerve cells (neural precursor cells).

Expectant moms, lactacting moms, throw your antacids away and look at your aluminum intake.  Other foods potentially high in aluminum include pre-prepared pancake mixes and other foods that are kept powdery and dry.  Look at the ingredients and save your baby’s brain from chronic and prolonged exposure.   Get an air filter and filter out the dust that can introduce aluminum into your baby’s body via the lungs or GI tract.

Aluminum is certainly not the only toxin that can induce microglial activation. But 10% of the aluminum absorbed stays in the brain for decades.  Moms and dads, look at the table an find ways to reduce aluminum exposure, and we might just be able to reduce the rates of autism/ASD worldwide.

The full chapter is available from the University of Kentucky website.

http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1030&context=ps_facpub

baby brain

 

Dr. Lyons-Weiler is the author of three book, the latest of which is “Environmental and Genetic Causes of Autism”, which can be ordered online or from your local independent bookseller. A companion website to the book includes over 1,000 references to studies on autism.

causes

My Journey from Ignorance

WHILE RETURNING from the United Nations building where I heard NYU Professor Mary Holland (School of Law) nail the issues of constitutional and international law on the right to informed consent to the floor, to a standing ovation, I received an email from Mary ( To my delight). I read, in part:

“I  started reading your Ebola book last night.  Wow, you have evolved a lot in your thinking on vaccines in a VERY short period, based on your definition of ‘antivaxxers’ at bottom of 206, top of 207.  Have you written up how your views evolved so quickly?  It might be a helpful roadmap towards turning others around.  Was this all in connection with the autism book, or did your views changing precede that book?”

Looking at my book this morning, I turned to page 206, with trepidation, to find the younger, knowing me, trying to save the world by chiding and deriding people whom I have come to learn much more about in the past two years:

“Again and again with Ebola we see, from Guinea to the US, societies struggling with the ethical problem of the needs (and wants) of a few vs. the safety (and lives) on the many”.

Ok, that’s not too bad.  A bit uppity, but I cannot disagree. But it gets worse.

“With over 100 cases confirmed, the US is, at the time of this writing, at high risk of an epidemic of measles because the herd immunity is lacking due to a dogmatic antivaccination movement”.

I warned you.

Deplorably, I continue:

“The efficacy of the measles vaccine in protecting children against terrible diseases should be reason enough for parents to insist on vaccinating their children, but the so-called ‘anti-vaxxers’ (people who believe vaccines place their children at risk of developing autism) fail to consider the greater good: They put others at risk by not participating in national programs for the greater good.”

I really do not like my former self. Naturally, I continue, because I knew SO much before I actually looked into the studies and the data:

“This perspective is more than mere 20:20 hindsight; such occurrences of cultural and institutional amnesia are certain to recur as our society becomes more reliant and trusting in technology, and we forget to respect the awesome power of biology and Nature”.

I really don’t know this guy, I swear.

Mary Holland will certainly be remembered as one of the most staunch defenders of human rights, well, in the history of abuses in medicine. So back to Mary’s question:

“Have you written up how your views evolved so quickly?  It might be a helpful roadmap towards turning others around.  Was this all in connection with the autism book, or did your views changing precede that book?”

Here’s how and why my views have changed. First, I was really rather upset about the fact that CDC Director Thomas Freiden stated in his testimony to Congress that there were no mutations in the Ebolavirus that was driving the epidemic.  I was upset because I had the 396 mutations on my laptop at the very moment he testified to Congress.  I capture that moment in “Ebola“. My anger at the CDC increased when I attended a secret White House conference call, held by the Ebola Czar, in which I asked about the 396 mutations – whether they influenced the ability of tests to detect Ebola, or altered its virulence or transmissibility. In that call, the entire scientific community was lied to again by a CDC Scientist who claimed that the virus was “99.9999% identical to the strain from Zaire in 1995”, which was not true at all.  I capture both of those events in “Ebola”, as well as how the White House then asked the Associated Press to stop covering potential cases of Ebola in the US.  I even ask in that book whether that was “fascism”.

Fast forward a couple of months to where I had decided to write “Cures vs. Profits“. I felt that we had bungled our response to Ebola so badly that I wanted to cheer myself up and write a book on the successes in biomedical research.  Having participated in so many studies over the past two decades, I knew of many reasons that the public should continue to support biomedical research, and I was going to share all that I knew, and discover more. The first two chapters deal with “the bad stuff” – the doctors who cheat at medicare fraud, which robs other patients of needed funds for real medicine – and the biomedical researchers who cheat at their research studies.

I wrote my chapters out on grapefruit, on cancer vaccines, on prostate cancer robotic surgery, and then something happened: I wrote a chapter on ADHD overdiagnosis. I tell the story of the destruction of a promising career of Dr. Gretchen Watson.  Pharma sent a “Key Opinion Leader” to EVMS to debate her over her study, and the next day she was told her case load was canceled, that her colleagues were told that she no longer worked at EVMS, and that she was to expected to resign.  She refused, and won an appeal to HR.  But then someone floated a rumor that she manipulated her data in the 1996 study showing overdiagnosis.

The investigation revealed no flaw – well, a typo in an appendix – but the damage to her career was done. The good news is that Dr. Watson has decided to write of book of her own after reading my chapter on ADHD.  She now also serves on the Board at IPAK.

When I finished writing the rest of “Cures“, including chapters on the history of hormone receptor status in breast cancer, chemosensitivity assays, characteristics of good research scientists, and cancer vaccines, I found the book missing something.

So I decided to write a chapter on Vaccines.

I’ll let the chapter on vaccines speak for itself- it begins with tales of how wonderful vaccines are, how they save lives.  I went back to review the autism/vaccine link, fully expecting to review the Andrew Wakefield issue briefly, how his claims that MMR were linked to vaccines. I read the retracted study.

I found that Andrew Wakefield never claimed that the MMR might cause autism.  Instead, I found the study to suggest that it was a question worth looking into.

My digging around then led to my discovery of reports that someone at CDC had revealed that CDC had manipulated data on the studies designed to disprove Wakefield by omitting results with a positive association.

The more I dug into the issue, and then into the literature, the more I found the science of vaccines falling far short of the science needed to insure public health via any medical procedure given to millions. And this is where I leave the issue in “Cures“. I added an addendum that reviews four open controversies in vaccines that cause me to question whether vaccines can be called an unmitigated success in translational research.

In retrospect, I see that position as something of an understatement.

My understanding of vaccines was (obviously) limited, and I needed to grasp the risks involved. I needed resolution. So after I completed “Cures“, I began writing about what I had learned. I spoke with people with an open mind. I started to listen not only to what these evil, selfish “anti-vaxxers” had to say, I started to really think about the consequences of the additives. I began to question the over-arching claims of safety.

And via some new contacts, I made connection with Tony Lyons of Skyhorse Publishing. After a few chats, he, Louis Conte and I agreed that I should write a book on the Genetics of Autism. (I love Louis – and knowing what I know of him now, my bet is that he thought I was a good prospect – but somehow I can hear him telling Tony that Jack has ‘a way to go, but I think he’ll get there’. Thank you Louis for the confidence.

So in I dove, into 3,000 research articles on autism.  Not on vaccines – on autism.  I wanted to know if the basic science could in any way reasonably support a hypothesis that vaccines or their additives cause autism. The answer is a resounding “Yes, yes, and yes”. Other articles in this blog will give you an idea of some of the evidence that exists on the role of chronic microglial activation and autism, for example.

To the readers of “Ebola” who feel confused or hurt by my, and others’ ignorance, please remember that there is a Great Unknowing, even among professionals.  Think about it – all “Anti-vaxxers” with vaccine-injured children were once pro-vaccine. As I advised some 500 participants at the VIALs Health Summit in Atlanta, GA, do not argue with them – educate them. Your anger and frustration is warranted, but help them move from ignorance to awareness and understanding.

I took it upon myself to consider 3,000 articles on autism for “Causes” (available at Amazon.com and in your local Barnes and Noble or indie bookstore).  (I skimmed 3,000, read >2,000, and cite >1,000). Look at what knowledge can do to a scientist who themselves feel cheated and lied to, someone who entrusted the CDC to perform objective science (See “The Tyranny of Pseudoscience“):

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The author at a CDC Rally, April 22nd, 2016.

 

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Educating the public and calling for Congress to Subpoena Dr. William Thompson at the CDC on the true nature of so-called “Science” conducted at the CDC on the link between vaccines and autism.

To My Fellow Scientists and Medical Health Care Professionals

I wrote “Ebola” in good faith, assuming that the position of the CDC on vaccines was based on sound science. It was unfathomable to me that

-Upon finding positive associations, CDC would routinely over-analyze data from studies until they could make associations go away, and when they could not succeed in doing that, they would simply omit the results;

-CDC would suspend an employee who drew these practices to the attention of then CDC Director Dr. Julie Gerberding (who subsequently took a position in charge of vaccine development at Merck);

-After CDC published these studies they called for an end to research on vaccine safety with regard to potential links to autism;

-CDC would ignore nearly all of the basic science that shows mechanisms of how neurotoxins in vaccines (not just MMR) could reasonably be expected to cause autism in some people;

-CDC’s position is based on ecological association studies, not randomized prospective clinical studies with proper controls.

-Our knowledge of vaccine safety is based on post-market surveillance;

-CDC would ignore all of the post-market surveillance on vaccine safety, claiming that the passively collected data in VAERS did not provide causal evidence;

-CDC would lie repeatedly under oath to Congress about the State of Science on the link between vaccines and autism;

-No one has ever conducted a vaccinated vs. unvaccinated study for association with negative health outcomes, including autism.

-CDC would communicate to the public that “Vaccines Do Not Cause Autism” on their website knowing full well that 6/12 vaccines on the schedule before the age of 7 have 0 studies one way, or the other, on whether they indeed may (or may not) contribute to the risk of autism.

I, like the rest of the world, relied on the CDC to be a reliable source of information on vaccine safety.  Yes, I vaccinated my children. I will not allow them to get the HPV vaccine. Here is why.

To the Parents of Vaccine-Injured Children who Regressed Into Autism

Your observations are the basis of a new era in vaccine science.  All science begins with observations. Help and relief is on the way. And there is nothing that can stop it.

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Dr. Lyons-Weiler (right) meets Marcella Piper-Terry (left) at the 2016 CDC Rally.
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Fellow Vaccine Risk Aware Protestors Calling for Congress to Subpoena Dr. Thomspson
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Dr. Lyons-Weiler meets the future Director of the CDC.

After the Rally, we enjoyed a summit at Life University hosted by VIALS. Here was our audience:

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Here I presented the CDC Schedule as backed by “Magic”, because no science exists on any link between 6 vaccines and autism, whereas some vaccines do, in fact have some studies that support association:

no science 2no science

That was a good day in Atlanta, GA. Here are the slides to share with your pediatrician:

VIALs health summit slides James LyonsWeiler MAGIC

CDCSCHEDULE
“MAGIC!!!”

 

 

Next stop, the United Nations:

 

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Dr. Lyons-Weiler attends a UN Session on Toxins in Our Children, April 26th, where Dr. Thompson’s revelations were shared with the world.


 

Mary Holland standing up for your rights to refuse medical procedures as a basic human right. To watch the unprecedented UN Session on Toxic Contamination of Children (4/26/2016), follow this link.

Mary Holland’s question to me was an important one:like many, if not most other professionals, I had argued my position on the vaccine/autism question from a position of ignorance.  They simply have not done their homework, and many have bought the CDC’s lies hook, line and sinker. They count on CDC to be honest and forthright. This include the AAP, the AMA, and, very likely, your pediatrician.

Most of them probably have not read a single study. They likely have never read the following words that Dr. William Thompson said to Dr. Hooker:

Thompson: “They don’t really want people to know that this data exists.”

Thompson: “…among the blacks, the ones that were getting vaccinated earlier, were more likely to have autism.”

Thompson: “It appears in the final publication is that race in general is downplayed. Of course it is.”

Thompson: “I actually think the most interesting results are the isolated, ones that don’t have their co morbid conditions. The effect is where you would think it would happen.”

Thompson: “I was just looking at—I was like, oh my God, I cannot believe we did what we did. But we did.”

Thompson: “The higher ups wanted to do certain things and I went along with it. In terms of chain of command, I was number four out of five. “

Thompson: “…Literally, everyone else got rid of all their documents, and so the only documents that exist right now from that study are mine.”

Thompson: “There are things that I haven’t even shared with you because I can’t prove it, and that’s what I struggle with. I don’t want to share things with you that I can’t prove, that there aren’t hard records. I am worried that the other four people will collude and say no, that’s not true.”

Thompson: “That’s what I keep seeing again, and again, and again where these senior people just do completely unethical, vile things and no one holds them accountable. “

Thompson: “The reason you don’t see anything else circulating on the study, it was five of us behind closed doors for two years.”

Thompson: “It’s the lowest point in my career that I went along with that paper.”

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Dr. William W. Thompson

My book “Cures vs. Profits” tells more of the story of Dr. Thompson and Hooker. At this point, I am willing to go on the record and say that I have zero – ZERO confidence in any science coming out of the CDC Immunization Safety division. And no one else should trust their research, either.

In fact, nothing they publish can be trusted. Not merely because of what Thompson said.

I’ve read their studies.

They are atrociously unsafe ventures in data cooking, model overfit, sad excuses for “control variables”, use of multicollinear variables, the product of repeated data analysis to a desired result (no association). They are a mess.

The individual people in question include

RADM Anne Schuchat, Principal Deputy Director of CDC

Dr. Frank DeStefano, Director of the Immunization Safety Office

Dr. Coleen Boyle Director, National Center on Birth Defects and Developmental Disabilities (NCBDDD)

Dr. Poul Thorsen (co-author on suspect CDC studies, wanted by HHS for embezzling over $1Million in funds that were to be used for autism research, living openly in Denmark).

and others.

In my research, I strive to remain objective. However, since 2004, when the research fraud at the CDC occurred, there have been over 1,000,000 cases of autism that potentially could have been prevented simply by splitting up the MMR into three vaccines, spacing the vaccines out, giving non-adjuvanted vaccines with 1 adjuvanted, screening for safe epitopes, removal of mercury from all vaccines, giving medical exemptions to parents who already have one autistic child (to avoid the genetic x environment interaction), dropping HepB until adulthood… so many simple things that could have been done to reduce early exposures to toxins. Where is the science for biomarkers to indicate which children might be most at risk of ASD due to vaccines?  Not done.  CDC called for no more science.

We Want Evidence-Based Public Health Policies, not Policies Based on Subjective Belief (aka “Magic”)

Right now, the so-called “Anti-vaxxers” I so woefully admonished in “Ebola” are not all “Anti-Vaxxers”. They do consist partly of some people who believe no safe vaccine could ever exist. I respectfully remind them that until the science is done to show that non-adjuvanted vaccines without mercury, aluminum, formaldehyde, etc are tested, their knowledge claim is an untested generalization about all vaccines. Out of well-deserved distrust, they call for no more science on vaccine safety – because they know that some will be injured by that very research.

But the Vaccine Risk Aware movement also includes people who are 100% Pro-Vaccine Safety. They suspect that safe and effective antigen presentation systems can be designed, that use exposure at the skin (microdermal abrasion), with epitopes that do not induce autoimmunity. They believe that taking the toxins out will likely make vaccines safer. But they do not make such claims.  They call for more science, not less, but on newer options for inducing immunity.

To watch my presentation at the VIALS Health Summit State of Science on Vaccine Safety: Autism, in which I explain how the CDC’s claims that vaccines do not cause autism must be based on magic, follow these links: (Part 1, Part 2, Part 3).

Calls for Retraction of CDC “Studies”

Because CDC committed scientific fraud, the studies they performed should be retracted. IPAK has informed the journals of this, and we have sent them copies of “Vaccine Whistleblower, by Kevin Barry, Esq.

I urge all of my colleagues to view the movie #Vaxxed.  Call your local theater and ask them to screen the movie. If you consider yourself an objective scientist, read “Whistleblower“, and RFK jr.’s book, “Thimerosal: Let the Science Speak“.  Order “Master Manipulator” by James Grundvig, which tells the story of Poul Thorsen, a CDC collaborator wanted for absconding with autism research cash (given what CDC would have done with the money, Thorsen may be a hero, for all we know).  For a deeper timeline view on how long corporate corruption has eroded science in our most esteemed institutions like the CDC, read “Science for Sale” by David Lewis.

I ask my professional colleagues from all walks of science and medicine then to join us in our calls for retraction of the CDC’s false studies: DeStefano et al., Madsen et al., and Verstraeten et al.  I will not stop educating professionals about the fraud because we need evidence-based medicine, not medicine based on guesses, or hopes, or magic.  Babies are dying in the womb due to mercury in flu vaccine reserved for pregnant women; babies are born autistic due to immunoneuroexcitotoxicity; they are born with seizure disorders; toddlers regress into autism after learning language. And yes, it may be due to cumulative and interactive effects of toxic chemicals from agriculture, industry, our home, etc.  But we can reduce the toxins we expose our children to.  Right now, autism risk is 1 in 68, up from 1 in 3000 in the 1970’s.  Let’s have #theconversation.

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Acknowledgements. I have literally thousands of people to thank for helping move from ignorance to awareness.  You know who you are. Thank you.

Please support VIALs with a generous donation.  Tell them Jack sent you!
To support Dr. Lyons-Weiler and his research associates at IPAK, visit ipaknowledge.org

VIALs health summit slides James LyonsWeiler MAGIC

causes

Aluminum, Alzheimer’s and Autism

TO THE READER: IMPORTANT DETAILS HAVE EMERGED FROM STUDIES ON THE CAUSES OF BRAIN DYSFUNCTION FROM STROKE AND ALZHEIMER’S DISEASE THAT LEAD DIRECTLY TO HOPE FOR EFFECTIVE AMELIORATION OF THE BRAIN-CELL DESTROYING PROCESSES IN AUTISM. READ THE ARTICLE ALL THE WAY THROUGH TO LEARN ABOUT TWO NUTRIENTS THAT CAN HAVE BEEN FOUND TO REDUCE BRAIN GLUTAMATE LEVELS, WHICH CAUSES CHRONIC MICROGLIAL ACTIVATION (CMA). CMA IS KNOWN TO OCCUR IN THE BRAINS OF AUTISTICS FROM AGE 4-44. THE POSSIBILITIES ARE IMMENSE. MORE RESEARCH IS URGENTLY NEEDED. -JLW (April 8, 2016)

THERE ARE TWO MAIN KNOWN PROCESSES involved in the onset of autism. The first is susceptibility to environmental toxins via mitochondrial dysfunction, which can be the combined result of environmental insults and mutations in mitochondrial genes and genes that directly influence mitochondrial function.  This combination of factors exists in as many as 20% of cases of autism.

The second is chronic microglial activation (CMA). Microglia are amazing nerve cells that serve as shepherds of learning, fostering connections at the synapse during reinforcement learning. They also play the role of the white blood cells (WBCs) of the brain, becoming activated due to injury or infection. Upon dying, brain cells release chemicals calls cytokines that activate microglia from tending shepherds to armed killers. They consume bacteria, viruses, and cellular debris, clearing the brain of the dead and dying cells. The eat impaired dendrites in their activated state.

Other cells called astrocytes mop up the chemical signals that cause microglial activation via molecules called receptors. One of these signals is glutamate.  CMA occurs when something causes glutamate build-up in the brain.  CMA can occur in autism patients with or without mitochondrial dysfunction, and both processes may be at work and interrelated in any given patient with autism.

Causes of Excess Glutamate in the Brain

Many environmental factors can cause excess glutamate. Eating it (MSG) is one way to upset the balance between glutamate in the blood and the brain. The higher the concentration of glutamate in the blood, the less able the brains glutamate pumps are able to dump excesses into the blood. Mercury and aluminum, both additives found in vaccines, can cause chronic microglial activation by harming astrocytes’ ability to uptake glutamate. Chronic microglial activation is found in people with autism from age 5 to 44 (Vargas et al., 2005).

Researchers at the Johns Hopkins University in the Neuroimmunopathology lab studied autistics aged 5-44 and found that their brains had widespread microglial hyperactivation and sensitivity to astrocytes, reflecting IL-6 cytokine mediated inflammation (Vargas et al., 2005). The chronic inflammatory conditions were most pronounced in the cerebellum, anterior cingulate and the medial frontal gyrus. The fact that the hyperactivated state persisted for decades is a critical observation from this study.

Reducing Brain Glutamate and Brain Damage from Stroke

A series of important studies have shown that techniques that clear excess glutamate from the brain during stroke reduces brain damage.  Campos et al. (2011a), demonstrated the effectiveness of oxaloacetate  (a known blood glutamate scavenge) in treating rats in which a stroke was induced. The found that intravenous injection of oxaloacetate decreased both blood and brain glutamate levels. This led to an astounding  80% reduction volume of the brain infarct, dramatically reducing brain edema. The neuroprotective effects of oxaloacetate are due to the depletion of blood glutamate levels – which occurs as a consequence of the activation of a blood-resident enzyme glutamate-oxaloacetate transaminase (GOT) (Gottlieb et al, 2003). When blood glutamate levels are low, the gradient across the blood-brain barrier is in the correct ratio to allow rapid glutamate clearing. This will result in a shut-down of microglial activation.

Similar results were found in human studies by the same team. Campos et al (2011b) studied a cohort of several hundred stroke victims at two hospitals. Using the same inclusion and exclusion criteria, they found that blood glutamate levels at the time of admission to the hospitals was a good predictor of outcome from stroke. (Read more at “GOT to ride the body of excess glutamate“.

These studies confirm earlier findings that both oxaloacetate and pyruvate are effective at reducing brain glutamate levels (Boyko et al., 2012).

Read this exciting study in the abstract from Castillo et al. (2015):

“Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other cellular components of the neurovascular unit. Several strategies have been developed against glutamate excitotoxicity, however none of them have not shown positive results in the clinical practice so far. Nowadays, the concept of blood/brain glutamate grabbing or scavenging is well recognized as a novel and attractive protective strategy to reduce the excitotoxic effect of excess extracellular glutamate that accumulates in the brain following an ischemic stroke. The main advantage of this novel therapeutic strategy is that it occurs in the blood circulation and therefore does not affect the normal brain neurophysiology, as it has been described for other drug treatments used against glutamate excitotoxicity. In this work we report all experimental data from the beginning of our studies, focused on stroke pathology, and we describe new findings about the potential application of this therapy. Future clinical trials will allow to know the real efficacy of this novel therapeutic strategy in stroke patients.”

Microglia, Glutamate and Alzheimer’s Disease

One of the most vocal minds pointing to CMA as a major process involved in autism was Dr. Russell Blaylock, MD.  The abstract above  reads just like studies from autism by Blaylock and others (substitute “stroke” with “autism”). Blaylock’s various writing and videos of his presentations have awakened many to the fact that autism is a medical condition, not a neurodevelopmental disorder per se. The medical aspects of autism mean that reversing the causes of the disorder, such as shutting down chronic microglial activation, should be possible. An important part of that is diet. Some foods (such as those containing MSG) will exacerbate brain trauma caused by the excitotoxicity cycle set up by immunotoxins in vaccines (aluminum and mercury). Tylenol should be avoided as it depletes glutathione, a necessary component of microglial glutamate reduction.

It has only more recently been found that immunoneuroexcitotoxicity is at the causal center of Alzheimer’s disease.  A rich literature exists that shows that CMA is found as a causal factor in Alzheimer’s disease, with specific causal links demonstrated between excess glutamate, and microglial dysfunction.

Here is an example from Solito and Sastre (2012):

Contrary to early views, we now know that systemic inflammatory/immune responses transmit to the brain. The microglia, the resident “macrophages” of the brain’s innate immune system, are most responsive, and increasing evidence suggests that they enter a hyper-reactive state in neurodegenerative conditions and aging. As sustained over-production of microglial pro-inflammatory mediators is neurotoxic, this raises great concern that systemic inflammation (that also escalates with aging) exacerbates or possibly triggers, neurological diseases (Alzheimer’s, prion, motoneuron disease). It is known that inflammation has an essential role in the progression of Alzheimer’s disease (AD), since amyloid-β (Aβ) is able to activate microglia, initiating an inflammatory response, which could have different consequences for neuronal survival. On one hand, microglia may delay the progression of AD by contributing to the clearance of Aβ, since they phagocyte Aβ and release enzymes responsible for Aβ degradation. Microglia also secrete growth factors and anti-inflammatory cytokines, which are neuroprotective. In addition, microglia removal of damaged cells is a very important step in the restoration of the normal brain environment, as if left such cells can become potent inflammatory stimuli, resulting in yet further tissue damage. On the other hand, as we age microglia become steadily less efficient at these processes, tending to become over-activated in response to stimulation and instigating too potent a reaction, which may cause neuronal damage in its own right. Therefore, it is critical to understand the state of activation of microglia in different AD stages to be able to determine the effect of potential anti-inflammatory therapies. We discuss here recent evidence supporting both the beneficial or detrimental performance of microglia in AD, and the attempt to find molecules/biomarkers for early diagnosis or therapeutic interventions.

One of the leaders in this area is Israeli scientist Dr. Vivian Teichberg, Ph.D., who proposed that clearing glutamate from the blood might cause a release of glutamate from the brain into the blood.  In a series of clever studies, researchers at the Weizmann Institute found that transforming glutamate in the blood into another form causes glutamate in the brain to exit – providing protection against glutamate storms associated with stroke.  (Read: “Protecting the Brain from A Glutamate Storm“). More on this exciting epiphany, below.

Aluminum, Alzheimer’s, and Glutamate Uptake

Aluminum has long been suspected to be a plausible causal contributing factor to the risk of Alzheimer’s disease. Geographic correlations of aluminum levels in drinking water (Martyn, et al., 1989), and the finding of high amounts of aluminum in the brains of some patients who died from Alzheimer’s disease (just one example, see Exley and Vickers (2014)  were initial indicators. More recent studies seem to confirm the link. A metaanalysis found a 71% increase in the risk of Alzheimer’s disease in individual with chronic exposure to aluminum (Wang et al., 2016). As people age, their microglia become less efficient at clearing Aβ deposits from the brain parenchyma (Thériault et al., 2015).

Chronic Microglial Activation and Aluminum from Vaccines

Nine of 11 available studies reviewed by Flaten et al. (2001) concluded that Alzheimer’s disease incidence was increased regions with highest aluminum in residential drinking water. Measures of inflammation, particularly in the brain, were also seen to be increased when aluminum was high in drinking water (Campbell et al., 2004) – and, importantly, activated microglial cells were also increased. Aluminum in vaccines is almost certainly a causal factor in chronic microglial activation.

Aluminum is found in most vaccines, and is a serious neurotoxin, in spite of a thwarted misinformation campaign to the contrary (Read “Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments are Ready!“). In mice, subcutaneous aluminum injections resulted in significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex Shaw CA et al., 2013). Reduced spatial memory capacity and impairment of motor function was observed after six doses (Shaw et al., 2009). Aluminum also influences other cells than microglia; it results in altered mitochondrial metabolism, globular astrocyte shape and astrocyte dysfunction (Lemire et al., 2009).

Olmos-Alonso et al. (2016) found increased proliferation of microglial cells in human Alzheimer’s disease. Stanford University researchers have reported that a drug called EP2 can reverse microglial activation.

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Chronic microglial activation  (CMA) leads to damage to synapses, loss of neural precursor cells, and neuronal death. The same process of CMA is seen in autism from ages 4-25 (Vargas et al.). Image modified from  Morales et al., 2014. Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci. 8:112. doi: 10.3389/fncel.2014.00112. eCollection 2014.).


Now The Most Exciting Part: Oxaloacetate and Pyruvate Supplements Clear Excess Glutamate from the Brain

Oxaloacetate is found in nature – and has numerous healthy benefits. It is non-toxic (similar toxicity to vitamin C) and is found in apples, pears, bananas, and spinach. (Read NDX USA’s easy-to-digest article “Oxaloacetate“.

Pyruvate is also found in nature. Foods containing it include red apples, cheese, dark beer, and red wine.  Here is a well-informed article  by Maia Appleby at SFGate on pyruvate supplements (“What Is Pyruvic Acid?”).

Both Oxaloacetate and Pyruvate are available in capsule form, however, the doses required to replicate the effects per body weight conducted in the studies showing their effects on glutamate levels in the brain are very high.  Here are some sources:

Oxaloacetate Supplement, 250 mg, by Natural Dynamix at Amazon.com

[Oxaloacetate (Oxaloacetic Acid) Mental Health Daily Link]

Pyruvate Supplement, 1000 mg, by Piping Rock Health Products at Amazon.com

According WebMD,  our bodies produce pyruvate when it breaks down sugar (glucose), and is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.  [WebMD Link]

[Disclaimer: These links are provided to the reader to inform on availability, are not meant as a recommendation. No health claims are made by the author, nor any recommendations. High doses of any supplement can have side effects. Check with your doctor before adding any supplements to your diet].

Conclusion

Chronic and acute microglial activation leads to brain trauma in stroke, Alzheimer’s and autism. By reasonable inference, supplements that reduce glutamate-induce chronic microglial activation in Alzheimer’s are very likely to have the same effects on some patients with autism.  Studies are urgently needed to determine if dietary oxaloacetate and pyruvate supplementation provide neuroprotection against chronic microglial activation in persons with autism.  Studies of glutamate levels and injection of oxaloacetate during severe neurological distress following vaccination should be undertaken immediately.

Dr. Lyons-Weiler is the President and CEO of The Institute for Pure and Applied Knowledge, which conducts basic, translational and clinical research in the public interest (without profit motive), and is author of three books, “The Environmental and Genetics Causes of AutismThe Environmental and Genetics Causes of Autism“,  “Cures vs. Profits“, and “Ebola: An Evolving Story“.

References

Boyko M et al., 2012. The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage. Neurotherapeutics. 9(3):649-57. doi: 10.1007/s13311-012-0129-6.

Campos F, Sobrino T, Ramos-Cabrer P, Argibay B, Agulla J, Pérez-Mato M, Rodríguez-González R, Brea D, Castillo J. 2011. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab. 2011 Jun;31(6):1378-86. doi: 10.1038/jcbfm.2011.3. Epub 2011 Jan 26.

Campbell A et al., 2004. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. J Neurosci Res. 75(4):565-72.

Campos F, Sobrino T, Ramos-Cabrer P, Castellanos M, Blanco M, Rodríguez-Yáñez M, Serena J, Leira R, Castillo J. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Jun;31(6):1387-93. doi: 10.1038/jcbfm.2011.4. Epub 2011 Jan 26.

Castillo J et al. 2015. A novel mechanism of neuroprotection: Blood glutamate grabber. J Cereb Blood Flow Metab. 2016 Feb;36(2):292-301. doi: 10.1177/0271678X15606721.

Exley C, Vickers T. 2014. Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report. J Med Case Rep. 8:41. doi: 10.1186/1752-1947-8-41.

Flaten TP, 2001. Aluminium as a risk factor in Alzheimer’s disease, with emphasis on drinking water. Brain Res Bull. 55(2):187-96.

Gottlieb M, Wang Y, Teichberg VI. 2003. Blood-Mediated Scavenging of Cerebrospinal Fluid Glutamate. Journal of Neurochemistry  87: 119–126.

Lemire J et al., 2009. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J Neurosci Res.;87(6):1474-83. doi: 10.1002/jnr.21965.

Olmos-Alonso A et al., 2016. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology. Brain 139(Pt 3):891-907. doi: 10.1093/brain/awv379.

Martyn, C. 1989. Geographical relationship between Alzheimer’s disease and aluminum in drinking water. Lancet 1:59.

Shaw CA and MS Petrik. 2009. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. J Inorg Biochem. 103(11):1555-62. doi: 10.1016/j.jinorgbio.2009.05.019.

Shaw CA et al., 2013. Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes. J Inorg Biochem. 128:237-44. doi: 10.1016/j.jinorgbio.2013.07.022.

Solito E, Sastre M. 2012. Microglia function in Alzheimer’s disease. Front Pharmacol. 3:14. doi: 10.3389/fphar.2012.00014. eCollection 2012.

Thériault, P et al. The dynamics of monocytes and microglia in Alzheimer’s disease Alzheimer’s Research & Therapy 20157:41 DOI: 10.1186/s13195-015-0125-2.

Vargas DL et al., 2005. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 57:67-81.

Wang Z et al., 2016.  Chronic exposure to aluminum and risk of Alzheimer’s disease: A meta-analysis. Neurosci Lett. 2016 Jan 1;610:200-6. doi: 10.1016/j.neulet.2015.11.014. Epub 2015 Nov 27.

Zlotnik A, Gurevich B, Tkachov S, et al. 2007. Brain Neuroprotection by Scavenging Blood Glutamate. Experimental Neurology 203: 213–220.

Books by Dr. Lyons-Weiler

Ebola: An Evolving Story (2015, World Scientific)

Genetic and Environmental Causes of Autism (2016, Skyhorse Publishing)

causes

Cures vs. Profits: Successes in Translational Research (2016)

Related Abstracts

Bondy SC. 2016. Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer’s disease and age-related neurodegeneration. Neurotoxicology. 52:222-9. doi: 10.1016/j.neuro.2015.12.002. 

Abstract
Aluminum (Al) is a very common component of the earth’s mineral composition. It is not essential element for life and is a constituent of rather inert minerals. Therefore, it has often been regarded as not presenting a significant health hazard. As a result, aluminum-containing agents been used in the preparation of many foodstuffs processing steps and also in elimination of particulate organic matter from water. More recently, the reduced pH of bodies of water resulting from acid rain has led to mobilization of aluminum-containing minerals into a more soluble form, and these have thus entered residential drinking water resources. By this means, the body burden of aluminum in humans has increased. Epidemiological and experimental findings indicate that aluminum is not as harmless as was previously thought, and that aluminum may contribute to the inception and advancement of Alzheimer’s disease. Epidemiological data is reinforced by indications that aluminum exposure can result in excess inflammatory activity within the brain. Activation of the immune system not initiated by an infectious agent, typifies the aging brain and is even more augmented in several neurodegenerative diseases. The origin of most age-related neurological disorders is generally not known but as they are largely not of genetic derivation, their development is likely triggered by unknown environmental factors. There is a growing and consistent body of evidence that points to aluminum as being one such significant influence. Evidence is presented that reinforces the likelihood that aluminum is a factor speeding the rate of brain aging. Such acceleration would inevitably enlarge the incidence of age-related neurological diseases.

Fanne RA, Nassar T, Heyman SN, Hijazi N, Higazi AA.. 2011. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R668-73. doi: 10.1152/ajpregu.00058.2011. 

Abstract
In patients with acute ischemic stroke, diabetes and hyperglycemia are associated with increased infarct size, more profound neurologic deficits and higher mortality. Notwithstanding extensive clinical and experimental data, treatment of stroke-associated hyperglycemia with insulin is controversial. In addition to hyperglycemia, diabetes and even early prediabetic insulin resistance are associated with increased levels of amino acids, including the neurotoxic glutamate, in the circulation. The pleiotropic metabolic effects of insulin include a reduction in the concentration of amino acids in the circulation. In this article, we show that in diabetic rats exposed to transient middle cerebral artery occlusion, a decrease of plasma glutamate by insulin or glucagon reduces CSF glutamate, improves brain histology, and preserves neurologic function. The neuroprotective effect of insulin and glucagon was similar, notwithstanding their opposite effects on blood glucose. The therapeutic window of both hormones overlapped with the short duration (~30 min) of elevated brain glutamate following brain trauma in rodents. Similar neuroprotective effects were found after administration of the glutamate scavenger oxaloacetate, which does not affect glucose metabolism. These data indicate that insulin and glucagon exert a neuroprotective effect within a very brief therapeutic window that correlates with their capacity to reduce glutamate, rather than by modifying glucose levels.

Pogue AI, Lukiw WJ. 2016. Aluminum, the genetic apparatus of the human CNS and Alzheimer’s disease (AD). Morphologie. 2016 Mar 8. pii: S1286-0115(16)00024-2. doi: 10.1016/j.morpho.2016.01.001.

Abstract
The genomes of eukaryotes orchestrate their expression to ensure an effective, homeostatic and functional gene signaling program, and this includes fundamentally altered patterns of transcription during aging, development, differentiation and disease. These actions constitute an extremely complex and intricate process as genetic operations such as transcription involve the very rapid translocation and polymerization of ribonucleotides using RNA polymerases, accessory transcription protein complexes and other interrelated chromatin proteins and genetic factors. As both free ribonucleotides and polymerized single-stranded RNA chains, ribonucleotides are highly charged with phosphate, and this genetic system is extremely vulnerable to disruption by a large number of electrostatic forces, and primarily by cationic metals such as aluminum. Aluminum has been shown by independent researchers to be particularly genotoxic to the genetic apparatus, and it has become reasonably clear that aluminum disturbs genetic signaling programs in the CNS that bear a surprising resemblance to those observed in Alzheimer’s disease (AD) brain. This paper will focus on a discussion of two molecular-genetic aspects of aluminum genotoxicity: (1) the observation that micro-RNA (miRNA)-mediated global gene expression patterns in aluminum-treated transgenic animal models of AD (Tg-AD) strongly resemble those found in AD; and (2) the concept of “human biochemical individuality” and the hypothesis that individuals with certain gene expression patterns may be especially sensitive and perhaps predisposed to aluminum genotoxicity.

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Neuroprotection in Strokes, Alzheimer’s Disease, and Autism

TO THE READER: DETAILS HAVE EMERGED FROM STUDIES ON THE CAUSES OF BRAIN DYSFUNCTION FROM STROKE AND ALZHEIMER’S THAT LEAD DIRECTLY TO HOPE FOR EFFECTIVE AMELIORATION OF THE BRAIN-CELL DESTROYING PROCESSES IN AUTISM. READ THE ARTICLE ALL THE WAY THROUGH TO LEARN ABOUT TWO NUTRIENTS THAT CAN HAVE BEEN FOUND TO REDUCE BRAIN GLUTAMATE LEVELS, WHICH CAUSES CHRONIC MICROGLIAL ACTIVATION (CMA). CMA IS KNOWN TO OCCUR IN THE BRAINS OF AUTISTICS FROM AGE 4-25. THE POSSIBILITIES ARE IMMENSE. MORE RESEARCH IS URGENTLY NEEDED. -JLW (April 8, 2016)

THERE ARE TWO MAIN KNOWN PROCESSES involved in the onset of autism. The first is susceptibility to environmental toxins via mitochondrial dysfunction, which can be the combined result of environmental insults and mutations in mitochondrial genes and genes that directly influence mitochondrial function.  This combination of factors exists in as many as 20% of cases of autism.

The second is chronic microglial activation (CMA). Microglia are amazing nerve cells that serve as shepherds of learning, fostering connections at the synapse during reinforcement learning. They also play the role of the white blood cells (WBCs) of the brain, becoming activated due to injury or infection. Upon dying, brain cells release chemicals calls cytokines that activate microglia from tending shepherds to armed killers. They consume bacteria, viruses, and cellular debris, clearing the brain of the dead and dying cells. The eat impaired dendrites in their activated state.

Other cells called astrocytes mop up the chemical signals that cause microglial activation via molecules called receptors. One of these signals is glutamate.  CMA occurs when something causes glutamate build-up in the brain.  CMA can occur in autism patients with or without mitochondrial dysfunction, and both processes may be at work and interrelated in any given patient with autism.

Causes of Excess Glutamate in the Brain

Many environmental factors can cause excess glutamate. Eating it (MSG) is one way to upset the balance between glutamate in the blood and the brain. The higher the concentration of glutamate in the blood, the less able the brains glutamate pumps are able to dump excesses into the blood. Mercury and aluminum, both additives found in vaccines, can cause chronic microglial activation by harming astrocytes’ ability to uptake glutamate. Chronic microglial activation is found in people with autism from age 5 to 44 (Vargas et al., 2005).

Researchers at the Johns Hopkins University in the Neuroimmunopathology lab studied autistics aged 5-44 and found that their brains had widespread microglial hyperactivation and sensitivity to astrocytes, reflecting IL-6 cytokine mediated inflammation (Vargas et al., 2005). The chronic inflammatory conditions were most pronounced in the cerebellum, anterior cingulate and the medial frontal gyrus. The fact that the hyperactivated state persisted for decades is a critical observation from this study.

Reducing Brain Glutamate and Brain Damage from Stroke

A series of important studies have shown that techniques that clear excess glutamate from the brain during stroke reduces brain damage.  Campos et al. (2011a), demonstrated the effectiveness of oxaloacetate  (a known blood glutamate scavenger) in treating rats in which a stroke was induced. The found that intravenous injection of oxaloacetate decreased both blood and brain glutamate levels. This led to an astounding  80% reduction volume of the brain infarct, dramatically reducing brain edema. The neuroprotective effects of oxaloacetate are due to the depletion of blood glutamate levels – which occurs as a consequence of the activation of a blood-resident enzyme glutamate-oxaloacetate transaminase (GOT) (Gottlieb et al, 2003). When blood glutamate levels are low, the gradient across the blood-brain barrier is in the correct ratio to allow rapid glutamate clearing. This will result in a shut-down of microglial activation.

Similar results were found in human studies by the same team. Campos et al (2011b) studied a cohort of several hundred stroke victims at two hospitals. Using the same inclusion and exclusion criteria, they found that blood glutamate levels at the time of admission to the hospitals was a good predictor of outcome from stroke. (Read more at “GOT to ride the body of excess glutamate“.

These studies confirm earlier findings that both oxaloacetate and pyruvate are effective at reducing brain glutamate levels (Boyko et al., 2012).

Read this exciting study in the abstract from Castillo et al. (2015):

“Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other cellular components of the neurovascular unit. Several strategies have been developed against glutamate excitotoxicity, however none of them have not shown positive results in the clinical practice so far. Nowadays, the concept of blood/brain glutamate grabbing or scavenging is well recognized as a novel and attractive protective strategy to reduce the excitotoxic effect of excess extracellular glutamate that accumulates in the brain following an ischemic stroke. The main advantage of this novel therapeutic strategy is that it occurs in the blood circulation and therefore does not affect the normal brain neurophysiology, as it has been described for other drug treatments used against glutamate excitotoxicity. In this work we report all experimental data from the beginning of our studies, focused on stroke pathology, and we describe new findings about the potential application of this therapy. Future clinical trials will allow to know the real efficacy of this novel therapeutic strategy in stroke patients.”

Microglia, Glutamate and Alzheimer’s Disease

One of the most vocal minds pointing to CMA as a major process involved in autism was Dr. Russell Blaylock, MD.  The abstract above  reads just like studies from autism by Blaylock and others (substitute “stroke” with “autism”). Blaylock’s various writing and videos of his presentations have awakened many to the fact that autism is a medical condition, not a neurodevelopmental disorder per se. The medical aspects of autism mean that reversing the causes of the disorder, such as shutting down chronic microglial activation, should be possible. An important part of that is diet. Some foods (such as those containing MSG) will exacerbate brain trauma caused by the excitotoxicity cycle set up by immunotoxins in vaccines (aluminum and mercury). Tylenol should be avoided as it depletes glutathione, a necessary component of microglial glutamate reduction.

It has only more recently been found that immunoneuroexcitotoxicity is at the causal center of Alzheimer’s disease.  A rich literature exists that shows that CMA is found as a causal factor in Alzheimer’s disease, with specific causal links demonstrated between excess glutamate, and microglial dysfunction.

Here is an example from Solito and Sastre (2012):

Contrary to early views, we now know that systemic inflammatory/immune responses transmit to the brain. The microglia, the resident “macrophages” of the brain’s innate immune system, are most responsive, and increasing evidence suggests that they enter a hyper-reactive state in neurodegenerative conditions and aging. As sustained over-production of microglial pro-inflammatory mediators is neurotoxic, this raises great concern that systemic inflammation (that also escalates with aging) exacerbates or possibly triggers, neurological diseases (Alzheimer’s, prion, motoneuron disease). It is known that inflammation has an essential role in the progression of Alzheimer’s disease (AD), since amyloid-β (Aβ) is able to activate microglia, initiating an inflammatory response, which could have different consequences for neuronal survival. On one hand, microglia may delay the progression of AD by contributing to the clearance of Aβ, since they phagocyte Aβ and release enzymes responsible for Aβ degradation. Microglia also secrete growth factors and anti-inflammatory cytokines, which are neuroprotective. In addition, microglia removal of damaged cells is a very important step in the restoration of the normal brain environment, as if left such cells can become potent inflammatory stimuli, resulting in yet further tissue damage. On the other hand, as we age microglia become steadily less efficient at these processes, tending to become over-activated in response to stimulation and instigating too potent a reaction, which may cause neuronal damage in its own right. Therefore, it is critical to understand the state of activation of microglia in different AD stages to be able to determine the effect of potential anti-inflammatory therapies. We discuss here recent evidence supporting both the beneficial or detrimental performance of microglia in AD, and the attempt to find molecules/biomarkers for early diagnosis or therapeutic interventions.

One of the leaders in this area is Israeli scientist Dr. Vivian Teichberg, Ph.D., who proposed that clearing glutamate from the blood might cause a release of glutamate from the brain into the blood.  In a series of clever studies, researchers at the Weizmann Institute found that transforming glutamate in the blood into another form causes glutamate in the brain to exit – providing protection against glutamate storms associated with stroke.  (Read: “Protecting the Brain from A Glutamate Storm“). More on this exciting epiphany, below.

Aluminum, Alzheimer’s, and Glutamate Uptake

Aluminum has long been suspected to be a plausible causal contributing factor to the risk of Alzheimer’s disease. Geographic correlations of aluminum levels in drinking water (Martyn, et al., 1989), and the finding of high amounts of aluminum in the brains of some patients who died from Alzheimer’s disease (just one example, see Exley and Vickers (2014)  were initial indicators. More recent studies seem to confirm the link. A metaanalysis found a 71% increase in the risk of Alzheimer’s disease in individual with chronic exposure to aluminum (Wang et al., 2016). As people age, their microglia become less efficient at clearing Aβ deposits from the brain parenchyma (Thériault et al., 2015).

Chronic Microglial Activation and Aluminum from Vaccines

Nine of 11 available studies reviewed by Flaten et al. (2001) concluded that Alzheimer’s disease incidence was increased regions with highest aluminum in residential drinking water. Measures of inflammation, particularly in the brain, were also seen to be increased when aluminum was high in drinking water (Campbell et al., 2004) – and, importantly, activated microglial cells were also increased. Aluminum in vaccines is almost certainly a causal factor in chronic microglial activation.

Aluminum is found in most vaccines, and is a serious neurotoxin, in spite of a thwarted misinformation campaign to the contrary (Read “Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments are Ready!“). In mice, subcutaneous aluminum injections resulted in significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex Shaw CA et al., 2013). Reduced spatial memory capacity and impairment of motor function was observed after six doses (Shaw et al., 2009). Aluminum also influences other cells than microglia; it results in altered mitochondrial metabolism, globular astrocyte shape and astrocyte dysfunction (Lemire et al., 2009).

Olmos-Alonso et al. (2016) found increased proliferation of microglial cells in human Alzheimer’s disease. Stanford University researchers have reported that a drug called EP2 can reverse microglial activation.

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Chronic microglial activation  (CMA) leads to damage to synapses, loss of neural precursor cells, and neuronal death. The same process of CMA is seen in autism from ages 4-25 (Vargas et al.). Image modified from  Morales et al., 2014. Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci. 8:112. doi: 10.3389/fncel.2014.00112. eCollection 2014.).

 


 

Now The Most Exciting Part: Oxaloacetate and Pyruvate Supplements Clear Excess Glutamate from the Brain

Oxaloacetate is found in nature – and has numerous healthy benefits. It is non-toxic (similar toxicity to vitamin C) and is found in apples, pears, bananas, and spinach. (Read NDX USA’s easy-to-digest article “Oxaloacetate“.

Pyruvate is also found in nature. Foods containing it include red apples, cheese, dark beer, and red wine.  Here is a well-informed article  by Maia Appleby at SFGate on pyruvate supplements (“What Is Pyruvic Acid?”).

Both Oxaloacetate and Pyruvate are available in capsule form, however, the doses required to replicate the effects per body weight conducted in the studies showing their effects on glutamate levels in the brain are very high.  Here are some sources:

Oxaloacetate Supplement, 250 mg, by Natural Dynamix at Amazon.com

[Oxaloacetate (Oxaloacetic Acid) Mental Health Daily Link]

Pyruvate Supplement, 1000 mg, by Piping Rock Health Products at Amazon.com

According WebMD,  our bodies produce pyruvate when it breaks down sugar (glucose), and is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.  [WebMD Link]

[Disclaimer: These links are provided to the reader to inform on availability, are not meant as a recommendation. No health claims are made by the author, nor any recommendations. High doses of any supplement can have side effects. Check with your doctor before adding any supplements to your diet].

Conclusion

Chronic and acute microglial activation leads to brain trauma in stroke, Alzheimer’s and autism. By reasonable inference, supplements that reduce glutamate-induce chronic microglial activation in Alzheimer’s are very likely to have the same effects on some patients with autism.  Studies are urgently needed to determine if dietary oxaloacetate and pyruvate supplementation provide neuroprotection against chronic microglial activation in persons with autism.  Studies of glutamate levels and injection of oxaloacetate during severe neurological distress following vaccination should be undertaken immediately.

Dr. Lyons-Weiler is the President and CEO of The Institute for Pure and Applied Knowledge, which conducts basic, translational and clinical research in the public interest (without profit motive), and is author of three books, “The Environmental and Genetics Causes of AutismThe Environmental and Genetics Causes of Autism“,  “Cures vs. Profits“, and “Ebola: An Evolving Story“.

References

Boyko M et al., 2012. The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage. Neurotherapeutics. 9(3):649-57. doi: 10.1007/s13311-012-0129-6.

Campos F, Sobrino T, Ramos-Cabrer P, Argibay B, Agulla J, Pérez-Mato M, Rodríguez-González R, Brea D, Castillo J. 2011. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab. 2011 Jun;31(6):1378-86. doi: 10.1038/jcbfm.2011.3. Epub 2011 Jan 26.

Campbell A et al., 2004. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. J Neurosci Res. 75(4):565-72.

Campos F, Sobrino T, Ramos-Cabrer P, Castellanos M, Blanco M, Rodríguez-Yáñez M, Serena J, Leira R, Castillo J. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Jun;31(6):1387-93. doi: 10.1038/jcbfm.2011.4. Epub 2011 Jan 26.

Castillo J et al. 2015. A novel mechanism of neuroprotection: Blood glutamate grabber. J Cereb Blood Flow Metab. 2016 Feb;36(2):292-301. doi: 10.1177/0271678X15606721.

Exley C, Vickers T. 2014. Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report. J Med Case Rep. 8:41. doi: 10.1186/1752-1947-8-41.

Flaten TP, 2001. Aluminium as a risk factor in Alzheimer’s disease, with emphasis on drinking water. Brain Res Bull. 55(2):187-96.

Gottlieb M, Wang Y, Teichberg VI. 2003. Blood-Mediated Scavenging of Cerebrospinal Fluid Glutamate. Journal of Neurochemistry  87: 119–126.

Lemire J et al., 2009. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J Neurosci Res.;87(6):1474-83. doi: 10.1002/jnr.21965.

Olmos-Alonso A et al., 2016. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology. Brain 139(Pt 3):891-907. doi: 10.1093/brain/awv379.

Martyn, C. 1989. Geographical relationship between Alzheimer’s disease and aluminum in drinking water. Lancet 1:59.

Shaw CA and MS Petrik. 2009. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. J Inorg Biochem. 103(11):1555-62. doi: 10.1016/j.jinorgbio.2009.05.019.

Shaw CA et al., 2013. Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes. J Inorg Biochem. 128:237-44. doi: 10.1016/j.jinorgbio.2013.07.022.

Solito E, Sastre M. 2012. Microglia function in Alzheimer’s disease. Front Pharmacol. 3:14. doi: 10.3389/fphar.2012.00014. eCollection 2012.

Thériault, P et al. The dynamics of monocytes and microglia in Alzheimer’s disease Alzheimer’s Research & Therapy 20157:41 DOI: 10.1186/s13195-015-0125-2.

Vargas DL et al., 2005. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 57:67-81.

Wang Z et al., 2016.  Chronic exposure to aluminum and risk of Alzheimer’s disease: A meta-analysis. Neurosci Lett. 2016 Jan 1;610:200-6. doi: 10.1016/j.neulet.2015.11.014. Epub 2015 Nov 27.

Zlotnik A, Gurevich B, Tkachov S, et al. 2007. Brain Neuroprotection by Scavenging Blood Glutamate. Experimental Neurology 203: 213–220.

 

Books by Dr. Lyons-Weiler

Ebola: An Evolving Story (2015, World Scientific)

Genetic and Environmental Causes of Autism (2016, Skyhorse Publishing)

Cures vs. Profits: Successes in Translational Research (2016)

Related Abstracts

Bondy SC. 2016. Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer’s disease and age-related neurodegeneration. Neurotoxicology. 52:222-9. doi: 10.1016/j.neuro.2015.12.002. 

Abstract
Aluminum (Al) is a very common component of the earth’s mineral composition. It is not essential element for life and is a constituent of rather inert minerals. Therefore, it has often been regarded as not presenting a significant health hazard. As a result, aluminum-containing agents been used in the preparation of many foodstuffs processing steps and also in elimination of particulate organic matter from water. More recently, the reduced pH of bodies of water resulting from acid rain has led to mobilization of aluminum-containing minerals into a more soluble form, and these have thus entered residential drinking water resources. By this means, the body burden of aluminum in humans has increased. Epidemiological and experimental findings indicate that aluminum is not as harmless as was previously thought, and that aluminum may contribute to the inception and advancement of Alzheimer’s disease. Epidemiological data is reinforced by indications that aluminum exposure can result in excess inflammatory activity within the brain. Activation of the immune system not initiated by an infectious agent, typifies the aging brain and is even more augmented in several neurodegenerative diseases. The origin of most age-related neurological disorders is generally not known but as they are largely not of genetic derivation, their development is likely triggered by unknown environmental factors. There is a growing and consistent body of evidence that points to aluminum as being one such significant influence. Evidence is presented that reinforces the likelihood that aluminum is a factor speeding the rate of brain aging. Such acceleration would inevitably enlarge the incidence of age-related neurological diseases.

Fanne RA, Nassar T, Heyman SN, Hijazi N, Higazi AA.. 2011. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R668-73. doi: 10.1152/ajpregu.00058.2011. 

Abstract
In patients with acute ischemic stroke, diabetes and hyperglycemia are associated with increased infarct size, more profound neurologic deficits and higher mortality. Notwithstanding extensive clinical and experimental data, treatment of stroke-associated hyperglycemia with insulin is controversial. In addition to hyperglycemia, diabetes and even early prediabetic insulin resistance are associated with increased levels of amino acids, including the neurotoxic glutamate, in the circulation. The pleiotropic metabolic effects of insulin include a reduction in the concentration of amino acids in the circulation. In this article, we show that in diabetic rats exposed to transient middle cerebral artery occlusion, a decrease of plasma glutamate by insulin or glucagon reduces CSF glutamate, improves brain histology, and preserves neurologic function. The neuroprotective effect of insulin and glucagon was similar, notwithstanding their opposite effects on blood glucose. The therapeutic window of both hormones overlapped with the short duration (~30 min) of elevated brain glutamate following brain trauma in rodents. Similar neuroprotective effects were found after administration of the glutamate scavenger oxaloacetate, which does not affect glucose metabolism. These data indicate that insulin and glucagon exert a neuroprotective effect within a very brief therapeutic window that correlates with their capacity to reduce glutamate, rather than by modifying glucose levels.

Pogue AI, Lukiw WJ. 2016. Aluminum, the genetic apparatus of the human CNS and Alzheimer’s disease (AD). Morphologie. 2016 Mar 8. pii: S1286-0115(16)00024-2. doi: 10.1016/j.morpho.2016.01.001.

Abstract
The genomes of eukaryotes orchestrate their expression to ensure an effective, homeostatic and functional gene signaling program, and this includes fundamentally altered patterns of transcription during aging, development, differentiation and disease. These actions constitute an extremely complex and intricate process as genetic operations such as transcription involve the very rapid translocation and polymerization of ribonucleotides using RNA polymerases, accessory transcription protein complexes and other interrelated chromatin proteins and genetic factors. As both free ribonucleotides and polymerized single-stranded RNA chains, ribonucleotides are highly charged with phosphate, and this genetic system is extremely vulnerable to disruption by a large number of electrostatic forces, and primarily by cationic metals such as aluminum. Aluminum has been shown by independent researchers to be particularly genotoxic to the genetic apparatus, and it has become reasonably clear that aluminum disturbs genetic signaling programs in the CNS that bear a surprising resemblance to those observed in Alzheimer’s disease (AD) brain. This paper will focus on a discussion of two molecular-genetic aspects of aluminum genotoxicity: (1) the observation that micro-RNA (miRNA)-mediated global gene expression patterns in aluminum-treated transgenic animal models of AD (Tg-AD) strongly resemble those found in AD; and (2) the concept of “human biochemical individuality” and the hypothesis that individuals with certain gene expression patterns may be especially sensitive and perhaps predisposed to aluminum genotoxicity.

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“You Know Nothing About Autism, John Snow”

IN THE TELEVISION PRE-HISTORY FICTIONAL MINISERIES ‘GAME OF THRONES’, a female character named Ygritte is fond of telling her lover, a Night Watchman, who lives caught between two warring cultures, the expression “You know nothing, Jon Snow”.  She tells him this to remind him that he has no idea why the Wildings, a tribe of undead people, are attacking their peoples, and, as hint to the fact that in spite of their different origins as people, she loves him.s

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There is another Snow of merit who lived between cultures – a culture of science and a culture of stoic and unforgiving ignorance. This John Snow has an important lesson for our time.

In 1854’s, London Physician John Snow was confronted with a severe outbreak of cholera.  The prevailing view of the cause of the cholera at the time was the ‘miasma’ theory, in which ‘bad air’, or something called ‘vibrones’ which the medical community postulated caused the spread of the illness.

London’s Soho District at the time was typical of London neighborhoods in the 1850’s.  Most homes had cess pits under their homes for human waste, and if the waste production exceeded the soil’s capacity, it would he hauled away, for a fee, and dumped into the river Thames.

The good Dr. Snow, pictured to the right, was not satisfied by the miasma theory. As the cholera outbreak worsened, he began mapping cases and eventually recognized that most John_Snowcases were clustered near a water pump on Broad Street. His careful observations led him to conclude that whatever ‘cholera poison’, as he referred to it, was behind the outbreak, it was somehow connected to the water pump. This was before germ theory was established and pathogens such as bacteria and viruses were unknown to medicine.

A religious colleague, The Reverend Henry Whitehead, from St. Luke’s Church, was a believer of the miasma theory. As any good man of the church would so, he attempted to disprove theories, and when he turned his attention to Dr. Snow’s theory of that cholera was a water-born illness, somehow connected to human waste, he was turned away from the nondescript miasma theory by the evidence accumulated by Snow in his maps. He even accompanied Dr. Snow on a hunt for the connection between human waste and the water pump, and together they discovered a home that had a cess pit that drained to a old cess pit only a few feet away from the well at the Broad Street Pump. The homeowners routinely dumped diapers (nappies) into the cess pit under their home.

Together, Snow and Whitehead convinced the town’s government to break the handle off the pump. Thereafter, the cholera epidemic ceased; however, the government (The London Board of Health) refused to acknowledge the links between human waste, water and cholera, instead sticking by the ill-defined miasma theory. (Beer drinkers, rejoice – the villagers turned to beer for their liquid intake – which of course was free from cholera due to the fermentation process).

CDC’s Miasma Theory of Autism

350px-Snow-cholera-map-1
John Snow’s Original Map Showing Clusters of Cholera Around the Broad Street Pump, 1854

 

In their fervor to convince the public that no link exists between vaccines and autism, the CDC has neglected to propound (offer) any viable theory for the increase in autism. Others have tried to blame changes in diagnosis, or genetics for the rise in autism, but neither of these two factors can explain the incredibly rapid rise from 1 in 3000 in the 1970’s to 1 in 68. In fact, the CDC has shown a remarkable lack of curiosity about what DOES cause autism. The CDC’s amorphous theory of autism is, empirically, identical to the miasma theory for cholera – because neither vibrones, nor CDCs’ theory of autism exist.

 

Cherry Picking: CDC’s Woeful, Biased Representation of The Available Science

In all of their communications to the public on causes of autism, CDC fails to consider the bulk of the available science that not only shows association between autism and vaccines, but also points squarely to the role of aluminum and mercury as fundamental to the etiology of autism via chronic microglial activation. I know this because I’ve read the science the CDC has not read. Between November 2015 and February 2016, I read over 3,000 published and peer-reviewed studies on autism – not on vaccines intentionally – but rather on autism.  I took the position of  geneticist who wanted to know how traits as unique as autism – lack of or loss of language abilities, aberrant motor movements, differences in executive functions – might be explained considering both genetic and environmental factors.

What I found were studies that clearly showed that neurotoxins such as aluminum, (read this before you claim aluminum is not a neurotoxin), mercury, valproaic acid, thalidomide, and other toxins are picked up by macrophages, deposited in the brain, and interfere with astrocytic glutamate uptake. The excess glutamate prevents microglial cells from de-activating, once activated, and the microglia consume dendrites and neural precursor cells. The autistic brain becomes uni-polar, with many one:one axon:dendrite connections. The microglia in their activated form are not available to shepherd multiple axon:dendrite connections during reinforcement learning, and thus the structures for inhibition feedback are missing. The autistic brain allows perceptual signals to get into the brain too far, too fast, and this is why their are perception sensitivities to light, and sounds. There are also perceptual differences, more easily controlled by shutting down one eye, for example (the sideways glance forces the use of peripheral vision, which reduces the input level to tolerable, so autistic are actually try to look and focus and pay attention by such behavior, not ignoring you!). Further, the input signals can travel so far so fast throughout the brain that they can activate motor neurons, leading to repetitive and uncontrolled behaviors.

This is just a small part of what we know – the rest is in the book. There is much, much more that is known about autism than the CDC’s Miasma-like position would allow for. And all of this amassed knowledge, paid for by our tax dollars, conducted by researchers outside of the CDC, is ignored by the CDC and summarily dismissed as ‘unreliable’. Consider, for example, the interchange between Senator Elizabeth Warren and Rear Admiral Schuchat (excerpt from “The Environmental and Genetic Causes of Autism“:

“Massachusetts Senator Elizabeth Warren asked Dr. Schuchat a few questions and in each response, Schuchat reassured her that vaccines were highly safe and effective and that ‘dozens of studies’ had been conducted that showed no association between autism and vaccines.

Warren: Is there any scientific evidence that vaccines cause profound mental disorders?

Dr. Schuchat: No.

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Near the end of her testimony, the following interchange occurred:

Warren: Parents should know that all of the credible scientific evidence suggests that modern vaccines are safe, modern vaccines are effective and modern vaccines are our best chance of protecting our children from diseases that can kill them, is that right?

Schuchat: That’s right.

The emphasis on “all of the credible scientific evidence” is mine, but the words are Warren’s, agreed to by Schuchat and they are critically important.

Schuchat dismissed most of the evidence cited in this book so far, which is a mountain of peer-reviewed, credible scientific studies. Since she agreed with Warren’s statement, Schuchat testified that all of the evidence that contradicted her own and the CDC’s conclusions was not credible.” – (James Lyons-Weiler, “The Environmental and Genetic Causes of Autism, (C) Skyhorse Publishing).

Here, Senator Warren, and the rest of the Senate, and by extension, the People of the United States of America are being lied to by the most senior ranking official in the CDC about not just a few paltry studies that might show links between vaccines and autism – but about ALL studies showing how, and why, vaccines can cause autism in some people.

That’s right. LIED TO.

The science that Schuchat is lying about is valid, and much of it is outlined in detail here, and in “Causes“.

Think about this misrepresentation the next time you hear someone say “the issue is settled” or “the science shows no link” or “all of the published studies show” no link between vaccines and autism.

Those statements are 100% incorrect. Here is the rest of the science.

Anti-Vax? Pro-Vax? How about a Third Option: SCIENCE.

The fact that the word is out that the CDC also omitted results from a key study, and over-cooked the data analysis as a matter of routine to make associations between vaccination and autism disappear – is scaring people. Like Schuchat. And Dr. Frank DeStefano. And Dr. Coleen Boyle. They have misled the public for over 15 years on autism. But more and more pediatricians are accepting that vaccines may cause autism, and therefore the CDC is fast becoming irrelevant. By fudging their results, they lied to their fellow scientists. They lied to the rest of the US Government. They lied to the People of the United States. They lied to Pharma. They lied to the FDA, the NIH, the NIAID, the AAP, the AMA.  They have lied to the Press. They have lied to the so-called internet ‘trolls’ who spend inordinate amounts of time insulting and demeaning the vaccine-risk aware population.

I have read the CDC’s so-called “science”, and I can see how they fudged their results. Remember, I’m an expert is multivariate and high-dimensional analysis. I know how to interpret a significant interaction term in a linear model – evidently the CDC apparently does not even know they exist.

The National Academy of Sciences and the Institute of Medicine rejected 17/22 studies put forward by the CDC as flawed. That leaves a scant 5 studies upon which our public health policy is based.

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Given that they have tried so hard to warp our perception, I propose that we move on from the CDC – and start doing bona fide vaccine safety science. Every vaccine, all health outcomes. Let’s use Virus-Like Particles (VLPs), screened for epitopes that match important human proteins, and reduce autoimmune diseases. Let’s use VLPs with sufficient antigen loads so adjuvants are not required. Let’s make them sterile and free from preservatives.

Because vaccines are the water pump, and autism is our cholera.  Wakefield, Hooker, Schoenfeld, Shaw, Seneff, Gallager, Goodman, Delong, Sharpe, Tomljenovic, Geier and Geier, Young, Nataf, Yasuda, Tstusui,  Blaurock-Busch, Molina, Bradstreet, McDonald,
Singh, Holmes, Lee, Vargas, Poling, Mikovitz, Palmter, Mohamed,  and many others, especially Dr. Russell Blaylock and Dr. William Thompson of the CDC… these are today’s John Snows [1].

Today’s John Snows have been calling for us to clean up vaccines – not to break the handle off the pump – but to clean up vaccines, and to shut down the epidemic. They do not wish to ban vaccines.  Quite the opposite – their goals are to make them so safe that the myths of vaccine safety perpetuated by the CDC become true, and then everyone can enjoy the full benefits.  Their science – and it is valid science, regardless of what Rr. Adm. Shuchat tried – and failed – to get us to believe – has shined a bright light on what is wrong with the current formulation of most vaccines.

Here is the CSPAN video of the interview in which Rr. Adm. Shuchat dimisses with one word ALL of the available peer-review science the CDC has decided is unreliable (that is, any science the CDC has not done themselves.

You can help move vaccination science away from the everlasting debate by moving on from the CDC as well. (See IPAK). The CDC vaccine division and leadership have consistently proved themselves to be unreliable as a sources of information on the science of vaccines. We have many more qualified scientists outside of the CDC than inside of the CDC who are capable of performing vaccine safety research. Let us wrest it from the CDC and put it in the hands of the NIH, NIAID, or Department of Homeland Security, under the following model:

Every vaccine, studied for 4 years, each studied independently by 5 institutions (extramural), focused on efficacy, and safety, with proper research oversight – run the studies as randomized prospective clinical trials. Three (3) of the five institutions win contracts by lottery, and two by competitive peer review. This will break any chance of intrusion by monied interests. All should publish their studies independently. Each vaccine should be subject to approval by the FDA, with separate committees studying safety and efficacy.

Autism is a public health crisis – but then so is autoimmunity. We know that certain epitopes in vaccines induce autoimmunity. All epitopes in pathogens with clear functional mapping to autoimmunity (such as basic mylein protein) should be banned from use. And we should conduct genetic screening to see if we can predict which patients are most likely to suffer from adverse events from vaccines.

Let’s leave the handle on the pump, and clean up the water. Everyone will be happier, safer, and, most importantly, healthier. And the collective denial of autism/vaccines can end.

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John Snow Memorial and Public House, Soho District, London.

 

Dr. John Snow’s report:

“On proceeding to the spot, I found that nearly all the deaths had taken place within a short distance of the [Broad Street] pump. There were only ten deaths in houses situated decidedly nearer to another street-pump. In five of these cases the families of the deceased persons informed me that they always sent to the pump in Broad Street, as they preferred the water to that of the pumps which were nearer. In three other cases, the deceased were children who went to school near the pump in Broad Street…

With regard to the deaths occurring in the locality belonging to the pump, there were 61 instances in which I was informed that the deceased persons used to drink the pump water from Broad Street, either constantly or occasionally…

The result of the inquiry, then, is, that there has been no particular outbreak or prevalence of cholera in this part of London except among the persons who were in the habit of drinking the water of the above-mentioned pump well.

I had an interview with the Board of Guardians of St James’s parish, on the evening of the 7th inst [September 7], and represented the above circumstances to them. In consequence of what I said, the handle of the pump was removed on the following day.”

— Dr. John Snow, letter to the Editor of the Medical Times and Gazette

 

Dr. William Thompson’s Report:

“I regret that my coauthors and I omitted statistically significant information in our 2004 article published in the journal Pediatrics. The omitted data suggested that African American males who received the MMR vaccine before age 36 months were at increased risk for autism.”

Dr. William Thompson, statement from his lawyer.

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“I can’t believe we did what we did, but we did… The CDC knew about the relationship between the age of first MMR vaccine and autism incidence in African-American boys as early as 2003, but chose to cover it up…we’ve missed ten years of research because the CDC is so paralyzed right now by anything related to autism.”

Dr. William Thompson in a taped conversation with Dr. Brian Hooker

[1] Note to colleagues – if your name is not here, and it should be, send me a note, I will gladly add it.

Much of the information in this article on Dr. John Snow comes from this entry in Wikipedia.

You can directly support reformed vaccine safety research at The Institute for Pure and Applied Knowledge.

James Lyons-Weiler, PhD

Dr. Lyons-Weiler’s latest book, “Cures vs. Profits”, has just been released an is available via Amazon.com.  His book “Environmental and Genetic Causes of Autism” is due out in November, 2016.

 

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Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages). To help support the publicity campaign, click on the book cover, above!

 

A Reasonable Shot: Vaccine Safety Research Reform

VACCINE BOTTLE SYRINGESINCE THE FIRST INOCULATIONS in Western Medicine, it has been apparent that we can fool the immune system into behaving in such a way that it will react as if we have been infected with actual, live pathogens, conferring immunity to disease from exposure.  Vaccines are widely hailed as unassailable examples of success in medicine. Sure, there are side effects, and some adverse events, too, but the risks of such adverse events are rare, or so the thinking goes…

A GROWING BODY OF SCIENTIFIC LITERATURE, however, is accumulating that points to the question: Can we do better on Vaccine Safety? This literature includes studies of the effects of adjuvants and preservatives, such as mercury and aluminum, as well as studies that show that the vaccine itself may contribute to wide number and diversity of types of serious adverse events, diseases and conditions.  A great mass of communication in the public forum includes statements designed to educate the public that these risks exist, while a Great Silence exists from government agencies tasked with, for example, disease control and prevention. There are denials of specific causal links, say, between autism and vaccines. The CDC’s contribution to scientific studies on vaccine safety somehow always, seems to manage to find no harm with remarkable consistency. That is rather odd, given the mountain of other studies that show that vaccines SHOULD cause autism in some people.

The void in the official knowledge base, however, is being rapidly filled by a growing awareness in the American public that what we are being told does not gel with our collective personal experiences.  Most Americans do not yet know, however, that the public policy on vaccination programs is not based on the entire body of science about vaccine safety, but it is, rather, based on studies selected by the CDC that show no harm. The necessary result is a biased policy, biased toward vaccine use. This bias is 100% intentional, as, in the name of greater good, the thinking goes, the risk to the few is outweighed by the risk to the many. Any adverse events seen during studies are a priori assumed to be unrelated to the vaccine, and scientists involve express concern that the public may confuse rare, adverse events that happen after vaccination with real adverse events due to vaccination. I do not know what classification of activity those types of studies are, but when they reject out of hand any adverse event as being caused by a vaccine, they are not science.

We are told as a population of concerned citizens that we do not use the proper “utility” functions, and that the risk to any specific individual is vastly outweighed by the benefit to the many. In considering individual vaccines, this may, or may not be so. I have come to learn from direct communication with a scientist who works in the national vaccination program that Brazil has been using whole-cell pertussis on impoverished pregnant women in their fight against whooping cough – while the relatively wealth enjoy the protective benefit and relative safety of acellular pertussis. Not to seem over-the-top, but this should horrify anyone who knows what whole-cell pertussis can do during pregnancy. No one in any government agency has proposed that the surge in microcephaly – which is geographically concentrated in the slums of Brazil – may be due to the use of whole-cell pertussis. Rather, they say, the microcephaly will eventually be shown to be due to Zika virus infection, even though many cases of microcephaly have occurred with no sign of Zika virus infection, and Zika virus has spread to over 40 other countries with no sign of increased microcephaly. (I have been told by the CDC itself that the data on potential microcephaly in French Polynesia is not reliable). The timeline for Zika is wrong, too – microcephaly started to increase in July 2012 in Brazil, whereas Zika came in with the World Cup Tournaments in July 2014.

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Timeline of Microcephaly and various other events some have posed ideas as potentially associated with microcephaly in Brazil. Note the uptick in microcephaly in 2012 – before Zika virus is thought to have been  introduced to Brazil in 2014. (C) 2006 JLW

Individual by individual disease, the cost functions/merits of vaccine use make sense – who wants their children to develop chicken pox, or mumps, and suffer fever, miss school, etc. No one want their child, or any other child, to develop viral meningitis, and the vaccines, we are told are effective at reducing the risk to the individual and therefore to the population. And the risks of adverse events, we are told, are rare.

Wholesale vaccination schedules against many diseases, however, is a different story. It is difficult to write the facts about this without appearing hyperbolic, but nevertheless it is a difficult truth that the entire vaccine schedule – which now includes over 70 injections over the course of child’s development – has never been tested for cumulative risk of neurological damage, or autoimmune disorders. Nearly all of the CDC’s position statements on the absence of the link between “vaccines” and autism are based on MMR studies – the other vaccines have not been, individually, or collectively tested. Yet the CDC website carries the unqualified statements “Vaccines Do Not Cause Autism” and “Ingredients in Vaccines Do Not Cause Autism”.  We are working to change that to a more reasonable position. What would the American people think of the CDC changed their statement to “Scientific Evidence Exists that Shows that Vaccines May Cause Autism in Some People”?  Would they , en masse, stop vaccinating?  This is where the bigger picture is needed.

In my book, “The Environmental and Genetic Causes of Autism”, I outline the entirety of the science that shows not only association of adjuvants and additives in vaccines and autism and ADHD, but also I review the functional studies that show precisely how these additives cause autism. The mountain of evidence is overwhelming – I read over 2,000* studies, and cited over 1,000. The 1,000 studies I chose were selected because they answered specific questions I had about genetic and environmental contributions to autism. The book, by design, tells the rest of the story. The overall impression that I had after reading all of those studies that “How could aluminum and mercury cumulative doses NOT cause autism in some people?”

The question is, of course, “Which people?” One answer is that babies of young, malnourished, underweight mothers are at increased risk. Another answer is that people who are born with genes predisposing them to immunoneurotoxicity due to exposure to any number of environmental neurotoxins – including those in vaccines – are at increased risk of autism. The demonstration and acknowledgment of vaccine-induced autism in a genetic minority is a blessing. On the one hand, knowledge that autism is rare in the vaccinated population, and that no gene contributes to more than 1% of cases of autism, and that autism genetic risk is low (I estimate <5%) allows us to breath easier.  Practically none of us are doomed to develop autism due to genetics alone. Very few of us will develop autism from vaccines. But the best news of all is that the information on which of us belong to the genetic minority that is at highest risk of autism from vaccines is, in principle, knowable. We can screen the population for variants that are shown, by science, to confer risk of autism due to vaccines. And the genetic screens are not prohibitively expensive.

This knowledge, I hope, is sufficient to cause a revolution in vaccine safety research and in the formulation of vaccines. The first step is to acknowledge the connection. But there are other things that we as consumers of vaccine products should demand of  vaccine manufacturers. If aluminum and mercury in vaccines act as neurotoxins in vaccines in a manner that can induce autism in some people, then they are also likely cause minor neurological damage in the rest of the population. Again, for any individual vaccine, the individual risk of damage is slight. But for a neurotoxin-laden schedule or acute exposure (such as 7 vaccines in one day), and the lifetime cumulative risk due to repeated vaccinations (many diseases plus boosters), we likely have a serious problem that should be addressed: are vaccines contributing to the increase rates of Alzheimer’s disease in our population? There is a growing body of evidence, reviewed in my book, that says yes, the precursors of Alzheimer’s are apparent involving the same molecular and cellular dysfunctions caused by vaccines in autism.

We cannot wait until current 0-16 year olds begin to develop Alzheimer’s disease at 30, or as Dr. Russell Blaylock warns, schizophrenia at 20, to find out. We should demand reform in vaccines overall.  Here is what I propose:

(1) TOTAL BAN ON MERCURY IN VACCINES.  Clearly the CDC is wrong in their recommendation of mercury-containing flu shots for pregnant women.  Increasingly, pediatricians are offering the Thimerosal-free flu vaccine for pregnant women.

(2) Administrative Overhaul of Responsibility. The NIH, not the CDC, should oversee vaccine safety research studies, and the research should be farmed out to the Universities and Research Hospitals throughout the country.  This would be extramural research – by the people, for the people. Every individual vaccine on the schedule, and the entire schedule, should be re-examined using random, prospective clinical trials that use Total Outcomes Awareness – lifelong follow-up, with annual health check-ups for all patients in the study.  Five (5) institutions should be funded to run independent clinical trials, 3 by lottery, and 2 by competitive grant mechanisms.  The results should be independently published with objective peer review.

(3) VLPs with Safe Epitopes Virus-like particles (VLPs) should be used for each and every vaccine – using epitopes that are demonstrated to be safe.  VLPs can be loaded with sufficient antigen- and in sufficient dose – so as to not require aluminum adjuvant.

“Safe Epitopes” are those that show no cross-reactivity with antigens in pathogens. That is, the antibodies for the pathogenic proteins should not be cross-reactive with any human protein. The computational studies needed to identify which human proteins may be at risk of autoimmune attack after infection by pathogens or by vaccination with live attenuated, weakened, or dead viruses are underway at the Institute for Pure and Applied Knowledge.  This problem has also been studied for years by Dr. Yehuda Schoenfeld, of Tel-Aviv Univeristy/Sheba Medical Center and by Dr. Darja Kanduc, University of Bari, Italy. The cost of such vaccines will drop when mass production begins, and the gains in terms of fewer vaccine-injured individuals (autism, ADHD, autoimmune disorders), well, that is priceless.

(4) Comprehensive Genetic Screens for Vaccine Safety Along with screening for polymorphisms that confer higher specific environmental toxin susceptibility, as outlined in my book, genetic screens should include a search for mutations that cause greater protein similarity between human proteins in certain individuals and the proteins present in vaccines (of any kind). This screen will reduce adverse events profoundly, and inform people before they consent to a specific vaccine of any red-flag risk. These polymorphisms and the attendant mutations are usually benign – and have nothing to do with the risk of disease itself. They may, however, be responsible for any auto-immune related pathogenesis of the diseases for which we need vaccines. Scientists at IPAK are working on this problem in our Vaccine Induced Immunological Damage program (VIID). For more information, click here.

One of my goals is to try to make sure that every American knows that vaccines may cause autism in some people – and what we as a society can,and should do about it.  If you would like to help, please visit The Institute for Pure and Applied Knowledge (see http://ipaknowledge.org) and do all you can do to help this pure public charity organization with donations, and recruit new members. Our calls for awareness of the full scientific knowledge on vaccine risk are being heard. We want to bring the public and industry together on the important issue of making vaccines safe – and effective- for everyone.

Postscript: I am aware that some people believe that no vaccine can ever be made safe. The science on VLP’s with safe epitopes and no adjuvants or preservatives has not been conducted, so we do not yet know their safety profile. This is call for overall reform – let’s get to work and find out!

*Downloading and skimmed >3,000; read >2,000, cite >1,000

IPAK: Reducing Human Pain and Suffering Through Knowledge.

book coversmallNew release from Skyhorse Publishing, available everywhere!

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New Book Released 2016 – Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages). To help support the publicity campaign, click on the book cover, above!

SPOTLIGHT: Why Discussions of Vaccine Safety are Necessary and Good

RECENTLY I have seen an increasing trend in various places where informed individuals who are concerned over vaccine safety are chided for being “irresponsible” because we are “doing harm” by causing people to be unduly concerned over side effects from vaccines.

First, we who are concerned are not responsible for vaccine safety. That is Pharma and the CDC’s responsibility. They have abdicated that responsibility with misinformation, willfully denying health care  consumers the right to informed consent. We are expressing our concern over the “evidence” the CDC cites in support of their stated policies.

The CDC website, for example, is woefully black and white on the issue of the link between vaccines and autism/ASD.  Ok, let’s take their word for it.

How then do we explain the Special Master’s Court’s finding that vaccines have led to autism either directly, or indirectly, in some cases? Those conspiracy nuts.

How do we explain the numerous places where the FDA has communicated concerns over autism induced by vaccines, including requiring Pharma to mention such observations in their vaccine safety inserts? Why in the world would the FDA do that? They are doing people harm by saying such things!

How do we explain the hundreds of thousands of observations on late-onset, regressive autism made by parents?  There is no such thing as thousands of ‘anecdotes’.  Science begins with observations.

How do explain why CDC scientist and employee Dr. William Thompson felt the need to inform Brian Hooker, who was about to analyze data forced out the CDC under the Freedom of Information Act, that he knew that Hooker would find associations, and then proceed to describe, blow by blow, how other individuals at the CDC omitted results, and analyzed the data until initially found associations disappeared?

Please, let us place the responsibility where it lies: Pharma and the CDC has misled the American public to such a degree that individuals feel that questions and statements about vaccine adverse events – include the minority of total that occur that are reported in the VAERS – are doing harm?

I have some news: adverse events from vaccines include deaths, permanent loss of normal brain function, overnight demyelination of the CNS after the flu vaccine:

Sacheli A, Bauer R 2014. Influenza vaccine-induced CNS demyelination in a 50-year-old male. Am J Case Rep. 2014 Aug 31;15:368-73. doi: 10.12659/AJCR.891416.

Shoamanesh A, Traboulsee A. 2011. Acute disseminated encephalomyelitis following influenza vaccination. Vaccine. 29(46):8182-5. doi: 10.1016/j.vaccine.2011.08.103.

Did I do that damage? Am I even remotely responsible for these two case studies? No. I am also not responsible for why most Americans believe, incorrectly, that there is no way that vaccines can cause autism. That is because the CDC is not telling the entire story.

For autism/ASD, it’s the aluminum, and the mercury, and the process is immunoneuroexcitotoxicity. Because this situation can develop due to vaccination, the CDC had to fudge their studies to show no association. ( I should say that vaccination is not the only cause of microglia becoming stuck in their activated state. And autism/ASD is not the only condition that can result from this immune disorder).

Yes, childhood diseases can cause illness and in rare instances deaths.  And those deaths concern me, and, in my view, they should concern everyone. Such as the 10 who died from pertussis in California a few years ago. What exactly are the rates of of measles, mumps, or chickenpox deaths in the United States?  They are very, very low, in large part due to advances in medical care and to vaccinations.

Autism/ASD is now 1 in 48 – that’s more than 2% in the US.  Can we please have a rational discussion on how to prevent vaccine-induced immunoneuroexcitotoxicity? Could we maybe develop vaccines without aluminum? Could we please tell women who are pregnant that receiving a vaccine induces a strong immune response, including responses to fetal brain proteins? Is it OK if we let them know that these truths are science-based, so they can make up their own mind, without intimidation? Could we please expect that our doctors and nurses would know – in terms of percentages – what the risks are? More importantly, are we allowed to expect them to understand what those risks mean?

Let’s take measles as an example. There were about 0.15 deaths/1000 in 1900.

Take the theoretical worst-case scenario. If everyone in the US was unvaccinated, and lost all natural immunity, and measles swept the nation, that would be 54,000 deaths. That’s a lot. Way too many. But that was 1900. We now know how to control fever. (Never give Acetominophen after vaccination: it depletes glutathione, making microglial activation more likely).

Rates would be much lower. Let’s still be generous, and take 20,000 deaths due to measles. That’s still a lot.

Do I think we should get rid of the measles vaccine? No way.

But we now are looking at a future where 6,000,000 Americans will have vaccine-induced autism/ASD.

Which is worse? Can we have that discussion?

No, we cannot even do any type of analysis of whether the 6,000,000 cases of autism/ASD are “worth” the lives lost, and other costs due to the spread of the disease due to lack of vaccination by an informed public. That reality has been squelched.

But we don’t have to. How about we keep the measles vaccine, and all other vaccines, inform the public on the truth of the risks, and get to work developing newer, safer vaccines that do not include aluminum, or mercury, and that do not evoke a chronic stimulation of microglia.  We could use Virus-Like Particles (VLPs).  We could required single-dose packaging. Who wants microglia eating neuronal precursor cells (baby brain cells) and over-pruning dendrites?

We could also develop risk biomarkers to tell us which kids are most likely to develop autism from vaccines.

Oh, wait, that’s right. We can’t. Because everyone knows that vaccines do not cause autism.

Everyone, that is, except, of course, the FDA, the Special Master’s Court, and the hundreds of thousand of people who saw their children regress first-hand.

Vaccines are not handed down from God. They are man-made. We do not have to accept the risks of side effects and adverse events. We can expect better. The CDC ignores 20 years of research, funding by the NSF and the NIH (tax dollars) and cites their own studies, which they fudged, most of which the National Academy of Science/Institutes of medicine rejected in 2012 as being unsound science.

I think it is reasonable things for us to expect to discuss these topics without being afraid of being ridiculed, or shamed.  I think people should cut a wide swath before they chide others for being ridiculous for being concerned, because in their view, the benefit to society from vaccines is so great, and the risk of any adverse event so small. I doubt they have even looked at the statistics.

So, I ask them: how many cases of vaccine-induced autism/ASD from vaccines are too many?

Their reply? “There is no link between autism and vaccines“.

They are so misinformed, no rational discussion is even possible.

Vaccines can, indeed cause autism. The risk are cumulative, over a lifetime, not over the mere two weeks that doctors are told consider an adverse event. I will debate anyone, anywhere on this topic, as long as they read “Vaccine Whistleblower: Exposing Autism Research Fraud at the CDC“, and “Thimerosal: Let the Science Speak”  first. I’ve read Paul Offit’s book. This article was my response.

Instead of rational discourse, we see banal, grade-school like behavior. Bullying. Insults. And, in the case of genetics, blaming the victim.

Instead of a reasoned consideration of the fact, we learn of (some) doctors refusing to treat people who are no up-to-date on their vaccines. What ever happened to the Hippocratic oath?

Instead, we hear of family members getting angry with those who have decided to exercise their right of choice.

Objectivity is key in any consideration of public health policy. As long at the CDC continue to mislead the American public to think that vaccines are perfectly safe, the discussion must continue. The more they continue their disinformation campaign, the less the necessary research gets done.

We need to identify biomarkers of autism risk from vaccines.  We can’t expect such studies. Why? Vaccines do not cause autism, so why fund such studies?

We need to do clinical studies on treatments that will tone down aluminum-induced chronic microglial cell over-activation. Such studies will not be funded. Why bother? Aluminum, according to some, is not even a serious neurotoxin. 

We need newer, safer vaccines. Why? Aluminum is a neurotoxin. .

And we need to cancel CDC’s vaccine safety research contract. Why? Because they have, and continue to mislead the public, because they omitted results and fudged the results in numerous studies. They have done more than abdicate their responsibility to inform and protect us. They have prevented all of the safety research that should have been going on over the last 15 years. We need to wrench the responsibility of vaccine safety research away from them, and we need to do it NOW, before they fudge any more studies. What else are they lying to us about?

To me, the CDC and Pharma are grossly negligent. Picking up on Mary Holland’s analogy, who in her December 11 2015 article in The Jurist  likened the issue of discussing vaccine safety to someone yelling “Gunfire!” in a crowded movie theater… don’t blame me. Blame the gunman. He’s the one pulling the trigger.

December 15, 2015

See Mary Holland’s Academic Commentary in The Jurist: Legally Censoring Speech on Vaccines and Autism: A Response

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Read: You Can Help Bring Major Reform to Vaccine Safety Research

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New Book Released 2016 – Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages). To help support the publicity campaign, click on the book cover, above!

How the CDC has Promoted Ignorance about Vaccine Safety

 CDCI HAVE BEEN READING widely both the primary literature and policy statements on vaccine safety from US Government Agencies as part of  the routine, due diligence required of objective scientist. It’s also par for the course for writing informative books. I would hate to think that I missed an important reference or source in any of my books. So I read on…

I have traced the ubiquitous “knowledge” that “vaccines do not cause autism” to the types of statements made by the US CDC. Perhaps in their quest to be clear, in their zeal to protect the population from contagious diseases, or perhaps because they have financial interests, the CDC loves to use black & white, unqualified statements.

Let’s look at three statements from the CDC website:

“Vaccines do not cause autism”

“There is no link between vaccines and autism.”

“Vaccine ingredients do not cause autism.”

The issue with these statement are that they are unqualified – meaning that they do not contain any qualifiers. Universal statements such as “never” and “always” are extremely rare in science and biomedicine.  We tend to hedge, using terms like “some”, and “may”, and “sometimes”, and for good reason. It’s the exceptions that count.

I am about to share with you information – certainly not new here, just ignored widely – that proves that these unqualified statements are wrong, misleading, and contribute to widespread ignorance on vaccine safety.

(1) The Special Masters court has found, and has made awards for damages, on repeated instances that vaccines have lead to neurological injuries that the Court has, in some cases, recognized as “autism”.  Two especially clear cases are Bailey Banks, who the court decided developed ADEM, leading to PPD-NOS (a type of autism), leading to an award of over $800,000, and Hanah Poling, whose family awarded $1.5 million for vaccine-induced autism. Other cases of vaccine induced neurological injuries leading to award include Eric Lassiter (diagnosed with autism), Elias Tembenis (PDD-NOS ), and Ryan Mojabi (diagnosed with autism, asthma and encephalopathy) and Richelle Oxley (encephalopathy).

(2) The CDC cites many studies that add to the conclusion that ‘vaccines do not cause autism’.

However, a 2012 National Academy of Science/Institutes of Medicine
report rejected 17/22 studies cited by the CDC as “flawed”.

The CDC continues to cite these studies, standing by them, and the policies upon which they are based, as if the National Academy of Sciences does not exist.

One of the studies was identified as a product of scientific fraud
by CDC Whistleblower Dr. William Thompson, who also pointed to numerous other studies were data were over-cooked. I’ve read the papers. Yes, they are over-cooked. See “Vaccine Whistleblower, Skyhorse Publishing ” for the full transcripts. They are jaw-dropping

The fact that the CDC continues to make unqualified statements, misleading the public, show their contempt of the Special Master’s Court position on these cases, reveals willful use of misstatements designed to misinform the public. As a result, the CDC can be considered liable for injuries caused by vaccines that could have been prevented if they did not mislead the public. Perhaps individuals would have taken a different path. Perhaps research would have moved forward to make vaccines safer.

(3) When the CDC is not involved , the scientific and biomedical research is clear: at least one mechanism by which autism can be caused by vaccines has been established: macrophages pick up neurotoxins (such as mercury and aluminum) and deposit them in organs, including the brain. There, these toxins can act,  in some people, to cause hyperactivation of microglial cells.

These cells usually clean up cellular debris, and act to  prune weak dendrites. When hyperactivated, they tend to go after any dendrites, over-pruning, leading to hypoconnectivity.  This causes the release of cytokines, leading to cell death apoptosis. Cytokines cause microglial cells to remain in the hyperctivated state, and a positive feedback loop is established. The immediate result is inflammation and encephalopathy. Importantly, this mechanism does not necessarily involve the recruitment of peripheral immune cells. The long-term effect are major developmental issues, in a variety of regions in the brain.

And the effects can vary from person to person. People with mutations in genes that encode protein involved in the cell’s normal detoxification pathways may suffer more severe damage (due to slower clearance).

The peer-reviewed published evidence for this mechanism will be reviewed & presented, with citations, in my book, “Genetic and Environmental Causes of Autism”.

We scientists have a responsibility to inform the public. I take that responsibility seriously. People who repeat unqualified claims such as those made by the CDC are spreading misinformation.

The important question is: how can we tell who will likely suffer this
outcome?

To begin with, we know that families with one autistic member are likely to have a second. That is, the risk of autism is higher for new babies born to autistic families. This implies a genetic risk. The CDC and the FDA should be saying that vaccines are  contraindicated both for people with autism, and for people with siblings who have autism.

Also, many genes are being found that contribute to autism risk. An era of research in identifying biomarkers that can predict adverse neurological reactions to vaccines is  needed, and it was needed ten years ago. Because the CDC is misleading the American public, no such initiative is deemed necessary. This must change.

The first step is for the CDC to add qualifiers to their public statements, such as “may” and “in some people”. Perhaps:

“Vaccines have been shown to induce autism in some people”, or

“Vaccines may cause autism in some people”

are accurate, factual statements, backed by science, and backed by the US legal system.

Help bring the truth out. Please see this initiative and donate today!

Dec 6, 2015

Cures_JLW_Cover_Art_front

New Books Released 2016 – Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages).

The Environmental and Genetic Causes of AutismThe Environmental and Genetic Causes of Autism (Skyhorse Publishing)

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The Pharma Bulls are Loose, and it’s the End of Democracy in America

Author’s Note: This article got me banned from authoring on  DailyKos. Which is really sad: I had long respected to Kos as a source of free-thought articles. I reproduce it here, with the comments from those policing the site for articles, comments, and readers who want to share the truth about the 1,000’s of research studies showing that vaccines can cause autism in some people. I reproduce it here for fear of them deleting the article, as they wantonly delete comments they do not agree with. Daily Kos is therefore biased, and not an open forum. Agree or disagree with my posts, I approve all comments (except those that say you can make $$$$ working from home, etc.)

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A free and open market is a conservative’s dream.Laissez-faire policies mean freedom of markets to explore, and evolve. Competition, the argument goes, drives innovation, and innovation means better goods and services for consumers. The natural checks and balances of supply & demand provide brakes on runaway aggregation of wealth, and all stakeholders – including investors, workers, consumers, producers – can live in a naturally harmonious system. Sure, there are losers, but that’s because there are winners – and the best survive – and this includes individuals in each of these categories.

Unless, of course, the evolution that occurs – and the innovations that occur – by design somehow manages to short-circuit the natural checks & balances that keep the market from ballooning. To make sure that doesn’t happen, and the help the economy get back on its feet, Keynsian mild interventions have been imagined to help sweeten soured economies.

Anti-monopoly policies have been invoked whenever “big business” has overstepped a certain boundary of control. That line in the sand has, traditionally, been recognizable by three features: mass accumulation of wealth, mass accumulation of influence, and the use of that influence to effect even more accumulation of both.

The US Government, acting in the interest of the people, has both a stick, and a carrot, to coerce and cajole the ever unrepentant free market back into a form that resembles a system that honors the egalitarian spirit infused in the very foundations our democracy.

We saw the stick when the industrialist Robber Barons of the last Century were seen to have grown too big for anyone’s comfort. Bell Telephone’s neat monopoly held the American public hostage, and the enforcement of anti-trust laws brought about competition, and, some argue, many of the key innovations in electronics that has led to the information age.

We saw the carrot when with the Great Recession of 2008, when, through the spread of a practice of microabuses led to toxic debt salads, which drew massive cumulative losses of investments tied to banks – and the steady downward spiral of real estate values that resulted threatened to bring America’s banks to their ginormous, too-big-to-fail knees. I actually wrote to then Secretary of State Paulsen on the Friday before his Monday meeting with the banks because I suspected his carrot would not be very sweet. I was right – he forced banks that did not need a bail-out to drink from the Kool-Aid to legitimize the debt. By including winners in with the potential losers, the bail-out could never be said to be a total failure. I even suggested that the Fed loan money to banks in amounts inversely proportionate to the rate at which they were willing to lend to consumers. Because Paulsen did not, there was a 4-5 month lending freeze after the bail-outs.

Fast forward now to 2015. What kind of economy do we have? The biggest of the big businesses, Pharmaceuticals, have figured out a few key strategies similar to both the Robber Barons and to the microabuses of the 2000’s. They pull in profits beyond the comprehension of most Americans – and yet investment is way down. This is an odd combination – profits not driven by investment. Former Secretary of Labor Robert Reich attributes this in his new book, Saving Capitalism, to fluctuations in Skill-based technical change (SBTC) economics. As a somewhat insider in biomedicine, biomedical research, and as an inventor of a new type of investment market, I thought I would take a stab at describing how, in today’s American economy, companies like the biggest in Pharma can pull off this hat trick. The key ingredients turn out to be very, very costly:

  1. Use of Key Opinion Leaders to break the rules on marketing. Key Opinion Leaders are entitled to make whatever claims they care to make, warranted or not by research leading to FDA policy. In my forthcoming book, “Cures vs. Profits: Successes in Translational Research” I describe on particularly egregious abuse of the truth by a Key Opinion Leader who oversaw the destruction of a very promising academic career of a researcher and clinician who first showed — in 1995 — that ADHD was overdiagnosed. Nothing is beyond the pale for some Key Opinion Leaders. They are recognized as such by Pharmaceutical companies, by the way, not by some egalitarian process of being vetted by one’s peers. It seems at times that the only qualification required for being a Key Opinion Leader is being willing to stretch, bend, ignore, hide, and obfuscate the truth.
  2. Abuse of Off-Label Prescriptions. The use of one drug for another ailment is allowed. Off-label prescriptions use has led to the widespread use of drugs such as Ritalyn and Adderall to “treat” ADHD – that’s right – their use in these capacities are not based on FDA-approval after clinical trials showing long-term safety or efficacy. The topic of ADHD overdiagnosis takes up nearly ¼ of “Cures”, and a good portion of it describes the drugging of our elderly in nursing homes, and what one nurse has done to end inappropriate treatment of that population not just off-label, but without the legally required script.
  3. Direct-to-Consumer (DTC) Marketing. Manipulation of demand and supply means complete market ownership by the producers. Pharma invents new diseases and hammers away at consumer’s minds with propaganda on how better their lives will be if they tell their doctors. Flowery music and attractive people smiling are used to sedate the mind as we are informed of the deadly side effects of ineffective drugs we do not need for conditions that do not exist.
  4. Ownership of the Legislative Branch of Government. Limits on campaign donations kept corporations at bay. Now the Office typically goes to the highest bidder. Not a single other Congressman acted on Rep. Bill Posey’s very public deposition of CDC Whistleblower Dr. William Thompsons’ confessions that he and others at the CDC committed fraud in numerous studies on the link between vaccines and autism. This topic is explored in depth in “Cures”, and more thoroughly, with the nearly complete transcripts of the recordings of Dr. Thompson’s revelations, in the book “Vaccine Whistleblower: Exposing Autism Fraud at the CDC” (Skyhorse Publishing).
  5. Ownership of the Media. No media outlet has touched the CDC Whistleblower story for fear of losing their #1 source of marketing revenue. The exception is Ben Swann. The Altermedia has done amuch more thorough job of covering the story.
  6. The Utter Corruption of Government Regulatory Agencies. I used to absolutely bristle (and still do) at the idea that a Senator or Congressman could, after working for years to arrange a long-term, immense no-bid contract with a defense industry corporation then depart public service to a cushy job at the same corporation they helped make rich. The US FDA and the US CDC were both founded to protect the people of the United States from ineffective and unsafe treatments (US FDA) and from serious, life-threatening diseases (US CDC). It has been said that there is a “revolving door” between Pharma, the US FDA and the US CDC: the same post-government ‘rewards’ await those in the CDC who have­ worked to insure bewildering economic success. The current push for complete vaccination is completely unnecessary from a public health perspective. While vaccines must be updated to keep up with evolution (#ebolaevolves), herd immunity already exists for most childhood diseases – and, when and where it does not, these childhood diseases are rarely life-threatening. The only thing that 100% vaccination can accomplish is higher revenues for Pharma. If you’re reading this, and you’re an American citizen, you “know” that there is “no link” between vaccines and autism. Ask yourself why you believe that. Then actually look into the research studies that have been done that find “no link”. I assure you, especially in light of Dr. Thompson’s findings, there is something rotten in Denmark (Insiders, allow yourself that chuckle. It’s been a long fight, forgive my levity). I’ve pitched on this topic elsewhere. For now, I’m content to say that there is a dire need to rapidly identify biomarkers of susceptibility to neurotoxins in vaccines, thimerosalmust be completely abandoned for all vaccines, including those we ship overseas, and that vaccines must be formulated without aluminum adjuvant (e.g., with Virus-Like Particles).
  7. Ergo, Corrupted Policies and Codified Corruption. It goes without saying that #6 leads to #7. However, the corrupted policies now include some well worth mentioning: the FDA will now approve drugs that are nearly as good as (i.e., slightly worse than) available treatments (as opposed to requiring that newer drugs are demonstrably superior). And the requirement of long-term efficacy & safety studies is all but ignored, without repercussion. The conscription of law-making via corporate donations means that the voices of American citizens are drowned out by dollars. We must fix this and limit campaign donations once more.
  8. Communicating to Fix Prices Through the Market. Milton Friedman held the position that monopoly mattered only to the extent that actual market behavior varied from the predictions of simple supply-and-demand analysis. Drug prices are priced on what the market will bear, not in a manner designed to compete. I review this problem thoroughly in the Preface of “Cures”. This occurs when one believes that the way to compete is not to sell more units via superior product or by competitive pricing, but instead, to make more money by any means necessary. When they enter a market with a new drug, they price it based on what the market will bear — not in a manner designed to outdo their competition. The result is runaway price increases — effective price-fixing, per product. It’s really enough to piss one off.
  9. They Own the Judicial Branch of Government. Litigation for vaccine-induced injuries, including neurological injuries that lead to a diagnosis of autism, are restricted to an “Office of Special Masters” “Vaccine Court”, a special federal court in which settlements for injuries are not paid by Pharma, but rather from an aggregate fund from a small tax collected on each and every vaccine. Pharma therefore has no concern over liability for damages done to the population. Findings of vaccine-induced autism are rare – and the tortuous logic used by the Special Masters to justify their findings of damages for symptoms of autism, but not autism itself, is ludicrous. There is a year-long waiting list and a statute of limitations on vaccine injuries — these two factors must change.

Pharma’s success in all of these areas has rendered our American democracy into nothing less than an overtly fascist (corporatist) state. The silence of Congressional Representatives and the media are particularly egregious. Pharma is now writing laws that allow them to do things that the FDA even as late as 2010 would never let them get away with. I shudder to think that I may have had something to do with their boldness. In “Cures”, I recount how I once told, in plenary session, a hundred or so Pharma CEO’s, CIO’s, and Pharma research scientists to ‘fire their current lawyers, or make them your lobbyists’ in reference to seeking legal, temporary monopoly for discovered cancer prophylaxes and treatments in naturally occurring compounds due to their reluctance to enter the market with naturally occurring compounds.

I’ll say it first: we no longer live in a democracy. We live in a fascist Pharmatopic Republic.

The saddest part about living in this fascist state is that most people in America are not even aware of this new reality. In fact, in the public shaming of those who want safe vaccines, the American public is an unwitting victim of mass propaganda – and those doing the shaming are analogous to jack-booted thugs. Those in the blogosphere resort immediately to ad-hominem attacks at the first hint of logic and rational discourse (see comments, below). Even asking a question on vaccine safety makes one suddenly “anti-vax”.  (Disclosure: Both of my sons are fully vaccinated. I draw the line at HPV.)

The ‘party-line’ is black and white: ‘vaccines do not cause autism’. That’s a remarkably rare statement in biomedicine — it claims absolute truthiness — without exception. Such unqualified generalizations are nearly always wrong. The amount of misinformation spewing forth from the US CDC on everything from Ebola to vaccines is astonishing to anyone with slightly more than a passing familiarity with biomedical research. See “Ebola: An Evolving Story” for some jaw-dropping facts about wanton disinformation campaigns from the CDC (no mutations, 99.99% similar to Zaire, both absolutely incorrect), and the disconnect between public health policy and the peer-reviewed research on Ebola. And see the reading lists on aluminum neurotoxicity I have assigned to Dr. Paul Offit, one of the most misleading men in America on the science of vaccine safety. Vaccines do, indeed, lead to encephalopathy, seizures, brain fog, encephalitis, autoimmune disorders and death- sometimes within minutes of administration (see VAERS). It’s time to stop pretending we don’t know this.

We cannot afford the vaccine injuries that are ever-accumulating in severity and number. I will continue to vote, although I doubt that any of the candidates in either party will take on Pharma. Even if they wanted to, I doubt that anyone in the Office of the President of the United States could do anything to change these realities. Bernie Sanders is aware of these issues, and I hope that if he is elected, he will give help those in the Senate and in Congress find the will to come forward and state the obvious: the US government has been overrun by Pharma. These issues, however, remain notably absent from his platform.

I hope all of my academic colleagues who know the truth about the sorry state of vaccine safety research will come out of the shadows, and into the light, and speak their minds. I will continue to work on issues like educating Editors of journals that publish vaccine safety research of the serious misgivings about the studies they have published, in hopes that they may find the need to launch a formal inquiry given the scale and the scope of the impact of vaccines on public health.

To join me in this, you can either donate to the Institute for Pure and Applied Knowledge, or, if you are a scientist or doctor of any kind, consider co-signing the Expression of Concern being mailed to 40 journals that publish vaccine safety research. These 40 journals will also be receiving copies of two books: “Vaccine Whistleblower: Exposing Autism Fraud at the CDC”, and “Thimerosal: Let the Science Speak”, courtesy Skyhorse Publishing and via your donation (to cover shipping & handling).

Don’t get me wrong – I love America. I don’t even mind profit. But it should be fair profit, won honestly by a combination of hard work and ethical economic practices. The American public has been bamboozled by shamwizards (a term I coin in “Cures”), and they have stolen our mantle. The only hope is that enough of us still have sufficient morality, and integrity of character to reinstate a free market. Integrity of character is people doing the right thing, even though it’s the hard thing to do. Doctors must actually study the vaccine safety science, not just ape the talking points of the corrupt CDC. Patients must insist on products that do not contain neurotoxins.  School nurses must push back on demands of treating students for ADHD – they must become patient advocates for each and every child for which a script was sought after a diagnosis by teacher or parent. Nurses who know better must push back on mandatory vaccination – and do the doctor’s job of first doing no harm. Psychiatrists must study and apply the exclusionary criteria for children whom they have been referred for a pre-considered diagnosis, and refuse to provide such a diagnosis when exclusionary principles apply. Researchers must follow the logical result that their biomedical studies yield, even when they go against formal policies. The CDC can no longer be trusted with vaccine research – we must wrest it from them and put it in the hands of five research independent academic research organizations – three by lottery and two by competitive contract – so the results are shown to generalize.

There are many players that can make a difference. The question is: will they? Will you?

Any biomedical researcher, medical doctor, health care professional who knows that vaccines with aluminum adjuvant can cause neurotoxicity, and who is aghast at the corruption at the CDC, and the clear violations and breaches of ethics in vaccine safety research (evidenced most clearly via recent whistleblowers from the CDC and Merck), who would like to step forward and be part of the sea change that is needed to put objectivism back into vaccine safety research, please support IPAK (The Institute for Pure and Applied Knowledge), in our first IPAK Issue Focus Fundraiser. We are sending 40 Statements of Concerns to 40 biomedical research journals that have published papers showing no association between vaccine and autism. All journals that have published papers by people named by Dr. William Thompson as complicit in vaccine safety research fraud, and the Office of the Attorney General, are being notified. We are also sending, as part of our Expression of Concern, and courtesy Skyhorse Publishing, one copy each of two books:“Thimerosal: Let the Science Speak” and “Vaccine Whistleblower: Exposing Autism Research Fraud at the CDC” to the Editors and Editors-in Chief of these 40 journals. Editors of journals are compelled to act upon such Statements of Concern. So far, 8 packages have been sent. You can help by signing the Expression of Concern, and by donating to the cause at ipaknowledge.org. If you are a professional, your signature, degree and affiliation will carry much weight.

It’s time to stop acting as though we don’t know about aluminum neurotoxicity, and it’s time we demand advances in research to make vaccines safe.

James Lyons-Weiler, PhD

Institute for Pure and Applied Knowledge is a 501(c)3 Pure Public Charity

Dr. Lyons-Weiler is available for speaking engagements. Contactebolapromo@gmail.com

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Update: As expected, within minutes of this post, the ad hominemattacks by nameless, faceless individuals on my character began.  However, there is no need to engage in a shouting match online, and I do not feel compelled to defend my credentials. The CDC’s vaccine safety research program is the thing in question. As I continue to wade through some 1,300 peer-reviewed research studies on autism, I can affirm that the black and white public policies, as stated by the CDC and the party line by medical associations that vaccines do not cause autism are not supported by the breadth of scientific evidence.  There are hundreds of research studies that demonstrate serious neurotoxicity of aluminum adjuvant, many dating back into the early 2000’s. The full breadth of that literature, including exciting developments and success in genetic-guided treatments, will be described in my upcoming book, “Genetic and Environmental Causes of Autism”.

Further, I have learned that an increasing number of pediatricians have decided to cease vaccination in autistic children after diagnosis. Due to genetics, individuals with one autistic child are at increased risk of having additional children who develop autism.  It is increasingly becoming the opinion that vaccination may therefore be contraindicated in family members of autistic individuals to mitigate risk (medical exemption). This is up to the individual doctor, who can also be informed by genetic and genomic assays, with follow-up biochemical testing to confirm specific disrupted pathways. Individuals may wish to share the literature on aluminum neurotoxicity with their doctor to help them afford their patients with their right to informed consent.

There is nothing special about vaccines that make them implausible as one of many sources of trouble for the brain during early development.  Even Dr. DeStefano, subject of an ongoing inquiry at the CDC for potential vaccine research fraud (and cover-up of said fraud), has admitted that vaccines may cause autism in a subset of people.  Let’s stop bickering and name-calling and get to the important work of studying ways of using the vast amount of information on genes & proteins involved in autism as biomarkers of risk indicators, and as guides to personalized medicine. Castigation of professionals (and by this I do not mean myself, I mean Pediatricians) who know full well that vaccines cause autism must stop. We must return objectivity to vaccine safety science.

76 COMMENTS

another vaxxer.

Dec 03 · 10:10:54 AM

Like every crackpot, ever, he claims “he’s not against vaccines, he’s just asking questions — questions about safety.”  Do these guys take classes where they are taught that this declaration is a magical charm to ward off all criticism?

And what’s up with ebolapromo-at-gmail.com?

Dec 03 · 11:02:05 AM

And he used to be a decent scientist until he went into this vaccine stuff.

Dec 03 · 01:06:59 PM

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Is it illegal to ask questions? One can ask questions about Vioxx, Advair, drug coated stents- but not about vaccines? Why is that?

You must be new around here.  “I’m only asking questions” is one of the standard tropes by which the anti-vaccine crackpots identify themselves to each other.  They are really quite unimaginative, dishing up the same slop over and over and over again.

Another trick they use goes by the handle “dead threading.”  They wait until the discussion has died down, then slip in — often several days later — in the hope that they can spew their lies and their poison without being challenged.  A pretty cowardly tactic, don’t you agree?  If they had a valid point, you would think they would want people to hear it.

Indeed, I just noticed that you signed up today.  Good luck and enjoy your stay.

Well- what’s the deal? Vioxx, Advair, etc. The credentials of the author are impeccable, the points he makes are valid. Why are you so afraid and angry? There are many countries in Europe where vax rates are 70% or lower- show me the pandemics!

[new]

If anyone else wanders by here and wonders what’s going on, head down to the very last comments and see for yourself that this user is a full bore textbook anti-vaxxer loon.

As if anyone had any doubts.

calling me names doesn’t get the article down…..your conspiracy theory that Daily Kos is anti vaccine is pretty thin gruel. Can you refute one single thing in the article (still up!) above? Anything? BTW- it’s a free country. Go get as many vaccines as you want, get a double or triple dose.

[new]

That’s even loonier than the rest of what this troll (repeatedly recced by Twyla, who has 74 comments, each and every one consisting of anti-vax CT) has said … the notion that this diary is a “Daily Kos article”, which he says elsewhere has been “vetted”.

Dec 05 · 11:11:27 PM

Good set-up, and then falls into anti-Vaxx conspiracy BS.  What a waste of time!

Dec 03 · 01:56:13 PM

I was actually tempted to buy the book until I got to that part.  Herd immunity is permanent, right?

Dec 03 · 04:13:50 PM

Well, that’s what I herd!

Dec 03 · 04:26:59 PM

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do you have anything double blind, placebo controlled on “herd immunity?” You know of course that vaccination is voluntary in Western Europe- some countries are way down in the 60’s and 70’s percent… no epidemics. In the US- most people over 30 are not immunized against measles or pertussis due to vaccine waning…. where are the outbreaks?

Dec 05 · 04:24:17 PM

DK does not post CT nonsense. This article was vetted, edited and published. Deal with it.

Dec 05 · 08:16:13 AM

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This now-banned troll’s nutty logic is a new one to me. Troll diaries posted at DKos are “vetted”? Who knew …

Dec 05 · 10:40:43 PM

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Frankly, I think its hilarious.

Dec 05 · 10:57:13 PM

here is the author’s cv- pretty damn impressive. Can you comment on the data in his post, where is he wrong specifically? http://jameslyonsweiler.com/author-and-research-scientist-james-lyons-weiler-phd-extended-biography/

Dec 05 · 03:54:41 PM

And here’s your CV:

Can you comment on this?

Why no, no you can’t.

“Pretty damn impressive!”

Dec 06 · 12:01:06 AM

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And when you go to the site, the biggest thing there is a donation link.  Can it get more scammy than that?  (That was a rhetorical question, but will probably be answered anyway, sad to say).

Dec 03 · 01:57:57 PM

And if it hadn’t been thoroughly flagged for being anti-vax, I’d call it out for Spam, too.  Available for speaking engagements, is he?

Dec 03 · 04:46:07 PM

[new]

In your mind why is it this article ant vaxx?

Anti-vaxx anti-science CT trash.

The ‘party-line’ is black and white: ‘vaccines do not cause autism’. That’s a remarkably rare statement in biomedicine — it claims absolute truthiness — without exception. Such unqualified generalizations are nearly always wrong.

Your unqualified generalization is certainly wrong, Mr. Irony.

Dec 03 · 09:50:43 PM

Yet the article is there! Right above for you to read and re-read! Just as is the CBS News piece on Bernadine Healy from 2008, as are numerous news articles on the same topic. You might also want to start accusing The Hill as being anti vax conspiracy nuts, because their October 21 2015 article featuring Dr. William Thompson is also still up. Lot of players in your “anti vax” ct, eh? How do you keep track of all of them?

Dec 05 · 08:27:15 AM

Hannah Poling. Bailey Banks.

Dec 05 · 01:36:48 PM

[new]

The comments from the latest anti-vax CT troll aren’t worth responding to.

jqb jqb

Dec 05 · 10:29:15 PM

Excellent article – thank you, Dr. Lyons-Weiler!

Dec 04 · 01:47:56 AM

You’re not even kidding, are you. This is anti-vax CT trash.

Dec 04 · 04:14:35 AM

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No, not kidding.

Dec 05 · 03:54:16 AM

You’re a bit slow, aren’t you … see my comment below. Your every single comment here at DKos has been anti-vax CT … about which you have lied, saying that you aren’t anti-vax. You’re  a bannable troll, but I won’t waste any more of my time on you.

Dec 05 · 04:14:40 AM

The article from Daily Kos is right up there- take another long, careful look at it. Now, call out The Daily Kos as an anti vaccine conspriacy website. Go ahead. Make my quarter of a century.

Dec 05 · 08:23:48 AM

The article isn’t “from Daily Kos”, you silly anti-vax CT troll.

Dec 05 · 10:31:14 PM

Say, did you invite your friends John Mayer2 and Isolabella here to sock for you? They’re both now banned … your time will come.

Dec 05 · 10:35:11 PM

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From your comment history I see that you’re an anti-vax CT spammer. Not sure how you have survived, but please do post more so you can get yourself banned.

Dec 04 · 04:17:24 AM

This article is a load of unsupportable fantasy.

Dec 04 · 03:28:27 AM

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how many bounce backs do you get after walloping a kid with three or nine vax in one visit? Do you even note vax status when a kid you whacked up earlier in the day comes back convulsing, febrile, seizing? Of course you don’t. Because you don’t know shit about vaccine injury, you just proved it. Stay away from my kids.

Dec 05 · 01:31:15 PM

There so many lies, misinformation, logical fallacies and downright ignorance in this article I had to take 14 Big Pharma drugs just to calm down.

But let’s debunk the nonsense in Point #6. Only 1 in 5000 potential drugs discovered by Pharmaceutical companies, and about 12-13% of drugs that enter clinical trials ever get approved by the FDA. It’s the same with drug regulatory agencies in the EU, Japan, and other countries.

Oh, and there’s Point 9, They Own the Judicial Branch of Government. Oh that’s a good one. Citations please? Oh you’re like one of those conspiracy theorists like the Republicans have.
You’re just a science denier who, using boatloads of verbiage, to show off your ignorance. Good job. My diary uses real science with real citations. You ought to read that, and it should advance the education of the science deniers by quite a bit.

Dec 05 · 12:52:52 PM

[new]

at least your pill popping keeps your hands steady. Also explains why you are so checked out from reality. Look! The article! Still up, still vetted and fact checked by Daily Koz! WTF?????

[new]

I must say, you are especially stupid even for a vaxxer — which is really quite an accomplishment.

[new]

how do you know how stupid I am or not? The same way you know the highly credentialed author of this article is anti vaccine? I can say with certainty that you are a person who jumps to ill informed conclusions so I would be hesitant to believe any single thing you write. Perhaps if you ratchet up your rhetoric.

Try shaking your cane at The Daily Kos. The article is still up, getting lots of play on FB. I sure hope all those medical journals do review the complaint he sends out. I donated, I’m thinking about going in big. Seems like a worthy cause.

I know that you are stupid, and spectacularly so, because you actually signed up here to write “The article! Still up, still vetted and fact checked by Daily Koz!”

Silly person, the presence of a diary does not imply that it was vetted and fact checked by the administration — that is not how things work around here.  The fact that the tip jar was hidden (something else you don’t understand) is the “tip” that your poisonous nonsense was decisively rejected by the community.

Begone, poisonous anti-science scumbag!  Go peddle your lies to the stupid and the gullible, you might have a chance there.

No, I don’t know anything about a tip jar, but I can see with my own eyes that this article is posted on The Daily Koz. I do not usually read this site at all, however the piece (still up!- comes up in search engines) makes some very good points which you have not even attempted to refute. For example- why do we need a Vaccine Injury Act if vaccines could withstand the same legal standards that all other medical products and procedures. I have to conclude that without the VICP, the vaccine industry would be much different.

“still vetted and fact checked by Daily Koz”

Silly troll has no idea where he is.

Dec 05 · 11:21:21 PM

Oh well, the conspiracy theorist author of this blog was banned by DK. Excellent news.

Dec 05 · 01:05:39 PM

yet the article is still up! fascinating!

As are many of your idiot comments, even though you have already been unceremoniously booted off the“Daily Koz”. Fascinating!!

Dec 06 · 12:18:52 AM

The conspiracy theory against vaccines expands, eh? Now, The Hill http://thehill.com/policy/healthcare/257581-house-republican-resurfaces-claims-of-cdc-vaccine-cover-up is involved as well?

Thanks for again mentioning Dr. Thompson- here is the original news release: http://www.morganverkamp.com/august-27-2014-press-release-statement-of-william-w-thompson-ph-d-regarding-the-2004-article-examining-the-possibility-of-a-relationship-between-mmr-vaccine-and-autism/ 

he is part of the dark underbelly ct as well?

Let us not forget Ben Swann…..

It is interesting that suddenly all these stories (see above) questioning vaccine safety are appearing in ever more main stream publications.

Can you explain the role of vaccines in the precipitous drop in typhus, tuberculosis, bubonic plague, and cholera over the past 150 years?

Dec 05 · 01:17:35 PM

This is how it always works: you show up mewling “what’s wrong with asking questions” and work your way up to full blown anti-vaxxer scummbag.

Fortunately, with respect to the dead threading mentioned above, you are so stupid and despised for your murderous antics that you have to hide like a cockroach and creep around in the shadows to spread your poison.

ummmm, I’m not anti vaccine, are you? Daily Kos is anti vaccine because they published this, is that your reasoning? So bitch at them, not me. The author has a very respectable science back round and he makes some excellent points. So what’s the problem? Why the nasty language? My normal disqus name is john Mayer, I had to add the 2 to get on this site. Why don’t you calm down and address the data the article (still up!) presents. How, why and where is it wrong?

Dec 05 · 03:59:37 PM

Who do you think you are fooling?  This is an open comment thread, anyone who comes by here can look to the top of this very page and see you chucking out standard brand anti-vaxxer talking points — you know, the ones that you guys keeping trotting out again and again despite their having been debunked repeatedly and definitively and from multiple perspectives.  Vaccines do not cause autism, end of story. Your persistence might otherwise be admirable if you could find a worthy outlet, but as it is you are simply spreading death and disease and suffering with your lies.

and that is exactly the point. at last we agree on something. you have yet to refute, or even try, any single point the author makes. calling me names might make you feel better but it does not answer what the guy wrote. so I will quit responding to you unless you pick on me or until you come up with something that addresses the article (still up there! amazing! that Daily Koz has gone all anti vaccine on us! what an unusual turn of events!)

Insta-bojo. At least our community appears to be developing immunity against this kind of woo.

Dec 05 · 05:28:17 PM

Unfortunately, not as long as this one is here: http://www.dailykos.com/user/Twyla

74 comments, all anti-vax CT, and uprates of her anti-vax Bojo buds John Meyer2 and Isolabella.

Dec 05 · 10:51:28 PM

Oh joy, anti-vaxxers returned.

Cary Grant photo 4172248241_46bb1a06a8_o.gif
And stop spreading disinformation that kills children, you monsters.

Dec 05 · 06:35:27 PM

With a fresh flock of socks.

Dec 05 · 07:41:04 PM

Like this one: www.dailykos.com/…

You Can Help Bring Major Reform to Vaccine Safety Research

IF YOU HAVE been paying attention to the vaccine safety research controversies, you will know the following names:

Dr. Brian Hooker

Dr. William Thompson

Dr. Frank DeStefano

You may even know the names Dr. Coleen Boyle, and Dr. Julie Gerberding – and you will know the role that Senator Bill Posey (R, FL) has played.

You will know what Skyhorse Publishing is, and why the books they publish are vital to the very foundation of science in America.

If you don’t know anything about these issues – about how Bill Thompson disclosed research fraud at the CDC, involving key studies that the CDC still cites as evidence of no link between autism and vaccine – and about how these revelations have been confirmed by independent scrutiny of the publications involved – and about how former CDC Director Julie Gerberding left the CDC to work for Merck after overseeing the CDC during the period of time when the fraudulent research was alleged to have occurred, browse around my blog a while, or read the Chapter on Vaccines in Cures vs. Profits, or better yet get Kevin Barry’s book.

If you DO know about these issues, then you may not know what you can do to help bring about true reform in vaccine safety research.

Skyhorse Publishing has donated 40 copies each of “Thimerosal: Let the Science Speak” and “Vaccine Whistleblower: Exposing Autism Research Fraud at the CDC”  to the Institute for Pure and Applied Knowledge (IPAK, ipaknowledge.org). IPAK is sending one copy of each book, along with a Statement of Concern, to the Editors or Editors-in-Chief of 40 peer-reviewed journals in which those involved in the shady vaccine safety research practices have published.  We have the books, and the Statements of Concern printed, and ready to go. Here’s the countdown:

UPDATE!

17 of 40 packages sent as of December 4, 2015.

IPAK is a registered 501(c)3 pure public charity. No one working in IPAK is allowed to have any financial interest in the research we conduct. Your donation will allow IPAK to send the next package.  This is an extremely important event in the history of vaccine research, and you can help turn the tide.  Our efforts do not stop at sending letters and packages. IPAK seeks to reform vaccine research to bring about objective, transparent, and, most importantly, peer-accountable practices for vaccine safety & efficacy studies. One of the most disturbing revelations by Bill Thompson was that the research teams at the CDC would change the study design, and the approach to analysis, without oversight by an Institutional Review Board (IRB) until they found a way to make associations between vaccination and autism appear to be non-significant. When they could not dissolve the associations they found via over-analysis, they simply left results out.

HOW YOU CAN SEND AN IPAK “CARE” PACKAGE TO AN EDITOR TODAY.

Visit ipaknowledge.org and donate for this special IPAK Issue Focus Fundraiser. Your donation is tax-deductible. Then also please accept my invitation to consider joining The Society for Pure and Applied Knowledge.  There is much work to do. Let’s go!

James Lyons-Weiler, PhD

Allison Park, PA

causes