A Message to Ethical MDs: The Problem with the 2017-8 Flu Vaccine is the 2016-7 Flu Vaccine

A Message to Ethical MDs: The Problem with the 2017-8 Flu Vaccine is the 2016-7 Flu Vaccine

AMERICANS are highly distracted.  They won’t recall the efficacy of the flu vaccine from year to year.  That’s why Sanjay Gupta can go on the news and remind us that his 30% estimate (likely an overestimate) of how well the flu vaccine works is not like past years, the good old days in which the vaccine was 60-70% effective, and not bat an eye.

But when was the last time the flu vaccine was 60-70% effective?  Eight years ago:

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This is the CDC’s data (link).  Clearly, Gupta’s “Years” is, in immunological memory, a singular “Year”. Only once out of the last 14 years was the flu vaccine above 59% – that the value was not 60-70%, it was 60%.

This type of misrepresentation is a consistent penchant within the media and of course from the CDC to exaggerate and highly emphasize only positive views and diminish, dismiss, or ignore any negative views on the safety and efficacy of vaccines.

The reality is the flu vaccination program has an average adjusted efficacy of 40%. In 10/14 years, the efficacy was <50% effective.  That’s deplorable. And the problem is not ‘herd immunity’.  The problem is the vaccine is self-defeating.

The Jury is In: The Flu Vaccine Reduces its Own Efficacy

Too many studies now exist that have independently come to the same conclusion: increases in the uptake of flu vaccine reduces that vaccine’s effectiveness in the following year – and some studies show the negative effects of mass influenza vaccination last two years.

The studies reporting those results are reviewed in my article, “Diseases with Unknown Etiology Trace Back to Mass Vaccination Against Influenza in 1976“, and they are extensive and damning.

That post also includes the results of an analysis that I performed on CDC’s own data, showing that increases in the uptake of flu vaccine in a given year reduces efficacy of the vaccine for the following two years by a factor of -1.167.   Assuming a linear relationship, the model predicts the absurd prediction that at 93% uptake, the flu vaccine will have zero efficacy in the following two years.  That means “negative global efficacy” at or above 94% uptake.

It’s not absurd because the model is wrong; it is absurd because the vaccine reduces net immunity. Enough science exists that shows reduced efficacy due to past uptake (again, all reviewed here). It’s absurd because mass vaccination has unforeseen effects that make it self-defeating.  A better word than absurd would be “disastrous”.  More people would be diagnosed with “flu” that exist in the population at 100% coverage.  What does that tell you?

Well, being the eternal objectivist (not the Ayn Rand type, the other, warmer type), the fact is that extrapolations are not trustworthy.  And that’s true, but not in the universal sense.  If extrapolation could not be made to work, we could not have landed on the moon, on Mars, on Jupiter’s moon Titan, or driven our cars out of our driveways, for that matter.  Sometimes extrapolations do work. The model could also tell be telling us that the extent of immune impairment could be so high that the rate of infections from non-influenza viruses could surpass 100%, meaning many people could have 2, or 3 types of non-influenza respiratory viruses and multiple reasons for diagnosis with “the flu”.

I’m content not to need the extrapolation. The direct evidence that exists that Thimerosal is not safe for the human immune system is overwhelming: it shuts down the protein ERAP1,  We need ERAP1 to shorten proteins bounds for the Class 1 MHC cell surface.   Like pertussis, influenza is also sustained to a degree by silent carriers created by vaccination with non-specific effects.  Certainly live shedding is high among the vaccinated (study cited here).  Why don’t we see CDC informing every doctor to swab for influenza types A and B (including 2009-H1N1), RSV types A and B, parainfluenza types 1–4, metapneumovirus, rhinovirus, coxsackievirus/echovirus, adenovirus types B and E, bocavirus, and coronavirus types NL63, HKU1, 229E, and OC43, all types tested for by the ResPlex II multiplex assay – and each pathogen a type of viral respiratory infection that can mimic the flu?  I don’t have that answer.  But it seems since such a small proportion of cases are H. influenza infection, the default treatment of patients for “flu” without a real diagnosis would be unethical, but that’s precisely what happens.  According to Dr. Hawk, about 2/3 of the cases of “flu” seen are influenza – the rest, he says, would be false positives diagnoses (if made without swabbing).

Patients have a right to know the specific nature of their infections, and survivors in families of those who die from respiratory infections deserve an accurate cause of death. Coroners should certainly be required to provide an accurate cause of death in so-called “flu” mortalities.  Health departments should be required to count only deaths due to confirmed influenza infection as “flu” – otherwise their numbers perpetuate misperception on the risk of influenza infection, and cause fear leading to increased vaccination.  How is this seen as a good thing?  The population deserves good and honest doctors and stewards of public health.

HHS could demand swab results for all suspected cases of “flu deaths” with a press release and enforce them with random audits.  This annual ritual of fear-mongering over “flu-deaths” hides the fact that as long as thimerosal is injected into patients, they are at increased risk of other infections.  And due to heterologous immunity, even without thimerosal, flu vaccines can confuse the immune system and muddle up ineffective immune response by trying to re-purpose B-cells trained on the wrong virus, hobbling the immune system making it unresponsive to similar viruses.  Such as next year’s flu strain.

We do need objectivity to arise immediately throughout the public health system in the US, starting with HHS, then to CDC and to all Health Departments around the country.  Many studies have also found problems with Tamiflu.  But no emergency epidemiological study is addressing the question – why are so many young people dying from “flu”?   Many of the reports I’ve seen include mention that they person had not only been vaccinated, they also had taken Tamiflu. And many had taken Tylenol.   It’s time to ask the tough questions. The science is there on problems with Tylenol for vaccine-induced fever, and it must be taken into consideration.  Fever due to respiratory infections after flu vaccination is still vaccine-induced.

A look at the issues with Tamiflu (see primary scientific literature reviewed here) shows that we cannot ignore the possibility that the human immune system is not infinitely resilient, and that medicine’s approaches to tackling “the flu” is imprecise, not evidence-based, and self-defeating.  I’m not talking about the number of antigens the human body can take; I’m talking about the amount of tweaking it can tolerate, especially given the aluminum-dense childhood vaccination schedule. The allopathic medical community would do very well to heed the studies that show that Vitamin D helps alleviate both vaccine injury and severity of viral infections.  It helps resolve the unfolded protein response without killing the cells. And the science of ER stress (endoplasmic reticulum stress) shows that Thimerosal is, after all, not safe for human use.  Same for aluminum.

Management of Risk vs. Management of Risk Perception

So let’s consider (again) the differences between an organization that has, historically anyway, been provided with our Nation’s trust of the control of risk (reality), and upon failing to do so, works overtime to the control of perception of risk (non-reality).  Public health depends on trust.  The public trust for CDC is not just waning – it’s gone.  They rely on top-down funded advocacy organizations to truss up their tarnished public image – and the individuals invariable end up attacking the character of anyone who dares ask important and relevant questions. Increasing number of academics are calling for an end to CDC policies, such as the blithe use of aluminum, a neurotoxin, in vaccines, and the continued use of Thimerosal in vaccines.

Real Reform is Coming – It’s a Mathematical Certainty

Vaccines injure people every day, and kill people every week.  Each injury and death informs family members, co-workers, and schoolmates.  The flaws in vaccines, combined with misinformation campaigns on safety, fuel the fire and build the vaccine risk aware army.  It’s a peaceful army, filled with individuals who are hurt so badly, they do not want others to suffer the same fate.  They are altruistic.  And under informed, ethical and distributed leadership, they are finding their momentum.

Vaccine safety science reform means removing those in the CDC and HHS that perpetuated the debacle as it grew to proportions that even they could no longer easily deny it.  And that’s fine.  Let them go.  There are many excellent professionals capable of replacing them – people who have not been involved in cooking studies to alter the public’s perception of vaccine risk. People who have withstood unwarranted and unfair criticism by those who live in cowardice of reality.  People who now no longer afraid to publish their views.   An important question is who among my colleagues in Academic Public Health, and which doctors in Pediatric medicine are willing to #bebrave and take on a debacle as huge as a failed national immunization program?  Who will stand up to the AAP and tell them they are wrong?

If you are that type of doctor, it will be easier if you trust those who have worked at this for years. Read Dr. Paul Thomas’ book, The Vaccine Friendly Plan.  After the resignations, have him come and teach the entire CDC and HHS what he knows.  Consider Dr. Alvin Moss’s wisdom – ask him to create a Conflicts of Interest Policy for CDC and HHS, as he has done for the rest of academic medicine. Bring in Dr. Bob Sears from California, who was willing to stare down threats of the loss of his license to practice medicine because he dared to continue to practice medicine in the face of wanton misinformation and pressure from the AAP. Consider Dr. Richard Frye, and Dr. Chris Exley from the UK, who care first and foremost about the truths that impact total health.  Dr. Frye would be great as the new NIH Director, in my opinion. Let these people form a new national public health direction that overrides existing contracts.  There are others.  Like Dr. Judy Mikovits whose character stands much taller than those who tried – and failed – to silence her – on the issue of adventitious agents in viral vaccines (specifically and quite problematic: retroviruses).  Ask Dr. Ted Fogarty about Ethical Vaccinomics, and testing for vaccine injuries. Bring in Dr. John Piesse from Australia and end his persecution there, and put his good will toward safety to work here.  We would be lucky to have him.

Create a Manhattan Project focused on reducing vaccine injuries, not on making currently licensed vaccines safer.  They are old, and stale, and tired, and they, too, need to go.  Bring in exciting new developments in artificial immunization like microneedle patches.  Bring in Dr. Kanduc to screen epitopes that are unsafe.  Drop aluminum, as many have now called for, and bring in calcium carbonate – if needed at all.  Let those pharmaceutical companies who created the disaster make good on their promises to stop making their vaccines.  Then we will see new approaches to artificial immunization that compete on the platform of safety.

Don’t just end COIs at ACIP: End ACIP. Create a Vaccine Safety Commission that enforces Science Integrity. Open up the markets.  Let ideas thrive.  Let consumers choose. Let the FDA do its job.  Let the people’s experiences be heard.  Establish a paradigm in which the end consumer has a say in the quality of the product.  Strip the CDC of the ability to hold patents.  End the CDC Foundation. End the differences between drugs and biologics and require randomized clinical trials – with proper placebos, not aluminum hydroxide – for vaccines.  Repeal the 1986 Act that protects drug companies from liability for faulty vaccines. Perform random spot checks of vaccines in practices for contamination. The total sum of policies in the National Immunization Program, and the burden of morbidity on the population is a serious threat to our National Security.

Let some new faces and voices drive this reform. Bring in Dr. Dan Neides who had to escape the Cleveland Clinic after speaking his conscience.  Let him oversee the transition.  Bring in Dr. Brian Hooker to personally issue the pink slips to those who must now go from the CDC.  Let all of those named here share his or her experience with Congress.  Have Dr. Thompson testify.  We need truth and reconciliation.  And we need it 42 years ago.

There are MDs who sit in the shadows, silent, and afraid of job loss, sanction, ridicule.  Step up.  Let your views be known to the current Administration.  Join Physicians for Informed Consent.  You are not alone.  You can help be part of the solution.  Attend Health Department meetings and speak up for Informed Consent.  Speak up for vaccine exclusions for kids in homes with high lead levels.  Speak up for spacing out vaccines and skipping them.  Speak up for tolerance and understanding of the pain and anguish parents of kids with autism experience when they are told it’s genetic, they know it’s environmental, and they are told they have to vaccinate their other babies.  Speak up against calling CPS for parents who want to take the time they have under the law to consider vaccinations. And, of course, do right by your patients.  Listen to their concerns.  Inform them of both risks and benefits, as required by Federal Regulations.  Let them know they are enrolling themselves or their children (and unborn baby) in post-licensure vaccine safety clinical trials (as required by Federal Regulations). Provide medical and philosophical exemptions for school waivers as required by the laws of your state and the rule of your own conscience.  The AAP does not represent the rights and will of the people of the United States of America.  Our legislation does.

Let’s aim to not make 2020 vaccination look anything like 2019.  We have solutions.  We’re now aiming for Healthy People 2050, and the current vaccines have very little to do with our vision.  By the way, these ideas don’t come (exclusively) from me. They are shared by hundreds of thousands of American citizens, many of whom have been made sick or lost loved ones to vaccines. #werenotgoingaway #releasetheothermemos #hearthiswell #notmine #Vaxxed #cdctruth #saveourbabies #bebrave #ipak #cdcwhistleblower #rfkcommission #educatebeforeyouvaccinate #vaxxed #learntherisk #wedid #cdclied #stopmandatoryvaccination #learntherisk

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http://www.davegranlund.com/cartoons/2014/12/11/flu-shots-less-effective/

 

 

 

My Journey from Ignorance

WHILE RETURNING from the United Nations building where I heard NYU Professor Mary Holland (School of Law) nail the issues of constitutional and international law on the right to informed consent to the floor, to a standing ovation, I received an email from Mary ( To my delight). I read, in part:

“I  started reading your Ebola book last night.  Wow, you have evolved a lot in your thinking on vaccines in a VERY short period, based on your definition of ‘antivaxxers’ at bottom of 206, top of 207.  Have you written up how your views evolved so quickly?  It might be a helpful roadmap towards turning others around.  Was this all in connection with the autism book, or did your views changing precede that book?”

Looking at my book this morning, I turned to page 206, with trepidation, to find the younger, knowing me, trying to save the world by chiding and deriding people whom I have come to learn much more about in the past two years:

“Again and again with Ebola we see, from Guinea to the US, societies struggling with the ethical problem of the needs (and wants) of a few vs. the safety (and lives) on the many”.

Ok, that’s not too bad.  A bit uppity, but I cannot disagree. But it gets worse.

“With over 100 cases confirmed, the US is, at the time of this writing, at high risk of an epidemic of measles because the herd immunity is lacking due to a dogmatic antivaccination movement”.

I warned you.

Deplorably, I continue:

“The efficacy of the measles vaccine in protecting children against terrible diseases should be reason enough for parents to insist on vaccinating their children, but the so-called ‘anti-vaxxers’ (people who believe vaccines place their children at risk of developing autism) fail to consider the greater good: They put others at risk by not participating in national programs for the greater good.”

I really do not like my former self. Naturally, I continue, because I knew SO much before I actually looked into the studies and the data:

“This perspective is more than mere 20:20 hindsight; such occurrences of cultural and institutional amnesia are certain to recur as our society becomes more reliant and trusting in technology, and we forget to respect the awesome power of biology and Nature”.

I really don’t know this guy, I swear.

Mary Holland will certainly be remembered as one of the most staunch defenders of human rights, well, in the history of abuses in medicine. So back to Mary’s question:

“Have you written up how your views evolved so quickly?  It might be a helpful roadmap towards turning others around.  Was this all in connection with the autism book, or did your views changing precede that book?”

Here’s how and why my views have changed. First, I was really rather upset about the fact that CDC Director Thomas Freiden stated in his testimony to Congress that there were no mutations in the Ebolavirus that was driving the epidemic.  I was upset because I had the 396 mutations on my laptop at the very moment he testified to Congress.  I capture that moment in “Ebola“. My anger at the CDC increased when I attended a secret White House conference call, held by the Ebola Czar, in which I asked about the 396 mutations – whether they influenced the ability of tests to detect Ebola, or altered its virulence or transmissibility. In that call, the entire scientific community was lied to again by a CDC Scientist who claimed that the virus was “99.9999% identical to the strain from Zaire in 1995”, which was not true at all.  I capture both of those events in “Ebola”, as well as how the White House then asked the Associated Press to stop covering potential cases of Ebola in the US.  I even ask in that book whether that was “fascism”.

Fast forward a couple of months to where I had decided to write “Cures vs. Profits“. I felt that we had bungled our response to Ebola so badly that I wanted to cheer myself up and write a book on the successes in biomedical research.  Having participated in so many studies over the past two decades, I knew of many reasons that the public should continue to support biomedical research, and I was going to share all that I knew, and discover more. The first two chapters deal with “the bad stuff” – the doctors who cheat at medicare fraud, which robs other patients of needed funds for real medicine – and the biomedical researchers who cheat at their research studies.

I wrote my chapters out on grapefruit, on cancer vaccines, on prostate cancer robotic surgery, and then something happened: I wrote a chapter on ADHD overdiagnosis. I tell the story of the destruction of a promising career of Dr. Gretchen Watson.  Pharma sent a “Key Opinion Leader” to EVMS to debate her over her study, and the next day she was told her case load was canceled, that her colleagues were told that she no longer worked at EVMS, and that she was to expected to resign.  She refused, and won an appeal to HR.  But then someone floated a rumor that she manipulated her data in the 1996 study showing overdiagnosis.

The investigation revealed no flaw – well, a typo in an appendix – but the damage to her career was done. The good news is that Dr. Watson has decided to write of book of her own after reading my chapter on ADHD.  She now also serves on the Board at IPAK.

When I finished writing the rest of “Cures“, including chapters on the history of hormone receptor status in breast cancer, chemosensitivity assays, characteristics of good research scientists, and cancer vaccines, I found the book missing something.

So I decided to write a chapter on Vaccines.

I’ll let the chapter on vaccines speak for itself- it begins with tales of how wonderful vaccines are, how they save lives.  I went back to review the autism/vaccine link, fully expecting to review the Andrew Wakefield issue briefly, how his claims that MMR were linked to vaccines. I read the retracted study.

I found that Andrew Wakefield never claimed that the MMR might cause autism.  Instead, I found the study to suggest that it was a question worth looking into.

My digging around then led to my discovery of reports that someone at CDC had revealed that CDC had manipulated data on the studies designed to disprove Wakefield by omitting results with a positive association.

The more I dug into the issue, and then into the literature, the more I found the science of vaccines falling far short of the science needed to insure public health via any medical procedure given to millions. And this is where I leave the issue in “Cures“. I added an addendum that reviews four open controversies in vaccines that cause me to question whether vaccines can be called an unmitigated success in translational research.

In retrospect, I see that position as something of an understatement.

My understanding of vaccines was (obviously) limited, and I needed to grasp the risks involved. I needed resolution. So after I completed “Cures“, I began writing about what I had learned. I spoke with people with an open mind. I started to listen not only to what these evil, selfish “anti-vaxxers” had to say, I started to really think about the consequences of the additives. I began to question the over-arching claims of safety.

And via some new contacts, I made connection with Tony Lyons of Skyhorse Publishing. After a few chats, he, Louis Conte and I agreed that I should write a book on the Genetics of Autism. (I love Louis – and knowing what I know of him now, my bet is that he thought I was a good prospect – but somehow I can hear him telling Tony that Jack has ‘a way to go, but I think he’ll get there’. Thank you Louis for the confidence.

So in I dove, into 3,000 research articles on autism.  Not on vaccines – on autism.  I wanted to know if the basic science could in any way reasonably support a hypothesis that vaccines or their additives cause autism. The answer is a resounding “Yes, yes, and yes”. Other articles in this blog will give you an idea of some of the evidence that exists on the role of chronic microglial activation and autism, for example.

To the readers of “Ebola” who feel confused or hurt by my, and others’ ignorance, please remember that there is a Great Unknowing, even among professionals.  Think about it – all “Anti-vaxxers” with vaccine-injured children were once pro-vaccine. As I advised some 500 participants at the VIALs Health Summit in Atlanta, GA, do not argue with them – educate them. Your anger and frustration is warranted, but help them move from ignorance to awareness and understanding.

I took it upon myself to consider 3,000 articles on autism for “Causes” (available at Amazon.com and in your local Barnes and Noble or indie bookstore).  (I skimmed 3,000, read >2,000, and cite >1,000). Look at what knowledge can do to a scientist who themselves feel cheated and lied to, someone who entrusted the CDC to perform objective science (See “The Tyranny of Pseudoscience“):

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The author at a CDC Rally, April 22nd, 2016.

 

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Educating the public and calling for Congress to Subpoena Dr. William Thompson at the CDC on the true nature of so-called “Science” conducted at the CDC on the link between vaccines and autism.

To My Fellow Scientists and Medical Health Care Professionals

I wrote “Ebola” in good faith, assuming that the position of the CDC on vaccines was based on sound science. It was unfathomable to me that

-Upon finding positive associations, CDC would routinely over-analyze data from studies until they could make associations go away, and when they could not succeed in doing that, they would simply omit the results;

-CDC would suspend an employee who drew these practices to the attention of then CDC Director Dr. Julie Gerberding (who subsequently took a position in charge of vaccine development at Merck);

-After CDC published these studies they called for an end to research on vaccine safety with regard to potential links to autism;

-CDC would ignore nearly all of the basic science that shows mechanisms of how neurotoxins in vaccines (not just MMR) could reasonably be expected to cause autism in some people;

-CDC’s position is based on ecological association studies, not randomized prospective clinical studies with proper controls.

-Our knowledge of vaccine safety is based on post-market surveillance;

-CDC would ignore all of the post-market surveillance on vaccine safety, claiming that the passively collected data in VAERS did not provide causal evidence;

-CDC would lie repeatedly under oath to Congress about the State of Science on the link between vaccines and autism;

-No one has ever conducted a vaccinated vs. unvaccinated study for association with negative health outcomes, including autism.

-CDC would communicate to the public that “Vaccines Do Not Cause Autism” on their website knowing full well that 6/12 vaccines on the schedule before the age of 7 have 0 studies one way, or the other, on whether they indeed may (or may not) contribute to the risk of autism.

I, like the rest of the world, relied on the CDC to be a reliable source of information on vaccine safety.  Yes, I vaccinated my children. I will not allow them to get the HPV vaccine. Here is why.

To the Parents of Vaccine-Injured Children who Regressed Into Autism

Your observations are the basis of a new era in vaccine science.  All science begins with observations. Help and relief is on the way. And there is nothing that can stop it.

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Dr. Lyons-Weiler (right) meets Marcella Piper-Terry (left) at the 2016 CDC Rally.
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Fellow Vaccine Risk Aware Protestors Calling for Congress to Subpoena Dr. Thomspson
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Dr. Lyons-Weiler meets the future Director of the CDC.

After the Rally, we enjoyed a summit at Life University hosted by VIALS. Here was our audience:

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Here I presented the CDC Schedule as backed by “Magic”, because no science exists on any link between 6 vaccines and autism, whereas some vaccines do, in fact have some studies that support association:

no science 2no science

That was a good day in Atlanta, GA. Here are the slides to share with your pediatrician:

VIALs health summit slides James LyonsWeiler MAGIC

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“MAGIC!!!”

 

 

Next stop, the United Nations:

 

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Dr. Lyons-Weiler attends a UN Session on Toxins in Our Children, April 26th, where Dr. Thompson’s revelations were shared with the world.


 

Mary Holland standing up for your rights to refuse medical procedures as a basic human right. To watch the unprecedented UN Session on Toxic Contamination of Children (4/26/2016), follow this link.

Mary Holland’s question to me was an important one:like many, if not most other professionals, I had argued my position on the vaccine/autism question from a position of ignorance.  They simply have not done their homework, and many have bought the CDC’s lies hook, line and sinker. They count on CDC to be honest and forthright. This include the AAP, the AMA, and, very likely, your pediatrician.

Most of them probably have not read a single study. They likely have never read the following words that Dr. William Thompson said to Dr. Hooker:

Thompson: “They don’t really want people to know that this data exists.”

Thompson: “…among the blacks, the ones that were getting vaccinated earlier, were more likely to have autism.”

Thompson: “It appears in the final publication is that race in general is downplayed. Of course it is.”

Thompson: “I actually think the most interesting results are the isolated, ones that don’t have their co morbid conditions. The effect is where you would think it would happen.”

Thompson: “I was just looking at—I was like, oh my God, I cannot believe we did what we did. But we did.”

Thompson: “The higher ups wanted to do certain things and I went along with it. In terms of chain of command, I was number four out of five. “

Thompson: “…Literally, everyone else got rid of all their documents, and so the only documents that exist right now from that study are mine.”

Thompson: “There are things that I haven’t even shared with you because I can’t prove it, and that’s what I struggle with. I don’t want to share things with you that I can’t prove, that there aren’t hard records. I am worried that the other four people will collude and say no, that’s not true.”

Thompson: “That’s what I keep seeing again, and again, and again where these senior people just do completely unethical, vile things and no one holds them accountable. “

Thompson: “The reason you don’t see anything else circulating on the study, it was five of us behind closed doors for two years.”

Thompson: “It’s the lowest point in my career that I went along with that paper.”

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Dr. William W. Thompson

My book “Cures vs. Profits” tells more of the story of Dr. Thompson and Hooker. At this point, I am willing to go on the record and say that I have zero – ZERO confidence in any science coming out of the CDC Immunization Safety division. And no one else should trust their research, either.

In fact, nothing they publish can be trusted. Not merely because of what Thompson said.

I’ve read their studies.

They are atrociously unsafe ventures in data cooking, model overfit, sad excuses for “control variables”, use of multicollinear variables, the product of repeated data analysis to a desired result (no association). They are a mess.

The individual people in question include

RADM Anne Schuchat, Principal Deputy Director of CDC

Dr. Frank DeStefano, Director of the Immunization Safety Office

Dr. Coleen Boyle Director, National Center on Birth Defects and Developmental Disabilities (NCBDDD)

Dr. Poul Thorsen (co-author on suspect CDC studies, wanted by HHS for embezzling over $1Million in funds that were to be used for autism research, living openly in Denmark).

and others.

In my research, I strive to remain objective. However, since 2004, when the research fraud at the CDC occurred, there have been over 1,000,000 cases of autism that potentially could have been prevented simply by splitting up the MMR into three vaccines, spacing the vaccines out, giving non-adjuvanted vaccines with 1 adjuvanted, screening for safe epitopes, removal of mercury from all vaccines, giving medical exemptions to parents who already have one autistic child (to avoid the genetic x environment interaction), dropping HepB until adulthood… so many simple things that could have been done to reduce early exposures to toxins. Where is the science for biomarkers to indicate which children might be most at risk of ASD due to vaccines?  Not done.  CDC called for no more science.

We Want Evidence-Based Public Health Policies, not Policies Based on Subjective Belief (aka “Magic”)

Right now, the so-called “Anti-vaxxers” I so woefully admonished in “Ebola” are not all “Anti-Vaxxers”. They do consist partly of some people who believe no safe vaccine could ever exist. I respectfully remind them that until the science is done to show that non-adjuvanted vaccines without mercury, aluminum, formaldehyde, etc are tested, their knowledge claim is an untested generalization about all vaccines. Out of well-deserved distrust, they call for no more science on vaccine safety – because they know that some will be injured by that very research.

But the Vaccine Risk Aware movement also includes people who are 100% Pro-Vaccine Safety. They suspect that safe and effective antigen presentation systems can be designed, that use exposure at the skin (microdermal abrasion), with epitopes that do not induce autoimmunity. They believe that taking the toxins out will likely make vaccines safer. But they do not make such claims.  They call for more science, not less, but on newer options for inducing immunity.

To watch my presentation at the VIALS Health Summit State of Science on Vaccine Safety: Autism, in which I explain how the CDC’s claims that vaccines do not cause autism must be based on magic, follow these links: (Part 1, Part 2, Part 3).

Calls for Retraction of CDC “Studies”

Because CDC committed scientific fraud, the studies they performed should be retracted. IPAK has informed the journals of this, and we have sent them copies of “Vaccine Whistleblower, by Kevin Barry, Esq.

I urge all of my colleagues to view the movie #Vaxxed.  Call your local theater and ask them to screen the movie. If you consider yourself an objective scientist, read “Whistleblower“, and RFK jr.’s book, “Thimerosal: Let the Science Speak“.  Order “Master Manipulator” by James Grundvig, which tells the story of Poul Thorsen, a CDC collaborator wanted for absconding with autism research cash (given what CDC would have done with the money, Thorsen may be a hero, for all we know).  For a deeper timeline view on how long corporate corruption has eroded science in our most esteemed institutions like the CDC, read “Science for Sale” by David Lewis.

I ask my professional colleagues from all walks of science and medicine then to join us in our calls for retraction of the CDC’s false studies: DeStefano et al., Madsen et al., and Verstraeten et al.  I will not stop educating professionals about the fraud because we need evidence-based medicine, not medicine based on guesses, or hopes, or magic.  Babies are dying in the womb due to mercury in flu vaccine reserved for pregnant women; babies are born autistic due to immunoneuroexcitotoxicity; they are born with seizure disorders; toddlers regress into autism after learning language. And yes, it may be due to cumulative and interactive effects of toxic chemicals from agriculture, industry, our home, etc.  But we can reduce the toxins we expose our children to.  Right now, autism risk is 1 in 68, up from 1 in 3000 in the 1970’s.  Let’s have #theconversation.

MeetingCropped

 

Acknowledgements. I have literally thousands of people to thank for helping move from ignorance to awareness.  You know who you are. Thank you.

Please support VIALs with a generous donation.  Tell them Jack sent you!
To support Dr. Lyons-Weiler and his research associates at IPAK, visit ipaknowledge.org

VIALs health summit slides James LyonsWeiler MAGIC

causes

Aluminum, Alzheimer’s and Autism

TO THE READER: IMPORTANT DETAILS HAVE EMERGED FROM STUDIES ON THE CAUSES OF BRAIN DYSFUNCTION FROM STROKE AND ALZHEIMER’S DISEASE THAT LEAD DIRECTLY TO HOPE FOR EFFECTIVE AMELIORATION OF THE BRAIN-CELL DESTROYING PROCESSES IN AUTISM. READ THE ARTICLE ALL THE WAY THROUGH TO LEARN ABOUT TWO NUTRIENTS THAT CAN HAVE BEEN FOUND TO REDUCE BRAIN GLUTAMATE LEVELS, WHICH CAUSES CHRONIC MICROGLIAL ACTIVATION (CMA). CMA IS KNOWN TO OCCUR IN THE BRAINS OF AUTISTICS FROM AGE 4-44. THE POSSIBILITIES ARE IMMENSE. MORE RESEARCH IS URGENTLY NEEDED. -JLW (April 8, 2016)

THERE ARE TWO MAIN KNOWN PROCESSES involved in the onset of autism. The first is susceptibility to environmental toxins via mitochondrial dysfunction, which can be the combined result of environmental insults and mutations in mitochondrial genes and genes that directly influence mitochondrial function.  This combination of factors exists in as many as 20% of cases of autism.

The second is chronic microglial activation (CMA). Microglia are amazing nerve cells that serve as shepherds of learning, fostering connections at the synapse during reinforcement learning. They also play the role of the white blood cells (WBCs) of the brain, becoming activated due to injury or infection. Upon dying, brain cells release chemicals calls cytokines that activate microglia from tending shepherds to armed killers. They consume bacteria, viruses, and cellular debris, clearing the brain of the dead and dying cells. The eat impaired dendrites in their activated state.

Other cells called astrocytes mop up the chemical signals that cause microglial activation via molecules called receptors. One of these signals is glutamate.  CMA occurs when something causes glutamate build-up in the brain.  CMA can occur in autism patients with or without mitochondrial dysfunction, and both processes may be at work and interrelated in any given patient with autism.

Causes of Excess Glutamate in the Brain

Many environmental factors can cause excess glutamate. Eating it (MSG) is one way to upset the balance between glutamate in the blood and the brain. The higher the concentration of glutamate in the blood, the less able the brains glutamate pumps are able to dump excesses into the blood. Mercury and aluminum, both additives found in vaccines, can cause chronic microglial activation by harming astrocytes’ ability to uptake glutamate. Chronic microglial activation is found in people with autism from age 5 to 44 (Vargas et al., 2005).

Researchers at the Johns Hopkins University in the Neuroimmunopathology lab studied autistics aged 5-44 and found that their brains had widespread microglial hyperactivation and sensitivity to astrocytes, reflecting IL-6 cytokine mediated inflammation (Vargas et al., 2005). The chronic inflammatory conditions were most pronounced in the cerebellum, anterior cingulate and the medial frontal gyrus. The fact that the hyperactivated state persisted for decades is a critical observation from this study.

Reducing Brain Glutamate and Brain Damage from Stroke

A series of important studies have shown that techniques that clear excess glutamate from the brain during stroke reduces brain damage.  Campos et al. (2011a), demonstrated the effectiveness of oxaloacetate  (a known blood glutamate scavenge) in treating rats in which a stroke was induced. The found that intravenous injection of oxaloacetate decreased both blood and brain glutamate levels. This led to an astounding  80% reduction volume of the brain infarct, dramatically reducing brain edema. The neuroprotective effects of oxaloacetate are due to the depletion of blood glutamate levels – which occurs as a consequence of the activation of a blood-resident enzyme glutamate-oxaloacetate transaminase (GOT) (Gottlieb et al, 2003). When blood glutamate levels are low, the gradient across the blood-brain barrier is in the correct ratio to allow rapid glutamate clearing. This will result in a shut-down of microglial activation.

Similar results were found in human studies by the same team. Campos et al (2011b) studied a cohort of several hundred stroke victims at two hospitals. Using the same inclusion and exclusion criteria, they found that blood glutamate levels at the time of admission to the hospitals was a good predictor of outcome from stroke. (Read more at “GOT to ride the body of excess glutamate“.

These studies confirm earlier findings that both oxaloacetate and pyruvate are effective at reducing brain glutamate levels (Boyko et al., 2012).

Read this exciting study in the abstract from Castillo et al. (2015):

“Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other cellular components of the neurovascular unit. Several strategies have been developed against glutamate excitotoxicity, however none of them have not shown positive results in the clinical practice so far. Nowadays, the concept of blood/brain glutamate grabbing or scavenging is well recognized as a novel and attractive protective strategy to reduce the excitotoxic effect of excess extracellular glutamate that accumulates in the brain following an ischemic stroke. The main advantage of this novel therapeutic strategy is that it occurs in the blood circulation and therefore does not affect the normal brain neurophysiology, as it has been described for other drug treatments used against glutamate excitotoxicity. In this work we report all experimental data from the beginning of our studies, focused on stroke pathology, and we describe new findings about the potential application of this therapy. Future clinical trials will allow to know the real efficacy of this novel therapeutic strategy in stroke patients.”

Microglia, Glutamate and Alzheimer’s Disease

One of the most vocal minds pointing to CMA as a major process involved in autism was Dr. Russell Blaylock, MD.  The abstract above  reads just like studies from autism by Blaylock and others (substitute “stroke” with “autism”). Blaylock’s various writing and videos of his presentations have awakened many to the fact that autism is a medical condition, not a neurodevelopmental disorder per se. The medical aspects of autism mean that reversing the causes of the disorder, such as shutting down chronic microglial activation, should be possible. An important part of that is diet. Some foods (such as those containing MSG) will exacerbate brain trauma caused by the excitotoxicity cycle set up by immunotoxins in vaccines (aluminum and mercury). Tylenol should be avoided as it depletes glutathione, a necessary component of microglial glutamate reduction.

It has only more recently been found that immunoneuroexcitotoxicity is at the causal center of Alzheimer’s disease.  A rich literature exists that shows that CMA is found as a causal factor in Alzheimer’s disease, with specific causal links demonstrated between excess glutamate, and microglial dysfunction.

Here is an example from Solito and Sastre (2012):

Contrary to early views, we now know that systemic inflammatory/immune responses transmit to the brain. The microglia, the resident “macrophages” of the brain’s innate immune system, are most responsive, and increasing evidence suggests that they enter a hyper-reactive state in neurodegenerative conditions and aging. As sustained over-production of microglial pro-inflammatory mediators is neurotoxic, this raises great concern that systemic inflammation (that also escalates with aging) exacerbates or possibly triggers, neurological diseases (Alzheimer’s, prion, motoneuron disease). It is known that inflammation has an essential role in the progression of Alzheimer’s disease (AD), since amyloid-β (Aβ) is able to activate microglia, initiating an inflammatory response, which could have different consequences for neuronal survival. On one hand, microglia may delay the progression of AD by contributing to the clearance of Aβ, since they phagocyte Aβ and release enzymes responsible for Aβ degradation. Microglia also secrete growth factors and anti-inflammatory cytokines, which are neuroprotective. In addition, microglia removal of damaged cells is a very important step in the restoration of the normal brain environment, as if left such cells can become potent inflammatory stimuli, resulting in yet further tissue damage. On the other hand, as we age microglia become steadily less efficient at these processes, tending to become over-activated in response to stimulation and instigating too potent a reaction, which may cause neuronal damage in its own right. Therefore, it is critical to understand the state of activation of microglia in different AD stages to be able to determine the effect of potential anti-inflammatory therapies. We discuss here recent evidence supporting both the beneficial or detrimental performance of microglia in AD, and the attempt to find molecules/biomarkers for early diagnosis or therapeutic interventions.

One of the leaders in this area is Israeli scientist Dr. Vivian Teichberg, Ph.D., who proposed that clearing glutamate from the blood might cause a release of glutamate from the brain into the blood.  In a series of clever studies, researchers at the Weizmann Institute found that transforming glutamate in the blood into another form causes glutamate in the brain to exit – providing protection against glutamate storms associated with stroke.  (Read: “Protecting the Brain from A Glutamate Storm“). More on this exciting epiphany, below.

Aluminum, Alzheimer’s, and Glutamate Uptake

Aluminum has long been suspected to be a plausible causal contributing factor to the risk of Alzheimer’s disease. Geographic correlations of aluminum levels in drinking water (Martyn, et al., 1989), and the finding of high amounts of aluminum in the brains of some patients who died from Alzheimer’s disease (just one example, see Exley and Vickers (2014)  were initial indicators. More recent studies seem to confirm the link. A metaanalysis found a 71% increase in the risk of Alzheimer’s disease in individual with chronic exposure to aluminum (Wang et al., 2016). As people age, their microglia become less efficient at clearing Aβ deposits from the brain parenchyma (Thériault et al., 2015).

Chronic Microglial Activation and Aluminum from Vaccines

Nine of 11 available studies reviewed by Flaten et al. (2001) concluded that Alzheimer’s disease incidence was increased regions with highest aluminum in residential drinking water. Measures of inflammation, particularly in the brain, were also seen to be increased when aluminum was high in drinking water (Campbell et al., 2004) – and, importantly, activated microglial cells were also increased. Aluminum in vaccines is almost certainly a causal factor in chronic microglial activation.

Aluminum is found in most vaccines, and is a serious neurotoxin, in spite of a thwarted misinformation campaign to the contrary (Read “Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments are Ready!“). In mice, subcutaneous aluminum injections resulted in significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex Shaw CA et al., 2013). Reduced spatial memory capacity and impairment of motor function was observed after six doses (Shaw et al., 2009). Aluminum also influences other cells than microglia; it results in altered mitochondrial metabolism, globular astrocyte shape and astrocyte dysfunction (Lemire et al., 2009).

Olmos-Alonso et al. (2016) found increased proliferation of microglial cells in human Alzheimer’s disease. Stanford University researchers have reported that a drug called EP2 can reverse microglial activation.

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Chronic microglial activation  (CMA) leads to damage to synapses, loss of neural precursor cells, and neuronal death. The same process of CMA is seen in autism from ages 4-25 (Vargas et al.). Image modified from  Morales et al., 2014. Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci. 8:112. doi: 10.3389/fncel.2014.00112. eCollection 2014.).


Now The Most Exciting Part: Oxaloacetate and Pyruvate Supplements Clear Excess Glutamate from the Brain

Oxaloacetate is found in nature – and has numerous healthy benefits. It is non-toxic (similar toxicity to vitamin C) and is found in apples, pears, bananas, and spinach. (Read NDX USA’s easy-to-digest article “Oxaloacetate“.

Pyruvate is also found in nature. Foods containing it include red apples, cheese, dark beer, and red wine.  Here is a well-informed article  by Maia Appleby at SFGate on pyruvate supplements (“What Is Pyruvic Acid?”).

Both Oxaloacetate and Pyruvate are available in capsule form, however, the doses required to replicate the effects per body weight conducted in the studies showing their effects on glutamate levels in the brain are very high.  Here are some sources:

Oxaloacetate Supplement, 250 mg, by Natural Dynamix at Amazon.com

[Oxaloacetate (Oxaloacetic Acid) Mental Health Daily Link]

Pyruvate Supplement, 1000 mg, by Piping Rock Health Products at Amazon.com

According WebMD,  our bodies produce pyruvate when it breaks down sugar (glucose), and is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.  [WebMD Link]

[Disclaimer: These links are provided to the reader to inform on availability, are not meant as a recommendation. No health claims are made by the author, nor any recommendations. High doses of any supplement can have side effects. Check with your doctor before adding any supplements to your diet].

Conclusion

Chronic and acute microglial activation leads to brain trauma in stroke, Alzheimer’s and autism. By reasonable inference, supplements that reduce glutamate-induce chronic microglial activation in Alzheimer’s are very likely to have the same effects on some patients with autism.  Studies are urgently needed to determine if dietary oxaloacetate and pyruvate supplementation provide neuroprotection against chronic microglial activation in persons with autism.  Studies of glutamate levels and injection of oxaloacetate during severe neurological distress following vaccination should be undertaken immediately.

Dr. Lyons-Weiler is the President and CEO of The Institute for Pure and Applied Knowledge, which conducts basic, translational and clinical research in the public interest (without profit motive), and is author of three books, “The Environmental and Genetics Causes of AutismThe Environmental and Genetics Causes of Autism“,  “Cures vs. Profits“, and “Ebola: An Evolving Story“.

References

Boyko M et al., 2012. The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage. Neurotherapeutics. 9(3):649-57. doi: 10.1007/s13311-012-0129-6.

Campos F, Sobrino T, Ramos-Cabrer P, Argibay B, Agulla J, Pérez-Mato M, Rodríguez-González R, Brea D, Castillo J. 2011. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab. 2011 Jun;31(6):1378-86. doi: 10.1038/jcbfm.2011.3. Epub 2011 Jan 26.

Campbell A et al., 2004. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. J Neurosci Res. 75(4):565-72.

Campos F, Sobrino T, Ramos-Cabrer P, Castellanos M, Blanco M, Rodríguez-Yáñez M, Serena J, Leira R, Castillo J. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Jun;31(6):1387-93. doi: 10.1038/jcbfm.2011.4. Epub 2011 Jan 26.

Castillo J et al. 2015. A novel mechanism of neuroprotection: Blood glutamate grabber. J Cereb Blood Flow Metab. 2016 Feb;36(2):292-301. doi: 10.1177/0271678X15606721.

Exley C, Vickers T. 2014. Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report. J Med Case Rep. 8:41. doi: 10.1186/1752-1947-8-41.

Flaten TP, 2001. Aluminium as a risk factor in Alzheimer’s disease, with emphasis on drinking water. Brain Res Bull. 55(2):187-96.

Gottlieb M, Wang Y, Teichberg VI. 2003. Blood-Mediated Scavenging of Cerebrospinal Fluid Glutamate. Journal of Neurochemistry  87: 119–126.

Lemire J et al., 2009. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J Neurosci Res.;87(6):1474-83. doi: 10.1002/jnr.21965.

Olmos-Alonso A et al., 2016. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology. Brain 139(Pt 3):891-907. doi: 10.1093/brain/awv379.

Martyn, C. 1989. Geographical relationship between Alzheimer’s disease and aluminum in drinking water. Lancet 1:59.

Shaw CA and MS Petrik. 2009. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. J Inorg Biochem. 103(11):1555-62. doi: 10.1016/j.jinorgbio.2009.05.019.

Shaw CA et al., 2013. Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes. J Inorg Biochem. 128:237-44. doi: 10.1016/j.jinorgbio.2013.07.022.

Solito E, Sastre M. 2012. Microglia function in Alzheimer’s disease. Front Pharmacol. 3:14. doi: 10.3389/fphar.2012.00014. eCollection 2012.

Thériault, P et al. The dynamics of monocytes and microglia in Alzheimer’s disease Alzheimer’s Research & Therapy 20157:41 DOI: 10.1186/s13195-015-0125-2.

Vargas DL et al., 2005. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 57:67-81.

Wang Z et al., 2016.  Chronic exposure to aluminum and risk of Alzheimer’s disease: A meta-analysis. Neurosci Lett. 2016 Jan 1;610:200-6. doi: 10.1016/j.neulet.2015.11.014. Epub 2015 Nov 27.

Zlotnik A, Gurevich B, Tkachov S, et al. 2007. Brain Neuroprotection by Scavenging Blood Glutamate. Experimental Neurology 203: 213–220.

Books by Dr. Lyons-Weiler

Ebola: An Evolving Story (2015, World Scientific)

Genetic and Environmental Causes of Autism (2016, Skyhorse Publishing)

causes

Cures vs. Profits: Successes in Translational Research (2016)

Related Abstracts

Bondy SC. 2016. Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer’s disease and age-related neurodegeneration. Neurotoxicology. 52:222-9. doi: 10.1016/j.neuro.2015.12.002. 

Abstract
Aluminum (Al) is a very common component of the earth’s mineral composition. It is not essential element for life and is a constituent of rather inert minerals. Therefore, it has often been regarded as not presenting a significant health hazard. As a result, aluminum-containing agents been used in the preparation of many foodstuffs processing steps and also in elimination of particulate organic matter from water. More recently, the reduced pH of bodies of water resulting from acid rain has led to mobilization of aluminum-containing minerals into a more soluble form, and these have thus entered residential drinking water resources. By this means, the body burden of aluminum in humans has increased. Epidemiological and experimental findings indicate that aluminum is not as harmless as was previously thought, and that aluminum may contribute to the inception and advancement of Alzheimer’s disease. Epidemiological data is reinforced by indications that aluminum exposure can result in excess inflammatory activity within the brain. Activation of the immune system not initiated by an infectious agent, typifies the aging brain and is even more augmented in several neurodegenerative diseases. The origin of most age-related neurological disorders is generally not known but as they are largely not of genetic derivation, their development is likely triggered by unknown environmental factors. There is a growing and consistent body of evidence that points to aluminum as being one such significant influence. Evidence is presented that reinforces the likelihood that aluminum is a factor speeding the rate of brain aging. Such acceleration would inevitably enlarge the incidence of age-related neurological diseases.

Fanne RA, Nassar T, Heyman SN, Hijazi N, Higazi AA.. 2011. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R668-73. doi: 10.1152/ajpregu.00058.2011. 

Abstract
In patients with acute ischemic stroke, diabetes and hyperglycemia are associated with increased infarct size, more profound neurologic deficits and higher mortality. Notwithstanding extensive clinical and experimental data, treatment of stroke-associated hyperglycemia with insulin is controversial. In addition to hyperglycemia, diabetes and even early prediabetic insulin resistance are associated with increased levels of amino acids, including the neurotoxic glutamate, in the circulation. The pleiotropic metabolic effects of insulin include a reduction in the concentration of amino acids in the circulation. In this article, we show that in diabetic rats exposed to transient middle cerebral artery occlusion, a decrease of plasma glutamate by insulin or glucagon reduces CSF glutamate, improves brain histology, and preserves neurologic function. The neuroprotective effect of insulin and glucagon was similar, notwithstanding their opposite effects on blood glucose. The therapeutic window of both hormones overlapped with the short duration (~30 min) of elevated brain glutamate following brain trauma in rodents. Similar neuroprotective effects were found after administration of the glutamate scavenger oxaloacetate, which does not affect glucose metabolism. These data indicate that insulin and glucagon exert a neuroprotective effect within a very brief therapeutic window that correlates with their capacity to reduce glutamate, rather than by modifying glucose levels.

Pogue AI, Lukiw WJ. 2016. Aluminum, the genetic apparatus of the human CNS and Alzheimer’s disease (AD). Morphologie. 2016 Mar 8. pii: S1286-0115(16)00024-2. doi: 10.1016/j.morpho.2016.01.001.

Abstract
The genomes of eukaryotes orchestrate their expression to ensure an effective, homeostatic and functional gene signaling program, and this includes fundamentally altered patterns of transcription during aging, development, differentiation and disease. These actions constitute an extremely complex and intricate process as genetic operations such as transcription involve the very rapid translocation and polymerization of ribonucleotides using RNA polymerases, accessory transcription protein complexes and other interrelated chromatin proteins and genetic factors. As both free ribonucleotides and polymerized single-stranded RNA chains, ribonucleotides are highly charged with phosphate, and this genetic system is extremely vulnerable to disruption by a large number of electrostatic forces, and primarily by cationic metals such as aluminum. Aluminum has been shown by independent researchers to be particularly genotoxic to the genetic apparatus, and it has become reasonably clear that aluminum disturbs genetic signaling programs in the CNS that bear a surprising resemblance to those observed in Alzheimer’s disease (AD) brain. This paper will focus on a discussion of two molecular-genetic aspects of aluminum genotoxicity: (1) the observation that micro-RNA (miRNA)-mediated global gene expression patterns in aluminum-treated transgenic animal models of AD (Tg-AD) strongly resemble those found in AD; and (2) the concept of “human biochemical individuality” and the hypothesis that individuals with certain gene expression patterns may be especially sensitive and perhaps predisposed to aluminum genotoxicity.

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Neuroprotection in Strokes, Alzheimer’s Disease, and Autism

TO THE READER: DETAILS HAVE EMERGED FROM STUDIES ON THE CAUSES OF BRAIN DYSFUNCTION FROM STROKE AND ALZHEIMER’S THAT LEAD DIRECTLY TO HOPE FOR EFFECTIVE AMELIORATION OF THE BRAIN-CELL DESTROYING PROCESSES IN AUTISM. READ THE ARTICLE ALL THE WAY THROUGH TO LEARN ABOUT TWO NUTRIENTS THAT CAN HAVE BEEN FOUND TO REDUCE BRAIN GLUTAMATE LEVELS, WHICH CAUSES CHRONIC MICROGLIAL ACTIVATION (CMA). CMA IS KNOWN TO OCCUR IN THE BRAINS OF AUTISTICS FROM AGE 4-25. THE POSSIBILITIES ARE IMMENSE. MORE RESEARCH IS URGENTLY NEEDED. -JLW (April 8, 2016)

THERE ARE TWO MAIN KNOWN PROCESSES involved in the onset of autism. The first is susceptibility to environmental toxins via mitochondrial dysfunction, which can be the combined result of environmental insults and mutations in mitochondrial genes and genes that directly influence mitochondrial function.  This combination of factors exists in as many as 20% of cases of autism.

The second is chronic microglial activation (CMA). Microglia are amazing nerve cells that serve as shepherds of learning, fostering connections at the synapse during reinforcement learning. They also play the role of the white blood cells (WBCs) of the brain, becoming activated due to injury or infection. Upon dying, brain cells release chemicals calls cytokines that activate microglia from tending shepherds to armed killers. They consume bacteria, viruses, and cellular debris, clearing the brain of the dead and dying cells. The eat impaired dendrites in their activated state.

Other cells called astrocytes mop up the chemical signals that cause microglial activation via molecules called receptors. One of these signals is glutamate.  CMA occurs when something causes glutamate build-up in the brain.  CMA can occur in autism patients with or without mitochondrial dysfunction, and both processes may be at work and interrelated in any given patient with autism.

Causes of Excess Glutamate in the Brain

Many environmental factors can cause excess glutamate. Eating it (MSG) is one way to upset the balance between glutamate in the blood and the brain. The higher the concentration of glutamate in the blood, the less able the brains glutamate pumps are able to dump excesses into the blood. Mercury and aluminum, both additives found in vaccines, can cause chronic microglial activation by harming astrocytes’ ability to uptake glutamate. Chronic microglial activation is found in people with autism from age 5 to 44 (Vargas et al., 2005).

Researchers at the Johns Hopkins University in the Neuroimmunopathology lab studied autistics aged 5-44 and found that their brains had widespread microglial hyperactivation and sensitivity to astrocytes, reflecting IL-6 cytokine mediated inflammation (Vargas et al., 2005). The chronic inflammatory conditions were most pronounced in the cerebellum, anterior cingulate and the medial frontal gyrus. The fact that the hyperactivated state persisted for decades is a critical observation from this study.

Reducing Brain Glutamate and Brain Damage from Stroke

A series of important studies have shown that techniques that clear excess glutamate from the brain during stroke reduces brain damage.  Campos et al. (2011a), demonstrated the effectiveness of oxaloacetate  (a known blood glutamate scavenger) in treating rats in which a stroke was induced. The found that intravenous injection of oxaloacetate decreased both blood and brain glutamate levels. This led to an astounding  80% reduction volume of the brain infarct, dramatically reducing brain edema. The neuroprotective effects of oxaloacetate are due to the depletion of blood glutamate levels – which occurs as a consequence of the activation of a blood-resident enzyme glutamate-oxaloacetate transaminase (GOT) (Gottlieb et al, 2003). When blood glutamate levels are low, the gradient across the blood-brain barrier is in the correct ratio to allow rapid glutamate clearing. This will result in a shut-down of microglial activation.

Similar results were found in human studies by the same team. Campos et al (2011b) studied a cohort of several hundred stroke victims at two hospitals. Using the same inclusion and exclusion criteria, they found that blood glutamate levels at the time of admission to the hospitals was a good predictor of outcome from stroke. (Read more at “GOT to ride the body of excess glutamate“.

These studies confirm earlier findings that both oxaloacetate and pyruvate are effective at reducing brain glutamate levels (Boyko et al., 2012).

Read this exciting study in the abstract from Castillo et al. (2015):

“Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other cellular components of the neurovascular unit. Several strategies have been developed against glutamate excitotoxicity, however none of them have not shown positive results in the clinical practice so far. Nowadays, the concept of blood/brain glutamate grabbing or scavenging is well recognized as a novel and attractive protective strategy to reduce the excitotoxic effect of excess extracellular glutamate that accumulates in the brain following an ischemic stroke. The main advantage of this novel therapeutic strategy is that it occurs in the blood circulation and therefore does not affect the normal brain neurophysiology, as it has been described for other drug treatments used against glutamate excitotoxicity. In this work we report all experimental data from the beginning of our studies, focused on stroke pathology, and we describe new findings about the potential application of this therapy. Future clinical trials will allow to know the real efficacy of this novel therapeutic strategy in stroke patients.”

Microglia, Glutamate and Alzheimer’s Disease

One of the most vocal minds pointing to CMA as a major process involved in autism was Dr. Russell Blaylock, MD.  The abstract above  reads just like studies from autism by Blaylock and others (substitute “stroke” with “autism”). Blaylock’s various writing and videos of his presentations have awakened many to the fact that autism is a medical condition, not a neurodevelopmental disorder per se. The medical aspects of autism mean that reversing the causes of the disorder, such as shutting down chronic microglial activation, should be possible. An important part of that is diet. Some foods (such as those containing MSG) will exacerbate brain trauma caused by the excitotoxicity cycle set up by immunotoxins in vaccines (aluminum and mercury). Tylenol should be avoided as it depletes glutathione, a necessary component of microglial glutamate reduction.

It has only more recently been found that immunoneuroexcitotoxicity is at the causal center of Alzheimer’s disease.  A rich literature exists that shows that CMA is found as a causal factor in Alzheimer’s disease, with specific causal links demonstrated between excess glutamate, and microglial dysfunction.

Here is an example from Solito and Sastre (2012):

Contrary to early views, we now know that systemic inflammatory/immune responses transmit to the brain. The microglia, the resident “macrophages” of the brain’s innate immune system, are most responsive, and increasing evidence suggests that they enter a hyper-reactive state in neurodegenerative conditions and aging. As sustained over-production of microglial pro-inflammatory mediators is neurotoxic, this raises great concern that systemic inflammation (that also escalates with aging) exacerbates or possibly triggers, neurological diseases (Alzheimer’s, prion, motoneuron disease). It is known that inflammation has an essential role in the progression of Alzheimer’s disease (AD), since amyloid-β (Aβ) is able to activate microglia, initiating an inflammatory response, which could have different consequences for neuronal survival. On one hand, microglia may delay the progression of AD by contributing to the clearance of Aβ, since they phagocyte Aβ and release enzymes responsible for Aβ degradation. Microglia also secrete growth factors and anti-inflammatory cytokines, which are neuroprotective. In addition, microglia removal of damaged cells is a very important step in the restoration of the normal brain environment, as if left such cells can become potent inflammatory stimuli, resulting in yet further tissue damage. On the other hand, as we age microglia become steadily less efficient at these processes, tending to become over-activated in response to stimulation and instigating too potent a reaction, which may cause neuronal damage in its own right. Therefore, it is critical to understand the state of activation of microglia in different AD stages to be able to determine the effect of potential anti-inflammatory therapies. We discuss here recent evidence supporting both the beneficial or detrimental performance of microglia in AD, and the attempt to find molecules/biomarkers for early diagnosis or therapeutic interventions.

One of the leaders in this area is Israeli scientist Dr. Vivian Teichberg, Ph.D., who proposed that clearing glutamate from the blood might cause a release of glutamate from the brain into the blood.  In a series of clever studies, researchers at the Weizmann Institute found that transforming glutamate in the blood into another form causes glutamate in the brain to exit – providing protection against glutamate storms associated with stroke.  (Read: “Protecting the Brain from A Glutamate Storm“). More on this exciting epiphany, below.

Aluminum, Alzheimer’s, and Glutamate Uptake

Aluminum has long been suspected to be a plausible causal contributing factor to the risk of Alzheimer’s disease. Geographic correlations of aluminum levels in drinking water (Martyn, et al., 1989), and the finding of high amounts of aluminum in the brains of some patients who died from Alzheimer’s disease (just one example, see Exley and Vickers (2014)  were initial indicators. More recent studies seem to confirm the link. A metaanalysis found a 71% increase in the risk of Alzheimer’s disease in individual with chronic exposure to aluminum (Wang et al., 2016). As people age, their microglia become less efficient at clearing Aβ deposits from the brain parenchyma (Thériault et al., 2015).

Chronic Microglial Activation and Aluminum from Vaccines

Nine of 11 available studies reviewed by Flaten et al. (2001) concluded that Alzheimer’s disease incidence was increased regions with highest aluminum in residential drinking water. Measures of inflammation, particularly in the brain, were also seen to be increased when aluminum was high in drinking water (Campbell et al., 2004) – and, importantly, activated microglial cells were also increased. Aluminum in vaccines is almost certainly a causal factor in chronic microglial activation.

Aluminum is found in most vaccines, and is a serious neurotoxin, in spite of a thwarted misinformation campaign to the contrary (Read “Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments are Ready!“). In mice, subcutaneous aluminum injections resulted in significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex Shaw CA et al., 2013). Reduced spatial memory capacity and impairment of motor function was observed after six doses (Shaw et al., 2009). Aluminum also influences other cells than microglia; it results in altered mitochondrial metabolism, globular astrocyte shape and astrocyte dysfunction (Lemire et al., 2009).

Olmos-Alonso et al. (2016) found increased proliferation of microglial cells in human Alzheimer’s disease. Stanford University researchers have reported that a drug called EP2 can reverse microglial activation.

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Chronic microglial activation  (CMA) leads to damage to synapses, loss of neural precursor cells, and neuronal death. The same process of CMA is seen in autism from ages 4-25 (Vargas et al.). Image modified from  Morales et al., 2014. Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci. 8:112. doi: 10.3389/fncel.2014.00112. eCollection 2014.).

 


 

Now The Most Exciting Part: Oxaloacetate and Pyruvate Supplements Clear Excess Glutamate from the Brain

Oxaloacetate is found in nature – and has numerous healthy benefits. It is non-toxic (similar toxicity to vitamin C) and is found in apples, pears, bananas, and spinach. (Read NDX USA’s easy-to-digest article “Oxaloacetate“.

Pyruvate is also found in nature. Foods containing it include red apples, cheese, dark beer, and red wine.  Here is a well-informed article  by Maia Appleby at SFGate on pyruvate supplements (“What Is Pyruvic Acid?”).

Both Oxaloacetate and Pyruvate are available in capsule form, however, the doses required to replicate the effects per body weight conducted in the studies showing their effects on glutamate levels in the brain are very high.  Here are some sources:

Oxaloacetate Supplement, 250 mg, by Natural Dynamix at Amazon.com

[Oxaloacetate (Oxaloacetic Acid) Mental Health Daily Link]

Pyruvate Supplement, 1000 mg, by Piping Rock Health Products at Amazon.com

According WebMD,  our bodies produce pyruvate when it breaks down sugar (glucose), and is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.  [WebMD Link]

[Disclaimer: These links are provided to the reader to inform on availability, are not meant as a recommendation. No health claims are made by the author, nor any recommendations. High doses of any supplement can have side effects. Check with your doctor before adding any supplements to your diet].

Conclusion

Chronic and acute microglial activation leads to brain trauma in stroke, Alzheimer’s and autism. By reasonable inference, supplements that reduce glutamate-induce chronic microglial activation in Alzheimer’s are very likely to have the same effects on some patients with autism.  Studies are urgently needed to determine if dietary oxaloacetate and pyruvate supplementation provide neuroprotection against chronic microglial activation in persons with autism.  Studies of glutamate levels and injection of oxaloacetate during severe neurological distress following vaccination should be undertaken immediately.

Dr. Lyons-Weiler is the President and CEO of The Institute for Pure and Applied Knowledge, which conducts basic, translational and clinical research in the public interest (without profit motive), and is author of three books, “The Environmental and Genetics Causes of AutismThe Environmental and Genetics Causes of Autism“,  “Cures vs. Profits“, and “Ebola: An Evolving Story“.

References

Boyko M et al., 2012. The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage. Neurotherapeutics. 9(3):649-57. doi: 10.1007/s13311-012-0129-6.

Campos F, Sobrino T, Ramos-Cabrer P, Argibay B, Agulla J, Pérez-Mato M, Rodríguez-González R, Brea D, Castillo J. 2011. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab. 2011 Jun;31(6):1378-86. doi: 10.1038/jcbfm.2011.3. Epub 2011 Jan 26.

Campbell A et al., 2004. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. J Neurosci Res. 75(4):565-72.

Campos F, Sobrino T, Ramos-Cabrer P, Castellanos M, Blanco M, Rodríguez-Yáñez M, Serena J, Leira R, Castillo J. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Jun;31(6):1387-93. doi: 10.1038/jcbfm.2011.4. Epub 2011 Jan 26.

Castillo J et al. 2015. A novel mechanism of neuroprotection: Blood glutamate grabber. J Cereb Blood Flow Metab. 2016 Feb;36(2):292-301. doi: 10.1177/0271678X15606721.

Exley C, Vickers T. 2014. Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report. J Med Case Rep. 8:41. doi: 10.1186/1752-1947-8-41.

Flaten TP, 2001. Aluminium as a risk factor in Alzheimer’s disease, with emphasis on drinking water. Brain Res Bull. 55(2):187-96.

Gottlieb M, Wang Y, Teichberg VI. 2003. Blood-Mediated Scavenging of Cerebrospinal Fluid Glutamate. Journal of Neurochemistry  87: 119–126.

Lemire J et al., 2009. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J Neurosci Res.;87(6):1474-83. doi: 10.1002/jnr.21965.

Olmos-Alonso A et al., 2016. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology. Brain 139(Pt 3):891-907. doi: 10.1093/brain/awv379.

Martyn, C. 1989. Geographical relationship between Alzheimer’s disease and aluminum in drinking water. Lancet 1:59.

Shaw CA and MS Petrik. 2009. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. J Inorg Biochem. 103(11):1555-62. doi: 10.1016/j.jinorgbio.2009.05.019.

Shaw CA et al., 2013. Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes. J Inorg Biochem. 128:237-44. doi: 10.1016/j.jinorgbio.2013.07.022.

Solito E, Sastre M. 2012. Microglia function in Alzheimer’s disease. Front Pharmacol. 3:14. doi: 10.3389/fphar.2012.00014. eCollection 2012.

Thériault, P et al. The dynamics of monocytes and microglia in Alzheimer’s disease Alzheimer’s Research & Therapy 20157:41 DOI: 10.1186/s13195-015-0125-2.

Vargas DL et al., 2005. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 57:67-81.

Wang Z et al., 2016.  Chronic exposure to aluminum and risk of Alzheimer’s disease: A meta-analysis. Neurosci Lett. 2016 Jan 1;610:200-6. doi: 10.1016/j.neulet.2015.11.014. Epub 2015 Nov 27.

Zlotnik A, Gurevich B, Tkachov S, et al. 2007. Brain Neuroprotection by Scavenging Blood Glutamate. Experimental Neurology 203: 213–220.

 

Books by Dr. Lyons-Weiler

Ebola: An Evolving Story (2015, World Scientific)

Genetic and Environmental Causes of Autism (2016, Skyhorse Publishing)

Cures vs. Profits: Successes in Translational Research (2016)

Related Abstracts

Bondy SC. 2016. Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer’s disease and age-related neurodegeneration. Neurotoxicology. 52:222-9. doi: 10.1016/j.neuro.2015.12.002. 

Abstract
Aluminum (Al) is a very common component of the earth’s mineral composition. It is not essential element for life and is a constituent of rather inert minerals. Therefore, it has often been regarded as not presenting a significant health hazard. As a result, aluminum-containing agents been used in the preparation of many foodstuffs processing steps and also in elimination of particulate organic matter from water. More recently, the reduced pH of bodies of water resulting from acid rain has led to mobilization of aluminum-containing minerals into a more soluble form, and these have thus entered residential drinking water resources. By this means, the body burden of aluminum in humans has increased. Epidemiological and experimental findings indicate that aluminum is not as harmless as was previously thought, and that aluminum may contribute to the inception and advancement of Alzheimer’s disease. Epidemiological data is reinforced by indications that aluminum exposure can result in excess inflammatory activity within the brain. Activation of the immune system not initiated by an infectious agent, typifies the aging brain and is even more augmented in several neurodegenerative diseases. The origin of most age-related neurological disorders is generally not known but as they are largely not of genetic derivation, their development is likely triggered by unknown environmental factors. There is a growing and consistent body of evidence that points to aluminum as being one such significant influence. Evidence is presented that reinforces the likelihood that aluminum is a factor speeding the rate of brain aging. Such acceleration would inevitably enlarge the incidence of age-related neurological diseases.

Fanne RA, Nassar T, Heyman SN, Hijazi N, Higazi AA.. 2011. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R668-73. doi: 10.1152/ajpregu.00058.2011. 

Abstract
In patients with acute ischemic stroke, diabetes and hyperglycemia are associated with increased infarct size, more profound neurologic deficits and higher mortality. Notwithstanding extensive clinical and experimental data, treatment of stroke-associated hyperglycemia with insulin is controversial. In addition to hyperglycemia, diabetes and even early prediabetic insulin resistance are associated with increased levels of amino acids, including the neurotoxic glutamate, in the circulation. The pleiotropic metabolic effects of insulin include a reduction in the concentration of amino acids in the circulation. In this article, we show that in diabetic rats exposed to transient middle cerebral artery occlusion, a decrease of plasma glutamate by insulin or glucagon reduces CSF glutamate, improves brain histology, and preserves neurologic function. The neuroprotective effect of insulin and glucagon was similar, notwithstanding their opposite effects on blood glucose. The therapeutic window of both hormones overlapped with the short duration (~30 min) of elevated brain glutamate following brain trauma in rodents. Similar neuroprotective effects were found after administration of the glutamate scavenger oxaloacetate, which does not affect glucose metabolism. These data indicate that insulin and glucagon exert a neuroprotective effect within a very brief therapeutic window that correlates with their capacity to reduce glutamate, rather than by modifying glucose levels.

Pogue AI, Lukiw WJ. 2016. Aluminum, the genetic apparatus of the human CNS and Alzheimer’s disease (AD). Morphologie. 2016 Mar 8. pii: S1286-0115(16)00024-2. doi: 10.1016/j.morpho.2016.01.001.

Abstract
The genomes of eukaryotes orchestrate their expression to ensure an effective, homeostatic and functional gene signaling program, and this includes fundamentally altered patterns of transcription during aging, development, differentiation and disease. These actions constitute an extremely complex and intricate process as genetic operations such as transcription involve the very rapid translocation and polymerization of ribonucleotides using RNA polymerases, accessory transcription protein complexes and other interrelated chromatin proteins and genetic factors. As both free ribonucleotides and polymerized single-stranded RNA chains, ribonucleotides are highly charged with phosphate, and this genetic system is extremely vulnerable to disruption by a large number of electrostatic forces, and primarily by cationic metals such as aluminum. Aluminum has been shown by independent researchers to be particularly genotoxic to the genetic apparatus, and it has become reasonably clear that aluminum disturbs genetic signaling programs in the CNS that bear a surprising resemblance to those observed in Alzheimer’s disease (AD) brain. This paper will focus on a discussion of two molecular-genetic aspects of aluminum genotoxicity: (1) the observation that micro-RNA (miRNA)-mediated global gene expression patterns in aluminum-treated transgenic animal models of AD (Tg-AD) strongly resemble those found in AD; and (2) the concept of “human biochemical individuality” and the hypothesis that individuals with certain gene expression patterns may be especially sensitive and perhaps predisposed to aluminum genotoxicity.

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SPOTLIGHT: Why Discussions of Vaccine Safety are Necessary and Good

RECENTLY I have seen an increasing trend in various places where informed individuals who are concerned over vaccine safety are chided for being “irresponsible” because we are “doing harm” by causing people to be unduly concerned over side effects from vaccines.

First, we who are concerned are not responsible for vaccine safety. That is Pharma and the CDC’s responsibility. They have abdicated that responsibility with misinformation, willfully denying health care  consumers the right to informed consent. We are expressing our concern over the “evidence” the CDC cites in support of their stated policies.

The CDC website, for example, is woefully black and white on the issue of the link between vaccines and autism/ASD.  Ok, let’s take their word for it.

How then do we explain the Special Master’s Court’s finding that vaccines have led to autism either directly, or indirectly, in some cases? Those conspiracy nuts.

How do we explain the numerous places where the FDA has communicated concerns over autism induced by vaccines, including requiring Pharma to mention such observations in their vaccine safety inserts? Why in the world would the FDA do that? They are doing people harm by saying such things!

How do we explain the hundreds of thousands of observations on late-onset, regressive autism made by parents?  There is no such thing as thousands of ‘anecdotes’.  Science begins with observations.

How do explain why CDC scientist and employee Dr. William Thompson felt the need to inform Brian Hooker, who was about to analyze data forced out the CDC under the Freedom of Information Act, that he knew that Hooker would find associations, and then proceed to describe, blow by blow, how other individuals at the CDC omitted results, and analyzed the data until initially found associations disappeared?

Please, let us place the responsibility where it lies: Pharma and the CDC has misled the American public to such a degree that individuals feel that questions and statements about vaccine adverse events – include the minority of total that occur that are reported in the VAERS – are doing harm?

I have some news: adverse events from vaccines include deaths, permanent loss of normal brain function, overnight demyelination of the CNS after the flu vaccine:

Sacheli A, Bauer R 2014. Influenza vaccine-induced CNS demyelination in a 50-year-old male. Am J Case Rep. 2014 Aug 31;15:368-73. doi: 10.12659/AJCR.891416.

Shoamanesh A, Traboulsee A. 2011. Acute disseminated encephalomyelitis following influenza vaccination. Vaccine. 29(46):8182-5. doi: 10.1016/j.vaccine.2011.08.103.

Did I do that damage? Am I even remotely responsible for these two case studies? No. I am also not responsible for why most Americans believe, incorrectly, that there is no way that vaccines can cause autism. That is because the CDC is not telling the entire story.

For autism/ASD, it’s the aluminum, and the mercury, and the process is immunoneuroexcitotoxicity. Because this situation can develop due to vaccination, the CDC had to fudge their studies to show no association. ( I should say that vaccination is not the only cause of microglia becoming stuck in their activated state. And autism/ASD is not the only condition that can result from this immune disorder).

Yes, childhood diseases can cause illness and in rare instances deaths.  And those deaths concern me, and, in my view, they should concern everyone. Such as the 10 who died from pertussis in California a few years ago. What exactly are the rates of of measles, mumps, or chickenpox deaths in the United States?  They are very, very low, in large part due to advances in medical care and to vaccinations.

Autism/ASD is now 1 in 48 – that’s more than 2% in the US.  Can we please have a rational discussion on how to prevent vaccine-induced immunoneuroexcitotoxicity? Could we maybe develop vaccines without aluminum? Could we please tell women who are pregnant that receiving a vaccine induces a strong immune response, including responses to fetal brain proteins? Is it OK if we let them know that these truths are science-based, so they can make up their own mind, without intimidation? Could we please expect that our doctors and nurses would know – in terms of percentages – what the risks are? More importantly, are we allowed to expect them to understand what those risks mean?

Let’s take measles as an example. There were about 0.15 deaths/1000 in 1900.

Take the theoretical worst-case scenario. If everyone in the US was unvaccinated, and lost all natural immunity, and measles swept the nation, that would be 54,000 deaths. That’s a lot. Way too many. But that was 1900. We now know how to control fever. (Never give Acetominophen after vaccination: it depletes glutathione, making microglial activation more likely).

Rates would be much lower. Let’s still be generous, and take 20,000 deaths due to measles. That’s still a lot.

Do I think we should get rid of the measles vaccine? No way.

But we now are looking at a future where 6,000,000 Americans will have vaccine-induced autism/ASD.

Which is worse? Can we have that discussion?

No, we cannot even do any type of analysis of whether the 6,000,000 cases of autism/ASD are “worth” the lives lost, and other costs due to the spread of the disease due to lack of vaccination by an informed public. That reality has been squelched.

But we don’t have to. How about we keep the measles vaccine, and all other vaccines, inform the public on the truth of the risks, and get to work developing newer, safer vaccines that do not include aluminum, or mercury, and that do not evoke a chronic stimulation of microglia.  We could use Virus-Like Particles (VLPs).  We could required single-dose packaging. Who wants microglia eating neuronal precursor cells (baby brain cells) and over-pruning dendrites?

We could also develop risk biomarkers to tell us which kids are most likely to develop autism from vaccines.

Oh, wait, that’s right. We can’t. Because everyone knows that vaccines do not cause autism.

Everyone, that is, except, of course, the FDA, the Special Master’s Court, and the hundreds of thousand of people who saw their children regress first-hand.

Vaccines are not handed down from God. They are man-made. We do not have to accept the risks of side effects and adverse events. We can expect better. The CDC ignores 20 years of research, funding by the NSF and the NIH (tax dollars) and cites their own studies, which they fudged, most of which the National Academy of Science/Institutes of medicine rejected in 2012 as being unsound science.

I think it is reasonable things for us to expect to discuss these topics without being afraid of being ridiculed, or shamed.  I think people should cut a wide swath before they chide others for being ridiculous for being concerned, because in their view, the benefit to society from vaccines is so great, and the risk of any adverse event so small. I doubt they have even looked at the statistics.

So, I ask them: how many cases of vaccine-induced autism/ASD from vaccines are too many?

Their reply? “There is no link between autism and vaccines“.

They are so misinformed, no rational discussion is even possible.

Vaccines can, indeed cause autism. The risk are cumulative, over a lifetime, not over the mere two weeks that doctors are told consider an adverse event. I will debate anyone, anywhere on this topic, as long as they read “Vaccine Whistleblower: Exposing Autism Research Fraud at the CDC“, and “Thimerosal: Let the Science Speak”  first. I’ve read Paul Offit’s book. This article was my response.

Instead of rational discourse, we see banal, grade-school like behavior. Bullying. Insults. And, in the case of genetics, blaming the victim.

Instead of a reasoned consideration of the fact, we learn of (some) doctors refusing to treat people who are no up-to-date on their vaccines. What ever happened to the Hippocratic oath?

Instead, we hear of family members getting angry with those who have decided to exercise their right of choice.

Objectivity is key in any consideration of public health policy. As long at the CDC continue to mislead the American public to think that vaccines are perfectly safe, the discussion must continue. The more they continue their disinformation campaign, the less the necessary research gets done.

We need to identify biomarkers of autism risk from vaccines.  We can’t expect such studies. Why? Vaccines do not cause autism, so why fund such studies?

We need to do clinical studies on treatments that will tone down aluminum-induced chronic microglial cell over-activation. Such studies will not be funded. Why bother? Aluminum, according to some, is not even a serious neurotoxin. 

We need newer, safer vaccines. Why? Aluminum is a neurotoxin. .

And we need to cancel CDC’s vaccine safety research contract. Why? Because they have, and continue to mislead the public, because they omitted results and fudged the results in numerous studies. They have done more than abdicate their responsibility to inform and protect us. They have prevented all of the safety research that should have been going on over the last 15 years. We need to wrench the responsibility of vaccine safety research away from them, and we need to do it NOW, before they fudge any more studies. What else are they lying to us about?

To me, the CDC and Pharma are grossly negligent. Picking up on Mary Holland’s analogy, who in her December 11 2015 article in The Jurist  likened the issue of discussing vaccine safety to someone yelling “Gunfire!” in a crowded movie theater… don’t blame me. Blame the gunman. He’s the one pulling the trigger.

December 15, 2015

See Mary Holland’s Academic Commentary in The Jurist: Legally Censoring Speech on Vaccines and Autism: A Response

causes

Read: You Can Help Bring Major Reform to Vaccine Safety Research

Cures_JLW_Cover_Art_front

New Book Released 2016 – Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages). To help support the publicity campaign, click on the book cover, above!

Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments Are Ready

AS COLLEGE PROFESSORS, my colleagues and I have always enjoyed the enthusiastic students who are eager to learn more. Those who stand out in myREADING memory are those who have requested more reading material. I have taught basic introductory biology, genetics, bioinformatics, courses in high-dimensional genomic and proteomic data analysis, and courses in study design and research ethics – and I always loved the gleam in the eye of students who just want to know.

Paging Dr. Offit!

Dr. Paul Offit earned millions of dollars from the sale of his patent for the Rotavirus vaccine after he voted to have it included in the pediatric vaccine schedule. He also appears to not be familiar with the body of peer-reviewed literature that condemns aluminum as a serious neurotoxin with well-characterized mechanisms of neurological damage.

In his book, “Deadly Choices: How the Anti-Vaccine Movement Threatens Us All” (Basic Books, New York), Offit is irresponsibly and recklessly dismissive of aluminum as a serious threat to the health of nearly all people by falsely reporting that:

“aluminum has been found to be harmful in only two groups of people: severely premature infants who receive large quantities of aluminum in intravenous fluids, and people on chronic dialysis (for kidney failure) who receive large quantities of aluminum in antacids”.

People absorb around very little of the aluminum they eat, but they absorb 100% of the aluminum injected in to their blood stream. [GENEROUSLY OFFERED CORRECTION/DETAILS: From Vaccine Papers, Al absorption from food is about 0.3%, typically within a range of 0.1-1%]. Offit claims, without citation, that aluminum in very quickly cleared from the body. He cites “researchers” (without citations) who studied aluminum concentrations in “blood” before and after receipt of aluminum-containing vaccines, and reports “No difference”.

Offit’s book was published in 2011. Unfortunately, it is evident that Offit did not even bother to search of the Pubmed, a wonderful public scientific research literature database at the National Center for Biotechnology Information, the standard resource for researchers who desire to know the latest on research topics in medicine, biology, psychiatry, and many other disciplines. A search reveals over 200 studies or papers on aluminum neurotoxicity before 2011. At the time of this writing (Nov. 2015), there are 393 studies or papers on the neurotoxicity of aluminum.

Some of these studies include direct discussions on the risk of aluminum in adjuvants in vaccines and provide data that demonstrate how aluminum works as a neurotoxin. Others discuss ways to alleviate neurotoxicity of aluminum. Others describe aluminum as a well-known neurotoxin responsible as a causal agent for neurodegenerative diseases.

Surely Offit, an expert placed on the National Vaccine Advisory Committee, the body in HHS responsible for making decisions on changes to the pediatric vaccine schedule, would have bothered to check the literature prior to 2011 while writing his book? If he had, he would have found studies with some compelling titles. The abstracts, and the papers themselves, are damning evidence for the use of aluminum as a vaccine adjuvant.

Here are some titles of the studies available at the time of his book-writing that individuals who are serious about vaccine safety might be interested in. Dr. Offit, for your convenience, I have included the links directly to the Pubmed entry:

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction.” (2009)

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.” (2009)

Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells.“(2009)

Role of metal ions in the abeta oligomerization in Alzheimer’s disease and in other neurological disorders.” (2008)

Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice.” (2007)

Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.” (2007)

Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer’s disease.” (2007)

Inflammation, neurodegenerative diseases, and environmental exposures.” (2004)

Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain.” (2004)

Neurotoxic effects of aluminium among foundry workers and Alzheimer’s disease.” (2004)

Neurological adverse events associated with vaccination.” (2002)

“The potential role of aluminium in Alzheimer’s disease.” (2002)

Just in case Dr. Offit is still involved in vaccine research, development or policy, and since he makes statements that appear in news articles on vaccine safety, I have taken the time to create a second reading list of more recent articles as well that Dr. Offit can add to his first reading list. Medical doctors really should keep abreast of new developments in medical research to stay professionally accredited.

But first, I have a hypothesis to share, which is indicated by past studies of numerous types. It came to me during my research for my forthcoming book, “Genetic and Environmental Causes of Autism”.

Is Macrophagic myofasciitis (MMF) Vaccine-Related Adult-Onset Autism/ASD?
A study in 2001 – a full decade before Offit’s book – reported central nervous system ailments eerily similar to those found in autism in patients diagnosed with macrophagic myofasciitis, symptomatic demyelinating CNS disorder, hemisensory or sensorimotor symptoms, bilateral pyramidal signs, cerebellar signs, visual loss, cognitive and behavioural disorders, and bladder dysfunction, supratentorial white matter hyperintense signals and corpus callosum atrophy (Authier et al., 2001).

Clinical features of MMF as described by Rigolet et al., (2014) are also strongly reminiscent of autism, including marked cognitive deficits (not related to pain, fatigue, or depression) including dysexecutive syndrome and visual memory impairment, and some cognitive deficits can appear unusually severe. Cognitive dysfunction was found to be stable over time. They also report that “classical therapeutic approaches are usually unsatisfactory making patient care difficult”.

Autism also involves cognitive deficits, executive function issues, memory impairment, and can involve severe cognitive deficits that are recalcitrant to treatment.

Additional Findings Support the Hypothesis

Mice injected with aluminum adjuvant doses equivalent to those given to US military service personnel showed both neuroinflammation and cell loss in the spinal cord and motor cortex, with consequent memory deficits (Petrik et al., 2007).

The cause of MMF has since been identified aluminum hydroxide from vaccines lesions (Gherardi et al., 2001; Authier et al., 2006; Gherardi et al., 2012; Rigolet M et al., 2014). Patients with MMF have an unusually long reaction at the site of injection of aluminum-containing vaccines in their muscle, and biospies show infiltration of muscle tissue by macrophages.

Here is chilling description of the effect of aluminum when used as an adjuvant:

“…poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in the brain” (Gherardi et al., 2015).

This is important: microglial cells are macrophages with dual roles in the brain: they perform routine surveillance and clean-up of cellular debris, viruses and bacteria. Upon infection, or serious brain damage, however, they become activated, change shape, and go on the attack. Microglial overactivation is a leading candidate for increased apoptosis and neurological damage associated with autism.

The neurotoxic effects of aluminum salts are also apparent: it increases levels of glial activation, inflammatory cytokines and amyloid precursor protein within the brain (Bondy, 2010). Amyloid precursor protein is one of the main culprits for Alzheimer’s disease.

The medical community and the public should revisit the issue of whether aluminum is a necessary adjuvant for vaccines. Evidently, for some vaccines that use virus-like particles as opposed to attenuated or live virus vaccines, no adjuvant is needed.

Reading List #2

Here is the rest of Dr. Offit’s reading list of studies and papers published after 2010:

Trace elements in scalp hair samples from patients with relapsing-remitting multiple sclerosis.” (2015)

Correlation of aluminum and manganese concentration in scalp hair samples of patients having neurological disorders.” (2015)

Aluminum-induced entropy in biological systems: implications for neurological disease.” (2014)

Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?” (2014)

A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder?” (2014)

Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report.” (2014)

Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration.” (2014)

Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes.” (2013)

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.” (2013)

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep.” (2013)

How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale.” (2013)

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.” (2011)

Aluminum vaccine adjuvants: are they safe?” (2011)

Metal ions affecting the neurological system.” (2011)

To be clear, Dr. Offit’s book could not include the references from the second reading list, as his book was published in 2011. But in the page and a half he takes to uses to claim that aluminum is only a problem for people with kidney failure and premature infants is terribly misleading, and is now also woefully out of date. As he and his profit-driven colleagues saw fit to allow vaccinations in babies between the age of 1 day to 2 years, it is of little reassurance that he knew that aluminum was harmful to premature babies.

Perhaps Dr. Offit was also not aware that the WHO Vaccine Safety Advisory Committee had, long before 2011, reported that there may be a subset of predisposed individuals who may be sensitive to aluminum-containing adjuvant (Authier et al., 2001).

Published scientific knowledge does not appear to play a role in the formation of vaccination policy in the United States.

November 16, 2015 (updated 11:22 AM)

Dr. James Lyons-Weiler is author of “Ebola: An Evolving Story” and “Cures vs. Profits: Successes in Translational Research“. He is also President, CEO and Chairman of the Board of the Institute for Pure and Applied Knowledge (IPAK).  IPAK is a pure public charity dedicated to providing impartial interpretation of research results without the influence of profit pressures. You can support IPAK with donations via the web. Your generous support will help Dr. Lyons-Weiler and his colleagues continue their efforts to keep the public, including Dr. Offit, informed.

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References

Authier FJ et al., 2001. Central nervous system disease in patients with macrophagic myofasciitis. Brain. 124(Pt 5):974-83.

Authier FJ, et al. 2006. AlOH3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background. Neuromuscul Disord 16(5):347–52.10.1016/j.nmd.2006.02.004

Bondy SC. 2010. The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology. 31(5):575-81. doi: 10.1016/j.neuro.2010.05.009.

Gherardi RK, et al. 2001. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Brain 124(Pt 9):1821–31.10.1093/brain/124.9.1821

Gherardi RK et al., 2001. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Brain. 124(Pt 9):1821-31.

Gherardi R and Authier FJ. 2012. Macrophagic myofasciitis: characterization and pathophysiology. Lupus 21(2):184–9.10.1177/0961203311429557

Gherardi RK et al., 2015. Biopersistence and brain translocation of aluminum adjuvants of vaccines. Front Neurol. 2015 Feb 5;6:4. doi: 10.3389/fneur.2015.00004. eCollection 2015.

Petrik MS et al., 2007. Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice. Neuromolecular Med 9:83–100.

Rigolet M et al., 2014. Clinical features in patients with long-lasting macrophagic myofasciitis. Front Neurol. 5:230. doi: 10.3389/fneur.2014.00230. eCollection 2014.

Cures_JLW_Cover_Art_front

New Books Released 2016

Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages).

The Environmental and Genetic Causes of Autism (Skyhorse Publishing)

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Books and Publications by James Lyons-Weiler

 

Getting A Feel for Authoring

Recently had the pleasure of going over the galleys of “Ebola”, and nearly 3/4 of the ways done with “Cures”, I’m getting to experience some of the perks of the life of an author.  For some reason, people open up to authors more, and want to share more ideas (which of course, I love).  I think part of it is that during the process of writing “Ebola”, I became a much better listener.   I had years of experience listening to investigators discuss their research plans, but I had a particular vested interest in those discussions: I wanted to effect the outcome of their research, and was trying to sell them my collaboration as a service.   I think being an author tells people that you’re interested in the human condition.

As an author, I’m finding that people from all walks of life open up to me, and really want to share all of their thoughts about a particular topic.  And I’ve found that I’m getting very good at bridging political, ideological and religious barriers.   There is something about the status of being an author on a scientific topic that causes most – emphasis on “most” – to afford one a tad more credibility.  I emphasize “most” because the reverse is true among experts in biodefense: they want me to prove that I have sufficient knowledge before they will brook a conversation!  Hopefully thus far I have not dissatisfied too many.

People from all walks of life know a lot more about some fairly complex issues than most in the biomedical field give them credit for.  They are aware of the issues – and they want to share their own understanding.  That’s why I think “Cures” will be very well received.  There are plenty of myths, and rumors about the evils of biomedicine – but there are just as many truths that are worth learning about.  Not all of the truths are pretty, but many are.  So in “Cures”, I’m focusing on finding the ever-elusive silver linings in tough topics like ADHD overdiagnosis.  It’s all too easy to sit on a rocking chair on my figurative front porch and complain to Gracie, or my neighbor, who sometimes comes over for iced tea, about how bad it is, and end the conversation with “Well, whaddya gonna do about it”?

The fact is, writing on these topics is empowering for me.  I have found a particular niche, and a particular combination of writing style that people say they like.  I mix the scientific literature with citations from the media – and quotes from experts – get all the peer-reviewed research results I can, and, using the combined powers of logic and passion for ending human pain and suffering, strive for a conversational, non-condescending tone, and somehow it comes out… interesting and informative.

People constantly ask me what my next book project will be, and right now, with “Cures”, when I describe the content, every person I have discussed it with has affirmed that they have heard that doctors don’t want cures, they want treatments, because treatments make them money.  Talk about taking a bull by the horns!  ADHD overdiagnosis and overtreatment, grapefruit and blood pressure, fecal microbiota transplants, mammograms, with an eye on history, and evolutionary biology, all open topics with plenty of confumantission among the public given discordant results from studies.  A contemplative, meditative, thorough treatment of the topics with the goal of identifying the positives… well it’s hard work, but it’s rewarding in its own right.  I’m learning a lot, too, which of course makes me happy.  The work will no doubt not be the last word on these complex topics, but I hope that my effort will help others understand what is known, what is not known, what is fact, and what is myth, when they hear that doctors don’t want to help patients with cures.  (Hint on the bottom line: there are attributes that tend to common to successful translational research studies, so motives be damned, I get to call out the good guys AND the bad guys – and I celebrate the good ones more than dwell on the bad).

If you’re an author, feel free to share w/me your transformative experiences as the world reacted to your “author” personality as opposed to your “scholar” personality.