Open Letter to CBC: Your Reply to Dr. Jackson’s Concerns Over Incorrect Information on Aluminum by Marketplace Contains More Incorrect Information on Aluminum

Open Letter to CBC: Your Reply to Dr. Jackson’s Concerns Over Incorrect Information on Aluminum by Marketplace Contains More Incorrect Information on Aluminum

For those paying attention, CBC’s Marketplace recently aired an unethical and ineffectual hidden camera ‘hit piece’ on the vaccine-risk-aware community assembled in an after-party in Washington, DC. We suspect many of CBC’s viewers were dismayed by the treatment of the professionals they targeted and the misinformation propagated by their reporters and the show’s guest.

One such viewer, Dr. Anaheed Jackson, wrote to CBC, and when their response deepened her concerns, she forwarded the communication to Dr. Lyons-Weiler. After consideration, we decided to co-author this blog article.

The CBC’s reply to Dr. Jackson contains gravely misleading and potentially dangerous misinformation on aluminum toxicity. We are taking the opportunity to share their misleading and misinformed response and to enumerate the errors they have made, in interpretation of the scientific literature on aluminum, important misinterpretations of published research, and a clear misunderstanding of the dynamics of aluminum clearance from the human body.

Here is the CBC’s response:

From: PAUL HAMBLETON xxxxxxxxxx@cbc.ca

Date: Fri, Feb 7, 2020 at 5:53 AM

Subject: CBC Response

To: info@healthyrootsclinic.com

Cc: Jennifer McGuire xxxxxxxxxx@cbc.ca, CBC Ombudsman xxxxxxx@cbc.ca

Dear Dr. Ana Jackson:

CBC: I am writing in reply to your email of January 17 addressed to CBC Ombudsman, Jack Nagler, about what you see as inaccurate information in a CBCNews.ca story posted earlier that day under the headline, “Nearly half of Canadians are concerned about vaccine safety. Here’s why.” Specifically, you wrote, the story says aluminum adjuvants used in vaccines “’completely flush out of the body.’” You cited two studies suggesting that they do not.

As the Director of Journalistic Standards, Jennifer McGuire, General Manager and Editor in Chief of CBC News, asked me to reply to you directly.

I appreciate hearing your views and I sincerely regret that you are disappointed in CBC in this instance. However, and I say this with respect, your view of the story is not one I share. I’ll explain why, but first I want to be clear about the story.

It focuses on how the anti-vaccination movement has convinced consumers – often the parents of young children – that vaccines are dangerous. Vaccination is widely accepted by medical science and government health authorities as a safe and beneficial way to protect children from the potentially serious consequences of a range of sometimes deadly childhood diseases. Yet, in the face of what is commonly described as overwhelming scientific evidence to the contrary, the anti-vaccination movement argues the risk is not in the disease, but in the vaccine given to prevent it. It would appear to be an unsustainable position, yet the influence of those worried about vaccination is growing along with their numbers.

Here, CBC misrepresents the position of the vaccine risk aware community, which hold that, contra the US CDC’s claims, vaccines are not “safe and effective” for everyone; i.e., they are not safe for some; i.e., they are, in fact, dangerous for some. 

What they cite as “overwhelming scientific evidence to the contrary” is actually observational science, i.e., retrospective correlational/ecological studies which fall far short of the gold standard of long-term, randomized, inert-placebo controlled studies. In such studies,  individuals are randomly assigned to a group to either receive the vaccine in question, or to receive an inert (biologically inactive) injection of saline. Neither CBC nor anyone can produce any such studies for long-term safety; the CDC and Pharma (vaccine manufacturers) rely exclusively on “post-market surveillance” studies that are incapable of testing the hypothesis of causality. When placebos have been used, they are not true placebos; they are either another vaccine, or, as is the case for the HPV vaccine, the aluminum adjuvant, neither of which are biologically inert. Thus, not a single vaccine on the childhood vaccination schedule has ever gone through proper double-blind, placebo controlled testing that is a requirement for all other drugs on the market. 

CBC: This online story, along with the accompanying broadcast story on CBC Marketplace (January 17), looked at how the anti-vaccination messaging is effective at encouraging doubt because of the way it manipulates emotions and biases. The story also sets out some of the common concerns Canadians have expressed about the dangers of vaccines and explains why experts say they should not be worried.

The primary message of the vaccine risk aware community is that given that the safety science falls short of testing causality, using only short periods of time in the initial safety trials, and relying only upon correlation studies, the medical community is misinformed on the true risk profiles of many vaccines. When parents or adults try to report a vaccine injury or even death to their doctors, they are met with denialism. Some doctors have told parents with infants who are experiencing seizures that it could not be the vaccine. If this sounds as if it is a message designed to evoke emotions, then perhaps doubters of mothers and fathers should ask themselves how they would feel if their own child was injured or killed by a vaccine and the doctors and the government denied it to their face.

The facts are that awards have been given for deaths and injury; in the US, the National Vaccine Injury Compensation Program, in which Dr. Lyons-Weiler is an expert on some cases, has awarded >US$4.5 Billion for vaccine injury and deaths. Journalistic standards demand that these facts be brought forward to provide balanced reporting.

One of those concerns is that vaccines contain chemicals that can be toxic at high levels, among them aluminum. It’s the most abundant metal in the earth’s crust and occurs naturally in soil, water and air. In fact it’s so prevalent in food that the CDC estimates that the average adult in the United States eats 7-9 mg of aluminum every day. Antacids contain 104-208 mg of aluminum, buffered aspirin 10-20 mg per tablet.

These statements betray another lack of effort for journalistic curiosity. Aluminum is the third most abundant element in the earth’s crust – where it is bound to silica to form bauxite – and is thereby not available to organisms in the biosphere, including humans. Humans only began being exposed to aluminum after the 1850, when the processes to extract aluminum from bauxite was invented. The history is readily available in Wikipedia:

Aluminium was difficult to refine and thus uncommon in actual usage. Soon after its discovery, the price of aluminium exceeded that of gold. It was only reduced after the initiation of the first industrial production by French chemist Henri Étienne Sainte-Claire Deville in 1856. Aluminium became much more available to the public with the Hall–Héroult process developed independently by French engineer Paul Héroult and American engineer Charles Martin Hall in 1886, and the Bayer process developed by Austrian chemist Carl Joseph Bayer in 1889. These processes have been used for aluminium production up to the present.

Regarding exposure from food and water, clearly CBC did not even bother to read the studies that were sent; according to Dr. Yokel of the University of Kentucky, we absorb only 0.3% of the aluminum we eat. So,

9000 mcg * 0.003 = 27 mcg of aluminum in an adult per day.

This is in comparison to the 850 to 1150 mcg found in vaccines that a child is directly exposed to through injection where a 100% absorption rate exists, and higher amounts if a doctor tries to inject the same child with more than one vaccine per day. CBC should have referred to the Appendix to the study sent to them by Dr. Jackson by Dr. Lyons-Weiler and colleagues. This peer-reviewed study by Dr. Lyons-Weiler and co-authors (McFarland et al, 2020) shows that when absorption in considered, as is appropriate for concerns of whole-body exposure and toxicity, for the first six months of life, infants receive far more aluminum from vaccines than from food, water, breastmilk, or formula.

It is also added in very small quantities to a few vaccines – chiefly those aimed at human papillomavirus (HPV), influenza, hepatitis and anthrax – but generally not to those given to children, including the measles, mumps and rubella (MMR) vaccine. For those few that do contain aluminum, they contain no more than 0.85 mg per dose – an amount 100 times smaller than in an antacid tablet – and in most cases they contain far less. 0.85 mg is about the same amount found in a litre of infant formula.

The CBC claims that “few” vaccines contain aluminum. Our understanding is that about 60% of vaccines on the US CDC schedule contain aluminum. Regarding 850 mcg per dose, CBC should have known, if they actually read the peer-reviewed and published reference material sent, that the expression

The expression “850 mcg per dose” itself is problematic: safe dosage limits would be expressed as “xx mcg/kg/day”, which was the reason why McFarland et al. bothered to use an estimated pediatric dose limit scaled to body weight.

Regarding an antacid tablet, 2000 mcg of aluminum with 0.3% absorbed would lead to 6 mcg of aluminum absorbed via the intestine, so an injected vaccine is about 140 times more aluminum than an antacid dose. Drinking 850 mcg of aluminum in a liter of water would result in absorption of only 2.55 mcg of aluminum. Thus, an 850 mcg vaccination will result in a dose that is 333 times that received from drinking a liter of water. Further, the aluminum in drinking water is not there naturally; it is added as a buffer to prevent the corrosion of water lines.

Since aluminum is, in fact, toxic, exposures from all sources is a cause for concern.

CBC: The segment went on to explain that adjuvants, such as aluminum, are added to some vaccines to enhance their effectiveness by “prompting the body to learn how to fight the disease instead of immediately flushing [the dead virus] out.” And it added that “all traces” of aluminum and everything else in the vaccine are “are flushed completely out of the body within a day or two.”

As evidence to the contrary, you included a link to a French study by R.K. Gherardi, and others, on the biopersistence of aluminum adjuvants, and a recent article by James Lyons-Weiler, and others, about the comparative retention of aluminum in three vaccination schedules. As you may know, Dr. Lyons-Weiler, a popular speaker at anti-vaccination movement meetings, was featured in the Marketplace television story.

If CBC were interested, they would have learned that Dr. Lyons-Weiler routinely leads the crowds that assemble to hear him speak in chants such as “What do you want?” Crowd: “Science!” “When do you want it?” “NOW!” Dr. Lyons-Weiler defends the public trust in objective science. Your video “exposé” claimed that he would “like” to be “seen” as a scientist; you evidently now recognize the error of your insinuation; Dr. Lyons-Weiler has requested an apology, but expects none.

I realize that there are some studies, often cited by those opposed to vaccination, that link aluminum adjuvants and their “biopersistence” to a wide range of afflictions sometimes described as the autoimmune/ inflammatory syndrome induced by adjuvants (ASIA), which is said to include macrophagic myofasciitis (MMF), the Gulf War syndrome (GWS), and “chronic toxicity” in infants, among other things.

The authors of the studies you cited raise many more questions than they offer answers. Both suggest multiple further avenues of study. Acknowledging the tentative nature of their work, Gherardi, for example, notes that the “imbalance between the huge number of vaccinated individuals and the relatively low number of MMF cases” suggests the involvement of other factors.

These “other factors” include genetics and as we have clarified, the concern for many in the vaccine risk aware community is not that vaccines are universally dangerous, as you have misstated the position, but that a subset of individuals appears to be at highest risk. Dr. Lyons-Weiler and others have provided you with links to videos in which the late Dr. Bernadine Healy, former director of the US National Institutes of Health, and Dr. Julie Gerberding, former director of the US Centers for Disease Control and Prevention (now a well-paid executive of Merck’s Vaccine Division Program) both told CNN News that a genetically susceptible subgroup likely exists that is higher risk of injury from vaccines. Dr. Andrew Zimmermann, a leading pro-vaccine pediatric neurologist and medical expert, claimed that “regressive encephalopathy” (brain swelling and damage) can occur after vaccination in certain children who have underlying mitochondrial disorders. He gave this testimony back in 2007 during a Federal Vaccine Court proceeding.

In the absence of convincing science of the dangers of “biopersistence,” there is overwhelming scientific and medical consensus on the safety and efficacy of vaccination. The story linked the section of aluminum adjuvants to a 2015 “Public Health Statement for Aluminum” issued by the Agency for Toxic Substances & Disease Registry, a division of the U.S. Centers for Disease Control and Prevention, that says “most” of the aluminum in food and “much of the small amount” that enters the bloodstream is “quickly” excreted.

It is odd that CBC would prefer a 2015 source to more updated, peer-reviewed sources. While directed by Dr. Gerberding, the ATSDR cherry-picked one mouse study out of dozens to justify a generous and extraordinary 1,000 mcg tolerable limit per day from oral exposures, when past limits had been either 1,000 or 2,000 mcg provisional tolerable limit per week. CBC has no scientific basis upon which to dismiss the studies showing chronic toxicity is expected, including studies by Dr. Lyons-Weiler and team and studies such as those by Dr. Gheradhi and Dr. Exeley in which aluminum content in humans was measured. 

Further, the ATSDR is, you quote, references ingested, not injected, aluminum. Being a different form of aluminum with a different route of exposure, the toxicity profiles are completely different. CBC is clearly not in a position to evaluate the “convincingness” of the studies they have been sent, given their lack of understanding of the basics of the relative exposure from ingested (0.3%) vs. injected (100%) forms of aluminum.

That seems to reflect the findings of most studies of the subject reviewed by our journalists. Among many others, we asked epidemiologist Dr. Natasha Crowcroft about aluminum. Dr. Crowcroft, who has authored over 250 peer-reviewed scientific papers, is the co-chair of the Canadian Association for Immunization Research, Evaluation and Education (CAIRE) and a member of the Canadian Immunization Research Network. She assured us that “kids who are vaccinated don’t have any increase in the aluminum levels in their plasma following immunization.”

There has only been one study that showed that plasma levels of aluminum in newborns did not change before and after vaccination with aluminum-containing Hepatitis B vaccine. That fact is not at all reassuring; we are concerned not only with acute toxicity but with long-term (chronic) whole-body toxicity. The presence of aluminum released over long periods of time following vaccine in studies cited by Dr. Lyons-Weiler and colleagues and by the US FDA show that only about 5% of aluminum is excreted from the body form a rational basis of concern. In one study, rabbits cleared only 5.6% of the injected aluminum hydroxide in urine after 28 days. Adults require multiple thousands of days to excrete a single injected dose. Infants’ kidneys are only 20% efficient compared to toddlers. These facts were all provided to CBC in the studies provided. Their journalistic integrity would compel them to understand these facts.

She also notes that that (sic) although high levels of aluminum in the blood can pose health risks, vaccines generally bypass the bloodstream altogether. “You’re giving it into (sic) a muscle,” she said. “You’re not injecting a vaccine into a vein; you’re giving it into usually a muscle, sometimes subcutaneously.” She notes that because of this, “it doesn’t go straight into the bloodstream, it doesn’t accumulate in tissues, it stays in the site where the immune system can package it up and get rid of it and then if it gets into any other compartment it gets cleared through the kidneys. And it gets cleared quite quickly; it’s gone very quickly.”

This doctor clearly does not understand how aluminum from vaccines is transported throughout the body. It mains mechanism of action is both apoptotic and necrotic cell death. Macrophages, which move in and out of the circulatory system, pick up the cellular debris (to which aluminum is adhered) and thus move it about the body. Aluminum also binds to transferrin, which is supposed to be available to relocate dietary iron to bone for the production of red blood cells.  A reasonable estimate of a ½ life of injected aluminum from is numerous studies, already sent to you, have found that aluminum is found in the brains of people with autism, Alzheimer’s disease, Parkinson’s disease and other conditions. Why you have chosen to ignore the materials and links sent to you by Dr. Lyons-Weiler, Del Bigtree, and others betray a lack of journalistic objectivity and an utter contempt of the integrity that real journalism requires.

She adds that the studies supporting “biopersistence” work off “an assumption that aluminum just stays there and builds up with each dose and all of that is just wrong. It doesn’t enter the bloodstream, so it doesn’t ‘go up’ in levels the way that drugs do.”

Here their expert is at odds with herself. If aluminum does not enter the circulatory system (which it does, adhered to cells and in macrophages), then why would we be reassured that there is no difference in plasma levels of aluminum in infants following vaccination with aluminum hydroxide? No study – none – shows that the reason is that it clears from the body immediately. Instead, it goes into various compartments of the body, including the brain, where the chronic toxicity sets in. Since the science conducted by Dr. Lyons-Weiler focuses on whole body clearance, their experts’ position is a misrepresentation of our concerns. Getting the basics of reporting right is imperative for “reporting”.

Thank you again for bringing your views to our attention, and for giving me an opportunity to respond. I hope my reply has assured you of the continuing integrity of Marketplace and CBC News.

If you do not find this answer satisfactory, you may wish to ask CBC Ombudsman, Jack Nagler, to review the matter. The Office of the Ombudsman, an independent and impartial body reporting directly to the President, is responsible for evaluating program compliance with the CBC’s journalistic policies. The Ombudsman may be reached by telephone at 416-205-2978, or by mail at Box 500, Terminal A, Toronto, Ontario M5W 1E6, or by fax at (416) 205-2825, or by e-mail at ombud@cbc.ca

Sincerely,

Paul

Paul Hambleton

Director of Journalistic Standards

CBC News

Cc. Jack Nagler, CBC Ombudsman

 Jennifer McGuire, General Manager and Editor in Chief, CBC News

In spite of these reassurances, the facts remain: You reported incorrectly that aluminum is flushed completely from the body, and we, and others, have provided ample evidence that this is an incorrect statement, and as a reporting agency, you should issue a correction and a retraction. Dr. Lyons-Weiler does not expect an apology that is due under the present circumstances.

It would behoove you to actually read the studies sent and the citations in those studies. Your organization shows a contempt for journalistic integrity and for objectivity in science. Millions of children and adults are suffering from conditions that may be related to vaccines; unknown numbers have died. The world needs a new form of objective journalism; for that, we refer readers to Del Bigtree (The Highwire ) and to Sharyl Attkisson (Full Measure) and Ben Swann (Truth in Media). Just as Dr. Lyons-Weiler represents objectivity in Science, these outlets represent refreshing objectivity in Journalism.

We wish you the best of luck in your endeavors.

Sincerely,

Dr. Anaheed Jackson, ND

James Lyons-Weiler, PhD

Neuroimmune Toxicity of Aluminum Adjuvants 1: Safety studies of aluminum in vaccines lack immunotoxicity analysis of this immunological adjuvant: Ignorance or deception? -Vinu Arumugham

This article is part of a series of guest articles to jameslyonsweiler.com on the neurological and immunological toxicity of aluminum-containing adjuvants in vaccines.  These articles appear by invitation to the authors.  -JLW

The safety studies most often referred by vaccine regulators when making claims about the safety of aluminum in vaccines, have ignored the immunotoxicity of aluminum.

Vaccinologists admit that they neither understand the general immunological mechanisms involved in vaccination nor do they understand the mechanisms involved in aluminum adjuvant action.

Thus vaccine regulators have no scientific basis to make vaccine safety claims. Given this situation one would expect that vaccine regulators would be very cautious about making vaccine safety claims. Instead, they collude with vaccine makers to actively hide vaccine safety problems and mislead the public.

The dual role of immunotoxicity and neurotoxicity of aluminum in autism is also covered. Cow’s milk contaminated aluminum adjuvanted vaccines cause the synthesis of folate receptor antibodies. These antibodies block folate uptake causing cerebral folate deficiency and autism. The folate deficiency in turn, causes aluminum accumulation in the brain, resulting in neurotoxicity and exacerbation of autism.

Background

Vaccine safety authorities such as the US Food and Drug Administration (FDA) and the Australian National Centre for Immunisation Research & Surveillance (NCIRS) use studies such as Mitkus et al. 1 and Jefferson et al.2 to claim that aluminum adjuvants in vaccines are safe.

Discussion

Mitkus et al.1 provide the following description of the effect of aluminum adjuvants on the immune system:

“Aluminum adjuvant are important components of vaccines, since they stimulate the immune system to respond more effectively to protein or polysaccharide antigens that have been adsorbed to the surface of insoluble aluminum particles. Specifically, these coated particles are phagocytized by cells of the innate immune system (e.g., macrophages) and activate intracytoplasmic sensors of pathogen-associated molecular patterns located within the cells, such as the nucleotide-binding domain leucine-rich repeat-containing family of sensors ([6]; Schroder and Tschopp [30]). The functional consequence of activation of this intracellular system is the activation of certain enzymatic caspases that cleave pro-interleukin (IL)-1β to interleukin (IL)-1β. The secretion of the mature cytokine, IL-1β, leads to an inflammatory reaction and a downstream Th2-dependent antibody response [7], which amplify the immune response to the antigen. Adjuvanted aluminum, therefore, plays a vital role in facilitating the response that underlies the immunoprotection afforded by vaccines.”

 

The rest of the Mitkus et al. review focuses on body burden of aluminum after it is absorbed from the muscle into the blood. They completely ignored any negative immunological effects that aluminum can have while it is still in the muscle (following intramuscular vaccine administration).

The quoted paragraph above assumes that the only proteins in the vaccine are viral/bacterial target proteins required for immunoprotection. In that case, as they state, the stimulation by aluminum plays a vital role in generating immunoprotection.

But obviously, vaccines contain numerous other proteins including food proteins (ovalbumin, milk, soy, yeast, oils from sesame, peanut, fish etc.)3,4, culture medium cell proteins (Vero monkey kidney cell proteins, calf serum proteins, WI38/MRC5 fibroblast cell proteins, chick embryo cell culture proteins etc.)3, non-target viral/bacterial proteins5, that are also adsorbed on to the surface of insoluble aluminum particles. As they state then, aluminum adjuvants stimulate the immune system to respond more effectively to ALL these proteins as well. The result is off-target immune responses that includes synthesis of antibodies against any and all of these proteins as well as cell-mediated immune responses.

The result of such a response of course includes food allergy6-9, asthma10, autism11,12 and autoimmune diseases13,14.

How can they perform a safety assessment of aluminum in vaccines while completely ignoring this immunological effect?

Jefferson et al.2 reviewed eight studies (listed in Table 2 of Jefferson et al.) on the effect of aluminum adjuvants. Any vaccine will need about 3-4 weeks to take effect. That’s how long it takes for the immune system to develop the appropriate immune response and antibodies. For this reason, vaccine effectiveness investigators wait at least one month post vaccination to assess effectiveness.15

Aluminum compounds are of course an immunological adjuvant in vaccines.16. So their immunological effect (positive or negative) can only be assessed if the follow-up period is greater than 4 weeks. However, only two out of eight studies in Jefferson et al. had a follow up period of >4 weeks. So rest of the studies they included were useless to assess immunological safety of aluminum adjuvants. Even those two studies ignored immune disorders such as allergies, asthma, autism or autoimmunity. As previously described, each of these immune disorders can be initiated by IgE mediated allergy11 or the Th2 response, which aluminum adjuvants are known to produce.1,17

So not only were the original studies flawed, Jefferson et al. made the mistake of including these flawed studies in their analysis. To really evaluate the safety of aluminum salts in vaccines, one would have to account for all known/potential immunological mechanisms involved with aluminum adjuvants. What are the potential negative outcomes due to that mechanism? What tests are needed to check for those outcomes? Would the outcomes be overt disease or will they be sub-clinical effects for years? This would determine follow-up times and decision on serological examination. For example: to assess if aluminum may be increasing the risk of sensitization to cow’s milk proteins contaminating the vaccine, one would not only have to wait for 4 weeks after vaccination, but also challenge the patient with cow’s milk, pre- and post- vaccination, to assess the impact. Similarly, to check if aluminum induced an autoimmune disease that may only show up years later, one would have to perform autoimmune serology pre- and post-vaccination checking for changes in autoantibody levels, as suggested by Wraith et al.18

These studies have never been performed. Why?  In fact, vaccine makers seem to go out of the way to obscure the adverse effects of aluminum adjuvants by injecting aluminum adjuvant into control subjects during vaccine clinical safety trials.15

Given this situation, the Jefferson et al. conclusion: “Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken.” is inexplicable, and raises serious questions about the manner in which vaccine safety investigations are conducted.

Evidence of aluminum adjuvant dangers

Morris et al.19 have called for the elimination of aluminum adjuvant in vaccines. Prof. Franco Celada, Dept. of Pathology, NYU School of Medicine, called for safety studies of aluminum adjuvant induced innate immune system activation (personal email communication, Oct 2017) in the context of low affinity self reactive (LASR) T cell mediated autoimmune diseases13,14 caused by animal protein contaminated vaccines.

Anders et al.20 have called for the re-evaluation of aluminum adjuvants in vaccines due to its role in boosting IgE mediated responses. In other words, a Th2-dependent antibody response as described by Mitkus et al.1 and Terhune et al.21 Terhune et al.22 further link Treg dysregulation in atopic disease to aluminum adjuvants.  Shoenfeld et al.23 describe aluminum adjuvant-induced autoimmunity.

Aluminum immunotoxicity followed by neurotoxicity in autism

Many vaccines contain casein or casamino acids of bovine milk origin and are thus contaminated with all bovine milk proteins.3,24 One such protein is the bovine folate receptor (FR) protein25. Such aluminum-adjuvanted, bovine FR protein contaminated vaccines can cause IgE mediated sensitization to the FR protein (aluminum adjuvant induced Th2 response1).4,6,10

Since FR concentration in bovine milk is low, the patient can still consume bovine milk without developing an allergic reaction.25,26 It has been shown that consuming milk when sensitized (via an oral immunotherapy protocol, for example) will result in the synthesis of IgG4 antibodies specific to milk proteins.8

In this case, bovine milk consumption causes FR specific IgG4 synthesis. These IgG4 antibodies cross-react with human folate receptors. Human and bovine FR proteins have 90% amino acid sequence homology.27  IgG4 specific to FR is the main antibody involved in binding/blocking folate receptors in the choroid plexus, blocking folate uptake to the brain.27

This results in cerebral folate deficiency and autism.28 Folate deficiency in turn, results in aluminum accumulation in the brain and aluminum-induced neurotoxicity.29-31

The source of the aluminum could of course be the diet, pollutant inhalation and aluminum-adjuvanted vaccines. Mold et al.32 have demonstrated such aluminum accumulation in human autistic brain tissue.

Conclusion

The FDA makes a mockery of science by comparing aluminum in vaccines to dietary aluminum.33 In that case, we should be drinking our aluminum adjuvanted vaccines, instead of intramuscular injection. The FDA’s Mitkus et al. study1 is entitled “Updated aluminum pharmacokinetics following infant exposures through diet and vaccination.”. They studied pharmacokinetics – how aluminum moves through the body. While aluminum pharmacokinetics related safety needs to be understood, they cannot ignore aluminum adjuvant immunotoxicity, if they were really interested in vaccine aluminum adjuvant safety. If the FDA is incapable of even determining the appropriate lines of safety investigations required, how can they be in charge of vaccine safety? How can we expect vaccines approved by the FDA to be safe?

Safety needs engineering not tinkering

For decades, vaccinologists have been reluctant to understand the immunological mechanism of how vaccines work, fail or hurt the body.

Pulendran et al.37 wrote:

“Despite their success, one of the great ironies of vaccinology is that the vast majority of vaccines have been developed empirically, with little or no understanding of the immunological mechanisms by which they induce protective immunity. However, the failure to develop vaccines against global pandemics such as infection with human immunodeficiency virus (HIV) despite decades of effort has underscored the need to understand the immunological mechanisms by which vaccines confer protective immunity.”

Mojsilovic16: “Some of the first adjuvants discovered back then, on empirical basis of trial and error, are still in widespread use today, but only recently some light on the molecular mechanisms of their action has been shed.”

There seems to be little interest among vaccine developers and regulators in understanding the mechanisms of immunoprotection or immunotoxicity of vaccines and adjuvants. This is no way to build a safety critical product, centuries after its invention.

Since the immunological mechanisms of vaccines are not understood, one would expect that vaccine makers and regulators will be extremely cautious about making vaccine safety claims. One would expect that they will thoroughly investigate even the slightest indication of vaccine-induced adverse events.

Instead, we find vaccine makers and regulators collude to hide vaccine safety problems. The ShingrixTM vaccine was recently approved after an inadequate safety evaluation.35 The FDA briefing document (Sep 2017) describes serious adverse events (SAEs) including supraventricular tachycardia following Shingrix vaccination in clinical studies. The Shingrix vaccine package insert (revised 10/2017)36 has no reference to supraventricular tachycardia at all.

Acknowledgment

Elizabeth Hart, Adelaide, South Australia, suggested this review and provided background material.

References

1. Mitkus RJ, King DB, Hess MA, Forshee RA, Walderhaug MO. Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. Vaccine. 2011 Nov 28;29(51):9538–43.

2. Jefferson T, Rudin M, Di Pietrantonj C. Adverse events after immunisation with aluminium-containing DTP vaccines: systematic review of the evidence. Lancet Infect Dis. United States; 2004 Feb;4(2):84–90.

3. Vaccine Excipient & Media Summary [Internet]. 2015 [cited 2016 Jan 16]. Available from: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf

4. Arumugham V. Professional Misconduct by NAM Committee on Food Allergy [Internet]. 2016. Available from: https://www.zenodo.org/record/1034559

5. Ahmed SS, Volkmuth W, Duca J, Corti L, Pallaoro M, Pezzicoli A, et al. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 (ABSTRACT ONLY). Sci Transl Med. 2015;7(294):294ra105–294ra105.

6. Arumugham V. Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy. J Dev Drugs. 2015;4(137):2.

7. Platts-Mills TAE. The allergy epidemics: 1870-2010. Journal of Allergy and Clinical Immunology. 2015. p. 3–13.

8. Hoyt AEW, Schuyler AJ, Heymann PW, Platts-Mills TAE, Commins SP. Alum-Containing Vaccines Increase Total and Food Allergen-Specific IgE, and Cow’s Milk Oral Desensitization Increases Bosd4 IgG4 While Peanut Avoidance Increases Arah2 IgE: The Complexity of Today’s Child with Food Allergy. J Allergy Clin Immunol. Elsevier; 2017 Jul 7;137(2):AB151.

 9. Alice Hoyt, Peter Heymann, Alexander Schuyler, Scott Commins TAEP-M. Changes in IgE Levels Following One-Year Immunizations in Two Children with Food Allergy [Internet]. 2015. Available from: https://wao.confex.com/wao/2015symp/webprogram/Paper9336.html

10. Arumugham V. Medical muddles that maim our children with allergies, asthma and autism [Internet]. Unpublished; 2017. Available from: https://www.zenodo.org/record/1034595

11. Arumugham V. Autism Spectrum Disorders: A special case of vaccine-induced cow’s milk allergy? [Internet]. 2017. Available from: https://www.zenodo.org/record/1034557

12. Arumugham V. Strong protein sequence alignment between autoantigens involved in maternal autoantibody related autism and vaccine antigens [Internet]. 2017. Available from: https://www.zenodo.org/record/1034571

13. Arumugham V. Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: a detailed look at Crohn’s disease and Vitiligo [Internet]. 2017. Available from: https://www.zenodo.org/record/1034777

14. Arumugham V. Bioinformatics analysis links type 1 diabetes to vaccines contaminated with animal proteins and autoreactive T cells express skin homing receptors consistent with injected vaccines as causal agent [Internet]. 2017. Available from: https://www.zenodo.org/record/1034775

15. Gardasil Package Insert [Internet]. Available from:

http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf

16. Mojsilovic SB. Immunological effects of adjuvants, their mechanisms, and relevance to vaccine safety. Cent Eur J Paediatr Vol 13, No 1 Cent Eur J Paediatr. 2017;

17. Lindblad EB. Aluminium compounds for use in vaccines. Immunology and Cell Biology. 2004. p. 497–505.

18. Wraith DC, Goldman M, Lambert P-H. Vaccination and autoimmune disease: what is the evidence? Lancet (London, England). England; 2003 Nov;362(9396):1659–66.

19. Morris G, Puri BK, Frye RE. The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved? Metab Brain Dis. United States; 2017 Oct;32(5):1335–55.

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21. Terhune TD, Deth RC. How aluminum adjuvants could promote and enhance non-target IgE synthesis in a genetically-vulnerable sub-population. J Immunotoxicol. England; 2013;10(2):210–22.

22. Terhune TD, Deth RC. A role for impaired regulatory T cell function in adverse responses to aluminum adjuvant-containing vaccines in genetically susceptible individuals. Vaccine. Netherlands; 2014 Sep;32(40):5149–55.

23. Shoenfeld Y, Agmon-Levin N. “ASIA” – autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. England; 2011 Feb;36(1):4–8.

 24. Kattan JD, Cox AL, Nowak-Wegrzyn A, Gimenez G, Bardina L, Sampson HA, et al. Allergic reactions to diphtheria, tetanus, and acellular pertussis vaccines among children with milk allergy. J Allergy Clin Immunol. 2011;Conference(var.pagings):AB238.

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https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM581605.

 

The Evolutionary Arms Race Theory of Autoimmune and Pathogen-Derived Disease

WHEN EVOLUTIONARY EXPLANATIONS are invoked to explain the existence or persistence of specific traits, the normative causal reasoning invokes a benefit to the individuals carrying the genes for those traits, a concept widely understood as individual fitness. Natural selection then results as an outcome of competition for the most limiting resources; nature providing a grand stage upon which all of the theatrical plays of life are worked out, with some characters thriving, and others denied contribution to the next generation: for them, their genetic fate a dismal tragedy.

Tomes of very clever ideas, and deep understanding on how complex evolution could become were worked out in for 90 years in the pages of journals that published theoretic works by such great minds as Sewall Wright, whose ideas on balancing selection explain how two traits, both slightly deleterious, could offset a certain march toward genetic doom, leading to the persistence of apparently deleterious traits in evolving populations over time. He and others worked out ways of thinking about complex genetic interactions, such as epistasis and pleiotropy. All shifts in gene frequencies in most populations, it was thought, could be well understood as a balance between the relative contribution of alleles to benefits in terms of survival and reproduction, and inconsistencies and unlikely or seemingly impossible outcomes could result from shifting balances across adaptive landscapes.

Utterly brilliant, this body of work was confronted with new thinking upon the the arrival of even the earliest modicum of data. Motoo Kimura showed, for example, that most of the changes in gene frequencies over time where not likely to involve a specific genetic contribution to differential survival and contribution, but were rather simply a mathematical necessity, driven by mutation pressure, with most nucleotide substitutions occur simply because there was not enough room in the population to hold all of the alleles at a particular locus.  This is most easily understood in very small populations, in which the smallness of the population makes random factors that influence the survival of specific genetic variants much more important than they would be were those alleles found in a larger population.  Alleles could come into existence by chance, and then, driven by chance, drift to fixation to the exclusion of other alleles, regardless of their relative contribution to survival and reproduction. Under Kimura’s neutral theory of evolution, and its descendant theories, mutation pressure places the limit on the rate of evolution, and most (the largest percentage) of genetic changes over time do not particularly influence survival or reproduction, or if they do, those changes are carried along by chance.

We should understand that evolution is a combination of Darwinian natural selection and neutral drift, both rates limited by the amount of genetic variation in a population, which itself is limited by factors such as mutation rates, and, for a given subpopulation, access to mates from other subpopulations that might contain different alleles and genotypes.

We understood then, and now, that mutations are not restricted to nucleotide substitutions, and that large, deleterious genomic differences can have large impacts on the relative survival and reproduction of individuals, and that many traits observable in a population are impacted by the effects of the environment on specific methylation patterns in parents’ (mostly mothers’) chromosomes, and that changes that occur during gametogenesis both of the nucleotide, genomic and epigenetic levels can be found in offspring.  Most of the important changes in phenotypes over time likely involve traits that are related to differential survival and reproduction, both of which can be measured objectively. In other words, what is important in terms of providing an evolutionary explanation can be consider both in terms of counting shifts in gene frequencies, and in their impact on survival and reproduction.

When I began studying genomic and genetic changes related to disease, I performed most of my studies in the service of others.  I worked hard to try to insure that the data analysis techniques and models we employed were at least empirically reproducible, if not founded upon a solid theoretical basis. When technologies brought the ability to assay entire genomes, transcriptomes, and proteomes, I worked overtime, often deep into the early morning hours, comparing alternative methods for data representation, normalization, finding differences, and interpreting in search of the most empirically justified frameworks to tell, from a single data set, which gene, proteins, or methylation patterns were likely to be truly important to a particular disease. I started in cancer (nearly all types), and from there moved into nearly every other domain in medicine, including immunology, diabetes, pulmonology, neurology, and so on.  In any given week I’d be involved in 4-5 different studies, and when finally tallied, during my 16 years working exclusively on these problems, I contributed results to over 100 studies. Many of the studies were, appropriately, at the pilot level.

I had on several occasions had the opportunity to work with experts in immunology, working on cancer. There was a good reason for that. Part of my attraction to come work at the University of Pittsburgh Cancer Institute was Dr. Ronald Herberman, who had assembled a cracker jack team of immunologists focused on various aspects of cancer. While working as a post-doc under Dr. Masatoshi Nei, I became immersed in his excellent studies on the evolution of the very complex MHC loci, and the amazing adaptive immune system, which uses combinatoric guessing at matching epitopes found in nature.  While at Penn State and at UPCI, it took a while, but over time I became intimately familiar with the roles of the various types of cells, tissues, and signals. It was an amazing time, and I had never been happier in my position.  From breast cancer to melanoma, pancreatic cancer and lung cancer, I had a chance to see some of the world’s foremost researchers working to understand both the causes of and processes of cancer, driven by mutations, and the optimal routes to treatment. Biomarkers were a huge part of the experience, as well as a search for their biological significance (function).

My interests in autoimmune disorders sank in while writing three books: Ebola: An Evolving Story; Cures vs. Profits:Successes in Translational Research, and The Environmental and Genetic Causes of Autism.  The experience of writing those three books allowed me to go into deep study of the primary literature on disease causality specifically on factors that impact our immune systems.  Factors that most profoundly influenced my understanding that leads to this Evolutionary Theory of Autoimmunity of course were threefold:

(1) intensive study on the role of cytokine storms in the pathogenesis caused by Ebola infection, specifically the devastating positive feedback loop caused by our immune systems’ responses to the effects of Ebola on our tissues, with releases of cytokines that activate escalating responses to cellular damage

(2) the theoretical and empirical basis for artificial immunization, and its attendant consequences (most often attempted using vaccines), and

(3) being inundated with information on the fact that dozens and dozens of conditions known as autoimmune disorders defy explanation.

Readers of “Causes” will come to understand that autism can often involve a form of ‘innate’ autoimmunity, in which specialized cells in the brain that play the role of scavenger of cellular debris and killers of intruders, like white blood cells, can become chronically activated in the presence of the persistent activating signal of the excitotoxic amino acid glutamate.  Ironically, I cannot consume monosodium glutamate, because it brings an onset of migraine headaches. This same amino acid, in some kids’ brains, stays at high levels and rather than ceasing their destruction, say, of unhealthy brain tissue, they go on the attack and destroy both dendrites and neural precursor cells, which release cytokines signalling cellular damage, injury, and death, causing sustained microglial activation. The original cause of the high glutamate levels in the brain of autistics may vary from case to case; it may involve a mutation in a glutamate receptor found on astrocytes, or it could be environmental damage to astrocytes via metals, which preferentially bind to astrocytes, and which have been shown to localize both to the nuclear pore and the cell membrane  The literature on traumatic brain injury and stroke is now rapidly filling with how helpful it is to keep microglial cells quiet before they set off a positive feedback of cellular destruction that keeps them chronically activated.

They will also come to understand that many of the adverse events seen in vaccines, and autoimmune disorders, which in most doctor’s minds have root causes that defy explanation, are in fact induced by the presentation of foreign antigens into the human in the presence of an adjuvant. Dr. Yehuda Schoenfeld presented this idea in 2010:

Shoenfeld Y, Agmon-Levin N. 2010. ‘ASIA’ – autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011 Feb;36(1):4-8. doi: 10.1016/j.jaut.2010.07.003.

Other studies by Schoenfeld and colleagues have found that ASIA has been reported from nearly every vaccine on the market, and that we may be able to predict who is at highest risk of developing autoimmunity from after vaccines:

Soriano A, Nesher G, Shoenfeld Y. 2015. Predicting post-vaccination autoimmunity: who might be at risk? Pharmacol Res. 2015 Feb;92:18-22. doi: 10.1016/j.phrs.2014.08.002. Epub 2014 Sep 30.

I suspect that in time most autoimmune disorders, which are known to involve adaptive immune systems attacking healthy human tissue, will be seen to ultimately have an evolutionary explanation. Part of it will seen an resulting from adaptive advantage to pathogens in their ability to effect their hosts in a manner in which transmission to new hosts is made more likely. While none of which could possibly be seen as resulting from adaptive advantage to humans, we will explore that in detail later. It must also be remembered that a part of the explanation could also be come to be seen to be the result of mere chance.

MULTIPLE SCLEROSIS is a devastating progressively degenerative disease that, at its heart, involves stripping of axonal sheaths from victims, leaving their nerve cells in the brain and the spinal cord unable to transmit signal due to a lack of insulation and improper ionic balancing associated with nerve impulses. Clearly, whatever has caused demyelination, and demyelination itself, cannot be seen in Darwinian terms to be adaptive to humans. This is about as far as evolutionary thinking has applied.  The dismissal of an evolutionary explanation based on the ideas that genes that encode ‘for autoimmunity’ would be quickly removed from a population is only halfway thought through. The more rapidly evolving organism on the scene, of course, is the pathogen itself.

From a pathogen’s perspective, for example, making its host immobile, especially if that host is a member of a social species, will increase the duration and frequency of contact between the affected and the unaffected, leading to increased transmission of the pathogen. Thus, from a pathogen’s fitness perspective, injuring its host, without killing it, would be adaptive. The pathogen itself could do the damage, such as infecting specific types of brain cells and impairing movement. Or, it could have the same effect by turning the hosts’ immune system against itself. We could expect that surface epitopes seen on viral proteins would be on adaptive landscape that could lead them, as a result of chance mutation after mutation, to become increasingly similar to key host proteins. In fact, many pathogens that infect humans have been infecting other primates for millenia, and the common, successful ones causing hardly any or no symptoms at all in their native hosts. But many pathogens do cause disease in their native hosts, including paralysis and death.

Within the human population, then, we could see that whichever proteins that are attacked by the immune system as a result of the development of cross-reactive antibodies would be on an adaptive landscape upon which there would be advantage to moving, random mutation by random mutation, further away from the offending pathogen’s epitope sequence.

We can make predictions on the basis of this theory: genes that encode spefic surface epitopes on pathogens that cause autoimmune disorders should show high rates of non-synonymous substitutions that cause increased conformational similarity to that of their hosts’ matching protein sequence, and hosts should be observed to show high rates of non-synonymous substitutions, as the run away from the offending pathogens’ epitope sequence and structure. A third prediction would be that the hosts’ proteins are much more constrained than the pathogens; they are, after all, already serving an essential function in the host, whereas the surface antigens on a pathogen may be more evolutionarily labile, freer to explore a wider area on its evolutionary adaptive landscape. (For more ideas on the importance of individual mutations vs. rates, see this article).

Adaptive Landscape 1 tif to jog

The first step toward testing this evolutionary arms’ race theory of autoimmunity is to determine which pathogens hold the best-matching epitopes.  The second step is to confirm that cross-reactive antibodies exist in autoimmune patients to specific epitopes of interest. This step also happens to be potentially very useful to patients both in terms of helping their doctors understand their disease, and could lead to individualized treatment via immunomodulation therapies. The third step is to measure, whenever possible, the rates of synonymous and non-synonymous substitutions over long enough periods of time to catch the pathogens’ protein racing toward the human sequence, and the matching human protein racing away from the pathogen sequence.

There are attendant logical predictions about variation in the rates of specific autoimmune disorders attributable to specific pathogens across human populations if genetic variation exists within the self-targeted proteins involved in autoimmune disorders.

We have begun these steps, pathogen by pathogen, autoimmune disease by autoimmune disease, at the Institute for Pure and Applied Knowledge, importantly beginning with the proteins that are already known to be targeted by our immune system during autoimmune disease.  Our findings thus far are quite promising, and may lead truly useful information, such as the knowledge of which pathogen’s epitopes should excluded from vaccine, for fear of inducing autoimmunity in a preventable manner.

One realization that we have had is that it is possible that the mechanism of pathogenesis, that is, the ways in which communicable pathogens cause disease in humans (and animals), may be precisely they same way they cause autoimmune disease. From the mildest sniffle, or the most raging fever, it seems likely that pathogen/host protein similarities, driven mostly by adaptive evolution in the pathogen, may explain most – if not all – of the symptoms by which we diagnose communicable diseases.  That would be very good to know.

My next stop in this journey will be the literature – the massive scientific literature on host/pathogen interactions – to see what is already known on this fascinating topic.  You can support our efforts at ipaknowledge.org.

-James Lyons-Weiler, PhD

October 31, 2016

I thank Celeste McGovern at Greenmedinfo for her well-written and informative post,

Attacking Ourselves: Top Doctors Reveal Vaccines Turn Our Immune System Against Us 

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