Study Shows Massive IQ Decrease in Males with Fluoride: JAMA Pediatrics Journal Editors Stunned

In reference to a study, entitled “Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offsprings in Canada”[1], published in JAMA Pediatrics, the journal editors were stunned by a finding that fluoridated water exposure in mothers during pregnancy reduces the IQ of their sons.

The study found that in boys, a 1 mg/L increase in the maternal urine fluoride concentration led to a 5-point decrease in boys’ IQs.

Dimitri Christakis and Frederick Rivara of JAMA Pediatrics, in a podcast, compare the findings as overturning decades-old presumptions of safety of fluoridated water.

Christakis: “Before they were anti vaxxers, there were sort of anti fluoriders. Right. And like the traditional teaching, when I was going through residency and early in my early professional career was that there was fluoride is completely safe. All these people that are trying to take it out of the water are nuts. It’s the best thing that’s ever happened for children’s dental health. And we just need to push back and get it into every water system.”

Christakis: “In fact, before there were anti-vaxxers, there were, sort-of, anti-fluoriders, and the traditional teaching when I was going through residency was that fluoride was completely safe, all these people that are trying to take it out of the water are nuts, it’s the best thing that ever happened…”

Christakis: “So when I first saw this title, my initial reaction was ‘What the hell?'”

Rivara had referenced the title of the study as “shocking” and later said

When discussing biological plausibility, citing animal models,

Christakis: “Even in the animal models, weirdly enough… the effect is seen in male than female rats, I don’t know to think about that… There have been other observational studies that have shown this, and there have been animal models as well, showed that fluoride was a neurotoxin, which, again, was totally news to me, I thought it was ‘junk science’…

Rivara: “That’d be like antivaxxers saying ‘Fluoride is bad for your brains, so let’s not do it.’ You know, that same kind of thing.”

The editors discussed how surprised they were to learn that only 3% of cities in Europe fluoridate their water.

The philosopher Karl Popper called this shock-reaction “Surprise”, and held that the more unlikely a robust result from a critical test appears to be, the higher the degree of corroboration that should be afforded the unlikely.

The comparison in this discussion to anti-vaxxers is ironic, given that fluoride and aluminum have known synergistic neurotoxicity[2], just like mercury and aluminum have known synergistic neurotoxicity[3].

The obvious question is: when will a major pediatrics journal have this level of healthy cognitive disequilibrium about vaccines and neurodevelopmental disorders, and vaccines and autoimmunity?

These editors’ reactions to this news about fluoride was the precise reaction I had upon reading all of the studies for my book on autism – the studies I had no idea about, the ones that were “totally news to me”.  The animal model studies showing plausbility of vaccination and autism (e.g., chronic microglial activation), the observational studies that DID find association (e.g., Gallagher and Goodman), and, of course the studies I could not read because they were never conducted, diswarranting the generalization that “Vaccines Do Not Cause Autism”.  I agree 100% with Christakis when he said that “Science is an iterative process”.

It is very good to see an opening of the eyes and minds explicitly represented by this podcast.  It is also good to see that that “those crazy Xr’s” model of science is dying. Christakis is going to recommend bottled or filtered water.  His colleague correctly points out that bottled water is not affordable for all families.

Perhaps we really should rethink the wisdom of fluoridation given the apparent effects on autism rates [4] and lifelong effects on dementia as well[5].  Science is, after all, for asking questions.

Here’s the podcast file:

JAMA Editors Shocked.mp3

I thank Bruce Lanphear for sending the studies and the podcast file along.  He’s working on a new book, which I think is on the effect of low-dose toxicity and synergism among toxins that we think, or thought, were safe.

References and Full “Shocking” Pubmed Searches

[1] https://www.ncbi.nlm.nih.gov/pubmed/30788699

[2] https://www.ncbi.nlm.nih.gov/pubmed/?term=fluoride+aluminum+synergistic

[3] https://www.ncbi.nlm.nih.gov/pubmed/?term=aluminum+mercury+synergistic

[4] https://www.ncbi.nlm.nih.gov/pubmed/31527457

[5] https://www.ncbi.nlm.nih.gov/pubmed/30868981

 

 

 

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A Tale of Three Metals and The Fate of Western Civilization

A Tale of Three Metals and The Fate of Western Civilization

1200px-MadlHatterByTenniel

Biff: LET’S DIG UP TOXINS, PURIFY THEM, AND INJECT THEM INTO OURSELVES! AND BABIES! AND PREGNANT WOMEN! AND LET’S PUT THEM INTO PAINT THAT WE USE IN OUR HOMES WE LIVE IN, AND PUMP THEM INTO THE AIR WE BREATHE! AND LET’S MAKE SURE THAT THE WATER WE DRINK COMES INTO OUR HOMES IN PIPES THAT LEACH LEAD!
Buff: ARE YOU MAD?
Biff: NO, BUT WE WILL BE!

The Romans drank beverages prepared in lead vessels, and brought spring water into their homes through lead pipes. Lead poisoning undoubtedly hastened the fall of the Roman empire. So when we think about the evidence that we are harming ourselves, and our children, with lead in the water, mercury in the air, mercury in flu vaccines, and aluminum in many other vaccines, one has to wonder: what are the likely effects on society?

  1. African Americans will suffer the most. Due to Vitamin D deficiency, African Americans at northern latitudes can be expected to be most sensitive to toxins because they rely on dietary Vitamin D to drive their cellular detoxification systems. The fix? Measure blood Vitamin D levels, and absent any mutation that would preclude increased doses of Vitamin D, improve brain health via addition Vitamin D supplementation.
  2. Young adults (millenials) will have different sociality, and higher rates of early-age psychological disorders such as schizophrenia. They may also experience higher rates of early age of onset Parkison’s disease, Alzheimer’s disease, and other neurodegenerative diseases. The fix? Filter aluminum out of the water, try silica-rich mineral waters, silica drops, with a preference for sources with the more biologically available silicic acid. In short, detoxify their food, water, and everything in their environment, and more (see below).
  3. Young children with special education needs will tend to be more violent and brain studies will show increased presence of amyloid precursor protein, the kind responsible for Alzheimer’s disease.
  4. There will be a population-wide downward shift in IQ.
  5. There will be a plague of multiple chemical sensitivity.
  6. Academics will be stretched thin and the curriculum dumbed down to the point where schools will have to stop giving grades. When 20% of the class can no longer function academically to take and exam, the rest will be asked to “help” their classmates learn.
  7. Families will become increasingly stressful social units. Divorce rates will skyrocket.
  8. People will become increasingly dependent on the State (Nanny State).
  9. Those most able to withstand the toxic effects of accumulating neurotoxins will become increasingly taxed because their income and property will have to sustain an increasingly demanding medico-government empire.
  10. When they, too, begin to fall apart, the tax base will falter.
  11. Violence will become increasingly common. Those most damaged will tend to kill and injure those who are capable.
  12. America will tear itself apart from within.

This doomsday scenario is not inevitable. So what can we do to prevent this?

  1. Listen to the mothers. They have experience in what works. NIH has avoided real research on neurodevelopment disorders that address neurotoxic metal exposure since the CDC worked so hard to defraud the public on the vaccine/autism link. They gambled, lost, and we now pay the cost.
  2. These solutions must be tested in combinations in clinical studies to insure safety, and also to validate them (if they do help). They must be studied NOW, before it’s too late.

Option 1. Environmental Detoxification. Remove all neotoxins from your home. Use reverse osmosis water filters, and use filtered water for everything – even cooking – because aluminum is used to condition the water coming from the tap. Fluoride is another issue, and your filtration should also remove fluoride. Eat organic foods and nothing out of aluminum containers. Certainly never cook in aluminum pots.

Option 2. Get the Aluminum Out. Consider using high silicic acid mineral water, or adding silicic acid drops to your filtered water to bind any aluminum from food. Other possibilities include malic acid, magnesium, and acetoacetic acid:

Principles of Orthomolecularism. R.A.S. Hemat: “Aluminum can be effectively complexed and excreted with silicon, a complex of malic acid and mg, and acetoacetic acid.”

Precise combinations that work best and are safe are not yet determined. That’s why we need studies.

Doctor Toni Bark, MD informs me that ketogenic diet can also help reduce brain inflammation and reduce the effects of toxic metals from the body and the brain – including the reduction of brain amyloid. And Dr. Richard Frey’s research on intranasal insulin and intranasal deferoxamine seems very promising for the actual removal of iron and aluminum from the brain. Care should be taken to conduct any such research under the direct care of a physician.

Option 3. Up the Vitamin D3, watch the A, Avoid Folic Acid. Dr. Keith Baggerly, MD, has determined that the FDA flubbed in it recommended daily Vit D intake. As a result, most Americans are Vit D deficient. Increased Vitamin D3 can be expected to improve many aspects of health by helping our cells properly fold proteins. Vits A and D are antagonistic, and so watch all sources of Vit A and make sure you and your child are not taking in too much Vitamin A. Read The Big Vitamin D Mistake. and Grant Genereux’s resources on Vit A toxicity [1] [2].

Much of our population has MTHFR mutations that cause problems with Folic Acid. Moms taking prenatal vitamins should seek methyl folate or folinic acid instead of folic acid. Children’s vitamins with methyl folate are also available.

Option 5. Reduce Brain Inflammation. Chronic low-grade inflammation is a hallmark of autism. Powerful brain antioxidants include N-acetylcysteine and glutathione. It seems likely that everyone with a brain could benefit from less brain inflammation.

Option 6. Improve the Gut. The commensal (helpful) bacteria in the large intestine can become significantly altered after antibiotic use to treat ear infections, most likely caused by harm from to the immune system from thimerosal. Pro-biotics may help, as will eating organic.

Option 7. Keep This Handy for Bad Head Days. Brain dysfunction from metal-induce excitotoxicity involves high glutmate levels in the brain. Oxaloacetate can reduce blood glutamate levels, allowing the excess glutamate in the brain to spill into the blood. Oxaloacetate is used after stroke to reduce the exitotoxic brain injury. Research is needed to determine if it should be used after vaccination to reduce the incidence of vaccine-induced excitotoxicity. And aluminum should be removed from vaccines because the schedule results in toxic doses in infants.

Option 8. HBOT is HOT. Consider Hyperbaric Oxygen Therapy (HBOT). HBOT can increase de novo neurogenesis. If the brain has suffered a loss of neurons due to toxic exposure, increased neurogenesis – at the right time in development – could ultimately be shown to increase IQ.

Option 9. Avoid Thimerosal. If you choose to use a flu vaccination, ask the doctor for the type of flu shot that does not contain thimerosal.

Option 10. Tell Congress You Want Research Reform.

No studies of the synergistic toxicity of aluminum, lead and mercury have been conducted at doses reflecting the vaccine schedule and daily exposure due to leaching of lead from pipes into homes.

We know which homes have lead pipes. Departments of Health should consider telling parents of children in those homes to avoid exposures to mercury and to aluminum – in other words, to skip vaccines that contain these neurotoxic metals. The children will become more educated, better behaved, make better decisions, commit fewer crimes, and overall have better lives. Toxicity of lead, aluminum and mercury is synergistic.

No studies of the options and combinations of options listed above have been conducted to determine if we could improve overall brain health in children and adults. This research is badly needed. YOU can make it happen.

Make an appointment with your Congressional Representative and ask them to create the Brain Health 2030 initiative designed to reverse the ill effects of the past 30 years of industry and medicine on brains, and on our childrens’ brains. These interventions are not intrusive. Studies could be done also with the Department of Education to determine whether reports of violence decrease, grades increase, drop-out rates decrease if entire SCHOOLS – including administrators – are enrolled in Healthy Brain programs, which could incorporate aspects of mindfulness.

You can join the Neurodevelopment Research Reform group on Facebook where ideas on the Brain Health 2030 initiative are shared. And you can support our efforts to compile the most promising evidence-based approaches to improving brain health by supporting IPAK’s Neurodevelopment Research Reform Initiative.

This article is a call for research reform. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Check with your physician before changing any mode of medical treatment for your child, or yourself.

Further Reading:

Lyons-Weiler, J and R. Ricketson. 2018. Reconsideration of the Immunotherapeutic Pediatric Safe Dose Levels of Aluminum. Journal and Trace Elements in Medicine and Biology 48:67 73.

https://www.sciencedirect.com/science/article/pii/S0946672X17300950

Thanks to Tim Lundeen for the Vit A information and of course to the outstanding medical doctor, Dr. Toni Bark, MD for permission to cite her expertise.

Neuroimmune Toxicity of Aluminum Adjuvants 1: Safety studies of aluminum in vaccines lack immunotoxicity analysis of this immunological adjuvant: Ignorance or deception? -Vinu Arumugham

This article is part of a series of guest articles to jameslyonsweiler.com on the neurological and immunological toxicity of aluminum-containing adjuvants in vaccines.  These articles appear by invitation to the authors.  -JLW

The safety studies most often referred by vaccine regulators when making claims about the safety of aluminum in vaccines, have ignored the immunotoxicity of aluminum.

Vaccinologists admit that they neither understand the general immunological mechanisms involved in vaccination nor do they understand the mechanisms involved in aluminum adjuvant action.

Thus vaccine regulators have no scientific basis to make vaccine safety claims. Given this situation one would expect that vaccine regulators would be very cautious about making vaccine safety claims. Instead, they collude with vaccine makers to actively hide vaccine safety problems and mislead the public.

The dual role of immunotoxicity and neurotoxicity of aluminum in autism is also covered. Cow’s milk contaminated aluminum adjuvanted vaccines cause the synthesis of folate receptor antibodies. These antibodies block folate uptake causing cerebral folate deficiency and autism. The folate deficiency in turn, causes aluminum accumulation in the brain, resulting in neurotoxicity and exacerbation of autism.

Background

Vaccine safety authorities such as the US Food and Drug Administration (FDA) and the Australian National Centre for Immunisation Research & Surveillance (NCIRS) use studies such as Mitkus et al. 1 and Jefferson et al.2 to claim that aluminum adjuvants in vaccines are safe.

Discussion

Mitkus et al.1 provide the following description of the effect of aluminum adjuvants on the immune system:

“Aluminum adjuvant are important components of vaccines, since they stimulate the immune system to respond more effectively to protein or polysaccharide antigens that have been adsorbed to the surface of insoluble aluminum particles. Specifically, these coated particles are phagocytized by cells of the innate immune system (e.g., macrophages) and activate intracytoplasmic sensors of pathogen-associated molecular patterns located within the cells, such as the nucleotide-binding domain leucine-rich repeat-containing family of sensors ([6]; Schroder and Tschopp [30]). The functional consequence of activation of this intracellular system is the activation of certain enzymatic caspases that cleave pro-interleukin (IL)-1β to interleukin (IL)-1β. The secretion of the mature cytokine, IL-1β, leads to an inflammatory reaction and a downstream Th2-dependent antibody response [7], which amplify the immune response to the antigen. Adjuvanted aluminum, therefore, plays a vital role in facilitating the response that underlies the immunoprotection afforded by vaccines.”

 

The rest of the Mitkus et al. review focuses on body burden of aluminum after it is absorbed from the muscle into the blood. They completely ignored any negative immunological effects that aluminum can have while it is still in the muscle (following intramuscular vaccine administration).

The quoted paragraph above assumes that the only proteins in the vaccine are viral/bacterial target proteins required for immunoprotection. In that case, as they state, the stimulation by aluminum plays a vital role in generating immunoprotection.

But obviously, vaccines contain numerous other proteins including food proteins (ovalbumin, milk, soy, yeast, oils from sesame, peanut, fish etc.)3,4, culture medium cell proteins (Vero monkey kidney cell proteins, calf serum proteins, WI38/MRC5 fibroblast cell proteins, chick embryo cell culture proteins etc.)3, non-target viral/bacterial proteins5, that are also adsorbed on to the surface of insoluble aluminum particles. As they state then, aluminum adjuvants stimulate the immune system to respond more effectively to ALL these proteins as well. The result is off-target immune responses that includes synthesis of antibodies against any and all of these proteins as well as cell-mediated immune responses.

The result of such a response of course includes food allergy6-9, asthma10, autism11,12 and autoimmune diseases13,14.

How can they perform a safety assessment of aluminum in vaccines while completely ignoring this immunological effect?

Jefferson et al.2 reviewed eight studies (listed in Table 2 of Jefferson et al.) on the effect of aluminum adjuvants. Any vaccine will need about 3-4 weeks to take effect. That’s how long it takes for the immune system to develop the appropriate immune response and antibodies. For this reason, vaccine effectiveness investigators wait at least one month post vaccination to assess effectiveness.15

Aluminum compounds are of course an immunological adjuvant in vaccines.16. So their immunological effect (positive or negative) can only be assessed if the follow-up period is greater than 4 weeks. However, only two out of eight studies in Jefferson et al. had a follow up period of >4 weeks. So rest of the studies they included were useless to assess immunological safety of aluminum adjuvants. Even those two studies ignored immune disorders such as allergies, asthma, autism or autoimmunity. As previously described, each of these immune disorders can be initiated by IgE mediated allergy11 or the Th2 response, which aluminum adjuvants are known to produce.1,17

So not only were the original studies flawed, Jefferson et al. made the mistake of including these flawed studies in their analysis. To really evaluate the safety of aluminum salts in vaccines, one would have to account for all known/potential immunological mechanisms involved with aluminum adjuvants. What are the potential negative outcomes due to that mechanism? What tests are needed to check for those outcomes? Would the outcomes be overt disease or will they be sub-clinical effects for years? This would determine follow-up times and decision on serological examination. For example: to assess if aluminum may be increasing the risk of sensitization to cow’s milk proteins contaminating the vaccine, one would not only have to wait for 4 weeks after vaccination, but also challenge the patient with cow’s milk, pre- and post- vaccination, to assess the impact. Similarly, to check if aluminum induced an autoimmune disease that may only show up years later, one would have to perform autoimmune serology pre- and post-vaccination checking for changes in autoantibody levels, as suggested by Wraith et al.18

These studies have never been performed. Why?  In fact, vaccine makers seem to go out of the way to obscure the adverse effects of aluminum adjuvants by injecting aluminum adjuvant into control subjects during vaccine clinical safety trials.15

Given this situation, the Jefferson et al. conclusion: “Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken.” is inexplicable, and raises serious questions about the manner in which vaccine safety investigations are conducted.

Evidence of aluminum adjuvant dangers

Morris et al.19 have called for the elimination of aluminum adjuvant in vaccines. Prof. Franco Celada, Dept. of Pathology, NYU School of Medicine, called for safety studies of aluminum adjuvant induced innate immune system activation (personal email communication, Oct 2017) in the context of low affinity self reactive (LASR) T cell mediated autoimmune diseases13,14 caused by animal protein contaminated vaccines.

Anders et al.20 have called for the re-evaluation of aluminum adjuvants in vaccines due to its role in boosting IgE mediated responses. In other words, a Th2-dependent antibody response as described by Mitkus et al.1 and Terhune et al.21 Terhune et al.22 further link Treg dysregulation in atopic disease to aluminum adjuvants.  Shoenfeld et al.23 describe aluminum adjuvant-induced autoimmunity.

Aluminum immunotoxicity followed by neurotoxicity in autism

Many vaccines contain casein or casamino acids of bovine milk origin and are thus contaminated with all bovine milk proteins.3,24 One such protein is the bovine folate receptor (FR) protein25. Such aluminum-adjuvanted, bovine FR protein contaminated vaccines can cause IgE mediated sensitization to the FR protein (aluminum adjuvant induced Th2 response1).4,6,10

Since FR concentration in bovine milk is low, the patient can still consume bovine milk without developing an allergic reaction.25,26 It has been shown that consuming milk when sensitized (via an oral immunotherapy protocol, for example) will result in the synthesis of IgG4 antibodies specific to milk proteins.8

In this case, bovine milk consumption causes FR specific IgG4 synthesis. These IgG4 antibodies cross-react with human folate receptors. Human and bovine FR proteins have 90% amino acid sequence homology.27  IgG4 specific to FR is the main antibody involved in binding/blocking folate receptors in the choroid plexus, blocking folate uptake to the brain.27

This results in cerebral folate deficiency and autism.28 Folate deficiency in turn, results in aluminum accumulation in the brain and aluminum-induced neurotoxicity.29-31

The source of the aluminum could of course be the diet, pollutant inhalation and aluminum-adjuvanted vaccines. Mold et al.32 have demonstrated such aluminum accumulation in human autistic brain tissue.

Conclusion

The FDA makes a mockery of science by comparing aluminum in vaccines to dietary aluminum.33 In that case, we should be drinking our aluminum adjuvanted vaccines, instead of intramuscular injection. The FDA’s Mitkus et al. study1 is entitled “Updated aluminum pharmacokinetics following infant exposures through diet and vaccination.”. They studied pharmacokinetics – how aluminum moves through the body. While aluminum pharmacokinetics related safety needs to be understood, they cannot ignore aluminum adjuvant immunotoxicity, if they were really interested in vaccine aluminum adjuvant safety. If the FDA is incapable of even determining the appropriate lines of safety investigations required, how can they be in charge of vaccine safety? How can we expect vaccines approved by the FDA to be safe?

Safety needs engineering not tinkering

For decades, vaccinologists have been reluctant to understand the immunological mechanism of how vaccines work, fail or hurt the body.

Pulendran et al.37 wrote:

“Despite their success, one of the great ironies of vaccinology is that the vast majority of vaccines have been developed empirically, with little or no understanding of the immunological mechanisms by which they induce protective immunity. However, the failure to develop vaccines against global pandemics such as infection with human immunodeficiency virus (HIV) despite decades of effort has underscored the need to understand the immunological mechanisms by which vaccines confer protective immunity.”

Mojsilovic16: “Some of the first adjuvants discovered back then, on empirical basis of trial and error, are still in widespread use today, but only recently some light on the molecular mechanisms of their action has been shed.”

There seems to be little interest among vaccine developers and regulators in understanding the mechanisms of immunoprotection or immunotoxicity of vaccines and adjuvants. This is no way to build a safety critical product, centuries after its invention.

Since the immunological mechanisms of vaccines are not understood, one would expect that vaccine makers and regulators will be extremely cautious about making vaccine safety claims. One would expect that they will thoroughly investigate even the slightest indication of vaccine-induced adverse events.

Instead, we find vaccine makers and regulators collude to hide vaccine safety problems. The ShingrixTM vaccine was recently approved after an inadequate safety evaluation.35 The FDA briefing document (Sep 2017) describes serious adverse events (SAEs) including supraventricular tachycardia following Shingrix vaccination in clinical studies. The Shingrix vaccine package insert (revised 10/2017)36 has no reference to supraventricular tachycardia at all.

Acknowledgment

Elizabeth Hart, Adelaide, South Australia, suggested this review and provided background material.

References

1. Mitkus RJ, King DB, Hess MA, Forshee RA, Walderhaug MO. Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. Vaccine. 2011 Nov 28;29(51):9538–43.

2. Jefferson T, Rudin M, Di Pietrantonj C. Adverse events after immunisation with aluminium-containing DTP vaccines: systematic review of the evidence. Lancet Infect Dis. United States; 2004 Feb;4(2):84–90.

3. Vaccine Excipient & Media Summary [Internet]. 2015 [cited 2016 Jan 16]. Available from: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf

4. Arumugham V. Professional Misconduct by NAM Committee on Food Allergy [Internet]. 2016. Available from: https://www.zenodo.org/record/1034559

5. Ahmed SS, Volkmuth W, Duca J, Corti L, Pallaoro M, Pezzicoli A, et al. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 (ABSTRACT ONLY). Sci Transl Med. 2015;7(294):294ra105–294ra105.

6. Arumugham V. Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy. J Dev Drugs. 2015;4(137):2.

7. Platts-Mills TAE. The allergy epidemics: 1870-2010. Journal of Allergy and Clinical Immunology. 2015. p. 3–13.

8. Hoyt AEW, Schuyler AJ, Heymann PW, Platts-Mills TAE, Commins SP. Alum-Containing Vaccines Increase Total and Food Allergen-Specific IgE, and Cow’s Milk Oral Desensitization Increases Bosd4 IgG4 While Peanut Avoidance Increases Arah2 IgE: The Complexity of Today’s Child with Food Allergy. J Allergy Clin Immunol. Elsevier; 2017 Jul 7;137(2):AB151.

 9. Alice Hoyt, Peter Heymann, Alexander Schuyler, Scott Commins TAEP-M. Changes in IgE Levels Following One-Year Immunizations in Two Children with Food Allergy [Internet]. 2015. Available from: https://wao.confex.com/wao/2015symp/webprogram/Paper9336.html

10. Arumugham V. Medical muddles that maim our children with allergies, asthma and autism [Internet]. Unpublished; 2017. Available from: https://www.zenodo.org/record/1034595

11. Arumugham V. Autism Spectrum Disorders: A special case of vaccine-induced cow’s milk allergy? [Internet]. 2017. Available from: https://www.zenodo.org/record/1034557

12. Arumugham V. Strong protein sequence alignment between autoantigens involved in maternal autoantibody related autism and vaccine antigens [Internet]. 2017. Available from: https://www.zenodo.org/record/1034571

13. Arumugham V. Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: a detailed look at Crohn’s disease and Vitiligo [Internet]. 2017. Available from: https://www.zenodo.org/record/1034777

14. Arumugham V. Bioinformatics analysis links type 1 diabetes to vaccines contaminated with animal proteins and autoreactive T cells express skin homing receptors consistent with injected vaccines as causal agent [Internet]. 2017. Available from: https://www.zenodo.org/record/1034775

15. Gardasil Package Insert [Internet]. Available from:

http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf

16. Mojsilovic SB. Immunological effects of adjuvants, their mechanisms, and relevance to vaccine safety. Cent Eur J Paediatr Vol 13, No 1 Cent Eur J Paediatr. 2017;

17. Lindblad EB. Aluminium compounds for use in vaccines. Immunology and Cell Biology. 2004. p. 497–505.

18. Wraith DC, Goldman M, Lambert P-H. Vaccination and autoimmune disease: what is the evidence? Lancet (London, England). England; 2003 Nov;362(9396):1659–66.

19. Morris G, Puri BK, Frye RE. The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved? Metab Brain Dis. United States; 2017 Oct;32(5):1335–55.

20. Markt A, Björkstén B, Granström M. Immunoglobulin E responses to diphtheria and tetanus toxoids after booster with aluminium-adsorbed and fluid DT-vaccines. Vaccine. 1995;13(7):669–73.

21. Terhune TD, Deth RC. How aluminum adjuvants could promote and enhance non-target IgE synthesis in a genetically-vulnerable sub-population. J Immunotoxicol. England; 2013;10(2):210–22.

22. Terhune TD, Deth RC. A role for impaired regulatory T cell function in adverse responses to aluminum adjuvant-containing vaccines in genetically susceptible individuals. Vaccine. Netherlands; 2014 Sep;32(40):5149–55.

23. Shoenfeld Y, Agmon-Levin N. “ASIA” – autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. England; 2011 Feb;36(1):4–8.

 24. Kattan JD, Cox AL, Nowak-Wegrzyn A, Gimenez G, Bardina L, Sampson HA, et al. Allergic reactions to diphtheria, tetanus, and acellular pertussis vaccines among children with milk allergy. J Allergy Clin Immunol. 2011;Conference(var.pagings):AB238.

25. Nygren-Babol L, Sternesjö , Björck L. Factors influencing levels of folate-binding protein in bovine Å milk. Int Dairy J. 2004;14(9):761–5.

26. USDA Food Composition Databases [Internet]. Available from: https://ndb.nal.usda.gov/ndb/

27. Ramaekers VT, Sequeira JM, Blau N, Quadros E V. A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome. Dev Med Child Neurol. 2008;50(5):346–52.

28. Arumugham V. Epidemiological studies that ignore mechanism of disease causation are flawed and mechanistic evidence demonstrates that vaccines cause autism [Internet]. 2017. Available from: https://doi.org/10.5281/zenodo.1041905

29. Baydar T, Nagymajtenyi L, Isimer A, Sahin G. Effect of folic acid supplementation on aluminum accumulation in rats. Nutrition. United States; 2005 Mar;21(3):406–10.

30. Yassa HA, George SM, Mohamed HK. Folic acid improve developmental toxicity induced by aluminum sulphates. Environ Toxicol Pharmacol. 2017;50(Supplement C):32–6.

31. Zhu M, Li B, Ma X, Huang C, Wu R, Zhu W, et al. Folic Acid Protected Neural Cells Against Aluminum- Maltolate-Induced Apoptosis by Preventing miR-19 Downregulation. Neurochem Res. 2016;41(8):2110–8.

32. Mold M, Umar D, King A, Exley C. Aluminium in brain tissue in autism. J Trace Elem Med Biol. 2018 Mar;46:76–82.

33. FDA. Study Reports Aluminum in Vaccines Poses Extremely Low Risk to Infants [Internet]. Available from: https://www.fda.gov/biologicsbloodvaccines/scienceresearch/ucm284520.htm

34. Pulendran B, Ahmed R. Immunological mechanisms of vaccination. Nat Immunol. United States; 2011 Jun;12(6):509–17.

35. Arumugham V. SHINGRIX vaccine is unsafe and its approval must be revoked [Internet]. 2017. Available from: https://www.zenodo.org/record/1038302

36. FDA. SHINGRIX vaccine package insert [Internet]. 2017. Available from:

https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM581605.

 

Protect Baby’s Brain from Aluminum Neurotoxicity – It’s Not Just the Vaccines

Anyone who reads my writings will know that I tend to not hold back in the “should” department – because ethics and morals in society depends not only in the proper conduct of science, but also in the proper translation into general knowledge and public health policy.  Those with their hands on the reins of public health policy appear to be more interested in defending flawed policies, and those of us who have come to learn of flaws in the science used to bolster those policies are bound by moral contract with a duty to warn our fellow human beings.

Well, at least some of feel that way.

I would be worthy of being labeled hypocritical, therefore, if I did not shout from my blog the news that there are other sources of aluminum that pregnant and nursing moms may well expose their developing babies to – one that is so commonly available, and the dose of aluminum so high that I shudder to think of any pregnant woman or nursing mom (or individual who likes their brain) taking a single dose.

That product is antacids.

In a chapter reviewing aluminum neurotoxicity (yes, Dr. Offit, aluminum is a long-known neurotoxin), Dr. Robert Yokel in 2012 reviewed estimates of the amount of aluminum absorbed from exposure from various sources, and the results certainly do not bode well for vaccines.  Here is a screen shot of the chapter:

Yokel1

And here is a screenshot of his Table 1, with aluminum from vaccines at 0.07ug daily exposure and aluminum from antacids at 80ug per day:

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The low amount calculated “per day”from vaccines, however, is misleading: the dose from a vaccine is given in a single day – and the body has to deal with 100% absorption in real time.  So the numbers to compare are 12-300µg/dose in a day to 80µg/day.  Se the “up to 5,000,000 µg” ingested?  The fact that only 80µg are absorbed per day shows you how little aluminum a normal-functioning GI tract actually absorbs. But that’s a lot for a mom to have in her body while she’s pregnant.  So much for the dismissive position that babies get more aluminum from baby formula. Mothers should breastfeed anyway – unbelievable, CDC recently said moms should not breastfeed to give the vaccines a chance to be more effective.

Add to the 80 from antacids and aluminum in the vaccines offered during pregnancy (bad idea in the first place), and add later aluminum to the baby after via vaccines after birth, you can see we may successively and repeatedly dose our youngest with a neurotoxicant. Aluminum (in a wide variety of forms) causes chronic microglial activation, which occurs when certain cells (microglia) in our brains get stuck in the “destroy” mode and take out dendrites trying to make connections and baby nerve cells (neural precursor cells).

Expectant moms, lactacting moms, throw your antacids away and look at your aluminum intake.  Other foods potentially high in aluminum include pre-prepared pancake mixes and other foods that are kept powdery and dry.  Look at the ingredients and save your baby’s brain from chronic and prolonged exposure.   Get an air filter and filter out the dust that can introduce aluminum into your baby’s body via the lungs or GI tract.

Aluminum is certainly not the only toxin that can induce microglial activation. But 10% of the aluminum absorbed stays in the brain for decades.  Moms and dads, look at the table an find ways to reduce aluminum exposure, and we might just be able to reduce the rates of autism/ASD worldwide.

The full chapter is available from the University of Kentucky website.

http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1030&context=ps_facpub

baby brain

 

Dr. Lyons-Weiler is the author of three book, the latest of which is “Environmental and Genetic Causes of Autism”, which can be ordered online or from your local independent bookseller. A companion website to the book includes over 1,000 references to studies on autism.

causes

My Journey from Ignorance

WHILE RETURNING from the United Nations building where I heard NYU Professor Mary Holland (School of Law) nail the issues of constitutional and international law on the right to informed consent to the floor, to a standing ovation, I received an email from Mary ( To my delight). I read, in part:

“I  started reading your Ebola book last night.  Wow, you have evolved a lot in your thinking on vaccines in a VERY short period, based on your definition of ‘antivaxxers’ at bottom of 206, top of 207.  Have you written up how your views evolved so quickly?  It might be a helpful roadmap towards turning others around.  Was this all in connection with the autism book, or did your views changing precede that book?”

Looking at my book this morning, I turned to page 206, with trepidation, to find the younger, knowing me, trying to save the world by chiding and deriding people whom I have come to learn much more about in the past two years:

“Again and again with Ebola we see, from Guinea to the US, societies struggling with the ethical problem of the needs (and wants) of a few vs. the safety (and lives) on the many”.

Ok, that’s not too bad.  A bit uppity, but I cannot disagree. But it gets worse.

“With over 100 cases confirmed, the US is, at the time of this writing, at high risk of an epidemic of measles because the herd immunity is lacking due to a dogmatic antivaccination movement”.

I warned you.

Deplorably, I continue:

“The efficacy of the measles vaccine in protecting children against terrible diseases should be reason enough for parents to insist on vaccinating their children, but the so-called ‘anti-vaxxers’ (people who believe vaccines place their children at risk of developing autism) fail to consider the greater good: They put others at risk by not participating in national programs for the greater good.”

I really do not like my former self. Naturally, I continue, because I knew SO much before I actually looked into the studies and the data:

“This perspective is more than mere 20:20 hindsight; such occurrences of cultural and institutional amnesia are certain to recur as our society becomes more reliant and trusting in technology, and we forget to respect the awesome power of biology and Nature”.

I really don’t know this guy, I swear.

Mary Holland will certainly be remembered as one of the most staunch defenders of human rights, well, in the history of abuses in medicine. So back to Mary’s question:

“Have you written up how your views evolved so quickly?  It might be a helpful roadmap towards turning others around.  Was this all in connection with the autism book, or did your views changing precede that book?”

Here’s how and why my views have changed. First, I was really rather upset about the fact that CDC Director Thomas Freiden stated in his testimony to Congress that there were no mutations in the Ebolavirus that was driving the epidemic.  I was upset because I had the 396 mutations on my laptop at the very moment he testified to Congress.  I capture that moment in “Ebola“. My anger at the CDC increased when I attended a secret White House conference call, held by the Ebola Czar, in which I asked about the 396 mutations – whether they influenced the ability of tests to detect Ebola, or altered its virulence or transmissibility. In that call, the entire scientific community was lied to again by a CDC Scientist who claimed that the virus was “99.9999% identical to the strain from Zaire in 1995”, which was not true at all.  I capture both of those events in “Ebola”, as well as how the White House then asked the Associated Press to stop covering potential cases of Ebola in the US.  I even ask in that book whether that was “fascism”.

Fast forward a couple of months to where I had decided to write “Cures vs. Profits“. I felt that we had bungled our response to Ebola so badly that I wanted to cheer myself up and write a book on the successes in biomedical research.  Having participated in so many studies over the past two decades, I knew of many reasons that the public should continue to support biomedical research, and I was going to share all that I knew, and discover more. The first two chapters deal with “the bad stuff” – the doctors who cheat at medicare fraud, which robs other patients of needed funds for real medicine – and the biomedical researchers who cheat at their research studies.

I wrote my chapters out on grapefruit, on cancer vaccines, on prostate cancer robotic surgery, and then something happened: I wrote a chapter on ADHD overdiagnosis. I tell the story of the destruction of a promising career of Dr. Gretchen Watson.  Pharma sent a “Key Opinion Leader” to EVMS to debate her over her study, and the next day she was told her case load was canceled, that her colleagues were told that she no longer worked at EVMS, and that she was to expected to resign.  She refused, and won an appeal to HR.  But then someone floated a rumor that she manipulated her data in the 1996 study showing overdiagnosis.

The investigation revealed no flaw – well, a typo in an appendix – but the damage to her career was done. The good news is that Dr. Watson has decided to write of book of her own after reading my chapter on ADHD.  She now also serves on the Board at IPAK.

When I finished writing the rest of “Cures“, including chapters on the history of hormone receptor status in breast cancer, chemosensitivity assays, characteristics of good research scientists, and cancer vaccines, I found the book missing something.

So I decided to write a chapter on Vaccines.

I’ll let the chapter on vaccines speak for itself- it begins with tales of how wonderful vaccines are, how they save lives.  I went back to review the autism/vaccine link, fully expecting to review the Andrew Wakefield issue briefly, how his claims that MMR were linked to vaccines. I read the retracted study.

I found that Andrew Wakefield never claimed that the MMR might cause autism.  Instead, I found the study to suggest that it was a question worth looking into.

My digging around then led to my discovery of reports that someone at CDC had revealed that CDC had manipulated data on the studies designed to disprove Wakefield by omitting results with a positive association.

The more I dug into the issue, and then into the literature, the more I found the science of vaccines falling far short of the science needed to insure public health via any medical procedure given to millions. And this is where I leave the issue in “Cures“. I added an addendum that reviews four open controversies in vaccines that cause me to question whether vaccines can be called an unmitigated success in translational research.

In retrospect, I see that position as something of an understatement.

My understanding of vaccines was (obviously) limited, and I needed to grasp the risks involved. I needed resolution. So after I completed “Cures“, I began writing about what I had learned. I spoke with people with an open mind. I started to listen not only to what these evil, selfish “anti-vaxxers” had to say, I started to really think about the consequences of the additives. I began to question the over-arching claims of safety.

And via some new contacts, I made connection with Tony Lyons of Skyhorse Publishing. After a few chats, he, Louis Conte and I agreed that I should write a book on the Genetics of Autism. (I love Louis – and knowing what I know of him now, my bet is that he thought I was a good prospect – but somehow I can hear him telling Tony that Jack has ‘a way to go, but I think he’ll get there’. Thank you Louis for the confidence.

So in I dove, into 3,000 research articles on autism.  Not on vaccines – on autism.  I wanted to know if the basic science could in any way reasonably support a hypothesis that vaccines or their additives cause autism. The answer is a resounding “Yes, yes, and yes”. Other articles in this blog will give you an idea of some of the evidence that exists on the role of chronic microglial activation and autism, for example.

To the readers of “Ebola” who feel confused or hurt by my, and others’ ignorance, please remember that there is a Great Unknowing, even among professionals.  Think about it – all “Anti-vaxxers” with vaccine-injured children were once pro-vaccine. As I advised some 500 participants at the VIALs Health Summit in Atlanta, GA, do not argue with them – educate them. Your anger and frustration is warranted, but help them move from ignorance to awareness and understanding.

I took it upon myself to consider 3,000 articles on autism for “Causes” (available at Amazon.com and in your local Barnes and Noble or indie bookstore).  (I skimmed 3,000, read >2,000, and cite >1,000). Look at what knowledge can do to a scientist who themselves feel cheated and lied to, someone who entrusted the CDC to perform objective science (See “The Tyranny of Pseudoscience“):

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The author at a CDC Rally, April 22nd, 2016.

 

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Educating the public and calling for Congress to Subpoena Dr. William Thompson at the CDC on the true nature of so-called “Science” conducted at the CDC on the link between vaccines and autism.

To My Fellow Scientists and Medical Health Care Professionals

I wrote “Ebola” in good faith, assuming that the position of the CDC on vaccines was based on sound science. It was unfathomable to me that

-Upon finding positive associations, CDC would routinely over-analyze data from studies until they could make associations go away, and when they could not succeed in doing that, they would simply omit the results;

-CDC would suspend an employee who drew these practices to the attention of then CDC Director Dr. Julie Gerberding (who subsequently took a position in charge of vaccine development at Merck);

-After CDC published these studies they called for an end to research on vaccine safety with regard to potential links to autism;

-CDC would ignore nearly all of the basic science that shows mechanisms of how neurotoxins in vaccines (not just MMR) could reasonably be expected to cause autism in some people;

-CDC’s position is based on ecological association studies, not randomized prospective clinical studies with proper controls.

-Our knowledge of vaccine safety is based on post-market surveillance;

-CDC would ignore all of the post-market surveillance on vaccine safety, claiming that the passively collected data in VAERS did not provide causal evidence;

-CDC would lie repeatedly under oath to Congress about the State of Science on the link between vaccines and autism;

-No one has ever conducted a vaccinated vs. unvaccinated study for association with negative health outcomes, including autism.

-CDC would communicate to the public that “Vaccines Do Not Cause Autism” on their website knowing full well that 6/12 vaccines on the schedule before the age of 7 have 0 studies one way, or the other, on whether they indeed may (or may not) contribute to the risk of autism.

I, like the rest of the world, relied on the CDC to be a reliable source of information on vaccine safety.  Yes, I vaccinated my children. I will not allow them to get the HPV vaccine. Here is why.

To the Parents of Vaccine-Injured Children who Regressed Into Autism

Your observations are the basis of a new era in vaccine science.  All science begins with observations. Help and relief is on the way. And there is nothing that can stop it.

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Dr. Lyons-Weiler (right) meets Marcella Piper-Terry (left) at the 2016 CDC Rally.
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Fellow Vaccine Risk Aware Protestors Calling for Congress to Subpoena Dr. Thomspson
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Dr. Lyons-Weiler meets the future Director of the CDC.

After the Rally, we enjoyed a summit at Life University hosted by VIALS. Here was our audience:

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Here I presented the CDC Schedule as backed by “Magic”, because no science exists on any link between 6 vaccines and autism, whereas some vaccines do, in fact have some studies that support association:

no science 2no science

That was a good day in Atlanta, GA. Here are the slides to share with your pediatrician:

VIALs health summit slides James LyonsWeiler MAGIC

CDCSCHEDULE
“MAGIC!!!”

 

 

Next stop, the United Nations:

 

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Dr. Lyons-Weiler attends a UN Session on Toxins in Our Children, April 26th, where Dr. Thompson’s revelations were shared with the world.


 

Mary Holland standing up for your rights to refuse medical procedures as a basic human right. To watch the unprecedented UN Session on Toxic Contamination of Children (4/26/2016), follow this link.

Mary Holland’s question to me was an important one:like many, if not most other professionals, I had argued my position on the vaccine/autism question from a position of ignorance.  They simply have not done their homework, and many have bought the CDC’s lies hook, line and sinker. They count on CDC to be honest and forthright. This include the AAP, the AMA, and, very likely, your pediatrician.

Most of them probably have not read a single study. They likely have never read the following words that Dr. William Thompson said to Dr. Hooker:

Thompson: “They don’t really want people to know that this data exists.”

Thompson: “…among the blacks, the ones that were getting vaccinated earlier, were more likely to have autism.”

Thompson: “It appears in the final publication is that race in general is downplayed. Of course it is.”

Thompson: “I actually think the most interesting results are the isolated, ones that don’t have their co morbid conditions. The effect is where you would think it would happen.”

Thompson: “I was just looking at—I was like, oh my God, I cannot believe we did what we did. But we did.”

Thompson: “The higher ups wanted to do certain things and I went along with it. In terms of chain of command, I was number four out of five. “

Thompson: “…Literally, everyone else got rid of all their documents, and so the only documents that exist right now from that study are mine.”

Thompson: “There are things that I haven’t even shared with you because I can’t prove it, and that’s what I struggle with. I don’t want to share things with you that I can’t prove, that there aren’t hard records. I am worried that the other four people will collude and say no, that’s not true.”

Thompson: “That’s what I keep seeing again, and again, and again where these senior people just do completely unethical, vile things and no one holds them accountable. “

Thompson: “The reason you don’t see anything else circulating on the study, it was five of us behind closed doors for two years.”

Thompson: “It’s the lowest point in my career that I went along with that paper.”

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Dr. William W. Thompson

My book “Cures vs. Profits” tells more of the story of Dr. Thompson and Hooker. At this point, I am willing to go on the record and say that I have zero – ZERO confidence in any science coming out of the CDC Immunization Safety division. And no one else should trust their research, either.

In fact, nothing they publish can be trusted. Not merely because of what Thompson said.

I’ve read their studies.

They are atrociously unsafe ventures in data cooking, model overfit, sad excuses for “control variables”, use of multicollinear variables, the product of repeated data analysis to a desired result (no association). They are a mess.

The individual people in question include

RADM Anne Schuchat, Principal Deputy Director of CDC

Dr. Frank DeStefano, Director of the Immunization Safety Office

Dr. Coleen Boyle Director, National Center on Birth Defects and Developmental Disabilities (NCBDDD)

Dr. Poul Thorsen (co-author on suspect CDC studies, wanted by HHS for embezzling over $1Million in funds that were to be used for autism research, living openly in Denmark).

and others.

In my research, I strive to remain objective. However, since 2004, when the research fraud at the CDC occurred, there have been over 1,000,000 cases of autism that potentially could have been prevented simply by splitting up the MMR into three vaccines, spacing the vaccines out, giving non-adjuvanted vaccines with 1 adjuvanted, screening for safe epitopes, removal of mercury from all vaccines, giving medical exemptions to parents who already have one autistic child (to avoid the genetic x environment interaction), dropping HepB until adulthood… so many simple things that could have been done to reduce early exposures to toxins. Where is the science for biomarkers to indicate which children might be most at risk of ASD due to vaccines?  Not done.  CDC called for no more science.

We Want Evidence-Based Public Health Policies, not Policies Based on Subjective Belief (aka “Magic”)

Right now, the so-called “Anti-vaxxers” I so woefully admonished in “Ebola” are not all “Anti-Vaxxers”. They do consist partly of some people who believe no safe vaccine could ever exist. I respectfully remind them that until the science is done to show that non-adjuvanted vaccines without mercury, aluminum, formaldehyde, etc are tested, their knowledge claim is an untested generalization about all vaccines. Out of well-deserved distrust, they call for no more science on vaccine safety – because they know that some will be injured by that very research.

But the Vaccine Risk Aware movement also includes people who are 100% Pro-Vaccine Safety. They suspect that safe and effective antigen presentation systems can be designed, that use exposure at the skin (microdermal abrasion), with epitopes that do not induce autoimmunity. They believe that taking the toxins out will likely make vaccines safer. But they do not make such claims.  They call for more science, not less, but on newer options for inducing immunity.

To watch my presentation at the VIALS Health Summit State of Science on Vaccine Safety: Autism, in which I explain how the CDC’s claims that vaccines do not cause autism must be based on magic, follow these links: (Part 1, Part 2, Part 3).

Calls for Retraction of CDC “Studies”

Because CDC committed scientific fraud, the studies they performed should be retracted. IPAK has informed the journals of this, and we have sent them copies of “Vaccine Whistleblower, by Kevin Barry, Esq.

I urge all of my colleagues to view the movie #Vaxxed.  Call your local theater and ask them to screen the movie. If you consider yourself an objective scientist, read “Whistleblower“, and RFK jr.’s book, “Thimerosal: Let the Science Speak“.  Order “Master Manipulator” by James Grundvig, which tells the story of Poul Thorsen, a CDC collaborator wanted for absconding with autism research cash (given what CDC would have done with the money, Thorsen may be a hero, for all we know).  For a deeper timeline view on how long corporate corruption has eroded science in our most esteemed institutions like the CDC, read “Science for Sale” by David Lewis.

I ask my professional colleagues from all walks of science and medicine then to join us in our calls for retraction of the CDC’s false studies: DeStefano et al., Madsen et al., and Verstraeten et al.  I will not stop educating professionals about the fraud because we need evidence-based medicine, not medicine based on guesses, or hopes, or magic.  Babies are dying in the womb due to mercury in flu vaccine reserved for pregnant women; babies are born autistic due to immunoneuroexcitotoxicity; they are born with seizure disorders; toddlers regress into autism after learning language. And yes, it may be due to cumulative and interactive effects of toxic chemicals from agriculture, industry, our home, etc.  But we can reduce the toxins we expose our children to.  Right now, autism risk is 1 in 68, up from 1 in 3000 in the 1970’s.  Let’s have #theconversation.

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Acknowledgements. I have literally thousands of people to thank for helping move from ignorance to awareness.  You know who you are. Thank you.

Please support VIALs with a generous donation.  Tell them Jack sent you!
To support Dr. Lyons-Weiler and his research associates at IPAK, visit ipaknowledge.org

VIALs health summit slides James LyonsWeiler MAGIC

causes

Aluminum, Alzheimer’s and Autism

TO THE READER: IMPORTANT DETAILS HAVE EMERGED FROM STUDIES ON THE CAUSES OF BRAIN DYSFUNCTION FROM STROKE AND ALZHEIMER’S DISEASE THAT LEAD DIRECTLY TO HOPE FOR EFFECTIVE AMELIORATION OF THE BRAIN-CELL DESTROYING PROCESSES IN AUTISM. READ THE ARTICLE ALL THE WAY THROUGH TO LEARN ABOUT TWO NUTRIENTS THAT CAN HAVE BEEN FOUND TO REDUCE BRAIN GLUTAMATE LEVELS, WHICH CAUSES CHRONIC MICROGLIAL ACTIVATION (CMA). CMA IS KNOWN TO OCCUR IN THE BRAINS OF AUTISTICS FROM AGE 4-44. THE POSSIBILITIES ARE IMMENSE. MORE RESEARCH IS URGENTLY NEEDED. -JLW (April 8, 2016)

THERE ARE TWO MAIN KNOWN PROCESSES involved in the onset of autism. The first is susceptibility to environmental toxins via mitochondrial dysfunction, which can be the combined result of environmental insults and mutations in mitochondrial genes and genes that directly influence mitochondrial function.  This combination of factors exists in as many as 20% of cases of autism.

The second is chronic microglial activation (CMA). Microglia are amazing nerve cells that serve as shepherds of learning, fostering connections at the synapse during reinforcement learning. They also play the role of the white blood cells (WBCs) of the brain, becoming activated due to injury or infection. Upon dying, brain cells release chemicals calls cytokines that activate microglia from tending shepherds to armed killers. They consume bacteria, viruses, and cellular debris, clearing the brain of the dead and dying cells. The eat impaired dendrites in their activated state.

Other cells called astrocytes mop up the chemical signals that cause microglial activation via molecules called receptors. One of these signals is glutamate.  CMA occurs when something causes glutamate build-up in the brain.  CMA can occur in autism patients with or without mitochondrial dysfunction, and both processes may be at work and interrelated in any given patient with autism.

Causes of Excess Glutamate in the Brain

Many environmental factors can cause excess glutamate. Eating it (MSG) is one way to upset the balance between glutamate in the blood and the brain. The higher the concentration of glutamate in the blood, the less able the brains glutamate pumps are able to dump excesses into the blood. Mercury and aluminum, both additives found in vaccines, can cause chronic microglial activation by harming astrocytes’ ability to uptake glutamate. Chronic microglial activation is found in people with autism from age 5 to 44 (Vargas et al., 2005).

Researchers at the Johns Hopkins University in the Neuroimmunopathology lab studied autistics aged 5-44 and found that their brains had widespread microglial hyperactivation and sensitivity to astrocytes, reflecting IL-6 cytokine mediated inflammation (Vargas et al., 2005). The chronic inflammatory conditions were most pronounced in the cerebellum, anterior cingulate and the medial frontal gyrus. The fact that the hyperactivated state persisted for decades is a critical observation from this study.

Reducing Brain Glutamate and Brain Damage from Stroke

A series of important studies have shown that techniques that clear excess glutamate from the brain during stroke reduces brain damage.  Campos et al. (2011a), demonstrated the effectiveness of oxaloacetate  (a known blood glutamate scavenge) in treating rats in which a stroke was induced. The found that intravenous injection of oxaloacetate decreased both blood and brain glutamate levels. This led to an astounding  80% reduction volume of the brain infarct, dramatically reducing brain edema. The neuroprotective effects of oxaloacetate are due to the depletion of blood glutamate levels – which occurs as a consequence of the activation of a blood-resident enzyme glutamate-oxaloacetate transaminase (GOT) (Gottlieb et al, 2003). When blood glutamate levels are low, the gradient across the blood-brain barrier is in the correct ratio to allow rapid glutamate clearing. This will result in a shut-down of microglial activation.

Similar results were found in human studies by the same team. Campos et al (2011b) studied a cohort of several hundred stroke victims at two hospitals. Using the same inclusion and exclusion criteria, they found that blood glutamate levels at the time of admission to the hospitals was a good predictor of outcome from stroke. (Read more at “GOT to ride the body of excess glutamate“.

These studies confirm earlier findings that both oxaloacetate and pyruvate are effective at reducing brain glutamate levels (Boyko et al., 2012).

Read this exciting study in the abstract from Castillo et al. (2015):

“Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other cellular components of the neurovascular unit. Several strategies have been developed against glutamate excitotoxicity, however none of them have not shown positive results in the clinical practice so far. Nowadays, the concept of blood/brain glutamate grabbing or scavenging is well recognized as a novel and attractive protective strategy to reduce the excitotoxic effect of excess extracellular glutamate that accumulates in the brain following an ischemic stroke. The main advantage of this novel therapeutic strategy is that it occurs in the blood circulation and therefore does not affect the normal brain neurophysiology, as it has been described for other drug treatments used against glutamate excitotoxicity. In this work we report all experimental data from the beginning of our studies, focused on stroke pathology, and we describe new findings about the potential application of this therapy. Future clinical trials will allow to know the real efficacy of this novel therapeutic strategy in stroke patients.”

Microglia, Glutamate and Alzheimer’s Disease

One of the most vocal minds pointing to CMA as a major process involved in autism was Dr. Russell Blaylock, MD.  The abstract above  reads just like studies from autism by Blaylock and others (substitute “stroke” with “autism”). Blaylock’s various writing and videos of his presentations have awakened many to the fact that autism is a medical condition, not a neurodevelopmental disorder per se. The medical aspects of autism mean that reversing the causes of the disorder, such as shutting down chronic microglial activation, should be possible. An important part of that is diet. Some foods (such as those containing MSG) will exacerbate brain trauma caused by the excitotoxicity cycle set up by immunotoxins in vaccines (aluminum and mercury). Tylenol should be avoided as it depletes glutathione, a necessary component of microglial glutamate reduction.

It has only more recently been found that immunoneuroexcitotoxicity is at the causal center of Alzheimer’s disease.  A rich literature exists that shows that CMA is found as a causal factor in Alzheimer’s disease, with specific causal links demonstrated between excess glutamate, and microglial dysfunction.

Here is an example from Solito and Sastre (2012):

Contrary to early views, we now know that systemic inflammatory/immune responses transmit to the brain. The microglia, the resident “macrophages” of the brain’s innate immune system, are most responsive, and increasing evidence suggests that they enter a hyper-reactive state in neurodegenerative conditions and aging. As sustained over-production of microglial pro-inflammatory mediators is neurotoxic, this raises great concern that systemic inflammation (that also escalates with aging) exacerbates or possibly triggers, neurological diseases (Alzheimer’s, prion, motoneuron disease). It is known that inflammation has an essential role in the progression of Alzheimer’s disease (AD), since amyloid-β (Aβ) is able to activate microglia, initiating an inflammatory response, which could have different consequences for neuronal survival. On one hand, microglia may delay the progression of AD by contributing to the clearance of Aβ, since they phagocyte Aβ and release enzymes responsible for Aβ degradation. Microglia also secrete growth factors and anti-inflammatory cytokines, which are neuroprotective. In addition, microglia removal of damaged cells is a very important step in the restoration of the normal brain environment, as if left such cells can become potent inflammatory stimuli, resulting in yet further tissue damage. On the other hand, as we age microglia become steadily less efficient at these processes, tending to become over-activated in response to stimulation and instigating too potent a reaction, which may cause neuronal damage in its own right. Therefore, it is critical to understand the state of activation of microglia in different AD stages to be able to determine the effect of potential anti-inflammatory therapies. We discuss here recent evidence supporting both the beneficial or detrimental performance of microglia in AD, and the attempt to find molecules/biomarkers for early diagnosis or therapeutic interventions.

One of the leaders in this area is Israeli scientist Dr. Vivian Teichberg, Ph.D., who proposed that clearing glutamate from the blood might cause a release of glutamate from the brain into the blood.  In a series of clever studies, researchers at the Weizmann Institute found that transforming glutamate in the blood into another form causes glutamate in the brain to exit – providing protection against glutamate storms associated with stroke.  (Read: “Protecting the Brain from A Glutamate Storm“). More on this exciting epiphany, below.

Aluminum, Alzheimer’s, and Glutamate Uptake

Aluminum has long been suspected to be a plausible causal contributing factor to the risk of Alzheimer’s disease. Geographic correlations of aluminum levels in drinking water (Martyn, et al., 1989), and the finding of high amounts of aluminum in the brains of some patients who died from Alzheimer’s disease (just one example, see Exley and Vickers (2014)  were initial indicators. More recent studies seem to confirm the link. A metaanalysis found a 71% increase in the risk of Alzheimer’s disease in individual with chronic exposure to aluminum (Wang et al., 2016). As people age, their microglia become less efficient at clearing Aβ deposits from the brain parenchyma (Thériault et al., 2015).

Chronic Microglial Activation and Aluminum from Vaccines

Nine of 11 available studies reviewed by Flaten et al. (2001) concluded that Alzheimer’s disease incidence was increased regions with highest aluminum in residential drinking water. Measures of inflammation, particularly in the brain, were also seen to be increased when aluminum was high in drinking water (Campbell et al., 2004) – and, importantly, activated microglial cells were also increased. Aluminum in vaccines is almost certainly a causal factor in chronic microglial activation.

Aluminum is found in most vaccines, and is a serious neurotoxin, in spite of a thwarted misinformation campaign to the contrary (Read “Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments are Ready!“). In mice, subcutaneous aluminum injections resulted in significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex Shaw CA et al., 2013). Reduced spatial memory capacity and impairment of motor function was observed after six doses (Shaw et al., 2009). Aluminum also influences other cells than microglia; it results in altered mitochondrial metabolism, globular astrocyte shape and astrocyte dysfunction (Lemire et al., 2009).

Olmos-Alonso et al. (2016) found increased proliferation of microglial cells in human Alzheimer’s disease. Stanford University researchers have reported that a drug called EP2 can reverse microglial activation.

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Chronic microglial activation  (CMA) leads to damage to synapses, loss of neural precursor cells, and neuronal death. The same process of CMA is seen in autism from ages 4-25 (Vargas et al.). Image modified from  Morales et al., 2014. Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci. 8:112. doi: 10.3389/fncel.2014.00112. eCollection 2014.).


Now The Most Exciting Part: Oxaloacetate and Pyruvate Supplements Clear Excess Glutamate from the Brain

Oxaloacetate is found in nature – and has numerous healthy benefits. It is non-toxic (similar toxicity to vitamin C) and is found in apples, pears, bananas, and spinach. (Read NDX USA’s easy-to-digest article “Oxaloacetate“.

Pyruvate is also found in nature. Foods containing it include red apples, cheese, dark beer, and red wine.  Here is a well-informed article  by Maia Appleby at SFGate on pyruvate supplements (“What Is Pyruvic Acid?”).

Both Oxaloacetate and Pyruvate are available in capsule form, however, the doses required to replicate the effects per body weight conducted in the studies showing their effects on glutamate levels in the brain are very high.  Here are some sources:

Oxaloacetate Supplement, 250 mg, by Natural Dynamix at Amazon.com

[Oxaloacetate (Oxaloacetic Acid) Mental Health Daily Link]

Pyruvate Supplement, 1000 mg, by Piping Rock Health Products at Amazon.com

According WebMD,  our bodies produce pyruvate when it breaks down sugar (glucose), and is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.  [WebMD Link]

[Disclaimer: These links are provided to the reader to inform on availability, are not meant as a recommendation. No health claims are made by the author, nor any recommendations. High doses of any supplement can have side effects. Check with your doctor before adding any supplements to your diet].

Conclusion

Chronic and acute microglial activation leads to brain trauma in stroke, Alzheimer’s and autism. By reasonable inference, supplements that reduce glutamate-induce chronic microglial activation in Alzheimer’s are very likely to have the same effects on some patients with autism.  Studies are urgently needed to determine if dietary oxaloacetate and pyruvate supplementation provide neuroprotection against chronic microglial activation in persons with autism.  Studies of glutamate levels and injection of oxaloacetate during severe neurological distress following vaccination should be undertaken immediately.

Dr. Lyons-Weiler is the President and CEO of The Institute for Pure and Applied Knowledge, which conducts basic, translational and clinical research in the public interest (without profit motive), and is author of three books, “The Environmental and Genetics Causes of AutismThe Environmental and Genetics Causes of Autism“,  “Cures vs. Profits“, and “Ebola: An Evolving Story“.

References

Boyko M et al., 2012. The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage. Neurotherapeutics. 9(3):649-57. doi: 10.1007/s13311-012-0129-6.

Campos F, Sobrino T, Ramos-Cabrer P, Argibay B, Agulla J, Pérez-Mato M, Rodríguez-González R, Brea D, Castillo J. 2011. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab. 2011 Jun;31(6):1378-86. doi: 10.1038/jcbfm.2011.3. Epub 2011 Jan 26.

Campbell A et al., 2004. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. J Neurosci Res. 75(4):565-72.

Campos F, Sobrino T, Ramos-Cabrer P, Castellanos M, Blanco M, Rodríguez-Yáñez M, Serena J, Leira R, Castillo J. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Jun;31(6):1387-93. doi: 10.1038/jcbfm.2011.4. Epub 2011 Jan 26.

Castillo J et al. 2015. A novel mechanism of neuroprotection: Blood glutamate grabber. J Cereb Blood Flow Metab. 2016 Feb;36(2):292-301. doi: 10.1177/0271678X15606721.

Exley C, Vickers T. 2014. Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report. J Med Case Rep. 8:41. doi: 10.1186/1752-1947-8-41.

Flaten TP, 2001. Aluminium as a risk factor in Alzheimer’s disease, with emphasis on drinking water. Brain Res Bull. 55(2):187-96.

Gottlieb M, Wang Y, Teichberg VI. 2003. Blood-Mediated Scavenging of Cerebrospinal Fluid Glutamate. Journal of Neurochemistry  87: 119–126.

Lemire J et al., 2009. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J Neurosci Res.;87(6):1474-83. doi: 10.1002/jnr.21965.

Olmos-Alonso A et al., 2016. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology. Brain 139(Pt 3):891-907. doi: 10.1093/brain/awv379.

Martyn, C. 1989. Geographical relationship between Alzheimer’s disease and aluminum in drinking water. Lancet 1:59.

Shaw CA and MS Petrik. 2009. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. J Inorg Biochem. 103(11):1555-62. doi: 10.1016/j.jinorgbio.2009.05.019.

Shaw CA et al., 2013. Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes. J Inorg Biochem. 128:237-44. doi: 10.1016/j.jinorgbio.2013.07.022.

Solito E, Sastre M. 2012. Microglia function in Alzheimer’s disease. Front Pharmacol. 3:14. doi: 10.3389/fphar.2012.00014. eCollection 2012.

Thériault, P et al. The dynamics of monocytes and microglia in Alzheimer’s disease Alzheimer’s Research & Therapy 20157:41 DOI: 10.1186/s13195-015-0125-2.

Vargas DL et al., 2005. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 57:67-81.

Wang Z et al., 2016.  Chronic exposure to aluminum and risk of Alzheimer’s disease: A meta-analysis. Neurosci Lett. 2016 Jan 1;610:200-6. doi: 10.1016/j.neulet.2015.11.014. Epub 2015 Nov 27.

Zlotnik A, Gurevich B, Tkachov S, et al. 2007. Brain Neuroprotection by Scavenging Blood Glutamate. Experimental Neurology 203: 213–220.

Books by Dr. Lyons-Weiler

Ebola: An Evolving Story (2015, World Scientific)

Genetic and Environmental Causes of Autism (2016, Skyhorse Publishing)

causes

Cures vs. Profits: Successes in Translational Research (2016)

Related Abstracts

Bondy SC. 2016. Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer’s disease and age-related neurodegeneration. Neurotoxicology. 52:222-9. doi: 10.1016/j.neuro.2015.12.002. 

Abstract
Aluminum (Al) is a very common component of the earth’s mineral composition. It is not essential element for life and is a constituent of rather inert minerals. Therefore, it has often been regarded as not presenting a significant health hazard. As a result, aluminum-containing agents been used in the preparation of many foodstuffs processing steps and also in elimination of particulate organic matter from water. More recently, the reduced pH of bodies of water resulting from acid rain has led to mobilization of aluminum-containing minerals into a more soluble form, and these have thus entered residential drinking water resources. By this means, the body burden of aluminum in humans has increased. Epidemiological and experimental findings indicate that aluminum is not as harmless as was previously thought, and that aluminum may contribute to the inception and advancement of Alzheimer’s disease. Epidemiological data is reinforced by indications that aluminum exposure can result in excess inflammatory activity within the brain. Activation of the immune system not initiated by an infectious agent, typifies the aging brain and is even more augmented in several neurodegenerative diseases. The origin of most age-related neurological disorders is generally not known but as they are largely not of genetic derivation, their development is likely triggered by unknown environmental factors. There is a growing and consistent body of evidence that points to aluminum as being one such significant influence. Evidence is presented that reinforces the likelihood that aluminum is a factor speeding the rate of brain aging. Such acceleration would inevitably enlarge the incidence of age-related neurological diseases.

Fanne RA, Nassar T, Heyman SN, Hijazi N, Higazi AA.. 2011. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R668-73. doi: 10.1152/ajpregu.00058.2011. 

Abstract
In patients with acute ischemic stroke, diabetes and hyperglycemia are associated with increased infarct size, more profound neurologic deficits and higher mortality. Notwithstanding extensive clinical and experimental data, treatment of stroke-associated hyperglycemia with insulin is controversial. In addition to hyperglycemia, diabetes and even early prediabetic insulin resistance are associated with increased levels of amino acids, including the neurotoxic glutamate, in the circulation. The pleiotropic metabolic effects of insulin include a reduction in the concentration of amino acids in the circulation. In this article, we show that in diabetic rats exposed to transient middle cerebral artery occlusion, a decrease of plasma glutamate by insulin or glucagon reduces CSF glutamate, improves brain histology, and preserves neurologic function. The neuroprotective effect of insulin and glucagon was similar, notwithstanding their opposite effects on blood glucose. The therapeutic window of both hormones overlapped with the short duration (~30 min) of elevated brain glutamate following brain trauma in rodents. Similar neuroprotective effects were found after administration of the glutamate scavenger oxaloacetate, which does not affect glucose metabolism. These data indicate that insulin and glucagon exert a neuroprotective effect within a very brief therapeutic window that correlates with their capacity to reduce glutamate, rather than by modifying glucose levels.

Pogue AI, Lukiw WJ. 2016. Aluminum, the genetic apparatus of the human CNS and Alzheimer’s disease (AD). Morphologie. 2016 Mar 8. pii: S1286-0115(16)00024-2. doi: 10.1016/j.morpho.2016.01.001.

Abstract
The genomes of eukaryotes orchestrate their expression to ensure an effective, homeostatic and functional gene signaling program, and this includes fundamentally altered patterns of transcription during aging, development, differentiation and disease. These actions constitute an extremely complex and intricate process as genetic operations such as transcription involve the very rapid translocation and polymerization of ribonucleotides using RNA polymerases, accessory transcription protein complexes and other interrelated chromatin proteins and genetic factors. As both free ribonucleotides and polymerized single-stranded RNA chains, ribonucleotides are highly charged with phosphate, and this genetic system is extremely vulnerable to disruption by a large number of electrostatic forces, and primarily by cationic metals such as aluminum. Aluminum has been shown by independent researchers to be particularly genotoxic to the genetic apparatus, and it has become reasonably clear that aluminum disturbs genetic signaling programs in the CNS that bear a surprising resemblance to those observed in Alzheimer’s disease (AD) brain. This paper will focus on a discussion of two molecular-genetic aspects of aluminum genotoxicity: (1) the observation that micro-RNA (miRNA)-mediated global gene expression patterns in aluminum-treated transgenic animal models of AD (Tg-AD) strongly resemble those found in AD; and (2) the concept of “human biochemical individuality” and the hypothesis that individuals with certain gene expression patterns may be especially sensitive and perhaps predisposed to aluminum genotoxicity.

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“You Know Nothing About Autism, John Snow”

IN THE TELEVISION PRE-HISTORY FICTIONAL MINISERIES ‘GAME OF THRONES’, a female character named Ygritte is fond of telling her lover, a Night Watchman, who lives caught between two warring cultures, the expression “You know nothing, Jon Snow”.  She tells him this to remind him that he has no idea why the Wildings, a tribe of undead people, are attacking their peoples, and, as hint to the fact that in spite of their different origins as people, she loves him.s

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There is another Snow of merit who lived between cultures – a culture of science and a culture of stoic and unforgiving ignorance. This John Snow has an important lesson for our time.

In 1854’s, London Physician John Snow was confronted with a severe outbreak of cholera.  The prevailing view of the cause of the cholera at the time was the ‘miasma’ theory, in which ‘bad air’, or something called ‘vibrones’ which the medical community postulated caused the spread of the illness.

London’s Soho District at the time was typical of London neighborhoods in the 1850’s.  Most homes had cess pits under their homes for human waste, and if the waste production exceeded the soil’s capacity, it would he hauled away, for a fee, and dumped into the river Thames.

The good Dr. Snow, pictured to the right, was not satisfied by the miasma theory. As the cholera outbreak worsened, he began mapping cases and eventually recognized that most John_Snowcases were clustered near a water pump on Broad Street. His careful observations led him to conclude that whatever ‘cholera poison’, as he referred to it, was behind the outbreak, it was somehow connected to the water pump. This was before germ theory was established and pathogens such as bacteria and viruses were unknown to medicine.

A religious colleague, The Reverend Henry Whitehead, from St. Luke’s Church, was a believer of the miasma theory. As any good man of the church would so, he attempted to disprove theories, and when he turned his attention to Dr. Snow’s theory of that cholera was a water-born illness, somehow connected to human waste, he was turned away from the nondescript miasma theory by the evidence accumulated by Snow in his maps. He even accompanied Dr. Snow on a hunt for the connection between human waste and the water pump, and together they discovered a home that had a cess pit that drained to a old cess pit only a few feet away from the well at the Broad Street Pump. The homeowners routinely dumped diapers (nappies) into the cess pit under their home.

Together, Snow and Whitehead convinced the town’s government to break the handle off the pump. Thereafter, the cholera epidemic ceased; however, the government (The London Board of Health) refused to acknowledge the links between human waste, water and cholera, instead sticking by the ill-defined miasma theory. (Beer drinkers, rejoice – the villagers turned to beer for their liquid intake – which of course was free from cholera due to the fermentation process).

CDC’s Miasma Theory of Autism

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John Snow’s Original Map Showing Clusters of Cholera Around the Broad Street Pump, 1854

 

In their fervor to convince the public that no link exists between vaccines and autism, the CDC has neglected to propound (offer) any viable theory for the increase in autism. Others have tried to blame changes in diagnosis, or genetics for the rise in autism, but neither of these two factors can explain the incredibly rapid rise from 1 in 3000 in the 1970’s to 1 in 68. In fact, the CDC has shown a remarkable lack of curiosity about what DOES cause autism. The CDC’s amorphous theory of autism is, empirically, identical to the miasma theory for cholera – because neither vibrones, nor CDCs’ theory of autism exist.

 

Cherry Picking: CDC’s Woeful, Biased Representation of The Available Science

In all of their communications to the public on causes of autism, CDC fails to consider the bulk of the available science that not only shows association between autism and vaccines, but also points squarely to the role of aluminum and mercury as fundamental to the etiology of autism via chronic microglial activation. I know this because I’ve read the science the CDC has not read. Between November 2015 and February 2016, I read over 3,000 published and peer-reviewed studies on autism – not on vaccines intentionally – but rather on autism.  I took the position of  geneticist who wanted to know how traits as unique as autism – lack of or loss of language abilities, aberrant motor movements, differences in executive functions – might be explained considering both genetic and environmental factors.

What I found were studies that clearly showed that neurotoxins such as aluminum, (read this before you claim aluminum is not a neurotoxin), mercury, valproaic acid, thalidomide, and other toxins are picked up by macrophages, deposited in the brain, and interfere with astrocytic glutamate uptake. The excess glutamate prevents microglial cells from de-activating, once activated, and the microglia consume dendrites and neural precursor cells. The autistic brain becomes uni-polar, with many one:one axon:dendrite connections. The microglia in their activated form are not available to shepherd multiple axon:dendrite connections during reinforcement learning, and thus the structures for inhibition feedback are missing. The autistic brain allows perceptual signals to get into the brain too far, too fast, and this is why their are perception sensitivities to light, and sounds. There are also perceptual differences, more easily controlled by shutting down one eye, for example (the sideways glance forces the use of peripheral vision, which reduces the input level to tolerable, so autistic are actually try to look and focus and pay attention by such behavior, not ignoring you!). Further, the input signals can travel so far so fast throughout the brain that they can activate motor neurons, leading to repetitive and uncontrolled behaviors.

This is just a small part of what we know – the rest is in the book. There is much, much more that is known about autism than the CDC’s Miasma-like position would allow for. And all of this amassed knowledge, paid for by our tax dollars, conducted by researchers outside of the CDC, is ignored by the CDC and summarily dismissed as ‘unreliable’. Consider, for example, the interchange between Senator Elizabeth Warren and Rear Admiral Schuchat (excerpt from “The Environmental and Genetic Causes of Autism“:

“Massachusetts Senator Elizabeth Warren asked Dr. Schuchat a few questions and in each response, Schuchat reassured her that vaccines were highly safe and effective and that ‘dozens of studies’ had been conducted that showed no association between autism and vaccines.

Warren: Is there any scientific evidence that vaccines cause profound mental disorders?

Dr. Schuchat: No.

warrenshuchat

Near the end of her testimony, the following interchange occurred:

Warren: Parents should know that all of the credible scientific evidence suggests that modern vaccines are safe, modern vaccines are effective and modern vaccines are our best chance of protecting our children from diseases that can kill them, is that right?

Schuchat: That’s right.

The emphasis on “all of the credible scientific evidence” is mine, but the words are Warren’s, agreed to by Schuchat and they are critically important.

Schuchat dismissed most of the evidence cited in this book so far, which is a mountain of peer-reviewed, credible scientific studies. Since she agreed with Warren’s statement, Schuchat testified that all of the evidence that contradicted her own and the CDC’s conclusions was not credible.” – (James Lyons-Weiler, “The Environmental and Genetic Causes of Autism, (C) Skyhorse Publishing).

Here, Senator Warren, and the rest of the Senate, and by extension, the People of the United States of America are being lied to by the most senior ranking official in the CDC about not just a few paltry studies that might show links between vaccines and autism – but about ALL studies showing how, and why, vaccines can cause autism in some people.

That’s right. LIED TO.

The science that Schuchat is lying about is valid, and much of it is outlined in detail here, and in “Causes“.

Think about this misrepresentation the next time you hear someone say “the issue is settled” or “the science shows no link” or “all of the published studies show” no link between vaccines and autism.

Those statements are 100% incorrect. Here is the rest of the science.

Anti-Vax? Pro-Vax? How about a Third Option: SCIENCE.

The fact that the word is out that the CDC also omitted results from a key study, and over-cooked the data analysis as a matter of routine to make associations between vaccination and autism disappear – is scaring people. Like Schuchat. And Dr. Frank DeStefano. And Dr. Coleen Boyle. They have misled the public for over 15 years on autism. But more and more pediatricians are accepting that vaccines may cause autism, and therefore the CDC is fast becoming irrelevant. By fudging their results, they lied to their fellow scientists. They lied to the rest of the US Government. They lied to the People of the United States. They lied to Pharma. They lied to the FDA, the NIH, the NIAID, the AAP, the AMA.  They have lied to the Press. They have lied to the so-called internet ‘trolls’ who spend inordinate amounts of time insulting and demeaning the vaccine-risk aware population.

I have read the CDC’s so-called “science”, and I can see how they fudged their results. Remember, I’m an expert is multivariate and high-dimensional analysis. I know how to interpret a significant interaction term in a linear model – evidently the CDC apparently does not even know they exist.

The National Academy of Sciences and the Institute of Medicine rejected 17/22 studies put forward by the CDC as flawed. That leaves a scant 5 studies upon which our public health policy is based.

IPAKinfograph

Given that they have tried so hard to warp our perception, I propose that we move on from the CDC – and start doing bona fide vaccine safety science. Every vaccine, all health outcomes. Let’s use Virus-Like Particles (VLPs), screened for epitopes that match important human proteins, and reduce autoimmune diseases. Let’s use VLPs with sufficient antigen loads so adjuvants are not required. Let’s make them sterile and free from preservatives.

Because vaccines are the water pump, and autism is our cholera.  Wakefield, Hooker, Schoenfeld, Shaw, Seneff, Gallager, Goodman, Delong, Sharpe, Tomljenovic, Geier and Geier, Young, Nataf, Yasuda, Tstusui,  Blaurock-Busch, Molina, Bradstreet, McDonald,
Singh, Holmes, Lee, Vargas, Poling, Mikovitz, Palmter, Mohamed,  and many others, especially Dr. Russell Blaylock and Dr. William Thompson of the CDC… these are today’s John Snows [1].

Today’s John Snows have been calling for us to clean up vaccines – not to break the handle off the pump – but to clean up vaccines, and to shut down the epidemic. They do not wish to ban vaccines.  Quite the opposite – their goals are to make them so safe that the myths of vaccine safety perpetuated by the CDC become true, and then everyone can enjoy the full benefits.  Their science – and it is valid science, regardless of what Rr. Adm. Shuchat tried – and failed – to get us to believe – has shined a bright light on what is wrong with the current formulation of most vaccines.

Here is the CSPAN video of the interview in which Rr. Adm. Shuchat dimisses with one word ALL of the available peer-review science the CDC has decided is unreliable (that is, any science the CDC has not done themselves.

You can help move vaccination science away from the everlasting debate by moving on from the CDC as well. (See IPAK). The CDC vaccine division and leadership have consistently proved themselves to be unreliable as a sources of information on the science of vaccines. We have many more qualified scientists outside of the CDC than inside of the CDC who are capable of performing vaccine safety research. Let us wrest it from the CDC and put it in the hands of the NIH, NIAID, or Department of Homeland Security, under the following model:

Every vaccine, studied for 4 years, each studied independently by 5 institutions (extramural), focused on efficacy, and safety, with proper research oversight – run the studies as randomized prospective clinical trials. Three (3) of the five institutions win contracts by lottery, and two by competitive peer review. This will break any chance of intrusion by monied interests. All should publish their studies independently. Each vaccine should be subject to approval by the FDA, with separate committees studying safety and efficacy.

Autism is a public health crisis – but then so is autoimmunity. We know that certain epitopes in vaccines induce autoimmunity. All epitopes in pathogens with clear functional mapping to autoimmunity (such as basic mylein protein) should be banned from use. And we should conduct genetic screening to see if we can predict which patients are most likely to suffer from adverse events from vaccines.

Let’s leave the handle on the pump, and clean up the water. Everyone will be happier, safer, and, most importantly, healthier. And the collective denial of autism/vaccines can end.

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John Snow Memorial and Public House, Soho District, London.

 

Dr. John Snow’s report:

“On proceeding to the spot, I found that nearly all the deaths had taken place within a short distance of the [Broad Street] pump. There were only ten deaths in houses situated decidedly nearer to another street-pump. In five of these cases the families of the deceased persons informed me that they always sent to the pump in Broad Street, as they preferred the water to that of the pumps which were nearer. In three other cases, the deceased were children who went to school near the pump in Broad Street…

With regard to the deaths occurring in the locality belonging to the pump, there were 61 instances in which I was informed that the deceased persons used to drink the pump water from Broad Street, either constantly or occasionally…

The result of the inquiry, then, is, that there has been no particular outbreak or prevalence of cholera in this part of London except among the persons who were in the habit of drinking the water of the above-mentioned pump well.

I had an interview with the Board of Guardians of St James’s parish, on the evening of the 7th inst [September 7], and represented the above circumstances to them. In consequence of what I said, the handle of the pump was removed on the following day.”

— Dr. John Snow, letter to the Editor of the Medical Times and Gazette

 

Dr. William Thompson’s Report:

“I regret that my coauthors and I omitted statistically significant information in our 2004 article published in the journal Pediatrics. The omitted data suggested that African American males who received the MMR vaccine before age 36 months were at increased risk for autism.”

Dr. William Thompson, statement from his lawyer.

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“I can’t believe we did what we did, but we did… The CDC knew about the relationship between the age of first MMR vaccine and autism incidence in African-American boys as early as 2003, but chose to cover it up…we’ve missed ten years of research because the CDC is so paralyzed right now by anything related to autism.”

Dr. William Thompson in a taped conversation with Dr. Brian Hooker

[1] Note to colleagues – if your name is not here, and it should be, send me a note, I will gladly add it.

Much of the information in this article on Dr. John Snow comes from this entry in Wikipedia.

You can directly support reformed vaccine safety research at The Institute for Pure and Applied Knowledge.

James Lyons-Weiler, PhD

Dr. Lyons-Weiler’s latest book, “Cures vs. Profits”, has just been released an is available via Amazon.com.  His book “Environmental and Genetic Causes of Autism” is due out in November, 2016.

 

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Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages). To help support the publicity campaign, click on the book cover, above!

 

How the CDC has Promoted Ignorance about Vaccine Safety

 CDCI HAVE BEEN READING widely both the primary literature and policy statements on vaccine safety from US Government Agencies as part of  the routine, due diligence required of objective scientist. It’s also par for the course for writing informative books. I would hate to think that I missed an important reference or source in any of my books. So I read on…

I have traced the ubiquitous “knowledge” that “vaccines do not cause autism” to the types of statements made by the US CDC. Perhaps in their quest to be clear, in their zeal to protect the population from contagious diseases, or perhaps because they have financial interests, the CDC loves to use black & white, unqualified statements.

Let’s look at three statements from the CDC website:

“Vaccines do not cause autism”

“There is no link between vaccines and autism.”

“Vaccine ingredients do not cause autism.”

The issue with these statement are that they are unqualified – meaning that they do not contain any qualifiers. Universal statements such as “never” and “always” are extremely rare in science and biomedicine.  We tend to hedge, using terms like “some”, and “may”, and “sometimes”, and for good reason. It’s the exceptions that count.

I am about to share with you information – certainly not new here, just ignored widely – that proves that these unqualified statements are wrong, misleading, and contribute to widespread ignorance on vaccine safety.

(1) The Special Masters court has found, and has made awards for damages, on repeated instances that vaccines have lead to neurological injuries that the Court has, in some cases, recognized as “autism”.  Two especially clear cases are Bailey Banks, who the court decided developed ADEM, leading to PPD-NOS (a type of autism), leading to an award of over $800,000, and Hanah Poling, whose family awarded $1.5 million for vaccine-induced autism. Other cases of vaccine induced neurological injuries leading to award include Eric Lassiter (diagnosed with autism), Elias Tembenis (PDD-NOS ), and Ryan Mojabi (diagnosed with autism, asthma and encephalopathy) and Richelle Oxley (encephalopathy).

(2) The CDC cites many studies that add to the conclusion that ‘vaccines do not cause autism’.

However, a 2012 National Academy of Science/Institutes of Medicine
report rejected 17/22 studies cited by the CDC as “flawed”.

The CDC continues to cite these studies, standing by them, and the policies upon which they are based, as if the National Academy of Sciences does not exist.

One of the studies was identified as a product of scientific fraud
by CDC Whistleblower Dr. William Thompson, who also pointed to numerous other studies were data were over-cooked. I’ve read the papers. Yes, they are over-cooked. See “Vaccine Whistleblower, Skyhorse Publishing ” for the full transcripts. They are jaw-dropping

The fact that the CDC continues to make unqualified statements, misleading the public, show their contempt of the Special Master’s Court position on these cases, reveals willful use of misstatements designed to misinform the public. As a result, the CDC can be considered liable for injuries caused by vaccines that could have been prevented if they did not mislead the public. Perhaps individuals would have taken a different path. Perhaps research would have moved forward to make vaccines safer.

(3) When the CDC is not involved , the scientific and biomedical research is clear: at least one mechanism by which autism can be caused by vaccines has been established: macrophages pick up neurotoxins (such as mercury and aluminum) and deposit them in organs, including the brain. There, these toxins can act,  in some people, to cause hyperactivation of microglial cells.

These cells usually clean up cellular debris, and act to  prune weak dendrites. When hyperactivated, they tend to go after any dendrites, over-pruning, leading to hypoconnectivity.  This causes the release of cytokines, leading to cell death apoptosis. Cytokines cause microglial cells to remain in the hyperctivated state, and a positive feedback loop is established. The immediate result is inflammation and encephalopathy. Importantly, this mechanism does not necessarily involve the recruitment of peripheral immune cells. The long-term effect are major developmental issues, in a variety of regions in the brain.

And the effects can vary from person to person. People with mutations in genes that encode protein involved in the cell’s normal detoxification pathways may suffer more severe damage (due to slower clearance).

The peer-reviewed published evidence for this mechanism will be reviewed & presented, with citations, in my book, “Genetic and Environmental Causes of Autism”.

We scientists have a responsibility to inform the public. I take that responsibility seriously. People who repeat unqualified claims such as those made by the CDC are spreading misinformation.

The important question is: how can we tell who will likely suffer this
outcome?

To begin with, we know that families with one autistic member are likely to have a second. That is, the risk of autism is higher for new babies born to autistic families. This implies a genetic risk. The CDC and the FDA should be saying that vaccines are  contraindicated both for people with autism, and for people with siblings who have autism.

Also, many genes are being found that contribute to autism risk. An era of research in identifying biomarkers that can predict adverse neurological reactions to vaccines is  needed, and it was needed ten years ago. Because the CDC is misleading the American public, no such initiative is deemed necessary. This must change.

The first step is for the CDC to add qualifiers to their public statements, such as “may” and “in some people”. Perhaps:

“Vaccines have been shown to induce autism in some people”, or

“Vaccines may cause autism in some people”

are accurate, factual statements, backed by science, and backed by the US legal system.

Help bring the truth out. Please see this initiative and donate today!

Dec 6, 2015

Cures_JLW_Cover_Art_front

New Books Released 2016 – Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages).

The Environmental and Genetic Causes of AutismThe Environmental and Genetic Causes of Autism (Skyhorse Publishing)

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You Can Help Bring Major Reform to Vaccine Safety Research

IF YOU HAVE been paying attention to the vaccine safety research controversies, you will know the following names:

Dr. Brian Hooker

Dr. William Thompson

Dr. Frank DeStefano

You may even know the names Dr. Coleen Boyle, and Dr. Julie Gerberding – and you will know the role that Senator Bill Posey (R, FL) has played.

You will know what Skyhorse Publishing is, and why the books they publish are vital to the very foundation of science in America.

If you don’t know anything about these issues – about how Bill Thompson disclosed research fraud at the CDC, involving key studies that the CDC still cites as evidence of no link between autism and vaccine – and about how these revelations have been confirmed by independent scrutiny of the publications involved – and about how former CDC Director Julie Gerberding left the CDC to work for Merck after overseeing the CDC during the period of time when the fraudulent research was alleged to have occurred, browse around my blog a while, or read the Chapter on Vaccines in Cures vs. Profits, or better yet get Kevin Barry’s book.

If you DO know about these issues, then you may not know what you can do to help bring about true reform in vaccine safety research.

Skyhorse Publishing has donated 40 copies each of “Thimerosal: Let the Science Speak” and “Vaccine Whistleblower: Exposing Autism Research Fraud at the CDC”  to the Institute for Pure and Applied Knowledge (IPAK, ipaknowledge.org). IPAK is sending one copy of each book, along with a Statement of Concern, to the Editors or Editors-in-Chief of 40 peer-reviewed journals in which those involved in the shady vaccine safety research practices have published.  We have the books, and the Statements of Concern printed, and ready to go. Here’s the countdown:

UPDATE!

17 of 40 packages sent as of December 4, 2015.

IPAK is a registered 501(c)3 pure public charity. No one working in IPAK is allowed to have any financial interest in the research we conduct. Your donation will allow IPAK to send the next package.  This is an extremely important event in the history of vaccine research, and you can help turn the tide.  Our efforts do not stop at sending letters and packages. IPAK seeks to reform vaccine research to bring about objective, transparent, and, most importantly, peer-accountable practices for vaccine safety & efficacy studies. One of the most disturbing revelations by Bill Thompson was that the research teams at the CDC would change the study design, and the approach to analysis, without oversight by an Institutional Review Board (IRB) until they found a way to make associations between vaccination and autism appear to be non-significant. When they could not dissolve the associations they found via over-analysis, they simply left results out.

HOW YOU CAN SEND AN IPAK “CARE” PACKAGE TO AN EDITOR TODAY.

Visit ipaknowledge.org and donate for this special IPAK Issue Focus Fundraiser. Your donation is tax-deductible. Then also please accept my invitation to consider joining The Society for Pure and Applied Knowledge.  There is much work to do. Let’s go!

James Lyons-Weiler, PhD

Allison Park, PA

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Paging Dr. Offit! Your Aluminum Neurotoxicity Reading Assignments Are Ready

AS COLLEGE PROFESSORS, my colleagues and I have always enjoyed the enthusiastic students who are eager to learn more. Those who stand out in myREADING memory are those who have requested more reading material. I have taught basic introductory biology, genetics, bioinformatics, courses in high-dimensional genomic and proteomic data analysis, and courses in study design and research ethics – and I always loved the gleam in the eye of students who just want to know.

Paging Dr. Offit!

Dr. Paul Offit earned millions of dollars from the sale of his patent for the Rotavirus vaccine after he voted to have it included in the pediatric vaccine schedule. He also appears to not be familiar with the body of peer-reviewed literature that condemns aluminum as a serious neurotoxin with well-characterized mechanisms of neurological damage.

In his book, “Deadly Choices: How the Anti-Vaccine Movement Threatens Us All” (Basic Books, New York), Offit is irresponsibly and recklessly dismissive of aluminum as a serious threat to the health of nearly all people by falsely reporting that:

“aluminum has been found to be harmful in only two groups of people: severely premature infants who receive large quantities of aluminum in intravenous fluids, and people on chronic dialysis (for kidney failure) who receive large quantities of aluminum in antacids”.

People absorb around very little of the aluminum they eat, but they absorb 100% of the aluminum injected in to their blood stream. [GENEROUSLY OFFERED CORRECTION/DETAILS: From Vaccine Papers, Al absorption from food is about 0.3%, typically within a range of 0.1-1%]. Offit claims, without citation, that aluminum in very quickly cleared from the body. He cites “researchers” (without citations) who studied aluminum concentrations in “blood” before and after receipt of aluminum-containing vaccines, and reports “No difference”.

Offit’s book was published in 2011. Unfortunately, it is evident that Offit did not even bother to search of the Pubmed, a wonderful public scientific research literature database at the National Center for Biotechnology Information, the standard resource for researchers who desire to know the latest on research topics in medicine, biology, psychiatry, and many other disciplines. A search reveals over 200 studies or papers on aluminum neurotoxicity before 2011. At the time of this writing (Nov. 2015), there are 393 studies or papers on the neurotoxicity of aluminum.

Some of these studies include direct discussions on the risk of aluminum in adjuvants in vaccines and provide data that demonstrate how aluminum works as a neurotoxin. Others discuss ways to alleviate neurotoxicity of aluminum. Others describe aluminum as a well-known neurotoxin responsible as a causal agent for neurodegenerative diseases.

Surely Offit, an expert placed on the National Vaccine Advisory Committee, the body in HHS responsible for making decisions on changes to the pediatric vaccine schedule, would have bothered to check the literature prior to 2011 while writing his book? If he had, he would have found studies with some compelling titles. The abstracts, and the papers themselves, are damning evidence for the use of aluminum as a vaccine adjuvant.

Here are some titles of the studies available at the time of his book-writing that individuals who are serious about vaccine safety might be interested in. Dr. Offit, for your convenience, I have included the links directly to the Pubmed entry:

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction.” (2009)

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.” (2009)

Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells.“(2009)

Role of metal ions in the abeta oligomerization in Alzheimer’s disease and in other neurological disorders.” (2008)

Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice.” (2007)

Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.” (2007)

Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer’s disease.” (2007)

Inflammation, neurodegenerative diseases, and environmental exposures.” (2004)

Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain.” (2004)

Neurotoxic effects of aluminium among foundry workers and Alzheimer’s disease.” (2004)

Neurological adverse events associated with vaccination.” (2002)

“The potential role of aluminium in Alzheimer’s disease.” (2002)

Just in case Dr. Offit is still involved in vaccine research, development or policy, and since he makes statements that appear in news articles on vaccine safety, I have taken the time to create a second reading list of more recent articles as well that Dr. Offit can add to his first reading list. Medical doctors really should keep abreast of new developments in medical research to stay professionally accredited.

But first, I have a hypothesis to share, which is indicated by past studies of numerous types. It came to me during my research for my forthcoming book, “Genetic and Environmental Causes of Autism”.

Is Macrophagic myofasciitis (MMF) Vaccine-Related Adult-Onset Autism/ASD?
A study in 2001 – a full decade before Offit’s book – reported central nervous system ailments eerily similar to those found in autism in patients diagnosed with macrophagic myofasciitis, symptomatic demyelinating CNS disorder, hemisensory or sensorimotor symptoms, bilateral pyramidal signs, cerebellar signs, visual loss, cognitive and behavioural disorders, and bladder dysfunction, supratentorial white matter hyperintense signals and corpus callosum atrophy (Authier et al., 2001).

Clinical features of MMF as described by Rigolet et al., (2014) are also strongly reminiscent of autism, including marked cognitive deficits (not related to pain, fatigue, or depression) including dysexecutive syndrome and visual memory impairment, and some cognitive deficits can appear unusually severe. Cognitive dysfunction was found to be stable over time. They also report that “classical therapeutic approaches are usually unsatisfactory making patient care difficult”.

Autism also involves cognitive deficits, executive function issues, memory impairment, and can involve severe cognitive deficits that are recalcitrant to treatment.

Additional Findings Support the Hypothesis

Mice injected with aluminum adjuvant doses equivalent to those given to US military service personnel showed both neuroinflammation and cell loss in the spinal cord and motor cortex, with consequent memory deficits (Petrik et al., 2007).

The cause of MMF has since been identified aluminum hydroxide from vaccines lesions (Gherardi et al., 2001; Authier et al., 2006; Gherardi et al., 2012; Rigolet M et al., 2014). Patients with MMF have an unusually long reaction at the site of injection of aluminum-containing vaccines in their muscle, and biospies show infiltration of muscle tissue by macrophages.

Here is chilling description of the effect of aluminum when used as an adjuvant:

“…poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in the brain” (Gherardi et al., 2015).

This is important: microglial cells are macrophages with dual roles in the brain: they perform routine surveillance and clean-up of cellular debris, viruses and bacteria. Upon infection, or serious brain damage, however, they become activated, change shape, and go on the attack. Microglial overactivation is a leading candidate for increased apoptosis and neurological damage associated with autism.

The neurotoxic effects of aluminum salts are also apparent: it increases levels of glial activation, inflammatory cytokines and amyloid precursor protein within the brain (Bondy, 2010). Amyloid precursor protein is one of the main culprits for Alzheimer’s disease.

The medical community and the public should revisit the issue of whether aluminum is a necessary adjuvant for vaccines. Evidently, for some vaccines that use virus-like particles as opposed to attenuated or live virus vaccines, no adjuvant is needed.

Reading List #2

Here is the rest of Dr. Offit’s reading list of studies and papers published after 2010:

Trace elements in scalp hair samples from patients with relapsing-remitting multiple sclerosis.” (2015)

Correlation of aluminum and manganese concentration in scalp hair samples of patients having neurological disorders.” (2015)

Aluminum-induced entropy in biological systems: implications for neurological disease.” (2014)

Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?” (2014)

A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder?” (2014)

Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report.” (2014)

Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration.” (2014)

Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes.” (2013)

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.” (2013)

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep.” (2013)

How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale.” (2013)

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.” (2011)

Aluminum vaccine adjuvants: are they safe?” (2011)

Metal ions affecting the neurological system.” (2011)

To be clear, Dr. Offit’s book could not include the references from the second reading list, as his book was published in 2011. But in the page and a half he takes to uses to claim that aluminum is only a problem for people with kidney failure and premature infants is terribly misleading, and is now also woefully out of date. As he and his profit-driven colleagues saw fit to allow vaccinations in babies between the age of 1 day to 2 years, it is of little reassurance that he knew that aluminum was harmful to premature babies.

Perhaps Dr. Offit was also not aware that the WHO Vaccine Safety Advisory Committee had, long before 2011, reported that there may be a subset of predisposed individuals who may be sensitive to aluminum-containing adjuvant (Authier et al., 2001).

Published scientific knowledge does not appear to play a role in the formation of vaccination policy in the United States.

November 16, 2015 (updated 11:22 AM)

Dr. James Lyons-Weiler is author of “Ebola: An Evolving Story” and “Cures vs. Profits: Successes in Translational Research“. He is also President, CEO and Chairman of the Board of the Institute for Pure and Applied Knowledge (IPAK).  IPAK is a pure public charity dedicated to providing impartial interpretation of research results without the influence of profit pressures. You can support IPAK with donations via the web. Your generous support will help Dr. Lyons-Weiler and his colleagues continue their efforts to keep the public, including Dr. Offit, informed.

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References

Authier FJ et al., 2001. Central nervous system disease in patients with macrophagic myofasciitis. Brain. 124(Pt 5):974-83.

Authier FJ, et al. 2006. AlOH3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background. Neuromuscul Disord 16(5):347–52.10.1016/j.nmd.2006.02.004

Bondy SC. 2010. The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology. 31(5):575-81. doi: 10.1016/j.neuro.2010.05.009.

Gherardi RK, et al. 2001. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Brain 124(Pt 9):1821–31.10.1093/brain/124.9.1821

Gherardi RK et al., 2001. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Brain. 124(Pt 9):1821-31.

Gherardi R and Authier FJ. 2012. Macrophagic myofasciitis: characterization and pathophysiology. Lupus 21(2):184–9.10.1177/0961203311429557

Gherardi RK et al., 2015. Biopersistence and brain translocation of aluminum adjuvants of vaccines. Front Neurol. 2015 Feb 5;6:4. doi: 10.3389/fneur.2015.00004. eCollection 2015.

Petrik MS et al., 2007. Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice. Neuromolecular Med 9:83–100.

Rigolet M et al., 2014. Clinical features in patients with long-lasting macrophagic myofasciitis. Front Neurol. 5:230. doi: 10.3389/fneur.2014.00230. eCollection 2014.

Cures_JLW_Cover_Art_front

New Books Released 2016

Cures vs. Profits: Successes in Translational Research (World Scientific (323 pages).

The Environmental and Genetic Causes of Autism (Skyhorse Publishing)

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Books and Publications by James Lyons-Weiler