Autoimmune Psychosis: Fingerprints of Aluminum-Induced Autoimmunity?

Autoimmune encephalitis is a condition in which the immune system attacks brain proteins.  It was first described by Dalmau in a patients with teratoma who exhibited high levels of autoantibodies that were reactive to neuronal tissue.  These patients also experienced severe psychotic and neurological manifestations, including anxiety, delusions, mania, short-term memory loss and seizures [1]. Immunomodulation and tumor resection reversed the symptoms.

It is well established that aluminum hydroxide can induce autoimmunity of many forms in animal models.  We recently had a paper on the issue of dose relevance to humans accepted and then not published by the journal Autoimmunological Reviews (first because it was too controversial, and then because we dared to have published a draft copy of the manuscript in the name of Open Science).  Our analysis showed that the per body weight aluminum hydroxide dosing in animal models overlapped the exposure experienced by humans when the animal model incorporated a genetic predisposition; a child at the age of two receiving 5 aluminum-containing vaccines would be receiving doses that overlap those with animals that reliably and consistently develop autoimmunity at those doses due to the combined genetic and environmental effects.

We also know that there is a genetic risk to many forms of psychosis.  Genetic variation at genes the encode for ion channel protein may increase individual risk for psychotic disorders. Specific variants at the L-type calcium channel locus are known to confer individual (specific) risk of psychosis within at least five neuropsychiatric disorders, including but not limited to schizophrenia and bipolar disorder [1].

A growing scientific and popular literature is pointing to autoimmune psychosis a real phenomenon, and to many people, it seems as if the whole world is going mad.  Social tensions on the rise in the US fomented by divisive political rhetoric has some pointing to a “Political Cold War” [2].

Earlier [3,4] and later [1] reviews list specific genes for which autoimmunological evidence is high.  However, these reviews call the condition “autoimmune encephalitis” or “synaptic autoimmune encephalitides”.  It is no longer useful to euphemize the condition, which should be re-labeled “autoimmune psychosis”.    Psychologists have also noted increase risk of psychosis in non-neuronal autoimmune conditions (such as Type 1 diabetes) [5], and some genetic variation at HLA-region genes are known to also be associated with psychiatric disorders.

It’s one thing to say that vaccines are for “the greater good” and point to belief in protection from herd immunity and not count the cost of vaccine injuries that society can recognize.  But it’s another to pump hundreds of millions of children with aluminum hydroxide against a backdrop of scientific knowledge that tells us that there may in fact be population-wide attendant consequences to the mental wellness of people in general, with some portion of the population doomed to psychosis – with no plan to work towards helping those individuals reverse the immunological dysfunction or remove the accumulated aluminum from their brains and bodies.

The lack of long-term whole health outcome studies on adverse events that may be associated with vaccination is reckless endangerment.  There is no impetus on the established allopathic model for practice and research to conduct studies of the combined role of genes and vaccines on chronic health – including mental health.  To me, that’s criminal negligence, and those who misinform the entire population that vaccines are safe for everyone – when in fact we know that they are not safe for some – do so at unknown risk to public safety.  We all live in the same society, share the same schools, shop at the same malls, eat the same restaurants.  Perhaps there are other risks that we should be more concerned about than having our kids miss a few days of school with historically mild illnesses.

[1] https://www.sciencedirect.com/science/article/pii/S156899721930148X#bb0070

[2] https://thehill.com/homenews/sunday-talk-shows/456111-princeton-professor-we-are-in-a-cold-civil-war

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086677/ 

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718498/

“The discovery of disorders that are associated with antibodies to neuronal cell-surface proteins has led to a paradigm shift in our understanding of CNS autoimmunity. These disorders can occur in patients with or without cancer—often children or young adults who develop psychosis, catatonic or autistic features, memory problems, abnormal movements, or seizures that were previously considered idiopathic”

[5] https://www.sciencedirect.com/science/article/pii/S0006322318316305

Additional Reading

Neuroscience News – Brain on Fire: Puzzling brain disease could now be better diagnosed and treated  https://neurosciencenews.com/brain-on-fire-treatment-14453/

Psychology Today – Autoimmune Disorders Linked to Psychosis https://www.psychologytoday.com/us/blog/finding-new-home/201807/autoimmune-disorders-linked-psychosis

PsychScence – Autoimmune Diseases Masquerading as Psychiatric Disorders- A Paradigm Shift in Psychiatry https://psychscene.com/autoimmunity-in-psychiatry/

AUTISM: MATERNALLY DERIVED ANTIBODIES SPECIFIC FOR FETAL BRAIN PROTEINS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2305723/

Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder 

Weibel et al., 1998. Acute Encephalopathy Followed by Permanent Brain Injury or Death Associated With Further Attenuated Measles Vaccines: A Review of Claims Submitted to the National Vaccine Injury Compensation Program. Pediatrics 101

NB: Maternal antibrain antibodies are more often present in mothers of autistic children than in mothers of typically developing children (Rossi et al., 2013; see Braunschweig et al., 2012, for a review).